P:Somatic pain

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Pain Term
Category Pain type
Synonyms None
Pain Specific Yes
Documents 318
Hot Single Events 51
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Somatic pain. They are ordered first by their pain relevance and then by number of times they were reported for Somatic pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT280190 Cbs Regulation of Gene_expression of Hist1h1t 1 0.04 0.58 0.32 60.16
2 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 0.04 1.81 1.7 40.24
3 INT341371 CRX Positive_regulation of Gene_expression of Ephb1 1 0.02 0.99 0.9 40.24
4 INT341370 CRX Positive_regulation of Gene_expression of Ceacam3 1 0.04 0.99 0.9 40.24
5 INT294487 Binding of Calm1 and Tcm 1 0.00 0.81 0.23 24.40
6 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21 5.00
7 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8 5.00
8 INT181491 Tryptase Positive_regulation of HTR1A 1 0.02 0.93 0.61 5.00
9 INT280189 Binding of Cbs and P2rx3 1 0.01 1.03 0.47 5.00
10 INT280188 Binding of Cbs and Trpv1 1 0.26 1.03 0.47 5.00
11 INT181294 HBM Positive_regulation of NGB 1 0.02 0.74 0.3 5.00
12 INT181295 MB Positive_regulation of NGB 1 0.10 0.73 0.3 5.00
13 INT157902 hs Positive_regulation of Gene_expression of Fos 1 0.01 0.08 0 5.00
14 INT157901 hs Positive_regulation of Fos 1 0.01 0.07 0 5.00
15 INT157903 Negative_regulation of hs Positive_regulation of Fos 1 0.01 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Somatic pain. They are ordered first by their pain relevance and then by number of times they were reported in Somatic pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.98
2 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.84
3 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 99.84
4 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 99.36
5 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 99.34
6 INT1898 Regulation of Crh 220 0.62 61.33 102.64 99.28
7 INT151111 Gene_expression of Pain1 33 0.40 33.6 30.73 98.80
8 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 98.46
9 INT1715 Positive_regulation of Nrm 51 0.70 24 47.53 98.20
10 INT95318 Binding of Pain1 17 0.22 21.26 20.14 98.02
11 INT477 Localization of Avp 813 0.81 131.58 300.4 97.74
12 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 97.48
13 INT181307 Gene_expression of NGB 1 0.76 11.15 9.18 97.44
14 INT7573 Positive_regulation of Nr3c2 38 0.67 20 21.84 97.04
15 INT7564 Positive_regulation of Nr3c1 16 0.68 4.98 6.25 97.04
16 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 96.84
17 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 96.56
18 INT17803 Regulation of Edn1 14 0.54 4.75 4.71 96.56
19 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54 96.56
20 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 96.16
21 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 95.96
22 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 94.28
23 INT5118 Regulation of SST 97 0.62 34.35 51.74 93.36
24 INT24850 Regulation of GRHL3 4 0.45 0.32 1.9 93.00
25 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 92.60
26 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 92.32
27 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73 92.04
28 INT48922 Regulation of Gene_expression of Ephb1 14 0.50 5.73 6.47 92.04
29 INT210013 Regulation of Gene_expression of Ceacam3 4 0.38 2.13 2.67 92.04
30 INT341368 Regulation of Positive_regulation of Ceacam3 1 0.21 0.91 1.25 92.04
31 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 91.60
32 INT66867 Gene_expression of Ceacam3 58 0.67 30.44 40.7 91.60
33 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05 91.60
34 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 91.60
35 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23 91.60
36 INT114578 Positive_regulation of Gene_expression of Ceacam3 18 0.47 14.95 12.22 91.60
37 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16 91.44
38 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95 91.20
39 INT37615 Gene_expression of ESCO1 6 0.72 1.1 4.15 90.72
40 INT66868 Positive_regulation of Ceacam3 40 0.69 26.61 28.9 90.24
41 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 88.88
42 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27 88.80
43 INT60196 Binding of FOS 33 0.47 13.11 6.95 88.56
44 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 88.52
45 INT181309 Positive_regulation of Gene_expression of NGB 1 0.46 1.84 1.65 87.80
46 INT181306 Regulation of Gene_expression of NGB 1 0.44 0.7 0.73 87.80
47 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 85.84
48 INT442 Localization of PDYN 99 0.81 11.87 72.75 85.40
49 INT17233 Positive_regulation of Localization of PDYN 9 0.69 2.84 10.06 85.40
50 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 83.04
51 INT53729 Localization of Cort 14 0.69 6.31 6.97 80.36
52 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 78.56
53 INT7894 Negative_regulation of Vip 59 0.59 11.76 27.36 78.48
54 INT108917 Positive_regulation of CRX 23 0.50 21.32 10.5 78.40
55 INT52357 Gene_expression of Sub1 6 0.16 2.49 2.25 77.52
56 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 77.24
57 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34 77.08
58 INT165449 Negative_regulation of Gene_expression of Ceacam3 5 0.36 2.47 3.45 77.08
59 INT63651 Gene_expression of Adcyap1r1 17 0.77 2.57 4.58 76.36
60 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06 76.24
61 INT163939 Gene_expression of Dexi 1 0.06 0.92 0.81 76.24
62 INT2541 Binding of Calca 200 0.48 67.14 134.62 75.04
63 INT110284 Negative_regulation of Positive_regulation of Nr3c2 4 0.53 2.08 2.48 75.00
64 INT10568 Regulation of H2-Ab1 9 0.20 1.86 6.79 75.00
65 INT4460 Regulation of Mpo 44 0.62 31.16 12.11 74.16
66 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 71.92
67 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 70.84
68 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 70.84
69 INT4895 Positive_regulation of Gene_expression of Tac4 16 0.69 2.46 11.51 70.84
70 INT105321 Positive_regulation of Sla 1 0.45 0.07 0.21 69.60
71 INT4887 Gene_expression of Tac4 70 0.77 11.66 40.97 68.52
72 INT130497 Gene_expression of Cbs 5 0.77 16.93 9.34 68.32
73 INT79149 Gene_expression of CSE 26 0.58 11.76 14.16 68.32
74 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 67.76
75 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63 67.76
76 INT25915 Negative_regulation of RPL7AP5 9 0.38 3.56 8.5 66.08
77 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 65.28
78 INT280198 Regulation of Hist1h1t 2 0.21 1.28 1.69 64.80
79 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26 63.48
80 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 63.32
81 INT181298 Localization of CYGB 1 0.26 0.24 0.31 62.28
82 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92 60.56
83 INT4971 Regulation of Cbs 2 0.44 1.66 1 60.16
84 INT1562 Localization of Crh 499 0.81 126.74 236.68 60.08
85 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 59.84
86 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 59.44
87 INT280195 Regulation of Gene_expression of Hist1h1t 1 0.04 1.09 0.63 59.28
88 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 58.96
89 INT154986 Binding of CRX 3 0.24 3.87 0.53 58.24
90 INT147366 Gene_expression of Hist1h1t 15 0.44 9.84 6.67 58.16
91 INT104351 Positive_regulation of Etohcta1 2 0.01 1.14 0.99 57.20
92 INT280193 Positive_regulation of Gene_expression of Cbs 1 0.69 6.59 3.81 55.72
93 INT280194 Regulation of Gene_expression of Cbs 1 0.61 1.54 0.73 55.72
94 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 52.08
95 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95 52.08
96 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 49.36
97 INT280196 Positive_regulation of Gene_expression of Hist1h1t 1 0.07 1.62 1.02 49.16
98 INT2649 Regulation of Calca 433 0.62 146.05 330.95 48.08
99 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 47.48
100 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 41.04
101 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 40.72
102 INT156696 Positive_regulation of Pain1 10 0.23 10.92 12.42 38.68
103 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 38.00
104 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 36.56
105 INT8824 Regulation of Vip 95 0.62 15.7 43.63 34.16
106 INT5040 Regulation of Gal 42 0.60 12.72 21.18 34.16
107 INT8986 Positive_regulation of Gene_expression of Gal 24 0.67 10.96 14.09 34.16
108 INT8424 Positive_regulation of Gene_expression of Vip 11 0.70 8.01 8.31 34.16
109 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72 33.60
110 INT29144 Gene_expression of Rvm 41 0.52 29.23 47.76 28.32
111 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 25.00
112 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13 25.00
113 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 25.00
114 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 25.00
115 INT9483 Gene_expression of Junb 34 0.78 3.24 12.08 25.00
116 INT9480 Gene_expression of Jund 14 0.77 3.58 5.25 25.00
117 INT68635 Negative_regulation of Ceacam3 7 0.55 3.16 7.85 22.48
118 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 15.04
119 INT223033 Localization of Pain1 2 0.21 1.81 1.97 7.52
120 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
121 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
122 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
123 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
124 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
125 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 5.00
126 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
127 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 5.00
128 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
129 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
130 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
131 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
132 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
133 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
134 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
135 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 5.00
136 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 5.00
137 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
138 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
139 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
140 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
141 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 5.00
142 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 5.00
143 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
144 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 5.00
145 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
146 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
147 INT1564 Localization of OPRM1 41 0.80 8.03 44.67 5.00
148 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 5.00
149 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
150 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
151 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
152 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
153 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
154 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
155 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 5.00
156 INT254567 Positive_regulation of Gene_expression of PAG1 10 0.39 31.15 24.26 5.00
157 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
158 INT5586 Binding of Fos 47 0.48 12.7 21.33 5.00
159 INT112338 Localization of Rvm 11 0.31 9.51 17.61 5.00
160 INT8526 Negative_regulation of Positive_regulation of Fos 26 0.59 5.99 17.52 5.00
161 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 5.00
162 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 5.00
163 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
164 INT49768 Positive_regulation of Kcnj5 58 0.41 11.89 16.02 5.00
165 INT19948 Gene_expression of Sds 34 0.63 14.69 15.44 5.00
166 INT129 Localization of OXTR 51 0.80 11.08 15.36 5.00
167 INT63553 Binding of PAG1 14 0.48 12.51 14.76 5.00
168 INT167521 Regulation of Pain1 11 0.27 10.88 14 5.00
169 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
170 INT3969 Positive_regulation of Sds 27 0.69 7.52 12.31 5.00
171 INT31341 Positive_regulation of CSE 15 0.60 11.57 12.29 5.00
172 INT118905 Positive_regulation of Positive_regulation of PAG1 8 0.40 7.55 12.25 5.00
173 INT7132 Localization of NPPA 53 0.81 19.79 10.86 5.00
174 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
175 INT181488 Positive_regulation of Spg21 13 0.12 15.52 10.03 5.00
176 INT254566 Negative_regulation of Gene_expression of PAG1 7 0.33 9.51 9.91 5.00
177 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47 5.00
178 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 5.00
179 INT81419 Localization of PAG1 10 0.64 11.1 8.01 5.00
180 INT36135 Negative_regulation of CSE 19 0.50 1.77 7.81 5.00
181 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 5.00
182 INT63365 Gene_expression of Spg21 21 0.65 12.9 7.37 5.00
183 INT181489 Localization of Spg21 16 0.12 10.89 6.84 5.00
184 INT43524 Positive_regulation of Sh2b2 16 0.58 2.95 5.78 5.00
185 INT254570 Regulation of Gene_expression of PAG1 3 0.35 6.72 5.76 5.00
186 INT71760 Binding of CSE 9 0.48 2.84 5.42 5.00
187 INT99091 Regulation of AR 70 0.45 31.68 5.05 5.00
188 INT97894 Positive_regulation of Gene_expression of Crh 27 0.70 11.82 4.82 5.00
189 INT5624 Transcription of Nppa 19 0.69 8.52 4.72 5.00
190 INT52993 Positive_regulation of Gene_expression of Rvm 4 0.40 4.21 4.68 5.00
191 INT5205 Localization of AR 43 0.80 12.87 4.63 5.00
192 INT24420 Transcription of Pomc 13 0.69 3.32 4.54 5.00
193 INT4283 Positive_regulation of Cbs 10 0.46 6.85 4.44 5.00
194 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 5.00
195 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 5.00
196 INT260159 Negative_regulation of Positive_regulation of PAG1 2 0.33 1.86 3.39 5.00
197 INT48292 Negative_regulation of Sh2b2 9 0.26 2.14 3.26 5.00
198 INT103739 Negative_regulation of Gene_expression of Crh 19 0.59 10.19 3.17 5.00
199 INT288550 Localization of CSE 2 0.59 1.32 3.08 5.00
200 INT157904 Positive_regulation of Gene_expression of CSE 2 0.39 1.35 3.01 5.00
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