P:Pain refractory

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Pain Term
Category Pain type
Synonyms Intractable Pain, Intractable Pains, Pains Intractable, Pains Refractory, Refractory Pain, Refractory Pains
Pain Specific Yes
Documents 314
Hot Single Events 37
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pain refractory. They are ordered first by their pain relevance and then by number of times they were reported for Pain refractory. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT166945 Ngf Positive_regulation of Trpv1 1 0.01 0.47 1.88 64.56
2 INT166947 Ngf Positive_regulation of KNG1 1 0.00 0.47 1.86 64.56
3 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
4 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
5 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
6 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95 5.00
7 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
8 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
9 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85 5.00
10 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77 5.00
11 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 5.00
12 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59 5.00
13 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34 5.00
14 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28 5.00
15 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28 5.00
16 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24 5.00
17 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24 5.00
18 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24 5.00
19 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24 5.00
20 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24 5.00
21 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24 5.00
22 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24 5.00
23 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24 5.00
24 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24 5.00
25 INT178059 Binding of EDN1 and EDNRA Positive_regulation of Phosphorylation of PXN 1 0.04 0.83 0.2 5.00
26 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2 5.00
27 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2 5.00
28 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17 5.00
29 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17 5.00
30 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16 5.00
31 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13 5.00
32 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12 5.00
33 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09 5.00
34 INT178072 Gene_expression of EDNRB Positive_regulation of EDN3 1 0.05 1.11 0.08 5.00
35 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08 5.00
36 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08 5.00
37 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08 5.00
38 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08 5.00
39 INT178060 EDN1 Positive_regulation of EDN1 Positive_regulation of HIF1A 1 0.03 1.13 0.08 5.00
40 INT178103 Binding of DBP and HIF1A 1 0.00 0.99 0.07 5.00
41 INT178093 EDN3 Positive_regulation of Gene_expression of EDNRB 1 0.05 1.01 0.07 5.00
42 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07 5.00
43 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 0.10 0.88 0.06 5.00
44 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06 5.00
45 INT178091 EDN1 Positive_regulation of Gene_expression of PTGER2 1 0.01 0.74 0.04 5.00
46 INT178098 EDN1 Positive_regulation of Transcription of VEGFA 1 0.08 0.76 0.04 5.00
47 INT178082 EDN1 Positive_regulation of VEGFA 1 0.08 0.77 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pain refractory. They are ordered first by their pain relevance and then by number of times they were reported in Pain refractory. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT62510 Positive_regulation of MCS 32 0.60 11.79 5.45 99.04
2 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 97.16
3 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 97.16
4 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 97.16
5 INT146091 Negative_regulation of IFNAR1 6 0.25 9.12 4.86 96.96
6 INT163028 Negative_regulation of Negative_regulation of IFNAR1 1 0.05 0.86 0.73 96.96
7 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.48
8 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 95.80
9 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 95.60
10 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33 95.60
11 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82 94.40
12 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 91.36
13 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75 90.48
14 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 90.36
15 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 89.84
16 INT6852 Localization of TNF 883 0.81 705.95 270.84 89.20
17 INT6481 Binding of TNF 624 0.48 510.2 214.82 88.04
18 INT97513 Localization of Mefv 6 0.71 8.14 1.55 87.92
19 INT17996 Binding of Crp 40 0.37 31.4 7.8 87.52
20 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 87.52
21 INT54978 Binding of EDNRA 36 0.41 14.97 7.86 84.80
22 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 84.00
23 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 84.00
24 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 83.80
25 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47 83.80
26 INT88868 Binding of MCS 45 0.40 37.43 7.98 82.80
27 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 82.44
28 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 82.44
29 INT22812 Positive_regulation of PTRH1 4 0.49 3.06 0.43 82.44
30 INT443 Localization of POMC 1020 0.81 284.52 443.17 81.92
31 INT20210 Localization of Ngf 69 0.79 46.22 38.57 81.76
32 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 81.52
33 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 81.52
34 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 81.52
35 INT53764 Gene_expression of SPN 5 0.75 5.62 0.38 81.52
36 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 81.48
37 INT14690 Localization of CSF2 124 0.80 85.17 27.26 81.32
38 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41 79.52
39 INT101049 Positive_regulation of CD5 6 0.67 5.71 0.68 79.52
40 INT121388 Positive_regulation of BCL6 2 0.28 2.71 0.32 79.52
41 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 79.44
42 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 78.48
43 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 77.32
44 INT33857 Negative_regulation of NTS 6 0.42 4.98 3.07 75.00
45 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 69.92
46 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88 67.80
47 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 66.88
48 INT121387 Negative_regulation of Gene_expression of CD5 3 0.40 2.6 0.25 62.88
49 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 62.56
50 INT15044 Localization of Nts 30 0.75 4.58 13.72 59.84
51 INT41727 Negative_regulation of Localization of Nts 3 0.39 1.48 3.15 59.84
52 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 59.04
53 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 58.72
54 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 56.72
55 INT157431 Binding of Sf1 1 0.05 0.99 0.39 56.24
56 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 53.84
57 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 52.80
58 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 52.80
59 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 52.72
60 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 49.52
61 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 49.52
62 INT626 Localization of CALCA 289 0.81 125.39 221.15 49.04
63 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 49.04
64 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 44.00
65 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 43.08
66 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39 29.12
67 INT23524 Positive_regulation of VCF 7 0.57 4.25 1.16 28.56
68 INT35406 Localization of Tnf 94 0.81 64.63 31.65 25.00
69 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37 25.00
70 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44 25.00
71 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 24.68
72 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 24.04
73 INT6361 Localization of Edn1 30 0.81 19.09 9.7 22.00
74 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 20.92
75 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 15.88
76 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 15.88
77 INT13354 Transcription of TNF 108 0.72 85.81 42.32 10.80
78 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 10.04
79 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39 10.04
80 INT296899 Regulation of Gene_expression of CTNND2 1 0.44 1.13 0.49 9.92
81 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 8.92
82 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 8.72
83 INT130343 Gene_expression of CTNND2 5 0.75 6.98 1.38 6.80
84 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
85 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
86 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
87 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
88 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 5.00
89 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
90 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
91 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
92 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
93 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
94 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
95 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
96 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
97 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 5.00
98 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
99 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
100 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
101 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
102 INT9664 Binding of LBP 127 0.48 94.9 63.42 5.00
103 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
104 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 5.00
105 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
106 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
107 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 5.00
108 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
109 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
110 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
111 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
112 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
113 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 5.00
114 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 5.00
115 INT103262 Localization of Nav1 53 0.81 19.23 34.44 5.00
116 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
117 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
118 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
119 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
120 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
121 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
122 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
123 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
124 INT8048 Gene_expression of Nts 45 0.74 8.9 21.84 5.00
125 INT1703 Regulation of PCa 52 0.52 23.65 20.6 5.00
126 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 5.00
127 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2 5.00
128 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
129 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
130 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
131 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 5.00
132 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 5.00
133 INT35487 Localization of PTGER2 103 0.46 51.24 17.45 5.00
134 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
135 INT23784 Gene_expression of FAIM3 25 0.55 2.89 17.14 5.00
136 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
137 INT62629 Localization of CNR1 35 0.76 11.86 16.3 5.00
138 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
139 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
140 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
141 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
142 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 5.00
143 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
144 INT20264 Gene_expression of Chkb 29 0.46 13.14 13.65 5.00
145 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
146 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 5.00
147 INT83601 Binding of CNR2 30 0.47 7.79 12.37 5.00
148 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
149 INT11359 Gene_expression of PLAU 84 0.76 49.54 12.31 5.00
150 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 5.00
151 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
152 INT38255 Localization of Chkb 32 0.80 10.98 11.07 5.00
153 INT158070 Localization of Aes 23 0.65 19.93 10.9 5.00
154 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
155 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 5.00
156 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 5.00
157 INT33957 Positive_regulation of OPRL1 14 0.68 2.89 9.72 5.00
158 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 5.00
159 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 5.00
160 INT111397 Localization of Timp1 17 0.70 11.67 8.76 5.00
161 INT10237 Binding of EDN1 40 0.48 16 8.48 5.00
162 INT4880 Regulation of MME 17 0.61 7.78 8.2 5.00
163 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 5.00
164 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 5.00
165 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87 5.00
166 INT10444 Positive_regulation of Gene_expression of CNR1 18 0.69 8.69 7.84 5.00
167 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
168 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56 5.00
169 INT77756 Positive_regulation of GTPBP4 16 0.11 2.6 7.29 5.00
170 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 5.00
171 INT264641 Binding of AES 25 0.42 18.56 6.98 5.00
172 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
173 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
174 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 5.00
175 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 5.00
176 INT9567 Binding of Nts 10 0.44 2.14 5.89 5.00
177 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 5.00
178 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49 5.00
179 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
180 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 5.00
181 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
182 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
183 INT31991 Gene_expression of NTS 33 0.75 12.98 4.99 5.00
184 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87 5.00
185 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 5.00
186 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 5.00
187 INT15474 Gene_expression of PLAUR 36 0.75 22.32 4.63 5.00
188 INT142488 Positive_regulation of Gene_expression of Chkb 7 0.23 4.09 4.54 5.00
189 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28 5.00
190 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 5.00
191 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 5.00
192 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 5.00
193 INT172173 Protein_catabolism of TNF 16 0.96 9.95 3.79 5.00
194 INT79299 Negative_regulation of NXT1 16 0.32 8.27 3.78 5.00
195 INT12598 Binding of DBP 20 0.48 13.11 3.62 5.00
196 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56 5.00
197 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 5.00
198 INT180591 Protein_catabolism of CYP27A1 18 0.56 8.46 3.44 5.00
199 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 5.00
200 INT76430 Gene_expression of SLC1A1 2 0.03 0.77 3.15 5.00
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