P:TRK receptor

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Pain Term
Category Family
Synonyms TRK Receptors
Pain Specific No
Documents 1
Hot Single Events 0
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for TRK receptor. They are ordered first by their pain relevance and then by number of times they were reported for TRK receptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 99.92
2 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 98.40
3 INT308650 Binding of nt and Ntrk2 1 0.01 0.41 0.21 98.40
4 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21 93.24
5 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
6 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
7 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
8 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
9 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
10 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
11 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
12 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
13 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
14 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
15 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
16 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2 5.00
17 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19 5.00
18 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
19 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19 5.00
20 INT308659 Binding of Ager and ecs 1 0.01 1.14 0.12 5.00
21 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 0.09 1.01 0.12 5.00
22 INT308660 Binding of Ager and App 1 0.08 1.22 0.12 5.00
23 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11 5.00
24 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09 5.00
25 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 5.00
26 INT308652 Binding of Renbp and Nps 1 0.01 1.38 0.09 5.00
27 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07 5.00
28 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07 5.00
29 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07 5.00
30 INT308649 Binding of Ppp1r13b and Iars 1 0.01 0.29 0.04 5.00
31 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03 5.00
32 INT308648 Binding of sps and Gopc 1 0.01 2.71 0 5.00
33 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0 5.00
34 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0 5.00
35 INT121225 Positive_regulation of Ngf Positive_regulation of Ntrk1 2 0.49 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for TRK receptor. They are ordered first by their pain relevance and then by number of times they were reported in TRK receptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT48240 Binding of Ngf 46 0.46 23.51 24.42 78.24
2 INT95651 Positive_regulation of Binding of Ngf 3 0.50 0.48 0.25 78.24
3 INT15505 Regulation of nt 6 0.24 1.5 1.88 74.00
4 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 67.80
5 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 34.36
6 INT63042 Binding of Apoe 59 0.48 31.23 5.88 15.04
7 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
8 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
9 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
10 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
11 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
12 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
13 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
14 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
15 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
16 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 5.00
17 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
18 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
19 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
20 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
21 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
22 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
23 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
24 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 5.00
25 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
26 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
27 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
28 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 5.00
29 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
30 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
31 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
32 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
33 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
34 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
35 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
36 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
37 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
38 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
39 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
40 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
41 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 5.00
42 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
43 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 5.00
44 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 5.00
45 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
46 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
47 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
48 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
49 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
50 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 5.00
51 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 5.00
52 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 5.00
53 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
54 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
55 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 5.00
56 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
57 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
58 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 5.00
59 INT45437 Localization of Acot1 84 0.79 17.37 22.18 5.00
60 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
61 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
62 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
63 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
64 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 5.00
65 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
66 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
67 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
68 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43 5.00
69 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95 5.00
70 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
71 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82 5.00
72 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38 5.00
73 INT100821 Localization of Ros1 59 0.60 45.26 11.92 5.00
74 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75 5.00
75 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 5.00
76 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63 5.00
77 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 5.00
78 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48 5.00
79 INT62576 Transcription of Creb1 34 0.69 16.97 10.6 5.00
80 INT3982 Gene_expression of Acot1 53 0.56 7.61 10.46 5.00
81 INT25613 Gene_expression of Il1f5 32 0.77 13.29 10.44 5.00
82 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 5.00
83 INT35284 Positive_regulation of Chrm1 14 0.67 5.64 10.11 5.00
84 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
85 INT6361 Localization of Edn1 30 0.81 19.09 9.7 5.00
86 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
87 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
88 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
89 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 5.00
90 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.00
91 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49 5.00
92 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 5.00
93 INT5114 Gene_expression of Ptgis 41 0.50 21.43 8.1 5.00
94 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
95 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 5.00
96 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
97 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4 5.00
98 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39 5.00
99 INT197493 Localization of Apoe 61 0.79 27.48 7.06 5.00
100 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 5.00
101 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
102 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 5.00
103 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69 5.00
104 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37 5.00
105 INT107173 Phosphorylation of App 20 0.82 12.64 5.3 5.00
106 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 5.00
107 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63 5.00
108 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 5.00
109 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
110 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 11 0.66 11.17 4.44 5.00
111 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 5.00
112 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37 5.00
113 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34 5.00
114 INT45433 Positive_regulation of Localization of Acot1 18 0.45 1.9 4.32 5.00
115 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13 5.00
116 INT224369 Binding of Ager 43 0.42 40.57 3.86 5.00
117 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74 5.00
118 INT131877 Negative_regulation of Nps 12 0.39 8.19 3.56 5.00
119 INT41490 Regulation of Acot1 14 0.45 1.59 3.34 5.00
120 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23 5.00
121 INT194625 Gene_expression of GSK 18 0.75 9.02 3.23 5.00
122 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2 5.00
123 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98 5.00
124 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 5.00
125 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 5.00
126 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 5.00
127 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32 5.00
128 INT142265 Regulation of Apoe 20 0.60 9.52 2.23 5.00
129 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22 5.00
130 INT55291 Gene_expression of Slc2a1 20 0.68 11.46 2.16 5.00
131 INT28739 Binding of Ins1 35 0.37 22.43 2.14 5.00
132 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13 5.00
133 INT33170 Binding of Chrm1 11 0.48 1.58 2.1 5.00
134 INT172559 Localization of Proc 16 0.02 21.49 2.08 5.00
135 INT201683 Phosphorylation of GSK 15 0.80 6.6 2.01 5.00
136 INT237322 Gene_expression of Irs1 52 0.77 21.07 2 5.00
137 INT105931 Binding of Ppp1r13b 5 0.27 1.29 1.77 5.00
138 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 5.00
139 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75 5.00
140 INT108252 Positive_regulation of Renbp 16 0.24 11.66 1.68 5.00
141 INT196873 Positive_regulation of Ly6 5 0.07 1.74 1.66 5.00
142 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63 5.00
143 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61 5.00
144 INT159718 Negative_regulation of Gene_expression of Acot1 4 0.16 1.4 1.56 5.00
145 INT19342 Regulation of Insr 12 0.24 6.11 1.54 5.00
146 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52 5.00
147 INT190519 Positive_regulation of Positive_regulation of Ros1 14 0.32 9.99 1.52 5.00
148 INT230805 Localization of Slc2a4 23 0.46 11 1.48 5.00
149 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48 5.00
150 INT194461 Positive_regulation of Chol1 11 0.67 6.46 1.45 5.00
151 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
152 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
153 INT95939 Positive_regulation of GSK 19 0.67 10 1.33 5.00
154 INT292714 Negative_regulation of Gene_expression of GSK 4 0.41 2.34 1.31 5.00
155 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3 5.00
156 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3 5.00
157 INT31397 Gene_expression of Iars 7 0.51 4.16 1.24 5.00
158 INT164205 Binding of Proc 12 0.36 12.31 1.19 5.00
159 INT108246 Regulation of Renbp 5 0.21 4.66 1.12 5.00
160 INT55294 Gene_expression of Slc2a4 17 0.70 6.84 1.11 5.00
161 INT207203 Transcription of Akt1 6 0.67 3.73 1.1 5.00
162 INT87765 Binding of Acot1 4 0.07 2.59 0.95 5.00
163 INT187347 Negative_regulation of Localization of Ngf 2 0.42 0.13 0.95 5.00
164 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94 5.00
165 INT180451 Positive_regulation of Apoa2 15 0.67 12.65 0.89 5.00
166 INT198872 Binding of Lrp1 9 0.36 2.73 0.89 5.00
167 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86 5.00
168 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85 5.00
169 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81 5.00
170 INT116830 Binding of Itpr3 10 0.45 0.29 0.78 5.00
171 INT63109 Gene_expression of Chol1 12 0.75 5.04 0.78 5.00
172 INT68297 Binding of MAPT 9 0.47 4.45 0.75 5.00
173 INT308613 Regulation of Ly6 1 0.05 2.65 0.74 5.00
174 INT170546 Gene_expression of Renbp 15 0.32 14.33 0.72 5.00
175 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64 5.00
176 INT140998 Regulation of GSK 3 0.60 1.13 0.62 5.00
177 INT130072 Transcription of Ins1 12 0.54 6.84 0.62 5.00
178 INT288361 Localization of Laptm5 2 0.09 0.32 0.61 5.00
179 INT214707 Gene_expression of Slc2a8 5 0.24 2.76 0.61 5.00
180 INT142800 Positive_regulation of Ldlr 21 0.68 14.75 0.6 5.00
181 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59 5.00
182 INT210522 Protein_catabolism of Ide 16 0.79 7.73 0.55 5.00
183 INT235515 Positive_regulation of Gene_expression of Renbp 5 0.24 5.19 0.54 5.00
184 INT166833 Phosphorylation of Proc 5 0.80 3.56 0.51 5.00
185 INT185152 Positive_regulation of T2dm2 7 0.17 14.93 0.46 5.00
186 INT205899 Gene_expression of Acat1 3 0.62 0.58 0.45 5.00
187 INT170554 Binding of Renbp 17 0.17 12.36 0.45 5.00
188 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41 5.00
189 INT246823 Phosphorylation of Iars 7 0.31 2.77 0.38 5.00
190 INT107340 Negative_regulation of Phosphorylation of MAPT 3 0.57 2.64 0.35 5.00
191 INT121782 Transcription of Mapk1 3 0.50 1.58 0.35 5.00
192 INT146107 Positive_regulation of Lrp1 4 0.37 1.91 0.34 5.00
193 INT186622 Negative_regulation of Chol1 9 0.42 3.86 0.32 5.00
194 INT103585 Gene_expression of MANEA 4 0.75 2.12 0.31 5.00
195 INT212985 Negative_regulation of Positive_regulation of Pik3r1 3 0.19 3.28 0.3 5.00
196 INT184526 Phosphorylation of Slc2a1 2 0.18 1.53 0.29 5.00
197 INT308633 Gene_expression of Cyp46a1 1 0.33 0.15 0.25 5.00
198 INT308616 Positive_regulation of Phosphorylation of Iars 1 0.15 0.63 0.24 5.00
199 INT216554 Localization of ABCB6 5 0.28 0.75 0.23 5.00
200 INT265341 Negative_regulation of Gene_expression of ecs 2 0.13 1.22 0.22 5.00
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