P:Painful diabetic neuropathy

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Pain Term
Category Disorder
Synonyms None
Pain Specific Yes
Documents 346
Hot Single Events 87
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Painful diabetic neuropathy. They are ordered first by their pain relevance and then by number of times they were reported for Painful diabetic neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73 100.00
2 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61 75.44
3 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56 73.20
4 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18 58.56
5 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67 57.84
6 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2 52.24
7 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15 52.08
8 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 46.72
9 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3 46.72
10 INT160985 Urb1 Negative_regulation of Negative_regulation of Faah 1 0.41 1.36 0.74 46.36
11 INT142437 Urb1 Negative_regulation of Faah 3 0.41 2.12 1.66 46.00
12 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57 45.08
13 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82 25.00
14 INT211694 Binding of Cntnap1 and Nav1 1 0.04 0 3.14 5.00
15 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84 5.00
16 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55 5.00
17 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 5.00
18 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34 5.00
19 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32 5.00
20 INT314211 Ngf Positive_regulation of Gene_expression of Agtrap 1 0.04 1.15 1.3 5.00
21 INT208990 Binding of CALM1 and Trpv1 1 0.10 0.07 1.29 5.00
22 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27 5.00
23 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24 5.00
24 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24 5.00
25 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88 5.00
26 INT208978 Ca2 Positive_regulation of Trpv1 1 0.22 0.29 0.71 5.00
27 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54 5.00
28 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46 5.00
29 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46 5.00
30 INT208983 Binding of Ca2 and Kcnma1 2 0.01 0.28 0.1 5.00
31 INT208979 Binding of Itpr3 and Trpc3 1 0.00 0.33 0.09 5.00
32 INT326574 Binding of Akt1 and Hsp90ab1 1 0.13 0.17 0.08 5.00
33 INT208989 Binding of CALM1 and Fig4 1 0.01 0 0.07 5.00
34 INT326573 Zic2 Positive_regulation of Localization of Hsf1 1 0.01 0.95 0.07 5.00
35 INT208988 Binding of CALM1 and Itpr3 1 0.01 0.15 0.05 5.00
36 INT208982 Negative_regulation of Binding of Itpr3 and Trpc3 1 0.00 0.17 0.04 5.00
37 INT326571 Binding of Hsf1 and Hsp90ab1 1 0.16 1.19 0.03 5.00
38 INT326570 Hsp90ab1 Regulation of Csprs 1 0.08 1.17 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Painful diabetic neuropathy. They are ordered first by their pain relevance and then by number of times they were reported in Painful diabetic neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93 100.00
2 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 100.00
3 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48 100.00
4 INT140245 Binding of Gli3 3 0.36 2.65 1.46 100.00
5 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 99.84
6 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 99.84
7 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 99.84
8 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 99.80
9 INT71494 Positive_regulation of Hspa1b 14 0.67 8.5 9.19 99.76
10 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 99.54
11 INT23834 Negative_regulation of AKR1B1 8 0.55 3.79 1.15 99.48
12 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 99.44
13 INT126525 Regulation of Negative_regulation of Mapk14 2 0.41 0.81 1.11 99.44
14 INT129015 Phosphorylation of Ngf 6 0.73 5.92 6.6 99.40
15 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88 99.34
16 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 99.20
17 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 99.18
18 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 99.16
19 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 99.16
20 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 99.12
21 INT42099 Regulation of AKR1B1 2 0.45 0.46 0.39 99.08
22 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 99.02
23 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64 98.84
24 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 98.80
25 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59 98.52
26 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68 98.52
27 INT65772 Positive_regulation of Positive_regulation of Bdkrb1 6 0.49 8.34 6.54 98.52
28 INT70790 Positive_regulation of Slc14a2 4 0.18 1.36 1.16 98.52
29 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 98.52
30 INT7313 Negative_regulation of CDNF 7 0.05 2.53 2.34 98.52
31 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 98.38
32 INT93350 Binding of Lepr 17 0.05 27.21 1.5 98.36
33 INT115200 Binding of Slc14a2 2 0.07 1.16 0.66 98.36
34 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 98.28
35 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 98.20
36 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 97.62
37 INT65211 Binding of Prkcg 38 0.48 14.75 16.92 97.62
38 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63 97.36
39 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 97.24
40 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 97.24
41 INT99336 Negative_regulation of FOLH1 30 0.57 8.83 11.53 97.24
42 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 96.96
43 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 96.88
44 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 96.44
45 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69 96.40
46 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 96.24
47 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 96.04
48 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 96.04
49 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 95.44
50 INT96557 Binding of Bdnf 46 0.47 21.74 24.26 95.44
51 INT168945 Positive_regulation of Binding of Bdnf 4 0.50 1.7 2.14 95.44
52 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 95.08
53 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 94.96
54 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15 94.80
55 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 94.72
56 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1 94.32
57 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61 94.32
58 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23 94.12
59 INT53476 Positive_regulation of Localization of Ptgs1 6 0.49 2.88 2.35 93.92
60 INT787 Localization of Ptgs1 31 0.80 12.36 11.55 93.92
61 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47 93.68
62 INT6437 Binding of YY1 154 0.47 26.3 90.46 92.92
63 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 92.88
64 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29 92.56
65 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 92.40
66 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 92.40
67 INT1114 Localization of Ins1 748 0.80 192.95 165.48 92.00
68 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 92.00
69 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 89.60
70 INT160983 Positive_regulation of Urb1 1 0.49 1.51 0.83 88.64
71 INT314194 Phosphorylation of DRGX 1 0.01 5.19 3.26 88.48
72 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 86.56
73 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 86.04
74 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 86.04
75 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 85.84
76 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71 85.16
77 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98 84.24
78 INT103172 Gene_expression of Slc12a5 81 0.77 39.45 36.22 84.20
79 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 83.92
80 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 83.88
81 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 83.88
82 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 83.88
83 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 83.88
84 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 82.96
85 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 82.00
86 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88 81.28
87 INT151111 Gene_expression of Pain1 33 0.40 33.6 30.73 80.16
88 INT10173 Binding of Tnf 45 0.48 35.6 14.32 79.04
89 INT176524 Binding of Mapk14 19 0.43 12.54 5.21 79.04
90 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 78.88
91 INT64203 Positive_regulation of Negative_regulation of Trpv1 5 0.47 3.39 3.67 78.16
92 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 78.04
93 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 77.92
94 INT122662 Negative_regulation of Negative_regulation of Trpv1 1 0.59 1.74 1.22 77.84
95 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28 77.52
96 INT89053 Positive_regulation of Phosphorylation of Trpv1 16 0.70 8.89 9.39 77.52
97 INT89056 Phosphorylation of Trpv1 46 0.82 13.52 22.16 77.52
98 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 76.96
99 INT95318 Binding of Pain1 17 0.22 21.26 20.14 76.88
100 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 76.80
101 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 76.56
102 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 75.92
103 INT91932 Positive_regulation of Scn10a 18 0.67 10.39 10.9 75.28
104 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 75.00
105 INT6058 Localization of Fos 73 0.81 16.7 30.84 75.00
106 INT128302 Localization of NeuN 24 0.73 9.81 5.27 75.00
107 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 75.00
108 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06 75.00
109 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 75.00
110 INT1087 Negative_regulation of Msr1 32 0.57 8.35 10.72 75.00
111 INT146458 Negative_regulation of Kcna4 3 0.40 3.44 2.42 75.00
112 INT168944 Transcription of Kcna4 1 0.44 2.22 1.25 75.00
113 INT129442 Negative_regulation of Atp6v0e1 1 0.17 1.27 0.66 75.00
114 INT73323 Negative_regulation of Scn10a 13 0.58 5.77 7.85 75.00
115 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 75.00
116 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08 75.00
117 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 75.00
118 INT65627 Negative_regulation of Kcna5 19 0.59 7.82 10.79 75.00
119 INT74075 Negative_regulation of Kcna3 20 0.59 4.68 8.64 75.00
120 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46 75.00
121 INT116215 Transcription of Kcna5 6 0.53 3.62 2.75 75.00
122 INT112368 Positive_regulation of Cacna1c 8 0.46 2.94 1.97 75.00
123 INT1088 Negative_regulation of Negative_regulation of Msr1 5 0.40 0.65 1.61 75.00
124 INT72458 Positive_regulation of Tnnt2 5 0.69 5.59 1.38 75.00
125 INT154587 Transcription of Kcna3 3 0.38 1.28 1.11 75.00
126 INT168943 Negative_regulation of Transcription of Kcna4 1 0.35 1.12 0.63 75.00
127 INT129443 Negative_regulation of Negative_regulation of Atp6v0e1 1 0.17 0.66 0.34 75.00
128 INT314189 Positive_regulation of Phosphorylation of Nr5a1 1 0.02 2.16 1.7 74.88
129 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74 74.72
130 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87 74.48
131 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41 73.52
132 INT314192 Negative_regulation of Git2 1 0.18 1.02 0.85 73.04
133 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 72.84
134 INT48890 Gene_expression of Gdnf 91 0.77 28.62 31.49 72.80
135 INT78625 Regulation of Gene_expression of Gdnf 7 0.37 2.5 3.47 72.80
136 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75 72.76
137 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49 72.76
138 INT125624 Gene_expression of Atp8a2 12 0.15 3.91 4.85 72.60
139 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 72.24
140 INT103171 Positive_regulation of Slc12a5 15 0.51 3.6 6.25 72.24
141 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 71.68
142 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 71.68
143 INT314187 Phosphorylation of Nr5a1 1 0.04 1.96 1.59 71.00
144 INT107655 Positive_regulation of Gene_expression of Grm5 6 0.67 5.09 5.06 70.84
145 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99 70.84
146 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45 70.84
147 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 70.56
148 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97 70.56
149 INT142690 Positive_regulation of Gene_expression of DRGX 10 0.23 8.54 5.69 69.36
150 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 69.36
151 INT72943 Negative_regulation of Binding of MIA3 2 0.00 1.23 1.36 69.20
152 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 69.00
153 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 68.60
154 INT32603 Binding of MIA3 10 0.14 7.08 1.76 68.48
155 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 68.44
156 INT314186 Gene_expression of Npm1 1 0.01 1.78 1.22 67.96
157 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 66.32
158 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 65.68
159 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 65.36
160 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 65.20
161 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 64.40
162 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 63.28
163 INT102897 Positive_regulation of Gene_expression of Gdnf 34 0.69 11.13 13.28 62.24
164 INT126910 Positive_regulation of Gene_expression of P2rx3 3 0.62 1.81 2.08 62.24
165 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 62.00
166 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 62.00
167 INT49454 Negative_regulation of Gene_expression of Gtf3a 13 0.08 9.99 2.43 62.00
168 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 61.72
169 INT81275 Negative_regulation of Gan 2 0.53 1.77 1.11 61.52
170 INT91916 Gene_expression of P2rx3 51 0.78 21.2 19.05 61.32
171 INT93281 Negative_regulation of Folh1 12 0.50 5.55 10.63 60.48
172 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 60.48
173 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 60.08
174 INT28336 Positive_regulation of Pax3 37 0.33 20.94 25.66 56.56
175 INT121224 Positive_regulation of Positive_regulation of Pax3 5 0.14 2.32 2.4 56.56
176 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 56.24
177 INT26054 Regulation of Gene_expression of Scn8a 7 0.08 2.86 4.49 55.76
178 INT103170 Negative_regulation of Gene_expression of Slc12a5 26 0.58 17.25 14.4 55.56
179 INT5430 Gene_expression of Scn8a 37 0.75 4.58 14.82 55.32
180 INT118907 Negative_regulation of Negative_regulation of Mapk14 2 0.57 2.09 1.77 54.88
181 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 53.52
182 INT314185 Localization of Npm1 1 0.02 0.44 0.39 52.52
183 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 51.60
184 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 50.00
185 INT68560 Regulation of Gli3 3 0.18 1.51 0.68 50.00
186 INT151940 Positive_regulation of Igh-Lev 2 0.41 4.51 0.41 50.00
187 INT314188 Regulation of Npm1 1 0.01 0.33 0.33 49.08
188 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 48.96
189 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 48.96
190 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03 46.00
191 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37 45.76
192 INT314193 Positive_regulation of Trap1 1 0.11 1.19 1.11 45.08
193 INT136934 Negative_regulation of Urb1 6 0.36 2.53 2.38 44.80
194 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 44.72
195 INT92662 Negative_regulation of Gene_expression of Ntf3 9 0.57 7.44 6.22 44.72
196 INT51777 Regulation of Negative_regulation of Akr1b1 4 0.45 2.91 1.48 44.08
197 INT20092 Regulation of Akr1b1 8 0.45 5.57 2.79 43.64
198 INT326555 Localization of Tomm70a 1 0.38 0.6 0 43.00
199 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 42.92
200 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 42.84
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