P:Opioid

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pChart

Pain Term
Category Drug class
Synonyms Opioids
Pain Specific Yes
Documents 33486
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Opioid. They are ordered first by their pain relevance and then by number of times they were reported for Opioid. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 100.00
2 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69 100.00
3 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82 100.00
4 INT33314 Binding of Ap1m1 and Ap1m2 1 0.07 0.97 5.42 100.00
5 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 0.05 0.07 1.37 100.00
6 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57 100.00
7 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52 100.00
8 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72 100.00
9 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92 100.00
10 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01 100.00
11 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8 100.00
12 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27 100.00
13 INT88193 Binding of IL2 and IL4 1 0.13 1.7 1.2 100.00
14 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43 100.00
15 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39 100.00
16 INT3434 Vip Positive_regulation of Localization of Prl 6 0.76 0.16 3.21 100.00
17 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48 100.00
18 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15 100.00
19 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55 100.00
20 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1 100.00
21 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01 100.00
22 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95 100.00
23 INT94033 Binding of Adarb1 and SLAMF6 1 0.01 0 1.61 100.00
24 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89 100.00
25 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3 100.00
26 INT105101 Pdyn Regulation of Samd10 1 0.00 0 1.02 100.00
27 INT132154 PSG7 Positive_regulation of Localization of MUC1 1 0.00 0 0.65 100.00
28 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08 100.00
29 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99 100.00
30 INT54844 Negative_regulation of Penk Positive_regulation of Vip 1 0.26 0 1.54 100.00
31 INT122029 Binding of Oprd1 and Positive_regulation of IFNA1 1 0.01 0.4 0.68 100.00
32 INT77330 Oprk1 Regulation of Localization of GRIN1 1 0.24 0 0.91 100.00
33 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25 100.00
34 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25 100.00
35 INT6890 Binding of P9Ehs1 and Opcml 1 0.01 0.14 0.46 100.00
36 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1 100.00
37 INT36597 Hrh1 Regulation of Rtcd1 1 0.04 0.36 1.01 100.00
38 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08 100.00
39 INT142128 Nrgn Regulation of Creb1 1 0.38 0.25 0.89 100.00
40 INT142129 Nrgn Regulation of Camk2a 1 0.48 0.25 0.89 100.00
41 INT29323 Trmt2a Negative_regulation of Binding of Srms 1 0.00 0 0.84 100.00
42 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44 100.00
43 INT33135 Binding of NFKBIL1 and PRL 1 0.09 0.29 1.01 100.00
44 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2 100.00
45 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 0.02 2.15 3.12 100.00
46 INT46972 Amt Positive_regulation of Localization of Prl 1 0.37 0.2 0.91 100.00
47 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68 100.00
48 INT59687 Gene_expression of Opcml Regulation of Binding of Oprd1 1 0.00 0.54 0.62 100.00
49 INT83903 Penk Positive_regulation of Npff 1 0.49 0 1.02 100.00
50 INT50624 Binding of Pebp1 and Opcml 2 0.13 0 0.38 100.00
51 INT66371 Pomc Regulation of Gene_expression of Crh 2 0.49 0 0.88 100.00
52 INT135563 Binding of Gtf3a and Ogfr 1 0.01 0.44 0.37 100.00
53 INT108413 Binding of OPRK1 and Oprd1 1 0.00 0.08 1.04 100.00
54 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09 100.00
55 INT34661 Abat Positive_regulation of Localization of Pomc 1 0.04 0 1.18 100.00
56 INT32484 Gnrhr Regulation of GHRH 1 0.01 0 0.55 100.00
57 INT80792 Prkcg Regulation of Oprd1 1 0.19 0.2 0.86 100.00
58 INT80793 Prkcg Regulation of Pkm2 1 0.29 0.2 0.83 100.00
59 INT55873 Binding of ADRA1D and GNRH1 1 0.08 0 0.54 100.00
60 INT55872 Binding of ADRA1D and CRH 1 0.26 0 0.54 100.00
61 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1 100.00
62 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72 100.00
63 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93 100.00
64 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92 100.00
65 INT60759 Ikbip Regulation of Gene_expression of Oprd1 1 0.01 0 0.52 100.00
66 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84 100.00
67 INT57555 Binding of Oprm1 and Oprl1 2 0.06 0.05 0.97 100.00
68 INT264948 BOC Negative_regulation of FPR1 1 0.13 0.18 0.48 100.00
69 INT264949 BOC Negative_regulation of Localization of FPR1 1 0.13 0.18 0.48 100.00
70 INT264975 BOC Negative_regulation of Localization of Oprd1 1 0.01 0.17 0.48 100.00
71 INT56882 Binding of YY1 and Ppbp 1 0.01 0 1.11 100.00
72 INT69788 Binding of Gpr1 and Pnoc 2 0.09 0 1.49 100.00
73 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27 100.00
74 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08 100.00
75 INT113628 Binding of OPRD1 and RHD 1 0.01 0 0.54 100.00
76 INT25169 GHRH Positive_regulation of Localization of Gh 1 0.12 0 0.29 100.00
77 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98 100.00
78 INT98671 ROS1 Positive_regulation of Gene_expression of Penk 1 0.00 0.52 0.25 100.00
79 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 0.10 0 0.62 100.00
80 INT169612 OGFR Regulation of RAN 1 0.23 0.14 0.3 100.00
81 INT169613 OGFR Regulation of IPO5 1 0.03 0.14 0.29 100.00
82 INT169615 Regulation of OGFR Regulation of IPO5 1 0.03 0.14 0.29 100.00
83 INT74044 GHRH Positive_regulation of Localization of Oprd1 1 0.02 0 0.25 100.00
84 INT51345 Binding of Vtn and Pomc 1 0.03 0 0.2 100.00
85 INT74043 Negative_regulation of Oprd1 Negative_regulation of Localization of GHRH 1 0.02 0 0.25 100.00
86 INT74042 Negative_regulation of Oprd1 Negative_regulation of Localization of GH1 1 0.01 0 0.25 100.00
87 INT95045 Binding of Commd3 and Oprl1 1 0.34 0 1.16 100.00
88 INT31942 Binding of FCGR1A and Oprd1 1 0.00 0 0.62 100.00
89 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47 100.00
90 INT86644 Binding of OPRD1 and DLL1 1 0.28 0.17 0.58 100.00
91 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07 100.00
92 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97 100.00
93 INT62461 Pomc Regulation of Il2 Positive_regulation of Crh 1 0.12 0.13 0.6 100.00
94 INT130157 Pomc Regulation of Gene_expression of Ednrb 1 0.14 0 0.52 100.00
95 INT130158 Pomc Regulation of Gene_expression of Crhr1 1 0.20 0 0.52 100.00
96 INT130163 Pomc Positive_regulation of Gene_expression of Crhr1 1 0.15 0 0.52 100.00
97 INT130161 IgG-2a Positive_regulation of Gene_expression of Crhr1 1 0.01 0 0.52 100.00
98 INT130159 IgG-2a Regulation of Gene_expression of Crhr1 1 0.01 0 0.52 100.00
99 INT110300 Cartpt Regulation of Adarb1 1 0.14 0 0.49 100.00
100 INT70925 Binding of Ifng and Il4 2 0.14 0.9 0.5 100.00
101 INT70924 Binding of Il2 and Il4 1 0.07 0.34 0.36 100.00
102 INT163572 Pomc Positive_regulation of Oprm1 1 0.06 0.1 0.37 100.00
103 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41 100.00
104 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31 100.00
105 INT19819 Penk Regulation of Gene_expression of Ins1 1 0.05 0 1.27 100.00
106 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96 100.00
107 INT56431 Vta1 Regulation of Regulation of Oprl1 1 0.07 0 0.89 100.00
108 INT59443 Oprd1 Positive_regulation of Gtf3a 1 0.06 0 0.39 100.00
109 INT94034 SLAMF6 Regulation of Binding of Adarb1 and SLAMF6 1 0.00 0 0.39 100.00
110 INT136821 Binding of CALCRL and OGFR 1 0.02 0.36 0.38 100.00
111 INT109454 Binding of PENK and OGFR 1 0.22 0.07 0.37 100.00
112 INT110134 Tlr4 Regulation of Regulation of Gnrh1 1 0.01 0.15 0.33 100.00
113 INT85909 Binding of Oprm1 and GREM1 1 0.00 0 0.32 100.00
114 INT132170 PSG7 Positive_regulation of Positive_regulation of Oprd1 1 0.00 0 0.26 100.00
115 INT127948 Binding of Ogfr and Gtf3a 1 0.04 0 0.17 100.00
116 INT127734 Binding of Insrr and Ogfr 1 0.01 0.35 0.17 100.00
117 INT42608 Pomc Positive_regulation of Oprd1 1 0.27 0 0.17 100.00
118 INT60448 NPY Positive_regulation of Gnrhr 1 0.01 0 0.29 100.00
119 INT60449 GAL Positive_regulation of Gnrhr 1 0.00 0 0.29 100.00
120 INT54344 Oprk1 Regulation of Prl 1 0.22 0 0.33 100.00
121 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58 100.00
122 INT94205 TACR1 Regulation of Gene_expression of SP5 1 0.04 0.72 1.06 100.00
123 INT58807 Pomc Negative_regulation of Localization of LH 2 0.06 0 1.02 100.00
124 INT117404 Binding of Pnoc and OR4F4 1 0.00 0.46 0.86 100.00
125 INT97913 NCOR2 Regulation of ABAT 1 0.00 0 0.85 100.00
126 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77 100.00
127 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76 100.00
128 INT81011 CNR1 Positive_regulation of Gene_expression of PENK 1 0.54 0 0.75 100.00
129 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 100.00
130 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64 100.00
131 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61 100.00
132 INT126951 PNOC Positive_regulation of OPRM1 1 0.21 0.06 0.6 100.00
133 INT63525 Cpe Positive_regulation of Gpi1 1 0.03 0 0.59 100.00
134 INT50434 Binding of Oprm1 and Mop3 1 0.00 0 0.58 100.00
135 INT62035 PDYN Regulation of Gene_expression of IGHE 1 0.33 0 0.57 100.00
136 INT58806 Qrfp Negative_regulation of Localization of LH 1 0.04 0 0.57 100.00
137 INT31861 Cd79b Regulation of Sst 1 0.49 0.31 0.56 100.00
138 INT122427 Ighm Positive_regulation of Positive_regulation of P9Ehs1 1 0.00 0 0.56 100.00
139 INT31862 Pdyn Regulation of Sst 1 0.45 0.31 0.56 100.00
140 INT21568 Oprk1 Regulation of Localization of Pomc 1 0.18 0 0.55 100.00
141 INT21567 Oprk1 Regulation of Pomc 1 0.18 0 0.55 100.00
142 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53 100.00
143 INT126654 Oprd1 Regulation of Oprm1 1 0.03 0.13 0.52 100.00
144 INT26009 Cck Negative_regulation of Positive_regulation of Cckbr 1 0.26 0 0.47 100.00
145 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41 100.00
146 INT82848 Binding of Gal and Pag1 1 0.23 0.71 0.41 100.00
147 INT67445 Oprd1 Regulation of Localization of POMC 1 0.00 0 0.39 100.00
148 INT56867 Binding of Rbm39 and Gm9007 1 0.00 0 0.37 100.00
149 INT56868 Binding of Rbm39 and Nle1 1 0.00 0 0.37 100.00
150 INT31213 Gnrh1 Positive_regulation of Localization of Pdyn 1 0.07 0 0.37 100.00
151 INT56866 Binding of Cck and Rbm39 1 0.02 0 0.37 100.00
152 INT67443 Oprd1 Regulation of Ugt1a10 1 0.00 0 0.36 100.00
153 INT26669 Nanog Regulation of Binding of Tlyr1 1 0.02 0 0.28 100.00
154 INT65507 Oprl1 Positive_regulation of Gene_expression of Pomc 1 0.28 0 0.26 100.00
155 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24 100.00
156 INT150582 Creb1 Positive_regulation of Gene_expression of Homer1 1 0.00 0 0.22 100.00
157 INT85687 Binding of SGCG and GPR50 1 0.40 0 0.2 100.00
158 INT104830 IGKV2OR2-1 Regulation of Gene_expression of IL10 1 0.00 0 0.15 100.00
159 INT77816 Binding of HOAC and Pnoc 1 0.07 0 0.15 100.00
160 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13 100.00
161 INT153637 Gene_expression of REST Positive_regulation of Gene_expression of Oprm1 1 0.03 0.08 0.1 100.00
162 INT226708 Oprd1 Positive_regulation of Tsg101 1 0.00 0.3 0.1 100.00
163 INT226709 Oprd1 Positive_regulation of Vps28 1 0.00 0.3 0.1 100.00
164 INT51342 Binding of Pomc and Vtn 1 0.23 0 0.1 100.00
165 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1 100.00
166 INT51344 Binding of Clu and Vtn 1 0.06 0 0.1 100.00
167 INT54502 Pomc Positive_regulation of Gene_expression of Il2 1 0.16 0 0.68 99.98
168 INT54504 Pomc Positive_regulation of Gene_expression of Il4 1 0.13 0 0.34 99.98
169 INT5534 Binding of Oxt and Avp 7 0.04 0.6 1.43 99.98
170 INT34980 Regulation of Trh Positive_regulation of Localization of Prl 1 0.50 0 0.49 99.98
171 INT9290 Pomc Regulation of Prl 2 0.09 0.69 0.71 99.98
172 INT43712 Pomc Regulation of LH 1 0.09 0 0.23 99.98
173 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6 99.98
174 INT166863 Kcnj9 Regulation of Kcnj6 1 0.20 0 0.56 99.96
175 INT109803 Binding of Avp and Oprl1 1 0.07 0.1 0.59 99.96
176 INT109802 Binding of Esr2 and Oprl1 1 0.22 0.1 0.59 99.96
177 INT64756 oh Negative_regulation of Gpi1 1 0.03 0 4.09 99.92
178 INT64759 oh Positive_regulation of oh Negative_regulation of Gpi1 1 0.01 0 1.01 99.92
179 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19 99.92
180 INT64892 ANTXR1 Regulation of Gtpbp4 1 0.00 0.47 0.28 99.92
181 INT113241 TRAF3IP2 Regulation of Transcription of OPRM1 1 0.05 0.82 0.52 99.92
182 INT101966 Pnoc Positive_regulation of Kcnj9 1 0.14 0.26 0.46 99.92
183 INT71089 Binding of HTR1A and Pnoc 1 0.01 0 0.35 99.92
184 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 0.31 0.07 0.8 99.90
185 INT108438 Grin2b Regulation of Pdyn 1 0.16 0.25 0.9 99.90
186 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41 99.90
187 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47 99.84
188 INT19702 hpc Regulation of Localization of LH 1 0.09 0.35 2.08 99.84
189 INT29366 Mnt Positive_regulation of Localization of Penk 1 0.01 0 0.96 99.84
190 INT8331 OPRD1 Regulation of Localization of GHRH 1 0.18 0.18 0.37 99.84
191 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39 99.82
192 INT31466 Binding of SGCG and CALCRL 1 0.02 0 0.23 99.82
193 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91 99.82
194 INT44342 Penk Negative_regulation of St6galnac2 1 0.00 0.13 0.37 99.82
195 INT44339 Penk Negative_regulation of Abo 1 0.02 0.13 0.37 99.82
196 INT32442 POMC Positive_regulation of POMC Positive_regulation of ELANE 1 0.15 0.18 1.66 99.80
197 INT95402 Mapk14 Regulation of Positive_regulation of Trib3 1 0.06 0.19 0.41 99.80
198 INT40239 Penk Regulation of Avp 1 0.07 0 1.84 99.80
199 INT40238 Penk Regulation of Oxt 1 0.04 0 1.83 99.80
200 INT140312 Oprm1 Regulation of Gene_expression of Penk 1 0.07 0.26 0.77 99.80

Single Events

The table below shows the top 200 pain related interactions that have been reported for Opioid. They are ordered first by their pain relevance and then by number of times they were reported in Opioid. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT158 Localization of Prl 2431 0.81 378.96 952.2 100.00
2 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 100.00
3 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 100.00
4 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 100.00
5 INT1045 Localization of LH 1211 0.81 87.04 456.25 100.00
6 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 100.00
7 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 100.00
8 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 100.00
9 INT292 Localization of Penk 876 0.81 88.44 669.14 100.00
10 INT3579 Localization of Oxt 555 0.81 43.35 292.44 100.00
11 INT443 Localization of POMC 1020 0.81 284.52 443.17 100.00
12 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
13 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 100.00
14 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 100.00
15 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 100.00
16 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
17 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 100.00
18 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 100.00
19 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 100.00
20 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 100.00
21 INT477 Localization of Avp 813 0.81 131.58 300.4 100.00
22 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 100.00
23 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
24 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 100.00
25 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 100.00
26 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
27 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 100.00
28 INT1308 Localization of Pomc 457 0.81 66.83 217.5 100.00
29 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 100.00
30 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 100.00
31 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 100.00
32 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 100.00
33 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 100.00
34 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
35 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 100.00
36 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 100.00
37 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
38 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 100.00
39 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 100.00
40 INT1562 Localization of Crh 499 0.81 126.74 236.68 100.00
41 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 100.00
42 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 100.00
43 INT287 Localization of Cck 518 0.81 86.84 364.04 100.00
44 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 100.00
45 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 100.00
46 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 100.00
47 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 100.00
48 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 100.00
49 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 100.00
50 INT2893 Localization of Oxt 219 0.80 28.96 79.43 100.00
51 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 100.00
52 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 100.00
53 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 100.00
54 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 100.00
55 INT6437 Binding of YY1 154 0.47 26.3 90.46 100.00
56 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 100.00
57 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 100.00
58 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 100.00
59 INT2366 Binding of Cck 192 0.48 30.64 163.46 100.00
60 INT4803 Transcription of Penk 435 0.72 59.09 182.4 100.00
61 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 100.00
62 INT1396 Binding of Penk 355 0.48 22.79 269.65 100.00
63 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 100.00
64 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 100.00
65 INT2379 Positive_regulation of Localization of LH 349 0.70 27.86 144.53 100.00
66 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 100.00
67 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 100.00
68 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 100.00
69 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 100.00
70 INT695 Binding of POMC 304 0.48 56.66 126.85 100.00
71 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 100.00
72 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 100.00
73 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 100.00
74 INT1438 Localization of Pomc 360 0.81 101.26 116.47 100.00
75 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 100.00
76 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7 100.00
77 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 100.00
78 INT114 Binding of Oprl1 139 0.48 23 103.35 100.00
79 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23 100.00
80 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 100.00
81 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 100.00
82 INT416 Regulation of LH 253 0.62 31.48 125.55 100.00
83 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12 100.00
84 INT1463 Binding of Pomc 129 0.48 15.89 56.27 100.00
85 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 100.00
86 INT7468 Negative_regulation of Localization of Oxt 109 0.59 9.46 66.79 100.00
87 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 100.00
88 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
89 INT847 Regulation of Lhb 131 0.61 22.08 46.54 100.00
90 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63 100.00
91 INT3948 Regulation of Cck 291 0.62 58.07 255.88 100.00
92 INT403 Localization of Trh 241 0.81 28.55 81.45 100.00
93 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 100.00
94 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 100.00
95 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 100.00
96 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 100.00
97 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 100.00
98 INT6299 Regulation of Localization of Lhb 104 0.61 8.98 48.79 100.00
99 INT62464 Gene_expression of Ogfr 21 0.78 20.39 10.82 100.00
100 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48 100.00
101 INT6826 Transcription of Pdyn 130 0.71 22.19 54.88 100.00
102 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 100.00
103 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 100.00
104 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
105 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 100.00
106 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 100.00
107 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 100.00
108 INT63701 Localization of KRIT1 11 0.78 2.02 9.17 100.00
109 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27 100.00
110 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 100.00
111 INT2148 Negative_regulation of Oxt 105 0.59 11.42 57 100.00
112 INT4153 Binding of Insrr 109 0.40 17.99 72.15 100.00
113 INT451 Regulation of Oxt 142 0.62 22.07 69.42 100.00
114 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23 100.00
115 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 100.00
116 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18 100.00
117 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71 100.00
118 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 100.00
119 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 100.00
120 INT53983 Gene_expression of Opcml 30 0.78 10.35 9.69 100.00
121 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 100.00
122 INT16033 Gene_expression of Ogfr 27 0.73 4.15 13.05 100.00
123 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13 100.00
124 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 100.00
125 INT1510 Binding of PDYN 94 0.48 4.68 56.44 100.00
126 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 100.00
127 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7 100.00
128 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 100.00
129 INT12717 Binding of Pck1 85 0.47 12.49 54.81 100.00
130 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 100.00
131 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78 100.00
132 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 100.00
133 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 100.00
134 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73 100.00
135 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 100.00
136 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38 100.00
137 INT1295 Binding of Pomc 85 0.48 12.92 42.8 100.00
138 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97 100.00
139 INT24780 Binding of Ap1m1 20 0.29 4.75 25.05 100.00
140 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83 100.00
141 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 100.00
142 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 100.00
143 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57 100.00
144 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34 100.00
145 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97 100.00
146 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81 100.00
147 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75 100.00
148 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42 100.00
149 INT442 Localization of PDYN 99 0.81 11.87 72.75 100.00
150 INT1898 Regulation of Crh 220 0.62 61.33 102.64 100.00
151 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91 100.00
152 INT114993 Binding of Myo5a 15 0.30 11.46 5.48 100.00
153 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86 100.00
154 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 100.00
155 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 100.00
156 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 100.00
157 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 100.00
158 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52 100.00
159 INT1530 Regulation of Gh 382 0.61 115.96 112.47 100.00
160 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 100.00
161 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84 100.00
162 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65 100.00
163 INT5771 Binding of Oprd1 37 0.48 2.6 27.54 100.00
164 INT30245 Binding of Pdyn 26 0.37 2.31 17 100.00
165 INT5454 Localization of CRH 124 0.79 79.18 41.53 100.00
166 INT10799 Localization of ENG 63 0.78 18.67 27.28 100.00
167 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22 100.00
168 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 100.00
169 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 100.00
170 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 100.00
171 INT135558 Positive_regulation of Gene_expression of Ogfr 10 0.70 17.13 4.6 100.00
172 INT6934 Binding of OPRD1 51 0.48 7.72 25.73 100.00
173 INT29812 Binding of Ap1m2 14 0.33 3.66 14.55 100.00
174 INT462 Regulation of Pomc 157 0.62 41.67 67.27 100.00
175 INT14137 Localization of Oprm1 56 0.81 2.88 36.09 100.00
176 INT7565 Transcription of Pomc 69 0.72 14.46 27.41 100.00
177 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31 100.00
178 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 100.00
179 INT21294 Gene_expression of OGFR 32 0.78 5.75 6.41 100.00
180 INT66532 Positive_regulation of Pnoc 46 0.70 14.99 41.39 100.00
181 INT1005 Localization of Sst 385 0.81 26.31 244.56 100.00
182 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 100.00
183 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95 100.00
184 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 100.00
185 INT55537 Positive_regulation of Coq10a 22 0.58 8.17 8.33 100.00
186 INT1160 Positive_regulation of Rbm39 122 0.57 28.19 90.28 100.00
187 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 100.00
188 INT2649 Regulation of Calca 433 0.62 146.05 330.95 100.00
189 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 100.00
190 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 100.00
191 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9 100.00
192 INT691 Binding of SST 67 0.48 24.66 32.67 100.00
193 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 100.00
194 INT87268 Positive_regulation of BMP8B 5 0.19 0.53 4.6 100.00
195 INT50810 Negative_regulation of Opcml 6 0.51 3.13 5.81 100.00
196 INT12471 Regulation of Insrr 52 0.35 17.8 48.31 100.00
197 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 100.00
198 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 100.00
199 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79 100.00
200 INT108989 Gene_expression of Negr1 1 0.26 4.22 6.27 100.00
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