P:Nortriptyline

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Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 390
Hot Single Events 99
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nortriptyline. They are ordered first by their pain relevance and then by number of times they were reported for Nortriptyline. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT113685 Binding of Cyp3a23/3a1 and Cyp2c11 1 0.35 0 0.65 99.54
2 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82 99.28
3 INT135364 Prr14 Positive_regulation of Mbd1 1 0.22 0.15 0.64 93.48
4 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64 93.48
5 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64 92.72
6 INT56235 Ifng Positive_regulation of Gene_expression of RT1-EC2 1 0.23 0.33 0.62 87.36
7 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01 73.64
8 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86 72.96
9 INT266811 Binding of HRH1 and HTR2C 1 0.23 2.06 1.4 72.28
10 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51 60.24
11 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1 57.24
12 INT251623 Car2 Regulation of Gene_expression of Fig4 1 0.02 0.31 0.08 33.92
13 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.68
14 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.68
15 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
16 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
17 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77 5.00
18 INT235604 Binding of Htr1a and Htr3a 1 0.01 0 0.74 5.00
19 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
20 INT311470 Binding of Crp and Il1 1 0.00 2.44 0.63 5.00
21 INT311466 Binding of Acsl1 and Il1 1 0.00 2.46 0.63 5.00
22 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00
23 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
24 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
25 INT311467 Binding of Crp and Acsl1 1 0.00 2.31 0.61 5.00
26 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
27 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52 5.00
28 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52 5.00
29 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
30 INT327562 Binding of MCS and AKR1B10 1 0.00 0.5 0.41 5.00
31 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4 5.00
32 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
33 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
34 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
35 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
36 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
37 INT348321 Binding of POMC and ASPM 1 0.02 0.39 0.23 5.00
38 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21 5.00
39 INT202253 Binding of COMT and TCN1 1 0.16 0 0.12 5.00
40 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nortriptyline. They are ordered first by their pain relevance and then by number of times they were reported in Nortriptyline. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT119909 Binding of Abcb1a 10 0.36 0.76 5.07 100.00
2 INT29368 Binding of ECT 25 0.41 11.65 5.81 100.00
3 INT101556 Regulation of Nt5e 5 0.40 2.81 5.2 99.98
4 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.84
5 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 99.84
6 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 99.84
7 INT53388 Negative_regulation of Cyp2c11 18 0.53 2.66 3.11 99.74
8 INT9932 Positive_regulation of Positive_regulation of Trh 13 0.50 1.8 7.63 99.60
9 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 99.44
10 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 99.20
11 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 99.20
12 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 98.86
13 INT251603 Positive_regulation of Transcription of Msn 1 0.41 0.42 0.29 98.74
14 INT251607 Transcription of Msn 1 0.57 0.93 0.46 98.46
15 INT110549 Negative_regulation of CYP2C8 15 0.59 0.54 4.78 98.44
16 INT95797 Positive_regulation of CYP2C8 8 0.50 0.55 1.94 98.44
17 INT80983 Regulation of Abcb1b 16 0.60 1.95 4.32 98.28
18 INT45133 Regulation of Binding of Alb 4 0.45 0.55 1.07 98.20
19 INT93009 Regulation of HBN1 24 0.17 17.6 2.03 98.20
20 INT56233 Gene_expression of RT1-Cl 1 0.18 1.25 2.36 98.16
21 INT56227 Negative_regulation of Gene_expression of RT1-Cl 1 0.13 0.4 0.78 98.16
22 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93 98.10
23 INT56775 Binding of Htr2c 16 0.47 3.77 8.74 97.98
24 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 97.80
25 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 97.28
26 INT425 Localization of PRL 455 0.81 189.64 144.8 97.28
27 INT234 Binding of Alb 151 0.48 52.34 32.97 97.24
28 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 96.64
29 INT11063 Negative_regulation of CES1 16 0.53 6.92 1.11 96.36
30 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 96.12
31 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 96.12
32 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 95.84
33 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 95.68
34 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05 95.52
35 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 95.40
36 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 94.96
37 INT5205 Localization of AR 43 0.80 12.87 4.63 94.60
38 INT81388 Localization of Xpr1 6 0.55 2.26 2.09 94.60
39 INT12412 Binding of MPG 21 0.47 3.92 4.94 94.52
40 INT4822 Localization of Ca2 417 0.80 99.57 96.45 94.40
41 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 94.28
42 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 94.08
43 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 93.92
44 INT13467 Positive_regulation of ABCB1 36 0.68 9.68 8.95 93.60
45 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08 93.60
46 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38 93.56
47 INT135351 Positive_regulation of Mbd1 1 0.63 0.34 1.46 93.48
48 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 93.24
49 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 93.20
50 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 92.96
51 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14 92.84
52 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 92.56
53 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69 92.44
54 INT812 Localization of INS 1026 0.81 515.6 145.31 92.16
55 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 91.72
56 INT91475 Binding of NDOR1 3 0.27 0.61 4.97 91.40
57 INT105746 Regulation of ECT 22 0.39 7.6 7.47 91.24
58 INT18543 Negative_regulation of ECT 20 0.37 8.4 5.25 91.24
59 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17 90.84
60 INT35366 Binding of AR 87 0.47 30.52 8.9 90.80
61 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 90.72
62 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 90.44
63 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 90.28
64 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06 90.08
65 INT113684 Negative_regulation of Gene_expression of Cyp3a23/3a1 5 0.36 2.04 1.71 90.08
66 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16 89.84
67 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 88.76
68 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 88.32
69 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 88.32
70 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 88.20
71 INT113683 Positive_regulation of Negative_regulation of Cyp3a23/3a1 2 0.49 0.48 1.94 88.00
72 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 87.92
73 INT56229 Positive_regulation of Gene_expression of RT1-EC2 3 0.25 2.06 2.06 87.36
74 INT47201 Gene_expression of RT1-EC2 7 0.38 3.15 3.49 87.36
75 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 87.36
76 INT25222 Positive_regulation of Gene_expression of Ifng 32 0.50 24.18 19.58 87.36
77 INT135350 Positive_regulation of Hdac2 2 0.43 0.63 1.03 87.32
78 INT135358 Positive_regulation of Transcription of Hdac2 1 0.43 0.15 0.67 87.32
79 INT135352 Transcription of Hdac2 2 0.59 0.94 0.75 86.96
80 INT56226 Positive_regulation of RT1-EC2 1 0.25 3.6 1.48 86.92
81 INT56232 Regulation of Positive_regulation of RT1-EC2 1 0.22 0.33 0.62 86.92
82 INT36581 Binding of Orm1 6 0.48 0.47 1.73 86.60
83 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19 86.16
84 INT56231 Regulation of Positive_regulation of Ifng 1 0.39 0.33 0.62 86.16
85 INT56225 Positive_regulation of Gene_expression of RT1-Cl 1 0.14 0.4 0.77 86.04
86 INT5186 Regulation of Ifng 11 0.45 8.78 5.9 85.84
87 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 83.88
88 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 83.80
89 INT32007 Gene_expression of ECT 56 0.62 18.94 11.13 83.12
90 INT288087 Regulation of Gene_expression of ECT 1 0.05 0.3 0.7 83.12
91 INT135353 Negative_regulation of LOC680498 2 0.21 0.92 0.75 82.88
92 INT56228 Positive_regulation of Positive_regulation of Ifng 2 0.43 2.83 1.4 82.84
93 INT4012 Negative_regulation of Psd 23 0.52 14.12 3.81 81.00
94 INT165981 Negative_regulation of UGT1A3 1 0.58 0.17 1.79 80.96
95 INT170239 Gene_expression of VARS 12 0.07 2.15 0.47 80.80
96 INT167182 Binding of Psd 9 0.41 13.08 1.06 80.72
97 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 80.60
98 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36 80.16
99 INT135354 Positive_regulation of Binding of Mbd1 1 0.39 0.1 0.36 80.16
100 INT120670 Negative_regulation of Negative_regulation of CYP2C8 1 0.43 0 0.31 79.96
101 INT120669 Negative_regulation of Positive_regulation of CYP2C8 1 0.43 0 0.31 79.96
102 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 79.52
103 INT12369 Negative_regulation of Htr3a 28 0.59 8.78 12.62 79.44
104 INT69564 Binding of Cyp3a23/3a1 11 0.34 4.67 3.2 79.20
105 INT165982 Regulation of UPB1 1 0.33 0.08 0.9 78.60
106 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 78.08
107 INT135357 Binding of Mbd1 1 0.29 0.1 0.35 77.92
108 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 77.84
109 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 77.84
110 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 77.84
111 INT73251 Regulation of UGT2B7 5 0.62 0.21 3.35 77.64
112 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 77.24
113 INT135355 Binding of Mecp2 4 0.37 0.83 1.72 76.88
114 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 76.20
115 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 75.84
116 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 75.72
117 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 75.28
118 INT124144 Negative_regulation of Mors1 21 0.41 2.87 24.71 75.00
119 INT87794 Positive_regulation of Mors1 19 0.38 4.74 20.23 75.00
120 INT40638 Binding of HRH1 14 0.44 5.81 5.09 74.56
121 INT49748 Binding of HTR2C 10 0.47 3.03 4.76 74.36
122 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 74.32
123 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29 74.20
124 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 73.68
125 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 73.52
126 INT147971 Positive_regulation of Negative_regulation of Smpd1 1 0.43 0 0.11 73.52
127 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 73.12
128 INT179686 Regulation of Gene_expression of COPD 10 0.34 14.1 1.52 73.12
129 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18 73.04
130 INT88571 Positive_regulation of Tcas1 4 0.34 2.08 4.42 72.96
131 INT18459 Regulation of Adra2c 6 0.45 0.42 3.4 72.80
132 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47 72.76
133 INT56230 Regulation of RT1-EC2 3 0.13 0.7 1.16 72.48
134 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 72.00
135 INT150867 Regulation of COPD 54 0.48 71.38 8.8 72.00
136 INT262366 Localization of Adh4 1 0.78 1.88 1 71.84
137 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 71.60
138 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18 71.04
139 INT293387 Regulation of Localization of AR 1 0.05 0 0.28 70.76
140 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 70.32
141 INT165899 Gene_expression of TNIP3 1 0.03 0 0.18 70.32
142 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 66.56
143 INT170444 Binding of Gopc 172 0.39 45.05 20.71 64.56
144 INT111112 Negative_regulation of UPB1 2 0.32 0.1 1.68 64.28
145 INT37907 Positive_regulation of Capns1 9 0.41 3.55 4.1 63.76
146 INT251612 Binding of Msn 1 0.31 0.42 1.57 63.44
147 INT128916 Regulation of CES1 5 0.40 2.95 0.29 63.28
148 INT27207 Gene_expression of Psd 31 0.73 15.44 2.75 63.24
149 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 63.16
150 INT91476 Positive_regulation of NDOR1 3 0.50 1.07 1 63.04
151 INT293386 Regulation of Positive_regulation of NDOR1 1 0.03 0 0.33 63.04
152 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 62.88
153 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 62.32
154 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82 61.36
155 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35 61.36
156 INT1218 Negative_regulation of Maob 24 0.59 9.76 9.39 61.20
157 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 60.96
158 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 60.92
159 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97 60.92
160 INT101 Negative_regulation of HRH1 8 0.57 3.48 2.55 60.84
161 INT62702 Negative_regulation of HTR2C 2 0.42 1.14 0.75 60.84
162 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64 60.04
163 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 58.48
164 INT154805 Gene_expression of Polymerase 13 0.16 4.4 0.65 58.44
165 INT189506 Gene_expression of Anxty 32 0.55 45.92 9.11 57.68
166 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03 57.52
167 INT6177 Binding of Htr1a 65 0.47 17.65 30.59 57.24
168 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 56.96
169 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 56.44
170 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 53.76
171 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 52.28
172 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 51.08
173 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 51.08
174 INT246628 Binding of CNNM3 2 0.03 0.69 0.18 47.52
175 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92 47.28
176 INT25745 Regulation of Tspo 6 0.45 0.25 3.1 47.12
177 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 46.72
178 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 46.64
179 INT31780 Binding of DIO2 17 0.36 10.07 10 46.64
180 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 46.08
181 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6 46.00
182 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 45.84
183 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07 45.84
184 INT162 Regulation of Prl 794 0.62 165.01 322.24 45.80
185 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 45.52
186 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 45.36
187 INT235710 Binding of SSR1 2 0.36 0.86 1.75 45.28
188 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 43.44
189 INT95318 Binding of Pain1 17 0.22 21.26 20.14 41.20
190 INT124940 Binding of MTNR1A 8 0.36 2.29 0.9 40.96
191 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57 39.84
192 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75 36.40
193 INT266813 Negative_regulation of CNNM3 1 0.03 0.78 0.14 36.32
194 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 34.32
195 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 34.32
196 INT232448 Positive_regulation of Gene_expression of TRH 1 0.32 0.08 0.17 34.32
197 INT200757 Gene_expression of Fig4 2 0.20 1.27 0.37 33.92
198 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 33.36
199 INT86914 Positive_regulation of Smpd1 11 0.43 4.73 1.74 32.80
200 INT147970 Positive_regulation of Positive_regulation of Smpd1 3 0.43 0.88 0.15 32.80
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