P:Spinothalamic tract neurons

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Pain Term
Category Anatomy
Synonyms Substantia Gelatinosa Neuron
Pain Specific No
Documents 88
Hot Single Events 41
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spinothalamic tract neurons. They are ordered first by their pain relevance and then by number of times they were reported for Spinothalamic tract neurons. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57 99.68
2 INT186162 Phosphorylation of Prkaca Positive_regulation of Phosphorylation of Prkcg 1 0.04 0.22 0.7 86.80
3 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 0.22 0.2 0.8 75.00
4 INT128041 Bdnf Positive_regulation of Trib3 1 0.10 0.29 0.79 75.00
5 INT128043 Positive_regulation of Ntrk2 Positive_regulation of Phosphorylation of Trib3 1 0.07 0.34 0.45 75.00
6 INT193328 Grid1 Regulation of Positive_regulation of Prkcg 1 0.00 0.1 1.1 35.12
7 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81 5.00
8 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
9 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
10 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01 5.00
11 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
12 INT186160 Negative_regulation of Grin2b Negative_regulation of Grin1 1 0.37 0.5 0.72 5.00
13 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
14 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
15 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
16 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
17 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62 5.00
18 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
19 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
20 INT208499 Positive_regulation of Nkx1-1 Positive_regulation of Npr1 1 0.00 0 0.27 5.00
21 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
22 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
23 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
24 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
25 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
26 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
27 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spinothalamic tract neurons. They are ordered first by their pain relevance and then by number of times they were reported in Spinothalamic tract neurons. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118265 Positive_regulation of C7 4 0.23 0.92 1.52 100.00
2 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 99.96
3 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01 99.84
4 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87 99.84
5 INT168534 Gene_expression of Grik5 3 0.38 0.64 0.9 99.68
6 INT168539 Regulation of Gene_expression of Grik5 1 0.02 0.09 0.34 99.68
7 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 99.48
8 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 99.48
9 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 99.48
10 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76 99.48
11 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 99.26
12 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16 99.26
13 INT168536 Localization of Grik5 1 0.07 0.09 0.34 99.24
14 INT120997 Regulation of Npy5r 1 0.00 0.54 0.6 98.88
15 INT160093 Gene_expression of C7 12 0.67 5.44 2.73 98.28
16 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 98.20
17 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 98.20
18 INT47691 Positive_regulation of Gene_expression of Ntrk2 17 0.62 13.64 6.96 98.20
19 INT89055 Phosphorylation of Prkaca 60 0.61 13.41 32.49 98.04
20 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 97.38
21 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 97.12
22 INT1715 Positive_regulation of Nrm 51 0.70 24 47.53 96.44
23 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52 96.28
24 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 96.24
25 INT18616 Positive_regulation of Positive_regulation of Adarb1 18 0.33 2.04 13.18 93.64
26 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 93.04
27 INT797 Regulation of Penk 812 0.62 111.13 542.24 92.32
28 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 90.28
29 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06 88.00
30 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 87.44
31 INT403 Localization of Trh 241 0.81 28.55 81.45 87.36
32 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 87.04
33 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 86.80
34 INT133461 Phosphorylation of Grina 2 0.19 1.46 2.25 83.84
35 INT186166 Regulation of Phosphorylation of Grina 1 0.11 0.08 0.93 83.84
36 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 83.36
37 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 83.36
38 INT4958 Gene_expression of Pcyt1b 18 0.65 3.4 5.66 82.72
39 INT265097 Positive_regulation of Pot1 1 0.22 0 0.14 80.72
40 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 80.36
41 INT7611 Positive_regulation of Cspg5 17 0.67 2.97 12.2 80.04
42 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 75.00
43 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 75.00
44 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10 75.00
45 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 75.00
46 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16 75.00
47 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 75.00
48 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 75.00
49 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 75.00
50 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 75.00
51 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77 75.00
52 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 75.00
53 INT106540 Negative_regulation of Phosphorylation of Grin1 15 0.58 9.32 29.13 75.00
54 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27 75.00
55 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59 75.00
56 INT100919 Positive_regulation of Grm1 21 0.70 7.82 11.55 75.00
57 INT21934 Negative_regulation of Negative_regulation of Pag1 11 0.39 7.91 11.37 75.00
58 INT58423 Gene_expression of Grid2 9 0.67 1.43 1.99 75.00
59 INT168538 Gene_expression of Hsd17b12 3 0.72 0.76 1.39 75.00
60 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 75.00
61 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 75.00
62 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 75.00
63 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 75.00
64 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 75.00
65 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 75.00
66 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 75.00
67 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 75.00
68 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 75.00
69 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 75.00
70 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51 75.00
71 INT124670 Gene_expression of Grik1 53 0.77 4.83 19.13 75.00
72 INT28857 Negative_regulation of Positive_regulation of Pag1 11 0.30 8.46 10.19 75.00
73 INT3438 Negative_regulation of Dock7 11 0.00 1.03 6.72 75.00
74 INT65056 Binding of Ntrk2 20 0.36 3.72 4.42 75.00
75 INT11261 Positive_regulation of PTPLA 3 0.50 4.4 3.74 75.00
76 INT53142 Negative_regulation of Gene_expression of Tac1 7 0.56 1.59 3.61 75.00
77 INT168537 Negative_regulation of Gene_expression of Grik1 3 0.57 0.11 1.44 75.00
78 INT100921 Positive_regulation of Positive_regulation of Grm1 2 0.47 1.01 1.24 75.00
79 INT46745 Positive_regulation of Dock7 2 0.00 0.31 1.12 75.00
80 INT38718 Negative_regulation of Stt3a 1 0.21 0 0.83 75.00
81 INT106541 Phosphorylation of Glra1 1 0.08 0 0.64 75.00
82 INT168535 Transcription of Grid2 1 0.11 0.08 0.4 75.00
83 INT128040 Positive_regulation of Binding of Ntrk2 1 0.49 0.32 0.37 75.00
84 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 73.36
85 INT79248 Regulation of Negative_regulation of Prkcg 13 0.44 3.44 9.78 69.96
86 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41 65.88
87 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31 62.92
88 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6 62.04
89 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 61.64
90 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18 59.00
91 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 50.80
92 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 47.36
93 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 46.00
94 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 41.40
95 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 40.68
96 INT81264 Positive_regulation of Localization of Ngf 13 0.58 9.82 9.53 31.96
97 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02 31.96
98 INT113770 Phosphorylation of Grid1 4 0.14 0.2 3.75 31.84
99 INT113769 Positive_regulation of Phosphorylation of Grid1 3 0.09 0.29 2.21 31.84
100 INT20210 Localization of Ngf 69 0.79 46.22 38.57 31.16
101 INT20216 Localization of NGF 40 0.80 18.16 16.61 31.16
102 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48 29.04
103 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 27.52
104 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 27.52
105 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32 27.52
106 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88 26.24
107 INT24432 Protein_catabolism of ITPA 3 0.96 0.33 0.26 25.00
108 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85 22.00
109 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67 18.68
110 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6 14.12
111 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 13.56
112 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44 9.00
113 INT136471 Phosphorylation of Tacr1 4 0.46 1.03 1.99 8.32
114 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
115 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
116 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
117 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 5.00
118 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 5.00
119 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
120 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 5.00
121 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 5.00
122 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 5.00
123 INT5587 Regulation of Fos 191 0.62 40.81 99.7 5.00
124 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 5.00
125 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57 5.00
126 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
127 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 5.00
128 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
129 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
130 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
131 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 5.00
132 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
133 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
134 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
135 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98 5.00
136 INT13938 Positive_regulation of Nkx1-1 64 0.68 30.83 58.75 5.00
137 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
138 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07 5.00
139 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
140 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14 5.00
141 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85 5.00
142 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
143 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78 5.00
144 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69 5.00
145 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66 5.00
146 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19 5.00
147 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11 5.00
148 INT117632 Gene_expression of Trpm8 99 0.78 29.41 30.9 5.00
149 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
150 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01 5.00
151 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54 5.00
152 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19 5.00
153 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6 5.00
154 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 5.00
155 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17 5.00
156 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07 5.00
157 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 5.00
158 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 5.00
159 INT12269 Gene_expression of Chrna9 39 0.73 6.98 18.44 5.00
160 INT50420 Transcription of Grin1 30 0.71 13.21 18.28 5.00
161 INT15370 Binding of Nkx1-1 24 0.29 5.84 18.16 5.00
162 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12 5.00
163 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3 5.00
164 INT16624 Localization of Grin1 38 0.79 8.46 17.15 5.00
165 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92 5.00
166 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26 5.00
167 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
168 INT103828 Negative_regulation of Gene_expression of TRPV1 23 0.59 13.63 13.81 5.00
169 INT74465 Negative_regulation of Nkx1-1 22 0.46 8.51 13.63 5.00
170 INT58596 Positive_regulation of Gene_expression of Nkx1-1 21 0.49 14.05 13.53 5.00
171 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17 5.00
172 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55 5.00
173 INT143767 Negative_regulation of Trpm8 26 0.58 12.34 10.83 5.00
174 INT113765 Phosphorylation of Adarb1 10 0.05 4.91 10.51 5.00
175 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5 5.00
176 INT80717 Gene_expression of Trpv3 20 0.72 10.05 9.96 5.00
177 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
178 INT134597 Binding of Trpa1 21 0.48 9.41 9.74 5.00
179 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69 5.00
180 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62 5.00
181 INT107898 Gene_expression of Trpv2 27 0.76 10.55 9.28 5.00
182 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28 5.00
183 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85 5.00
184 INT12663 Localization of Nkx1-1 16 0.74 3.77 8.74 5.00
185 INT146241 Positive_regulation of Gene_expression of Trpa1 23 0.69 8.07 8.74 5.00
186 INT148703 Gene_expression of NOVA2 73 0.65 18.05 8.3 5.00
187 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2 5.00
188 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
189 INT75684 Regulation of Aif1 32 0.47 8.03 7.89 5.00
190 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 5.00
191 INT16869 Positive_regulation of Prl 24 0.70 15.7 7.63 5.00
192 INT21435 Positive_regulation of Negative_regulation of Adarb1 7 0.39 3.13 6.5 5.00
193 INT50419 Gene_expression of Grina 13 0.25 6.11 6.42 5.00
194 INT124881 Binding of Trpv4 35 0.47 7.71 6.24 5.00
195 INT116617 Phosphorylation of Rorb 15 0.07 3.43 6.12 5.00
196 INT144086 Positive_regulation of Prok2 12 0.69 9.54 6.06 5.00
197 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 5.00
198 INT71477 Negative_regulation of Positive_regulation of Prkaca 10 0.37 1.69 5.57 5.00
199 INT146347 Negative_regulation of Gene_expression of Trpm8 9 0.55 6.96 5.42 5.00
200 INT92541 Localization of Grin2b 11 0.75 2.85 5.14 5.00
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