P:Osteoarthritis

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Pain Term
Category Disorder
Synonyms None
Pain Specific No
Documents 7962
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteoarthritis. They are ordered first by their pain relevance and then by number of times they were reported for Osteoarthritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18 100.00
2 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2 100.00
3 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35 100.00
4 INT322201 Binding of OAP and SLC34A1 1 0.01 1.49 0.77 100.00
5 INT247469 RCT Regulation of OAP 1 0.02 1.8 1.19 100.00
6 INT209923 IL17A Negative_regulation of PPARA 1 0.14 2.46 0.99 100.00
7 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87 100.00
8 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17 100.00
9 INT174451 Trav6-3 Regulation of Transcription of Cxcr3 1 0.06 1.86 1 100.00
10 INT323774 Binding of Il6 and OPA6 1 0.01 0.85 0.37 100.00
11 INT203166 Negative_regulation of CPOX Positive_regulation of Gene_expression of LTB4R 1 0.00 0.65 0.34 100.00
12 INT171250 Binding of BMI1 and OAP 1 0.13 1.02 0.22 100.00
13 INT225787 Ppi-rs Positive_regulation of Gene_expression of Ank 1 0.06 1.44 0.19 100.00
14 INT311923 OAP Positive_regulation of Gtf3a 1 0.00 0.7 0.19 100.00
15 INT346230 IL1B Positive_regulation of Binding of RUNX2 1 0.17 0.38 0.19 100.00
16 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77 100.00
17 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77 100.00
18 INT220191 Binding of COL2A1 and PTGER2 1 0.22 0.35 0.18 100.00
19 INT275319 Tg(Ngf)47Kma Positive_regulation of Gpr143 1 0.00 0.59 0.17 100.00
20 INT275318 Binding of Gpr143 and Adamts4 1 0.00 0.6 0.17 100.00
21 INT275317 Binding of Gpr143 and Adamts5 1 0.01 0.61 0.17 100.00
22 INT248310 Crx Regulation of MATN3 1 0.07 0.65 0.45 100.00
23 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7 100.00
24 INT172149 IL17A Positive_regulation of Gene_expression of IL1B 1 0.01 0.5 0.43 100.00
25 INT172138 IL17A Positive_regulation of Gene_expression of TNF 1 0.07 0.5 0.43 100.00
26 INT307675 Binding of IL1R1 and SNRNP70 1 0.02 1.05 0.45 99.92
27 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05 99.92
28 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32 99.88
29 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32 99.88
30 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69 99.84
31 INT251015 OLR1 Regulation of Protein_catabolism of MMP3 1 0.03 0.91 0.4 99.84
32 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31 99.84
33 INT203163 LTB4R Regulation of Gene_expression of ALOX5 1 0.00 0.98 0.41 99.80
34 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77 99.80
35 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65 99.74
36 INT207466 LGALS3 Positive_regulation of Gene_expression of ADAMTS5 1 0.15 0.88 0.51 99.72
37 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15 99.70
38 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05 99.70
39 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31 99.68
40 INT97198 MSD Positive_regulation of MSD Negative_regulation of SGCG 1 0.00 0.36 0.32 99.68
41 INT178576 CNTN2 Positive_regulation of DPYD 1 0.05 2.18 0.76 99.66
42 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75 99.66
43 INT178577 CNTN2 Positive_regulation of IL2RA 1 0.03 2.16 0.75 99.66
44 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75 99.66
45 INT178575 CNTN2 Positive_regulation of PTHLH Positive_regulation of Positive_regulation of PTHLH 1 0.26 2.16 0.75 99.66
46 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29 99.64
47 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6 99.64
48 INT207461 LGALS3 Positive_regulation of Gene_expression of MMP3 1 0.18 0.48 0.21 99.62
49 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97 99.60
50 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77 99.60
51 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63 99.60
52 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66 99.60
53 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44 99.60
54 INT227903 TNF Positive_regulation of Gene_expression of ADAMTS5 1 0.01 0.56 0.24 99.60
55 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32 99.60
56 INT207465 LGALS3 Regulation of MMP3 1 0.16 0.26 0.22 99.60
57 INT220189 Binding of COL2A1 and TIMP1 1 0.04 0.1 0.05 99.60
58 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5 99.56
59 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38 99.56
60 INT220213 Mmp13 Regulation of Protein_catabolism of COL2A1 1 0.49 0.29 0.14 99.56
61 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62 99.52
62 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14 99.48
63 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93 99.48
64 INT346232 PREP Negative_regulation of Binding of IL1B 1 0.04 0.47 0.23 99.36
65 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64 99.36
66 INT312099 ELANE Positive_regulation of Gene_expression of PTGER2 1 0.02 0.64 0.32 99.32
67 INT220195 PTGER2 Negative_regulation of Localization of COL2A1 1 0.26 0.51 0.09 99.32
68 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23 99.28
69 INT346229 PREP Positive_regulation of MAPK14 1 0.13 0.63 0.34 99.26
70 INT207464 LGALS3 Regulation of ADAMTS5 1 0.19 0.26 0.21 99.20
71 INT97197 MSD Negative_regulation of SGCG 1 0.02 0.36 0.32 99.20
72 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 99.18
73 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87 99.12
74 INT346235 IL1B Positive_regulation of Gene_expression of MAPK14 1 0.15 0.64 0.32 99.12
75 INT160399 Tns3 Regulation of Casr 1 0.30 0.1 0.22 99.08
76 INT160402 Tns3 Regulation of Positive_regulation of Casr 1 0.30 0.1 0.22 99.08
77 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02 99.02
78 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64 99.00
79 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38 99.00
80 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37 99.00
81 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36 99.00
82 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33 99.00
83 INT275320 Binding of Adamts5 and Adamts4 1 0.02 0.6 0.17 99.00
84 INT245313 Negative_regulation of Binding of MMP2 and TIMP1 1 0.01 0.45 0.11 98.92
85 INT196523 Binding of MMP2 and TIMP1 3 0.43 1.94 0.85 98.92
86 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69 98.88
87 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23 98.88
88 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94 98.80
89 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05 98.80
90 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23 98.80
91 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64 98.76
92 INT312089 LTB4R Positive_regulation of ALOX5AP 1 0.01 0.32 0.16 98.74
93 INT312095 LTB4R Positive_regulation of ALOX5 1 0.01 0.32 0.16 98.74
94 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68 98.72
95 INT209922 IL1B Positive_regulation of Gene_expression of NOS1 1 0.06 0.41 0.12 98.72
96 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1 98.60
97 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69 98.60
98 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69 98.60
99 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69 98.60
100 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67 98.60
101 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3 98.48
102 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3 98.48
103 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31 98.48
104 INT231713 Binding of SUGT1 and GPR174 1 0.00 0.82 0.47 98.48
105 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49 98.40
106 INT203177 Negative_regulation of CPOX Positive_regulation of Gene_expression of Lts1 1 0.00 0.72 0.46 98.32
107 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96 98.28
108 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1 98.28
109 INT224420 Regulation of Binding of NFKB2 and TNFRSF11B 1 0.13 1.39 0.6 98.20
110 INT224419 Binding of NFKB2 and TNFRSF11B 1 0.11 1.37 0.6 98.20
111 INT231715 GAGE2C Regulation of Localization of IL6 1 0.01 0.58 0.33 98.16
112 INT231714 GPR174 Regulation of Localization of IL6 1 0.01 0.58 0.33 98.16
113 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22 98.16
114 INT182303 Positive_regulation of Prkaca Positive_regulation of EDN1 Positive_regulation of NOS2 1 0.01 0.27 0.15 98.16
115 INT250878 Il1a Positive_regulation of Fgf8 Positive_regulation of Ecm1 1 0.01 0.85 0.38 97.96
116 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38 97.96
117 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39 97.96
118 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38 97.96
119 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38 97.96
120 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37 97.92
121 INT278938 MAPK14 Positive_regulation of Gene_expression of PRKCA 1 0.05 0.65 0.37 97.92
122 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36 97.92
123 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74 97.88
124 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12 97.76
125 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57 97.76
126 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38 97.64
127 INT312091 ALOX5AP Regulation of Transcription of ALOX5 1 0.13 0.37 0.18 97.60
128 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 97.56
129 INT278971 IL1B Positive_regulation of Gene_expression of NOS2 1 0.14 0.79 0.27 97.56
130 INT187176 Binding of BSG and MMP1 1 0.09 1.18 1.08 97.56
131 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 97.52
132 INT182244 EDN1 Positive_regulation of EDN1 Positive_regulation of NOS2 1 0.25 0.29 0.07 97.40
133 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33 97.36
134 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33 97.36
135 INT323886 BMI1 Regulation of Gene_expression of MMP13 1 0.01 1.13 0.12 97.36
136 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09 97.36
137 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34 97.28
138 INT134302 Cpox Negative_regulation of PTGS2 Negative_regulation of Gene_expression of Ptger2 1 0.00 0.78 0.34 97.28
139 INT240065 KCNIP3 Regulation of Transcription of PDYN 1 0.42 0.88 0.67 97.24
140 INT203165 Binding of IL10 and PTGER2 1 0.01 0.5 0.25 97.20
141 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29 97.20
142 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29 97.20
143 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39 97.16
144 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61 97.08
145 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59 97.08
146 INT171990 Binding of DMD and VDR 5 0.05 2.58 0.39 96.88
147 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45 96.80
148 INT220197 PTGER2 Negative_regulation of TIMP1 1 0.03 0.23 0.12 96.80
149 INT194914 Mtx1 Regulation of Gene_expression of Nfasc 1 0.00 0.71 0.58 96.76
150 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95 96.68
151 INT346304 Col2a1 Positive_regulation of Localization of PTGER2 1 0.00 0.18 0.09 96.64
152 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44 96.60
153 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28 96.60
154 INT266396 Binding of Ager and S100a4 1 0.01 0.59 0.1 96.60
155 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76 96.56
156 INT134301 Cpox Negative_regulation of Gene_expression of Ptger2 1 0.00 0.77 0.34 96.56
157 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77 96.40
158 INT278947 PTGER2 Regulation of Gene_expression of IL8 1 0.04 0.32 0.16 96.16
159 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21 96.04
160 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17 95.80
161 INT312096 ELANE Positive_regulation of Transcription of ALOX5 1 0.06 0.27 0.13 95.76
162 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15 95.60
163 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26 95.48
164 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25 95.48
165 INT203169 CPOX Regulation of Gene_expression of PTGER2 2 0.00 0.48 0.29 95.40
166 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35 95.40
167 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35 95.40
168 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35 95.36
169 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19 95.28
170 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19 95.28
171 INT346145 Binding of ADM and TPX2 1 0.01 1.05 0.35 95.24
172 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14 95.20
173 INT231712 GAGE2C Regulation of Transcription of IL6 1 0.01 1.01 0.57 95.16
174 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54 95.12
175 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26 95.08
176 INT346133 RAMP2 Regulation of ADM 1 0.13 2.06 0.78 95.08
177 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4 94.92
178 INT333927 GLUL Positive_regulation of HSPA5 1 0.17 0.78 0.24 94.92
179 INT231711 GPR174 Regulation of Transcription of IL6 1 0.01 0.96 0.54 94.72
180 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 94.72
181 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23 94.72
182 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 94.40
183 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05 94.32
184 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3 94.24
185 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05 94.24
186 INT328223 Mmp14 Regulation of Positive_regulation of Mmp13 1 0.07 0.69 0.29 94.24
187 INT264524 PTGDS Negative_regulation of Gene_expression of MMP1 1 0.09 0.5 0.22 94.16
188 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22 94.16
189 INT264517 PTGDS Positive_regulation of TFDP1 1 0.17 0.5 0.22 94.16
190 INT264516 PTGDS Positive_regulation of TFDP1 Negative_regulation of Gene_expression of MMP1 1 0.02 0.5 0.22 94.16
191 INT264519 PTGDS Negative_regulation of Positive_regulation of TFDP1 1 0.15 0.5 0.22 94.16
192 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17 93.92
193 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43 93.88
194 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43 93.88
195 INT278952 MST1 Regulation of Gene_expression of PTGER2 1 0.00 0.41 0.25 93.84
196 INT278954 MST1 Regulation of Gene_expression of NOS2 1 0.01 0.41 0.25 93.84
197 INT278967 MST1 Regulation of Gene_expression of CPOX 1 0.00 0.41 0.25 93.84
198 INT278941 MST1 Regulation of Gene_expression of IL8 1 0.01 0.4 0.25 93.84
199 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73 93.84
200 INT225785 Enpp3 Regulation of Ppi-rs 1 0.00 0.69 0.11 93.84

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteoarthritis. They are ordered first by their pain relevance and then by number of times they were reported in Osteoarthritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 100.00
2 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 100.00
3 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 100.00
4 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 100.00
5 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 100.00
6 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 100.00
7 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 100.00
8 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 100.00
9 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 100.00
10 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22 100.00
11 INT49437 Gene_expression of OAP 25 0.54 20.12 7.34 100.00
12 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 100.00
13 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 100.00
14 INT6484 Binding of IL1B 122 0.47 75.84 35.07 100.00
15 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42 100.00
16 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 100.00
17 INT195415 Regulation of Gene_expression of ALOX5AP 10 0.45 6.43 3.13 100.00
18 INT18639 Positive_regulation of OAP 16 0.69 10.49 4.57 100.00
19 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 100.00
20 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65 100.00
21 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 100.00
22 INT117924 Gene_expression of MAP2K3 2 0.72 5.82 2.32 100.00
23 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
24 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 100.00
25 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13 100.00
26 INT82829 Gene_expression of COMP 104 0.78 57 9.81 100.00
27 INT171254 Binding of OAP 7 0.39 8.04 3.42 100.00
28 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23 100.00
29 INT85015 Gene_expression of ADM 29 0.73 30.75 10.21 100.00
30 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 100.00
31 INT91338 Binding of Lep 31 0.48 26.86 5.39 100.00
32 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 100.00
33 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 100.00
34 INT181596 Binding of IL1R1 9 0.36 7.99 4.32 100.00
35 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11 100.00
36 INT231737 Localization of OAP 5 0.50 7.4 2.63 100.00
37 INT86437 Binding of IL6 154 0.48 121.22 29.3 100.00
38 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 100.00
39 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 100.00
40 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 100.00
41 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71 100.00
42 INT178604 Gene_expression of TPX2 13 0.37 20.29 6.04 100.00
43 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 100.00
44 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 100.00
45 INT138772 Binding of Koa 2 0.31 4.06 2.76 100.00
46 INT18636 Negative_regulation of OAP 9 0.37 5.05 2.13 100.00
47 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 100.00
48 INT209893 Positive_regulation of Gene_expression of TNFRSF11B 31 0.68 11.77 4.8 100.00
49 INT10100 Binding of ELANE 22 0.47 15.32 5.19 100.00
50 INT174427 Positive_regulation of Gene_expression of Cxcr3 8 0.66 10.7 4.66 100.00
51 INT194957 Binding of ASPN 5 0.27 2.95 1.09 100.00
52 INT181859 Positive_regulation of Gene_expression of HYAL2 1 0.25 4.99 2.45 100.00
53 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 100.00
54 INT180163 Positive_regulation of Nfasc 49 0.40 31.96 9.41 100.00
55 INT324529 Negative_regulation of Binding of PREP 1 0.37 2.48 1.05 100.00
56 INT185502 Binding of PREP 6 0.37 4.04 1.09 100.00
57 INT2250 Binding of REG3A 3 0.47 3.58 1.33 100.00
58 INT182295 Regulation of MMP13 6 0.27 3.33 1.77 100.00
59 INT135234 Regulation of ETFDH 13 0.29 10.8 3.4 100.00
60 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 100.00
61 INT307684 Binding of IL1RL2 1 0.30 2.39 1.01 100.00
62 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 100.00
63 INT118095 Regulation of COMP 7 0.43 9.69 3.33 100.00
64 INT192268 Regulation of Gene_expression of Lts1 6 0.06 3.78 1.49 100.00
65 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16 100.00
66 INT346246 Positive_regulation of Gene_expression of MAP2K6 1 0.45 1.74 0.78 100.00
67 INT346248 Positive_regulation of Gene_expression of MAP2K3 1 0.47 1.73 0.78 100.00
68 INT178606 Positive_regulation of Gene_expression of TPX2 4 0.08 8.73 2.71 100.00
69 INT37296 Binding of Esr1 117 0.43 62.51 27.33 100.00
70 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 100.00
71 INT250048 Positive_regulation of Gpr143 12 0.43 5.85 6.1 100.00
72 INT1168 Binding of PROC 62 0.38 44.15 9.04 100.00
73 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 100.00
74 INT202008 Binding of OPA6 2 0.35 1.98 1.11 100.00
75 INT162258 Negative_regulation of Gene_expression of COMP 35 0.58 19.14 3.55 100.00
76 INT297414 Localization of Koa 1 0.20 3 2.08 100.00
77 INT145235 Protein_catabolism of Mmp13 3 0.89 2.46 2.03 100.00
78 INT297413 Gene_expression of Koa 2 0.22 1.88 1.37 100.00
79 INT352919 Positive_regulation of Gene_expression of RHOB 1 0.35 2.21 0.96 100.00
80 INT202050 Gene_expression of URB1 1 0.07 5.64 3.81 100.00
81 INT324530 Positive_regulation of Gene_expression of PREP 2 0.44 1.45 0.58 100.00
82 INT59900 Binding of MATN3 13 0.42 17.19 3.59 100.00
83 INT76573 Negative_regulation of Vcam1 26 0.58 24.36 9.84 100.00
84 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 100.00
85 INT248309 Positive_regulation of Binding of MATN3 1 0.08 1.81 1.11 100.00
86 INT59899 Regulation of MATN3 4 0.45 7.61 1.6 100.00
87 INT169023 Positive_regulation of MATN3 2 0.43 3.67 1.23 100.00
88 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73 100.00
89 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1 100.00
90 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 100.00
91 INT279122 Regulation of Gene_expression of COMP 3 0.39 8.82 3.19 100.00
92 INT39867 Binding of Col2a1 9 0.35 7.65 3.18 100.00
93 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85 100.00
94 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 100.00
95 INT63553 Binding of PAG1 14 0.48 12.51 14.76 100.00
96 INT346258 Negative_regulation of Gene_expression of MAP2K6 1 0.38 1.08 0.45 100.00
97 INT346251 Negative_regulation of Gene_expression of MAP2K3 1 0.40 1.08 0.45 100.00
98 INT250880 Gene_expression of st 1 0.01 3.25 1.63 100.00
99 INT311921 Negative_regulation of Gene_expression of OAP 1 0.02 0.94 0.69 100.00
100 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 100.00
101 INT224483 Regulation of Regulation of MMP13 2 0.15 1.16 0.86 100.00
102 INT311920 Regulation of Gene_expression of OAP 1 0.02 0.92 0.67 100.00
103 INT36173 Positive_regulation of Gs 17 0.43 7.48 8.19 100.00
104 INT311922 Protein_catabolism of OAP 1 0.03 1.06 0.55 100.00
105 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91 100.00
106 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 100.00
107 INT12642 Gene_expression of TRIM47 3 0.54 1.18 2.49 100.00
108 INT245200 Protein_catabolism of Koa 2 0.29 1.69 0.93 100.00
109 INT125870 Gene_expression of CD47 3 0.76 5.11 1.71 100.00
110 INT135879 Localization of MATN3 12 0.80 10.31 1.44 100.00
111 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16 100.00
112 INT172179 Positive_regulation of Gene_expression of IL11 7 0.55 4.29 2.43 100.00
113 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 100.00
114 INT79063 Regulation of Gene_expression of NOS2 6 0.43 3.68 1.7 100.00
115 INT224492 Regulation of Regulation of MMP1 1 0.09 0.77 0.66 100.00
116 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 100.00
117 INT141969 Positive_regulation of Gene_expression of ADM 4 0.57 4.07 1.2 100.00
118 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 100.00
119 INT64821 Positive_regulation of SLPI 11 0.67 5.08 1.48 100.00
120 INT227216 Binding of TRIM47 2 0.30 1.11 0.34 100.00
121 INT46849 Regulation of TPX2 5 0.24 6.27 2.1 100.00
122 INT155928 Positive_regulation of Gene_expression of PARP1 13 0.68 6.54 2.1 100.00
123 INT312240 Negative_regulation of Gene_expression of RUNX2 2 0.39 0.74 0.3 100.00
124 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 100.00
125 INT263523 Regulation of Binding of BMI1 1 0.34 3.01 1.3 100.00
126 INT131844 Gene_expression of MATN3 12 0.78 9.65 0.92 100.00
127 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 100.00
128 INT57504 Positive_regulation of Positive_regulation of GUSB 2 0.33 1.25 1.16 100.00
129 INT3164 Positive_regulation of GUSB 4 0.49 2.67 1.47 100.00
130 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 100.00
131 INT57503 Positive_regulation of Positive_regulation of HEXDC 1 0.50 1 0.96 100.00
132 INT352915 Negative_regulation of Gene_expression of GPX3 1 0.03 0.81 0.33 100.00
133 INT322203 Negative_regulation of TRIM47 1 0.34 0.56 0.28 100.00
134 INT192269 Regulation of Lts1 5 0.08 3.53 0.75 100.00
135 INT134145 Negative_regulation of Gene_expression of PTGES 11 0.51 5.32 2.73 100.00
136 INT39282 Negative_regulation of SOD2 27 0.59 16.89 7.03 100.00
137 INT11362 Regulation of Localization of SERPINE1 3 0.39 1.55 0.69 100.00
138 INT97016 Regulation of Binding of CALM1 4 0.39 0.79 2.09 100.00
139 INT248308 Regulation of Localization of MATN3 2 0.27 2.48 0.71 100.00
140 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42 100.00
141 INT224486 Regulation of Phosphorylation of MAPK8 2 0.33 0.52 0.52 100.00
142 INT224498 Regulation of Positive_regulation of EPHB2 1 0.26 0.46 0.52 100.00
143 INT29389 Positive_regulation of OA1 1 0.02 0.85 0.42 100.00
144 INT29390 Binding of OA1 1 0.01 0.84 0.42 100.00
145 INT323378 Positive_regulation of Koa 1 0.17 1.02 0.56 100.00
146 INT149106 Binding of SOD3 1 0.42 0.53 0.19 100.00
147 INT323377 Positive_regulation of Protein_catabolism of Koa 1 0.17 1.01 0.53 100.00
148 INT311099 Positive_regulation of Negative_regulation of TIMP3 2 0.22 0.78 0.45 100.00
149 INT125005 Negative_regulation of SLPI 9 0.42 5.79 4.43 100.00
150 INT176461 Protein_catabolism of Esr1 1 0.12 0.37 0.16 100.00
151 INT202006 Gene_expression of OPA6 1 0.58 0.68 0.35 100.00
152 INT292223 Positive_regulation of Gene_expression of NFAT5 2 0.50 1.11 0.16 100.00
153 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 100.00
154 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53 100.00
155 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 100.00
156 INT313229 Negative_regulation of Positive_regulation of SLPI 1 0.26 0.41 0.14 100.00
157 INT81194 Binding of CPOX 40 0.29 23.7 18.95 100.00
158 INT323817 Positive_regulation of Gene_expression of SLC6A12 1 0.48 0.26 0.13 100.00
159 INT106320 Positive_regulation of Gene_expression of S100A4 2 0.48 0.84 0.65 100.00
160 INT202007 Negative_regulation of OPA6 1 0.37 0.6 0.35 100.00
161 INT88103 Regulation of CCAL1 1 0.00 0.1 0.18 100.00
162 INT124050 Binding of Sema5a 1 0.03 2.46 2.3 100.00
163 INT68115 Binding of LPCAT3 1 0.27 1.28 0.8 100.00
164 INT207472 Negative_regulation of Gene_expression of LGALS3 1 0.41 0.58 0.22 100.00
165 INT138773 Negative_regulation of Koa 2 0.37 0.28 0.13 100.00
166 INT238920 Positive_regulation of SLC9A3R2 44 0.50 27.86 10.51 99.98
167 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 99.98
168 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 99.98
169 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 99.98
170 INT247294 Regulation of Gene_expression of HRAS 1 0.04 1.8 1.02 99.98
171 INT184052 Localization of Socs1 3 0.59 4.07 1.54 99.98
172 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 99.98
173 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 99.96
174 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58 99.96
175 INT231721 Binding of DIP 1 0.16 5.53 3.24 99.96
176 INT20981 Binding of HRAS 42 0.48 24.49 4.23 99.96
177 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12 99.96
178 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 99.96
179 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 99.96
180 INT231725 Positive_regulation of DIP 1 0.20 0.84 0.36 99.96
181 INT247301 Binding of HAS1 1 0.32 1.02 0.84 99.96
182 INT28020 Binding of Adipoq 10 0.36 11.49 0.77 99.96
183 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67 99.96
184 INT122548 Negative_regulation of Localization of FGF2 3 0.41 1.01 0.22 99.96
185 INT318953 Positive_regulation of AA467197 1 0.22 0.17 0.08 99.96
186 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 99.92
187 INT165054 Gene_expression of MIR146A 45 0.58 82.87 28.82 99.92
188 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 99.92
189 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 99.92
190 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97 99.92
191 INT133508 Positive_regulation of TKTL1 8 0.60 6.37 4.8 99.92
192 INT316776 Positive_regulation of Gene_expression of ANKH 1 0.31 5.29 1.49 99.92
193 INT180497 Binding of MRI1 45 0.42 28.35 14.77 99.92
194 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 99.92
195 INT75907 Binding of LEP 53 0.46 46.65 8.44 99.92
196 INT66709 Transcription of IGF1 13 0.71 5.65 1.64 99.92
197 INT269144 Gene_expression of Mia1 8 0.59 11.84 6.16 99.92
198 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 99.92
199 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 99.92
200 INT72166 Positive_regulation of Gene_expression of RETNLB 14 0.24 10.23 7.27 99.92
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