P:Rostral ventrolateral medulla

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Pain Term
Category Anatomy
Synonyms None
Pain Specific No
Documents 302
Hot Single Events 200
Hot Interactions 23

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Rostral ventrolateral medulla. They are ordered first by their pain relevance and then by number of times they were reported for Rostral ventrolateral medulla. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95 100.00
2 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3 100.00
3 INT304537 Map2k1 Positive_regulation of PRKG1 1 0.01 0.66 0.16 100.00
4 INT304535 Mapk1 Positive_regulation of PRKG1 1 0.05 0.65 0.16 100.00
5 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16 100.00
6 INT304496 Mknk1 Positive_regulation of Gene_expression of Nos1 1 0.19 0.18 0.15 100.00
7 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36 99.92
8 INT304530 Mknk1 Regulation of Mdk 1 0.01 0.19 0.2 99.84
9 INT304505 Binding of Mapk1 and Uts2d 1 0.01 0.64 0.36 99.42
10 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25 99.02
11 INT304532 Binding of Mdk and Mapk1 1 0.02 0.63 0.35 98.44
12 INT304529 Negative_regulation of Binding of Mdk and Mapk1 1 0.02 0.63 0.35 98.44
13 INT304495 Trib3 Positive_regulation of Mapk1 1 0.02 1.4 0.35 98.40
14 INT352055 Negative_regulation of Binding of Spn and Gpr156 1 0.09 0.28 0.31 97.12
15 INT352054 Binding of Spn and Gpr156 1 0.08 0.28 0.31 97.12
16 INT285327 Binding of Cox8b and Gtf2ird2 1 0.00 0.9 0.29 94.08
17 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3 93.24
18 INT304536 Mknk1 Positive_regulation of PRKG1 1 0.03 0.53 0.3 93.24
19 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08 92.84
20 INT304502 Mknk1 Positive_regulation of Phosphorylation of Nos1 1 0.19 0.16 0.11 92.80
21 INT132696 Binding of Arc and Pag1 1 0.00 0.5 0.67 88.40
22 INT304531 Apcs Regulation of Mtap 1 0.06 0.52 0.14 85.28
23 INT304499 Map2k1 Positive_regulation of Mapk1 1 0.12 0.8 0.1 83.68
24 INT60827 Ddc Positive_regulation of Localization of Abat 1 0.12 0.34 0.94 79.92
25 INT60828 Ddc Positive_regulation of Abat 1 0.13 0.34 0.93 79.28
26 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23 75.00
27 INT304500 Binding of Rps6ka1 and Mapk1 1 0.16 0.18 0.12 66.28
28 INT245348 Binding of Abat and Vta1 1 0.03 0.53 2.01 5.00
29 INT245347 Binding of Penk and Vta1 1 0.05 0.14 1.53 5.00
30 INT245349 Binding of Abat and Gpr156 1 0.02 0.26 1 5.00
31 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85 5.00
32 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8 5.00
33 INT175700 Nos3 Negative_regulation of smc 1 0.01 1.05 0.59 5.00
34 INT352057 Spns1 Regulation of Gpr156 1 0.06 0 0.12 5.00
35 INT278984 Binding of CFH and NCS1 1 0.02 0.63 0.05 5.00
36 INT250090 OXT Regulation of POMC 1 0.02 0.1 0.04 5.00
37 INT250091 OXT Regulation of OXT Regulation of POMC 1 0.00 0.1 0.04 5.00
38 INT250089 OXT Regulation of Localization of POMC 1 0.02 0.1 0.04 5.00
39 INT265023 Gsr Negative_regulation of Binding of GSR 1 0.04 0.13 0 5.00
40 INT332735 Binding of Shbg and Hr 1 0.06 0.6 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Rostral ventrolateral medulla. They are ordered first by their pain relevance and then by number of times they were reported in Rostral ventrolateral medulla. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72 100.00
2 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 100.00
3 INT80395 Negative_regulation of Vom1r68 7 0.23 1.11 2.76 100.00
4 INT89677 Gene_expression of PRKG1 38 0.78 13.98 8.56 100.00
5 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
6 INT1613 Binding of Nts 58 0.48 10.55 28.18 100.00
7 INT946 Negative_regulation of Nts 60 0.57 4.61 34.44 100.00
8 INT143462 Positive_regulation of Positive_regulation of Ddx39b 1 0.20 0.57 0.56 100.00
9 INT143464 Positive_regulation of Positive_regulation of Cybb 2 0.13 1.57 0.73 100.00
10 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34 100.00
11 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 100.00
12 INT7138 Regulation of Regulation of Avp 10 0.36 1.99 6.37 100.00
13 INT4799 Negative_regulation of Gene_expression of Nts 7 0.40 2.03 3.35 100.00
14 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 99.98
15 INT4803 Transcription of Penk 435 0.72 59.09 182.4 99.98
16 INT38518 Positive_regulation of Negative_regulation of Grhpr 3 0.03 1.44 0.97 99.98
17 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 99.96
18 INT32205 Regulation of Positive_regulation of Trib3 9 0.11 2.82 4.1 99.96
19 INT4207 Regulation of Avp 267 0.62 63.72 115.33 99.96
20 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 99.92
21 INT93054 Regulation of Vom1r68 4 0.20 0.17 1.26 99.92
22 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 99.92
23 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 99.92
24 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 99.86
25 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.84
26 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 99.84
27 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87 99.84
28 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 99.84
29 INT15597 Negative_regulation of Gene_expression of Jun 20 0.48 6.04 11.08 99.84
30 INT60933 Positive_regulation of Apcs 16 0.67 11.69 3.68 99.84
31 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 99.84
32 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25 99.84
33 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22 99.84
34 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91 99.84
35 INT89678 Positive_regulation of Gene_expression of PRKG1 15 0.70 5.99 3.84 99.84
36 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29 99.84
37 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 99.84
38 INT304507 Regulation of Positive_regulation of PRKG1 1 0.03 0.47 0.23 99.84
39 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37 99.84
40 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96 99.78
41 INT82676 Negative_regulation of Gene_expression of Ddc 4 0.55 0.55 1.43 99.78
42 INT6230 Localization of Ddc 40 0.79 13.11 20.88 99.76
43 INT155563 Positive_regulation of Mknk1 2 0.54 2.12 1.08 99.76
44 INT143463 Phosphorylation of Gbp2 1 0.20 0.5 0.52 99.76
45 INT143465 Phosphorylation of Ddx39b 1 0.33 0.5 0.51 99.76
46 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 99.74
47 INT3410 Positive_regulation of Artles 9 0.04 2.57 2.5 99.74
48 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 99.72
49 INT304523 Positive_regulation of Gucy2e 2 0.45 1.49 0.28 99.72
50 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35 99.70
51 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16 99.70
52 INT111196 Negative_regulation of Negative_regulation of Agtr1a 2 0.42 0.49 0.65 99.70
53 INT1352 Localization of Acot1 728 0.80 73.01 296.01 99.68
54 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 99.68
55 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56 99.68
56 INT7664 Negative_regulation of Grip2 68 0.49 10.11 29.93 99.68
57 INT52233 Transcription of Jun 37 0.66 6.39 11.15 99.68
58 INT4735 Gene_expression of Acot1 80 0.71 13.22 26.68 99.68
59 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.68
60 INT127262 Negative_regulation of Transcription of Jun 1 0.30 0.52 0.61 99.68
61 INT33854 Localization of OPA1 19 0.65 10.55 5.04 99.68
62 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 99.68
63 INT93760 Regulation of Negative_regulation of Grip2 1 0.27 0 0.41 99.68
64 INT1158 Regulation of Agt 106 0.61 29.4 30.29 99.66
65 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05 99.64
66 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77 99.64
67 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 99.64
68 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.64
69 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 99.64
70 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 99.60
71 INT304511 Gene_expression of Hnf1a 2 0.04 0.39 0.32 99.60
72 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 99.58
73 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63 99.56
74 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58 99.56
75 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54 99.56
76 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 99.54
77 INT35928 Positive_regulation of Baat 12 0.69 12.23 5.43 99.54
78 INT3784 Regulation of Hmbs 4 0.38 2.79 2.11 99.52
79 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81 99.52
80 INT97032 Gene_expression of Snai1 3 0.52 0.58 1.04 99.50
81 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.44
82 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 99.44
83 INT12751 Gene_expression of Pigm 91 0.58 22.42 29.2 99.44
84 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89 99.44
85 INT50713 Positive_regulation of Nisch 6 0.69 1.5 4.33 99.42
86 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 99.40
87 INT211910 Negative_regulation of Map2k2 2 0.26 0.59 0.63 99.38
88 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49 99.38
89 INT304528 Gene_expression of Map2k1 3 0.58 1.76 0.37 99.36
90 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 99.32
91 INT17969 Negative_regulation of Regulation of Cck 9 0.43 1.03 7.04 99.32
92 INT3948 Regulation of Cck 291 0.62 58.07 255.88 99.32
93 INT49110 Regulation of Grip2 46 0.61 13.57 30.87 99.32
94 INT19146 Negative_regulation of Apoa2 19 0.36 5.34 6.73 99.30
95 INT14114 Binding of Adra2a 30 0.48 4.24 18.53 99.28
96 INT3703 Negative_regulation of Grhpr 38 0.50 11.43 9.2 99.24
97 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 99.20
98 INT1225 Regulation of Snai1 10 0.30 1.05 2.72 99.18
99 INT135495 Regulation of Positive_regulation of Snai1 1 0.23 0 0.33 99.18
100 INT285324 Negative_regulation of Cox8b 1 0.07 1.59 0.37 99.12
101 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92 99.10
102 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 99.08
103 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05 99.00
104 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 99.00
105 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72 98.96
106 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 98.96
107 INT20914 Positive_regulation of Snai1 13 0.41 3.41 7.69 98.94
108 INT304526 Binding of Map2k1 1 0.11 0.6 0.32 98.92
109 INT143461 Positive_regulation of Ddx39b 1 0.28 0.55 0.54 98.90
110 INT143466 Positive_regulation of Cybb 4 0.34 2.67 0.88 98.90
111 INT3439 Localization of Abat 1017 0.78 112.39 727.06 98.88
112 INT109015 Positive_regulation of Positive_regulation of PRKG1 5 0.38 2.04 1.87 98.86
113 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6 98.84
114 INT45914 Gene_expression of Apcs 22 0.65 24.25 8.48 98.84
115 INT8733 Localization of Oprm1 61 0.75 7.55 64.61 98.84
116 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11 98.76
117 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 98.72
118 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32 98.72
119 INT2156 Positive_regulation of Positive_regulation of LH 33 0.69 3.18 14.33 98.72
120 INT71405 Binding of Glra2 1 0.12 0.1 0.87 98.68
121 INT36489 Regulation of Apcs 12 0.58 10.6 2.78 98.66
122 INT18489 Binding of Man2a2 59 0.48 11.27 29.38 98.64
123 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35 98.64
124 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15 98.60
125 INT63542 Positive_regulation of Serpini1 3 0.20 0.51 1.98 98.60
126 INT285323 Positive_regulation of Hnf1b 1 0.02 0.88 0.29 98.56
127 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03 98.52
128 INT1396 Binding of Penk 355 0.48 22.79 269.65 98.48
129 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 98.40
130 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39 98.38
131 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 98.38
132 INT269380 Negative_regulation of Gene_expression of PRKG1 3 0.19 1.3 0.56 98.38
133 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27 98.38
134 INT46687 Negative_regulation of Snd1 7 0.38 2.47 2.59 98.28
135 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41 98.20
136 INT350 Localization of Th 79 0.80 10.26 41.17 98.12
137 INT105723 Negative_regulation of Mat1a 2 0.41 0.96 0.58 98.12
138 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59 98.12
139 INT129281 Positive_regulation of Gene_expression of Casp9 1 0.31 0.84 0.48 98.08
140 INT129280 Gene_expression of Casp9 9 0.68 5.48 2.25 98.08
141 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18 98.08
142 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74 98.08
143 INT171476 Negative_regulation of Regulation of HTR1A 1 0.42 1.05 0.52 98.08
144 INT36923 Binding of Mdk 7 0.35 3.81 2.58 98.04
145 INT16883 Positive_regulation of Gene_expression of Pigm 11 0.39 3.93 6.89 98.04
146 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 98.00
147 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38 97.92
148 INT304516 Regulation of Mknk1 1 0.21 1.16 0.42 97.92
149 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 97.92
150 INT90296 Binding of NISCH 2 0.31 0.3 0.49 97.92
151 INT88861 Positive_regulation of Gene_expression of Hsp90aa1 4 0.64 7.43 0.9 97.86
152 INT77656 Gene_expression of Hsp90aa1 12 0.78 24.27 1.81 97.86
153 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 97.84
154 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 97.80
155 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23 97.80
156 INT78948 Positive_regulation of Positive_regulation of Nisch 2 0.03 0.49 0.78 97.72
157 INT304519 Positive_regulation of Gene_expression of Map2k1 1 0.15 0.41 0.22 97.68
158 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 97.64
159 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 97.64
160 INT15821 Positive_regulation of Myo9b 1 0.53 0 1.05 97.64
161 INT51837 Negative_regulation of TACR1 17 0.43 6.5 9.12 97.64
162 INT15820 Regulation of Positive_regulation of Myo9b 1 0.47 0 0.68 97.64
163 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41 97.64
164 INT14132 Negative_regulation of HTR1A 25 0.57 4.93 10.91 97.64
165 INT114773 Negative_regulation of GABBR1 4 0.43 0.55 2.33 97.64
166 INT154998 Negative_regulation of NOP56P1 1 0.10 0.39 0.58 97.64
167 INT5993 Positive_regulation of Nts 122 0.70 26.82 70.45 97.60
168 INT6115 Positive_regulation of Pigm 82 0.64 16.96 25.73 97.60
169 INT17103 Negative_regulation of Prep 15 0.38 4.95 4.71 97.50
170 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 97.44
171 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 97.44
172 INT44824 Positive_regulation of Sp5 10 0.50 2.31 6.03 97.36
173 INT4284 Regulation of Ddc 17 0.43 8.17 7.31 97.24
174 INT127910 Negative_regulation of PPP1R1A 1 0.02 0.15 0.75 97.16
175 INT18785 Binding of Nisch 12 0.43 1.03 4.28 97.00
176 INT285325 Regulation of Coq10a 1 0.29 1.34 0.45 96.92
177 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 96.92
178 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61 96.92
179 INT9476 Regulation of Gene_expression of Jun 14 0.43 4.25 7.61 96.92
180 INT10927 Transcription of FLII 1 0.16 0.19 0.55 96.92
181 INT6058 Localization of Fos 73 0.81 16.7 30.84 96.84
182 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 96.80
183 INT11779 Binding of Iars 4 0.26 1.38 0.78 96.76
184 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84 96.64
185 INT78949 Positive_regulation of Nisch 3 0.18 0.57 1.3 96.52
186 INT32625 Positive_regulation of Uchl1 2 0.49 1.39 1.4 96.48
187 INT10555 Gene_expression of FLII 37 0.75 7.81 17.6 96.48
188 INT23951 Negative_regulation of Spn 4 0.15 2.17 1.12 96.28
189 INT18539 Gene_expression of Pnmt 33 0.78 3.08 12.47 96.24
190 INT45448 Gene_expression of Vom1r68 9 0.03 1.94 1.5 96.24
191 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64 95.88
192 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87 95.86
193 INT74688 Regulation of Nos1 55 0.62 22.16 25.3 95.84
194 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 95.84
195 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 95.80
196 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 95.58
197 INT10056 Positive_regulation of Fabp6 77 0.59 36.99 16.8 95.28
198 INT285321 Phosphorylation of Coq10a 1 0.53 0.59 0.18 95.28
199 INT12757 Negative_regulation of Positive_regulation of Acot1 16 0.42 2.27 8.25 95.16
200 INT186542 Regulation of MTAP 3 0.06 1.66 0.46 95.12
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