P:Spontaneous pain

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Pain Term
Category Pain type
Synonyms Stimulus Independent Pain
Pain Specific Yes
Documents 810
Hot Single Events 200
Hot Interactions 21

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Spontaneous pain. They are ordered first by their pain relevance and then by number of times they were reported for Spontaneous pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81 96.72
2 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81 96.72
3 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81 96.72
4 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78 96.72
5 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78 96.72
6 INT147654 DYT10 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.93 1.62 91.80
7 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62 91.80
8 INT315769 GRIN1 Negative_regulation of Plbd1 1 0.00 0.57 0.87 89.92
9 INT127400 Negative_regulation of Mdk Negative_regulation of Gene_expression of Elk1 1 0.01 0.71 0.45 89.60
10 INT127392 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin1 1 0.08 0.71 0.45 89.60
11 INT127399 Negative_regulation of Mdk Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.7 0.45 89.60
12 INT127398 Negative_regulation of Mdk Negative_regulation of Gene_expression of Tacr1 1 0.01 0.71 0.45 89.60
13 INT127393 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Nfkb1 1 0.10 0.7 0.45 89.60
14 INT127397 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin1 1 0.01 0.71 0.45 89.60
15 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45 89.60
16 INT127396 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin2a 1 0.00 0.71 0.45 89.60
17 INT127391 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Elk1 1 0.08 0.71 0.45 89.60
18 INT127395 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Tacr1 1 0.07 0.71 0.45 89.60
19 INT127390 Negative_regulation of Ephb1 Negative_regulation of Phosphorylation of Elk1 1 0.08 0.7 0.44 89.60
20 INT127401 Negative_regulation of Mdk Negative_regulation of Phosphorylation of Elk1 1 0.01 0.7 0.44 89.60
21 INT346835 Gene_expression of Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.27 1.07 1.03 80.64
22 INT144608 Mapk7 Negative_regulation of Gene_expression of Fos 2 0.65 0.43 0.42 75.00
23 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89 74.04
24 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45 72.84
25 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12 70.92
26 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43 69.72
27 INT140895 PTGS2 Positive_regulation of Gene_expression of VEGFA 1 0.27 0.07 0.07 66.32
28 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5 64.80
29 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04 58.96
30 INT153963 Gatsl2 Regulation of Abat 1 0.02 0.97 1.03 58.72
31 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96 58.60
32 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92 58.12
33 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92 58.12
34 INT227545 Hspa9 Positive_regulation of Prep 1 0.18 0.59 0.96 57.48
35 INT182558 Binding of Ptgir and Trpv1 1 0.16 1.12 1.37 55.44
36 INT147653 TACR1 Positive_regulation of TRPV1 1 0.02 0.72 1.29 54.20
37 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13 50.96
38 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98 50.96
39 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92 49.44
40 INT197470 Binding of Sostdc1 and Hbtq 1 0.00 0.87 0.87 46.28
41 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06 29.80
42 INT197469 Binding of Dpcd and Hbtq 1 0.00 0 0 29.40
43 INT197466 Dpcd Positive_regulation of Sostdc1 1 0.00 0 0 19.92
44 INT197468 Dpcd Positive_regulation of Hbtq 1 0.00 0 0 19.92
45 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25 5.00
46 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5 5.00
47 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78 5.00
48 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67 5.00
49 INT150455 Binding of Prss12 and Nts 3 0.24 1.42 2.66 5.00
50 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64 5.00
51 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07 5.00
52 INT283050 Binding of Gad2 and Trpm8 1 0.23 2.02 1.93 5.00
53 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84 5.00
54 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79 5.00
55 INT182565 Ptger2 Regulation of Trpv1 1 0.25 1.34 1.73 5.00
56 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67 5.00
57 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65 5.00
58 INT182563 Ptger2 Positive_regulation of Ptger1 1 0.22 1.4 1.64 5.00
59 INT20530 Nts Regulation of Prss12 5 0.24 0.74 1.23 5.00
60 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21 5.00
61 INT335435 Ngf Positive_regulation of Ltb4r 1 0.52 1.06 1.16 5.00
62 INT187805 Ms18 Regulation of Positive_regulation of Slc1a3 1 0.26 0.87 1.12 5.00
63 INT182550 Ptger1 Negative_regulation of Trpv1 1 0.35 0.73 1.12 5.00
64 INT296950 Tacr1 Negative_regulation of Gene_expression of Cck 1 0.30 0.94 1.11 5.00
65 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05 5.00
66 INT182552 Ptgir Positive_regulation of Ptger1 1 0.15 1.31 1.02 5.00
67 INT182561 Ptger3 Positive_regulation of Ptger1 1 0.15 1.31 1.02 5.00
68 INT182560 Ptger2 Positive_regulation of Ptgir 1 0.12 1.31 1.02 5.00
69 INT164287 Ltb4r Positive_regulation of Cysltr2 2 0.41 1.88 1.02 5.00
70 INT164281 Ltb4r Positive_regulation of Cysltr1 2 0.32 1.87 1.02 5.00
71 INT182556 Ptger4 Positive_regulation of Ptgir 1 0.08 1.31 1.02 5.00
72 INT182567 Ptger4 Positive_regulation of Ptger1 1 0.15 1.31 1.02 5.00
73 INT182566 Ptger3 Positive_regulation of Ptgir 1 0.08 1.31 1.02 5.00
74 INT307100 Trpv1 Regulation of Binding of Trpa1 1 0.31 1.81 0.97 5.00
75 INT307103 Trpa1 Regulation of Binding of Trpv1 1 0.31 1.81 0.97 5.00
76 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96 5.00
77 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96 5.00
78 INT331109 Tpnr1 Regulation of Gene_expression of Calca 1 0.06 0.97 0.94 5.00
79 INT344381 Olfr360 Negative_regulation of Gene_expression of Grin2b 1 0.01 1.17 0.93 5.00
80 INT344390 Olfr360 Negative_regulation of Phosphorylation of Grin2b 1 0.01 1.17 0.93 5.00
81 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92 5.00
82 INT318462 Nnat Positive_regulation of Nfkb1 1 0.46 0.9 0.88 5.00
83 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85 5.00
84 INT182555 Ptgir Regulation of Trpv1 1 0.12 0.61 0.85 5.00
85 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
86 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83 5.00
87 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8 5.00
88 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77 5.00
89 INT344383 Olfr360 Regulation of Gene_expression of Efnb1 1 0.01 1.27 0.74 5.00
90 INT219274 Binding of Cx3cr1 and Cx3cl1 1 0.17 1.08 0.74 5.00
91 INT283049 Car2 Positive_regulation of Trpa1 1 0.20 1.33 0.67 5.00
92 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66 5.00
93 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 1 0.01 1.05 0.66 5.00
94 INT33561 Crh Positive_regulation of POMC 3 0.45 1.19 0.64 5.00
95 INT334594 Binding of GNAI1 and MRGPRD 1 0.01 0.19 0.63 5.00
96 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62 5.00
97 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61 5.00
98 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61 5.00
99 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61 5.00
100 INT227544 Hspa9 Regulation of Gene_expression of Prep 1 0.15 0.57 0.61 5.00
101 INT181491 Tryptase Positive_regulation of HTR1A 1 0.02 0.93 0.61 5.00
102 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61 5.00
103 INT182562 Ptger2 Positive_regulation of Trpv1 1 0.30 0.09 0.61 5.00
104 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6 5.00
105 INT324925 Ros1 Positive_regulation of Bdkrb1 1 0.08 0.67 0.6 5.00
106 INT335432 Ltc4s Regulation of Cysltr2 1 0.11 0.38 0.58 5.00
107 INT335436 Ltc4s Regulation of Gene_expression of Cysltr2 1 0.18 0.38 0.58 5.00
108 INT236489 Gtf3a Regulation of Pain1 1 0.00 0.52 0.56 5.00
109 INT236492 Gtf3a Regulation of SNRNP70 1 0.00 0.52 0.56 5.00
110 INT335433 Cysltr2 Regulation of Trpv1 1 0.28 0.45 0.55 5.00
111 INT334592 MRGPRD Positive_regulation of ABAT 1 0.03 0.32 0.54 5.00
112 INT216918 Binding of Ca2 and Abat 1 0.01 0.45 0.53 5.00
113 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53 5.00
114 INT216919 Ngf Positive_regulation of Gene_expression of P2rx3 1 0.18 0.69 0.53 5.00
115 INT182557 Ptger2 Regulation of Regulation of Trpv1 1 0.25 0.68 0.52 5.00
116 INT292075 FSCN1 Positive_regulation of Gene_expression of Csnk1a1 1 0.03 0.57 0.52 5.00
117 INT182554 Ptger2 Regulation of Ptger1 1 0.11 0.68 0.52 5.00
118 INT182551 Ptgir Negative_regulation of Trpv1 1 0.19 0.7 0.51 5.00
119 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48 5.00
120 INT335438 Ltb4r2 Positive_regulation of Cysltr2 1 0.04 0.77 0.42 5.00
121 INT335437 Ltb4r2 Positive_regulation of Cysltr1 1 0.03 0.77 0.41 5.00
122 INT335439 Ltb4r Positive_regulation of Ltb4r2 1 0.09 0.76 0.41 5.00
123 INT263072 Kncn Regulation of Transcription of Trpm8 1 0.08 0.99 0.36 5.00
124 INT182559 Binding of Pi4kb and Trpv1 1 0.02 0.2 0.35 5.00
125 INT190652 Mdk Positive_regulation of Phosphorylation of Mapk1 2 0.50 0.85 0.33 5.00
126 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28 5.00
127 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28 5.00
128 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22 5.00
129 INT177477 Crh Positive_regulation of Crh Regulation of POMC 1 0.02 0.86 0.22 5.00
130 INT177479 Negative_regulation of Crh Regulation of POMC 1 0.05 0.84 0.21 5.00
131 INT190651 Mdk Negative_regulation of Positive_regulation of Mapk1 1 0.40 0.23 0.19 5.00
132 INT299370 Binding of Mapk8 and Life1 1 0.04 0.73 0.18 5.00
133 INT177480 Positive_regulation of Crh Positive_regulation of Regulation of POMC 1 0.06 0.46 0.14 5.00
134 INT249849 Ufm1 Positive_regulation of Fgf2 1 0.01 0.56 0.14 5.00
135 INT249852 Ufm1 Positive_regulation of VEGFA 1 0.00 0.55 0.14 5.00
136 INT283947 Positive_regulation of Car1 Positive_regulation of Ptgfrn 1 0.01 0 0.14 5.00
137 INT276511 Binding of Nts and Mir431 1 0.00 0 0.1 5.00
138 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1 5.00
139 INT249851 VEGFA Positive_regulation of Gene_expression of Nos3 1 0.05 0.44 0.1 5.00
140 INT227547 Hspa9 Regulation of Gene_expression of Rnpep 1 0.02 0.31 0.08 5.00
141 INT227546 Hspa9 Regulation of Rnpep 1 0.01 0.31 0.08 5.00
142 INT310820 Trav6-3 Positive_regulation of Phosphorylation of Jun 1 0.04 0.22 0.04 5.00
143 INT299368 Mkks Positive_regulation of Mapk8 1 0.41 0.17 0.03 5.00
144 INT249850 Binding of Ptprc and Cd34 1 0.13 0.48 0 5.00
145 INT197467 Binding of Dpcd and Memor1 1 0.00 0.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Spontaneous pain. They are ordered first by their pain relevance and then by number of times they were reported in Spontaneous pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 100.00
2 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06 100.00
3 INT144607 Positive_regulation of Gene_expression of Mapk7 8 0.61 2.09 2.82 100.00
4 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29 99.98
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 99.96
6 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 99.96
7 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 99.76
8 INT45636 Positive_regulation of Melm1 2 0.09 0.95 1.8 99.72
9 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17 99.70
10 INT242105 Positive_regulation of Positive_regulation of CFP 5 0.49 1.93 1.32 99.60
11 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.56
12 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.56
13 INT92572 Gene_expression of Mapk7 17 0.78 3.71 4.76 99.52
14 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87 99.40
15 INT7437 Gene_expression of CFP 21 0.65 4.93 3.89 99.40
16 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 99.36
17 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97 99.32
18 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98 99.32
19 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 99.32
20 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68 99.32
21 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81 99.32
22 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08 99.32
23 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 99.18
24 INT3948 Regulation of Cck 291 0.62 58.07 255.88 99.16
25 INT116709 Negative_regulation of Mapk4 5 0.10 4.48 3.97 99.08
26 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 99.06
27 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82 99.06
28 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01 99.06
29 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.06
30 INT7028 Localization of Pdyn 90 0.81 8.89 73.54 99.04
31 INT6231 Gene_expression of Col6a6 5 0.26 2.56 1.78 99.00
32 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 98.82
33 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 98.82
34 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 98.82
35 INT116710 Positive_regulation of Phosphorylation of Mapk4 4 0.11 5.45 4.85 98.82
36 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 98.82
37 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65 98.82
38 INT168280 Positive_regulation of Phosphorylation of Il1b 1 0.49 1.1 0.93 98.82
39 INT116707 Positive_regulation of Mapk4 8 0.21 9.83 7.96 98.82
40 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72 98.80
41 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 98.78
42 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 98.68
43 INT7134 Localization of KNG1 127 0.79 65.73 67.97 98.68
44 INT116706 Phosphorylation of Mapk4 9 0.25 8.5 7.79 98.48
45 INT153960 Negative_regulation of Gene_expression of Slc6a1 1 0.42 2.4 2.54 98.36
46 INT95313 Gene_expression of Slc6a1 6 0.76 3.96 6.14 98.36
47 INT15296 Regulation of Rbm39 45 0.29 10.66 29.27 98.36
48 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 98.30
49 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 98.30
50 INT310810 Regulation of Localization of Hrec 1 0.02 0.51 0.57 98.28
51 INT132551 Negative_regulation of Plxna2 3 0.36 0.86 1.11 98.16
52 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 98.12
53 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36 98.12
54 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 98.10
55 INT6232 Positive_regulation of Col6a6 2 0.21 1.67 1.76 98.08
56 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 98.04
57 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 97.92
58 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 97.92
59 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 97.92
60 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 97.92
61 INT1160 Positive_regulation of Rbm39 122 0.57 28.19 90.28 97.92
62 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 97.88
63 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34 97.84
64 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 97.68
65 INT90371 Localization of Hrec 28 0.05 19.11 10.12 97.68
66 INT95317 Positive_regulation of Slc6a1 6 0.69 5.91 7.94 97.64
67 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05 97.44
68 INT164558 Binding of PERP 3 0.14 1.55 1.67 97.44
69 INT141038 Positive_regulation of Gene_expression of Hcn4 4 0.38 3.58 3.12 97.32
70 INT227492 Negative_regulation of Regulation of CFP 1 0.03 1.25 1.11 97.26
71 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5 97.24
72 INT2649 Regulation of Calca 433 0.62 146.05 330.95 97.16
73 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 97.00
74 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25 96.96
75 INT63553 Binding of PAG1 14 0.48 12.51 14.76 96.96
76 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18 96.96
77 INT68789 Regulation of CFP 17 0.51 4.76 3.98 96.88
78 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 96.76
79 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 96.72
80 INT2541 Binding of Calca 200 0.48 67.14 134.62 96.44
81 INT12424 Binding of Npy 48 0.48 8.23 24.26 96.44
82 INT161394 Binding of Mks1 2 0.02 1.52 0.62 96.44
83 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83 96.40
84 INT124960 Regulation of Scn11a 9 0.52 8.39 5.49 96.32
85 INT142941 Negative_regulation of Scn11a 14 0.43 12.2 13.38 96.32
86 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 96.28
87 INT127389 Positive_regulation of Phosphorylation of Elk1 4 0.30 2.05 1.43 96.20
88 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35 96.20
89 INT127387 Positive_regulation of Phosphorylation of Nfkb1 4 0.38 3.91 2.59 96.20
90 INT36400 Regulation of SCN10A 7 0.62 2.73 1.97 96.20
91 INT85395 Gene_expression of Scn11a 62 0.78 17.97 26.89 96.16
92 INT120521 Negative_regulation of Gene_expression of Scn11a 2 0.42 2.12 1.3 96.16
93 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 95.92
94 INT101593 Positive_regulation of Gene_expression of TRPM8 16 0.70 13.79 4.23 95.92
95 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 95.80
96 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 95.56
97 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 95.56
98 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 95.56
99 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2 95.56
100 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 95.56
101 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 95.56
102 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 95.44
103 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 95.36
104 INT83894 Positive_regulation of TRPM8 37 0.70 18.28 11.7 95.36
105 INT141036 Negative_regulation of Aifm1 1 0.00 1.26 1.07 95.36
106 INT121977 Phosphorylation of Nfkb1 15 0.51 9.83 7.77 95.24
107 INT318153 Binding of Etohd1 1 0.03 0.93 0.53 95.16
108 INT112037 Negative_regulation of Positive_regulation of Trpv1 19 0.59 8.9 10.55 94.96
109 INT62564 Gene_expression of Syp 40 0.76 15.56 17 94.88
110 INT106476 Regulation of Gene_expression of Syp 3 0.60 2.32 2.3 94.88
111 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 94.84
112 INT85433 Phosphorylation of Elk1 5 0.50 1.83 1.62 94.84
113 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 94.72
114 INT59878 Negative_regulation of Transcription of Prkcg 3 0.43 2.15 2.85 94.72
115 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 94.64
116 INT346826 Positive_regulation of Gene_expression of Efnb2 1 0.46 3.88 3.71 94.56
117 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 94.56
118 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11 94.56
119 INT249733 Protein_catabolism of Itgb6 1 0.03 5.77 2.99 94.48
120 INT120261 Binding of P2rx2 19 0.28 5.8 6.72 94.44
121 INT141037 Positive_regulation of Aifm1 3 0.45 3.32 1.38 94.40
122 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 94.36
123 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31 94.28
124 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 94.28
125 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 94.28
126 INT59879 Transcription of Prkcg 9 0.69 2.29 5.3 94.20
127 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 94.20
128 INT256282 Gene_expression of Efnb2 3 0.76 17.61 16.41 94.16
129 INT1613 Binding of Nts 58 0.48 10.55 28.18 94.00
130 INT148901 Binding of Sort1 2 0.39 3.65 4.32 94.00
131 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 93.84
132 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 93.84
133 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 93.64
134 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 93.60
135 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 93.52
136 INT103624 Negative_regulation of Gene_expression of Grin2a 5 0.56 1.58 1.9 93.52
137 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 93.48
138 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69 93.48
139 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 93.48
140 INT100926 Positive_regulation of Gene_expression of Grin2a 11 0.63 3.24 6.41 93.48
141 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16 93.32
142 INT259766 Positive_regulation of Localization of Fbn2 1 0.03 3.09 1.51 93.32
143 INT118232 Regulation of Gene_expression of NALCN 3 0.13 1.92 2.25 93.24
144 INT86544 Positive_regulation of Camk2a 20 0.47 4.59 11.37 93.16
145 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 93.12
146 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24 93.12
147 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 93.08
148 INT151387 Gene_expression of Cav3 14 0.78 4 5.31 93.04
149 INT61585 Gene_expression of NALCN 25 0.52 6.52 8.18 92.92
150 INT259760 Localization of Fbn2 5 0.05 5.55 2.85 92.92
151 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 92.84
152 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 92.84
153 INT63383 Binding of Cnr1 77 0.48 22.28 44.61 92.80
154 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7 92.72
155 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 92.64
156 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 92.60
157 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91 92.60
158 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47 92.40
159 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 92.32
160 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26 92.32
161 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 92.16
162 INT4803 Transcription of Penk 435 0.72 59.09 182.4 92.16
163 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37 92.16
164 INT41494 Negative_regulation of Gene_expression of Tacr1 25 0.58 11.73 19.91 92.16
165 INT5045 Regulation of VIP 26 0.62 7.15 11.61 92.16
166 INT69839 Regulation of Mzb1 5 0.57 0.93 1.9 92.16
167 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 92.08
168 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 92.08
169 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 92.08
170 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 92.08
171 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 92.08
172 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 92.00
173 INT140896 Gene_expression of GPNMB 9 0.51 7.38 0.4 92.00
174 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 91.60
175 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53 91.60
176 INT91916 Gene_expression of P2rx3 51 0.78 21.2 19.05 91.24
177 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83 91.12
178 INT136038 Negative_regulation of LOC691170 1 0.02 0.59 0.97 91.08
179 INT66466 Regulation of Positive_regulation of Pdyn 3 0.39 2.46 1.89 91.04
180 INT103262 Localization of Nav1 53 0.81 19.23 34.44 91.00
181 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19 90.68
182 INT195203 Binding of Tenc1 14 0.32 13.97 8.28 90.68
183 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 90.68
184 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 90.48
185 INT127500 Gene_expression of TRPA1 79 0.78 24.58 23.3 90.36
186 INT64046 Negative_regulation of DYT10 20 0.57 7.86 16.15 90.32
187 INT59818 Negative_regulation of PLCB1 7 0.57 2.24 2.28 90.32
188 INT141615 Gene_expression of Cysltr2 2 0.72 13.44 14.09 90.24
189 INT217447 Positive_regulation of Positive_regulation of Nfatc1 4 0.46 3.34 2.2 90.20
190 INT203184 Transcription of C7orf49 1 0.05 1.7 1.4 90.08
191 INT344368 Positive_regulation of Gene_expression of Efnb1 13 0.63 18.39 13.31 89.96
192 INT120432 Regulation of Trpa1 22 0.61 9.65 12.36 89.96
193 INT691 Binding of SST 67 0.48 24.66 32.67 89.92
194 INT77583 Positive_regulation of Gene_expression of Htr1a 6 0.49 4.23 3.72 89.84
195 INT91784 Positive_regulation of Transcription of Htr1a 2 0.45 1.38 1.31 89.84
196 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02 89.60
197 INT331104 Regulation of Rhoay-ps1 1 0.07 0.93 1.53 89.52
198 INT273335 Negative_regulation of Localization of Mcpt1 5 0.32 2.66 1.83 89.48
199 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74 89.48
200 INT90792 Localization of Il10 144 0.80 87.88 30.03 89.08
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