P:Rheumatism

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pChart

Pain Term
Category Disorder
Synonyms None
Pain Specific No
Documents 989
Hot Single Events 80
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rheumatism. They are ordered first by their pain relevance and then by number of times they were reported for Rheumatism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74 92.12
2 INT239474 Binding of ACR and Ifx 1 0.02 0.36 0.45 82.28
3 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25 76.08
4 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28 75.32
5 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18 58.64
6 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4 50.00
7 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47 47.12
8 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47 47.12
9 INT173936 Hrt1 Regulation of Gtf3a 1 0.00 1.16 0.44 46.72
10 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96 45.04
11 INT181998 TNFRSF11B Negative_regulation of Gene_expression of CTSK 1 0.07 1.98 0.27 37.60
12 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74 34.16
13 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73 32.64
14 INT329297 Binding of Cd226 and Aff3 1 0.18 1.54 0.64 29.52
15 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 27.92
16 INT237683 Positive_regulation of LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03 17.84
17 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07 17.52
18 INT237682 LDHA Positive_regulation of MAPK14 1 0.02 0.16 0.03 17.28
19 INT237680 LDHA Positive_regulation of MAPK8 1 0.02 0.16 0.03 17.28
20 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18 14.32
21 INT248298 Binding of Cd40 and Rf 1 0.08 0 0 14.16
22 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06 5.56
23 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
24 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
25 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16 5.00
26 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
27 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
28 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
29 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
30 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
31 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
32 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
33 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91 5.00
34 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
35 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
36 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53 5.00
37 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 5.00
38 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
39 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
40 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99 5.00
41 INT182203 Binding of CXCL1 and CXCR2 1 0.14 1.25 0.95 5.00
42 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95 5.00
43 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95 5.00
44 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95 5.00
45 INT182210 Binding of CXCR4 and CXCL13 1 0.32 1.25 0.95 5.00
46 INT182193 Binding of CXCR2 and CXCL5 1 0.30 1.25 0.94 5.00
47 INT182206 Binding of CXCR5 and IL8 1 0.30 1.25 0.94 5.00
48 INT182188 Binding of CXCR5 and CXCL5 1 0.34 1.24 0.94 5.00
49 INT182199 Binding of CXCR5 and CXCL1 1 0.16 1.24 0.94 5.00
50 INT182197 Binding of CXCR2 and CCL16 1 0.00 1.24 0.94 5.00
51 INT182205 Binding of CXCL5 and CXCR4 1 0.29 1.24 0.94 5.00
52 INT182198 Binding of CXCR5 and CXCL12 1 0.33 1.25 0.94 5.00
53 INT182195 Binding of CXCL1 and CXCR4 1 0.13 1.25 0.94 5.00
54 INT182189 Binding of CXCL1 and CXCL13 1 0.14 1.24 0.93 5.00
55 INT182209 Binding of CXCL12 and CXCL13 1 0.30 1.24 0.93 5.00
56 INT182196 Binding of IL8 and CXCL13 1 0.27 1.24 0.93 5.00
57 INT182204 Binding of CXCL5 and CXCL13 1 0.30 1.24 0.93 5.00
58 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9 5.00
59 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9 5.00
60 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
61 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
62 INT232417 Binding of Mtx1 and Ifx 1 0.04 0.99 0.86 5.00
63 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 5.00
64 INT231693 Binding of IGKV2-19 and BDNF-AS 1 0.00 2.39 0.81 5.00
65 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
66 INT182201 Binding of CXCR5 and CXCR4 1 0.36 1.15 0.72 5.00
67 INT182202 Binding of CXCR2 and CXCR4 1 0.31 1.15 0.72 5.00
68 INT187171 Binding of Tnfrsf1b and Gtf3a 1 0.03 2.15 0.72 5.00
69 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7 5.00
70 INT284040 Gtf3a Positive_regulation of Csf3 1 0.01 1.7 0.7 5.00
71 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66 5.00
72 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 5.00
73 INT316889 Binding of Cd19 and Cr2 1 0.07 1.7 0.61 5.00
74 INT316882 Binding of Cd22 and Cr2 1 0.02 1.71 0.61 5.00
75 INT284048 Binding of Cia1 and Vtcn1 1 0.02 1.37 0.6 5.00
76 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56 5.00
77 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56 5.00
78 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56 5.00
79 INT334013 Ccl25 Positive_regulation of Gene_expression of Lrp1 1 0.07 0.98 0.56 5.00
80 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55 5.00
81 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55 5.00
82 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54 5.00
83 INT321842 Binding of Ros1 and SCFV 1 0.01 1.34 0.54 5.00
84 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 5.00
85 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 5.00
86 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51 5.00
87 INT284041 Negative_regulation of Binding of Vtcn1 and Sh4 1 0.07 1.29 0.5 5.00
88 INT172081 TNF Regulation of IFNA1 1 0.03 1.13 0.5 5.00
89 INT284045 Binding of Vtcn1 and Sh4 1 0.06 1.29 0.5 5.00
90 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 5.00
91 INT284049 Arigm1 Negative_regulation of Cia1 1 0.00 1.11 0.5 5.00
92 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49 5.00
93 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 5.00
94 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48 5.00
95 INT330522 Binding of CD8A and TNFSF10 1 0.17 1.24 0.48 5.00
96 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
97 INT284044 Sh4 Positive_regulation of Cia1 1 0.20 0.72 0.43 5.00
98 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43 5.00
99 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
100 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43 5.00
101 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 5.00
102 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 5.00
103 INT334025 Binding of CCR9 and Ccl25 1 0.40 0.96 0.4 5.00
104 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4 5.00
105 INT352970 IL4 Negative_regulation of Positive_regulation of TH1L 1 0.01 0.91 0.4 5.00
106 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4 5.00
107 INT334009 Binding of CCL25 and CCR9 1 0.40 0.96 0.4 5.00
108 INT330519 Binding of CD8A and DICER1 1 0.08 0.99 0.38 5.00
109 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 5.00
110 INT330516 Binding of CD8A and CCR6 1 0.07 0.99 0.38 5.00
111 INT330517 Binding of CD8A and HLA-DRB4 1 0.08 0.99 0.38 5.00
112 INT284046 Sh4 Negative_regulation of Vtcn1 1 0.10 1.13 0.36 5.00
113 INT284039 Binding of fc and Vtcn1 1 0.02 0.58 0.35 5.00
114 INT94473 Binding of Cd3e and Trav6-3 2 0.05 0 0.34 5.00
115 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34 5.00
116 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34 5.00
117 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33 5.00
118 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32 5.00
119 INT264504 Binding of CRYGD and PTPN22 1 0.04 0.42 0.31 5.00
120 INT316883 Positive_regulation of Binding of Cd19 and Cd22 1 0.02 0.86 0.31 5.00
121 INT316884 Positive_regulation of Binding of Cr2 and Bcr 1 0.06 0.86 0.31 5.00
122 INT316886 Positive_regulation of Binding of Cd22 and Cr2 1 0.02 0.86 0.31 5.00
123 INT334024 Ccl25 Positive_regulation of Gene_expression of CD36 1 0.31 0.36 0.31 5.00
124 INT316881 Positive_regulation of Binding of Cd19 and Bcr 1 0.08 0.86 0.31 5.00
125 INT316887 Binding of Cd19 and Cd22 1 0.02 0.85 0.31 5.00
126 INT211308 Binding of Cd4 and Cd8a 3 0.19 0.3 0.31 5.00
127 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31 5.00
128 INT284047 Vtcn1 Negative_regulation of Gene_expression of Ighg2b 1 0.05 0.68 0.3 5.00
129 INT316885 Binding of Cr2 and Bcr 1 0.06 0.85 0.3 5.00
130 INT316888 Binding of Cd19 and Bcr 1 0.08 0.85 0.3 5.00
131 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3 5.00
132 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3 5.00
133 INT180570 Binding of HEYL and Positive_regulation of DMD 1 0.00 1.08 0.28 5.00
134 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 5.00
135 INT334023 pma Positive_regulation of Gene_expression of CD36 1 0.04 0.31 0.28 5.00
136 INT180564 HEYL Regulation of Regulation of DMD 1 0.00 0.88 0.28 5.00
137 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28 5.00
138 INT187170 Binding of Ltbr and Tnfrsf1b 1 0.06 0.88 0.28 5.00
139 INT287699 TNF Regulation of Binding of VEGFA 1 0.02 0.46 0.27 5.00
140 INT346196 AMELX Negative_regulation of CRP 1 0.04 0.36 0.26 5.00
141 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26 5.00
142 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 5.00
143 INT311968 TNF Regulation of Transcription of IFNA1 1 0.01 0.59 0.25 5.00
144 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24 5.00
145 INT335821 MIR146A Regulation of Gene_expression of Il17a 1 0.05 0.75 0.24 5.00
146 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24 5.00
147 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23 5.00
148 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23 5.00
149 INT284433 Kdm5d Regulation of KITLG 1 0.00 0.57 0.23 5.00
150 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 5.00
151 INT284432 KITLG Regulation of Kdm5d 1 0.00 0.57 0.23 5.00
152 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22 5.00
153 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 5.00
154 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21 5.00
155 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21 5.00
156 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21 5.00
157 INT330520 Positive_regulation of Binding of CD8A and TNFSF10 1 0.19 0.62 0.21 5.00
158 INT252366 Binding of RUNX1 and CD80 1 0.01 0.54 0.2 5.00
159 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2 5.00
160 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2 5.00
161 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19 5.00
162 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18 5.00
163 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18 5.00
164 INT345924 IL6 Regulation of Gene_expression of SPHAR 1 0.00 0.21 0.18 5.00
165 INT252367 Binding of RUNX1 and CTLA4 1 0.02 0.48 0.18 5.00
166 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18 5.00
167 INT181996 TNFRSF11B Positive_regulation of Gene_expression of TIMP1 1 0.00 0.67 0.18 5.00
168 INT173938 Il1rn Negative_regulation of Il1 1 0.00 0.18 0.17 5.00
169 INT275412 Binding of TYROBP and LILRB2 1 0.02 0.29 0.16 5.00
170 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16 5.00
171 INT211311 Trav6-3 Positive_regulation of Gene_expression of Lcp1 1 0.13 0.2 0.15 5.00
172 INT211310 Trav6-3 Positive_regulation of Positive_regulation of Il2 1 0.02 0.2 0.15 5.00
173 INT211309 Trav6-3 Positive_regulation of Gene_expression of Klra8 1 0.13 0.2 0.15 5.00
174 INT180566 Binding of COMP and DMD 1 0.02 0.72 0.15 5.00
175 INT181997 TNFRSF11B Negative_regulation of CTSK 1 0.05 0.58 0.14 5.00
176 INT173942 Binding of DMD and Atp6v1e1 1 0.00 0 0.13 5.00
177 INT173937 Hrt1 Regulation of Il1 1 0.00 0.28 0.13 5.00
178 INT211313 Binding of Cd3e and Cd8a 1 0.02 0.19 0.13 5.00
179 INT180567 HEYL Regulation of Positive_regulation of IBSP 1 0.01 0.18 0.12 5.00
180 INT181740 Il1 Positive_regulation of Csf2 1 0.02 0 0.12 5.00
181 INT178593 Binding of CPOX and TPX2 1 0.02 0.88 0.12 5.00
182 INT209952 Binding of SNRNP70 and IGKV2-19 1 0.00 0.47 0.11 5.00
183 INT173948 Gh Positive_regulation of Gene_expression of IGF1 2 0.36 0.77 0.1 5.00
184 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1 5.00
185 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1 5.00
186 INT258517 Negative_regulation of CPOX Negative_regulation of Binding of PTGIR 1 0.04 0.33 0.1 5.00
187 INT304010 Afw1 Negative_regulation of Gene_expression of ISYNA1 1 0.00 0.27 0.1 5.00
188 INT335771 MIR155 Regulation of IRAK1 1 0.04 0.29 0.09 5.00
189 INT335772 MIR155 Regulation of SOCS1 1 0.01 0.29 0.09 5.00
190 INT180561 HEYL Negative_regulation of IBSP 1 0.01 0.19 0.09 5.00
191 INT175966 Kctd1 Negative_regulation of Positive_regulation of CASP3 1 0.09 0.82 0.06 5.00
192 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06 5.00
193 INT334027 Ccl25 Regulation of Gene_expression of CD36 1 0.14 0.24 0.05 5.00
194 INT334026 pma Regulation of Gene_expression of CD36 1 0.02 0.16 0.05 5.00
195 INT175946 RSF1 Positive_regulation of Positive_regulation of CASP3 1 0.01 0.41 0.03 5.00
196 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03 5.00
197 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03 5.00
198 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0 5.00
199 INT219423 Binding of AHR and ARNT 4 0.24 0.46 0 5.00
200 INT219409 CCNF Regulation of E2F2 1 0.22 0.11 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rheumatism. They are ordered first by their pain relevance and then by number of times they were reported in Rheumatism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 100.00
2 INT172020 Localization of Acr 1 0.06 0.61 0.31 100.00
3 INT237703 Phosphorylation of IRF6 2 0.05 0.91 0.47 99.92
4 INT16720 Negative_regulation of Xdh 35 0.59 14 6.67 99.54
5 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.46
6 INT284037 Localization of Dhdds 1 0.24 1.14 0.35 99.28
7 INT45324 Positive_regulation of Otc 8 0.59 3.94 3.36 99.24
8 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 99.12
9 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 99.12
10 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 99.12
11 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 99.04
12 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 99.00
13 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 98.88
14 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 98.64
15 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 98.38
16 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 98.36
17 INT117598 Regulation of ACR 118 0.26 41.25 48.01 97.68
18 INT190418 Positive_regulation of AAVS1 15 0.49 4.71 0.98 97.48
19 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 97.28
20 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16 97.24
21 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79 97.24
22 INT546 Binding of ALB 311 0.48 85.98 60.14 97.08
23 INT76838 Binding of Asprv1 7 0.36 1.42 3.13 97.04
24 INT231694 Negative_regulation of IGKV2-19 14 0.03 7.09 2.64 96.80
25 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 96.32
26 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 96.00
27 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 95.88
28 INT1114 Localization of Ins1 748 0.80 192.95 165.48 95.56
29 INT67597 Negative_regulation of Das 17 0.37 9.95 5.05 93.92
30 INT220216 Gene_expression of HUNK 1 0.41 14.77 4.24 93.64
31 INT17996 Binding of Crp 40 0.37 31.4 7.8 93.60
32 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 93.48
33 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 93.04
34 INT68679 Gene_expression of BW35 1 0.65 1.29 0.42 93.04
35 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 92.40
36 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 92.12
37 INT117735 Positive_regulation of Regulation of Nfkb1 3 0.44 2.93 0.91 92.12
38 INT112970 Regulation of Ccr1 8 0.29 7.77 1.93 92.10
39 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 92.04
40 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 91.72
41 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 91.60
42 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 91.56
43 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 91.52
44 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 91.16
45 INT352259 Positive_regulation of Tnfsf15 1 0.04 0.73 0.44 91.12
46 INT6481 Binding of TNF 624 0.48 510.2 214.82 90.80
47 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 90.40
48 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 90.40
49 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 90.40
50 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 90.40
51 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 90.36
52 INT9854 Localization of GGT1 11 0.78 6.09 3.57 90.36
53 INT37248 Localization of Naglu 2 0.45 0.74 0.58 90.36
54 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 89.12
55 INT180578 Regulation of HEYL 3 0.06 3.15 0.49 87.96
56 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 87.68
57 INT9660 Regulation of TNF 363 0.62 312.94 139.99 87.04
58 INT105880 Regulation of Gene_expression of BDNF-AS 4 0.06 2.44 0.82 86.88
59 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 86.64
60 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 86.44
61 INT172003 Regulation of ERAL1 2 0.07 0.62 0.25 86.08
62 INT335809 Positive_regulation of RA5 1 0.05 1.64 0.58 85.84
63 INT143181 Positive_regulation of RA3 2 0.14 1.75 0.58 85.84
64 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 85.76
65 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 85.52
66 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 85.12
67 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 84.84
68 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 84.60
69 INT233322 Negative_regulation of Localization of HIVEP1 4 0.10 6.1 0.57 84.44
70 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 84.44
71 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 84.32
72 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 84.12
73 INT192676 Binding of PTEN 14 0.46 10.58 3.06 83.36
74 INT105021 Binding of GOPC 187 0.40 60.39 20.38 83.36
75 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 83.16
76 INT251 Regulation of INS 398 0.62 232.47 55.04 82.80
77 INT284028 Gene_expression of Dhdds 1 0.21 2.76 1.11 82.48
78 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 82.28
79 INT182215 Regulation of CXCR5 4 0.27 4.49 2.18 81.36
80 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 80.44
81 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 79.84
82 INT130092 Binding of IGKV2-19 6 0.36 3.97 1.51 79.20
83 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48 79.12
84 INT335803 Regulation of Localization of RA4 1 0.13 1.62 0.53 78.28
85 INT335795 Regulation of Localization of RA1 2 0.26 2.7 0.53 78.28
86 INT335814 Regulation of Localization of RA2 1 0.14 1.62 0.53 78.28
87 INT335802 Localization of RA4 1 0.22 1.6 0.52 78.28
88 INT335811 Localization of RA2 1 0.24 1.6 0.52 78.28
89 INT335263 Localization of RA1 3 0.47 3.04 0.52 78.28
90 INT58198 Negative_regulation of Gene_expression of BDNF-AS 4 0.42 2 0.62 78.04
91 INT335266 Regulation of RA1 2 0.27 2.57 0.52 77.48
92 INT335818 Regulation of RA2 1 0.04 1.61 0.52 77.28
93 INT335815 Regulation of RA4 1 0.08 1.6 0.52 76.96
94 INT246524 Binding of QPCT 4 0.05 3.65 0.72 76.48
95 INT4207 Regulation of Avp 267 0.62 63.72 115.33 76.16
96 INT6484 Binding of IL1B 122 0.47 75.84 35.07 76.00
97 INT220219 Binding of HUNK 1 0.26 12.47 3.78 75.88
98 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 75.16
99 INT14887 Gene_expression of Mbp 55 0.75 36.13 16.11 75.00
100 INT10476 Binding of ALOX5 26 0.36 7.69 3.2 75.00
101 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 75.00
102 INT7580 Positive_regulation of Mbp 54 0.70 23.37 17.14 75.00
103 INT1168 Binding of PROC 62 0.38 44.15 9.04 75.00
104 INT2971 Regulation of IGHE 42 0.61 28.81 7.87 75.00
105 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71 75.00
106 INT57779 Positive_regulation of Regulation of IGHE 1 0.04 1.36 0.19 75.00
107 INT57780 Gene_expression of RNASE2 1 0.03 1.49 0.13 75.00
108 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01 74.80
109 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 74.56
110 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 74.16
111 INT131784 Negative_regulation of Localization of Nociq1 1 0.37 0.52 0.47 74.04
112 INT131783 Localization of Nociq1 2 0.60 1.46 1.08 73.56
113 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37 73.52
114 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25 73.52
115 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 72.88
116 INT321838 Gene_expression of SMARCAD1 1 0.65 0.92 0.32 72.72
117 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 72.32
118 INT335799 Positive_regulation of RA11 1 0.08 3.21 1.13 72.12
119 INT335813 Positive_regulation of RA7 1 0.15 3.2 1.13 72.12
120 INT335794 Positive_regulation of RA10 1 0.08 1.6 0.52 72.12
121 INT335800 Positive_regulation of RA6 1 0.15 1.59 0.51 72.12
122 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 72.04
123 INT158643 Negative_regulation of Negative_regulation of CCND1 2 0.31 2.43 0.45 71.96
124 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 71.76
125 INT158644 Negative_regulation of CDC25A 2 0.23 2.63 1.55 71.76
126 INT128498 Regulation of CCND1 17 0.39 12.51 0.58 71.76
127 INT158645 Regulation of CDC25A 2 0.39 1.34 0.36 71.76
128 INT113104 Gene_expression of SCFV 18 0.65 7.13 1.2 71.28
129 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 71.24
130 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 71.04
131 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 70.88
132 INT100912 Regulation of Kdm5d 52 0.32 20.39 4.72 70.44
133 INT126473 Regulation of KITLG 5 0.14 7.86 2.34 70.44
134 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39 69.92
135 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 69.44
136 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 68.76
137 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05 68.48
138 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 68.32
139 INT15849 Gene_expression of FRTS 27 0.58 7.14 5.14 68.32
140 INT86625 Binding of Pla2g1b 8 0.24 2.52 2.43 68.12
141 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 67.52
142 INT107401 Regulation of Das 9 0.18 3.02 1.31 66.88
143 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 66.72
144 INT153800 Positive_regulation of Protein_catabolism of PARP1 18 0.49 16.16 1.89 66.72
145 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25 66.40
146 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63 66.40
147 INT1060 Negative_regulation of Pla2g1b 50 0.57 22.91 18.12 66.28
148 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 65.12
149 INT42994 Binding of BDNF-AS 21 0.35 14.17 4 64.96
150 INT122485 Negative_regulation of CASP9 18 0.46 15.78 1.12 64.80
151 INT182223 Gene_expression of CXCR5 57 0.76 51.49 28.4 64.72
152 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 64.52
153 INT156108 Regulation of TSS 5 0.23 0.59 1.45 64.40
154 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 64.24
155 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 64.08
156 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 64.00
157 INT6849 Localization of IL1B 229 0.81 112.56 69.63 64.00
158 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 64.00
159 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 63.28
160 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94 63.28
161 INT18527 Localization of Aap 31 0.72 5.6 14.42 62.96
162 INT95367 Negative_regulation of Positive_regulation of IRF6 7 0.21 3.5 1.34 62.16
163 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 62.16
164 INT76098 Positive_regulation of Positive_regulation of IRF6 16 0.27 6.05 3.35 62.16
165 INT271098 Negative_regulation of Positive_regulation of JUND 1 0.01 1.69 0.16 61.96
166 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63 61.68
167 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 61.48
168 INT75133 Positive_regulation of JUND 15 0.51 6.69 3.26 61.48
169 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 61.20
170 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25 60.72
171 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 60.56
172 INT32256 Gene_expression of PLXNA3 11 0.75 7.8 4.92 60.56
173 INT67248 Gene_expression of TACC2 12 0.50 13.51 3.65 60.40
174 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13 59.92
175 INT9440 Binding of MSMB 4 0.38 3.66 2.61 59.92
176 INT147514 Negative_regulation of CRYGD 15 0.13 9.41 5.1 59.44
177 INT75841 Binding of Trav6-3 66 0.47 29.14 7.63 59.08
178 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 58.80
179 INT211297 Phosphorylation of Trav6-3 5 0.27 1.56 0.32 58.68
180 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 58.52
181 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 58.48
182 INT248324 Regulation of IGKV2-19 4 0.00 2.3 1.27 58.44
183 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 58.04
184 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 57.84
185 INT220215 Positive_regulation of HUNK 1 0.28 1.11 0.29 57.72
186 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 57.60
187 INT248325 Positive_regulation of Localization of Aes 4 0.26 1.88 2.07 57.60
188 INT204717 Gene_expression of Sh4 5 0.73 30.17 10.19 57.56
189 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 57.56
190 INT158070 Localization of Aes 23 0.65 19.93 10.9 57.24
191 INT182293 Binding of MAPK8 11 0.34 4.6 0.77 57.00
192 INT182852 Regulation of AAVS1 4 0.12 4.6 1.03 56.72
193 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 56.24
194 INT56160 Binding of Ifx 14 0.36 11.39 5.74 56.24
195 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23 56.24
196 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 56.12
197 INT36330 Positive_regulation of Positive_regulation of GOT1 4 0.32 4.42 1.26 56.12
198 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 56.12
199 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 56.12
200 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 56.12
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