P:Tetrahydrobiopterin

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Pain Term
Category Molecule
Synonyms None
Pain Specific No
Documents 64
Hot Single Events 135
Hot Interactions 13

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tetrahydrobiopterin. They are ordered first by their pain relevance and then by number of times they were reported for Tetrahydrobiopterin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54 100.00
2 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02 99.60
3 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51 99.60
4 INT317427 IFN1@ Positive_regulation of ISYNA1 1 0.12 0.49 0.45 98.52
5 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43 98.52
6 INT159350 Zfp956 Negative_regulation of Nos2 1 0.03 0.3 0.21 98.52
7 INT86634 POMC Positive_regulation of TYR 2 0.42 0 0.24 97.56
8 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65 97.20
9 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05 84.72
10 INT293900 TYRP1 Regulation of IGKC 1 0.01 0.11 0.27 84.24
11 INT293901 Positive_regulation of TYRP1 Regulation of IGKC 1 0.02 0.06 0.15 84.24
12 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6 80.48
13 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67 80.12
14 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22 79.20
15 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22 78.68
16 INT131603 POMC Regulation of TYR 1 0.52 0 0.13 75.00
17 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1 68.68
18 INT181646 interleukin-17 Positive_regulation of ISYNA1 1 0.01 0.26 0.2 60.64
19 INT181617 IL17A Positive_regulation of ISYNA1 1 0.01 0.27 0.2 60.64
20 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1 55.64
21 INT172817 Crp Positive_regulation of Regulation of Nos3 1 0.09 0.84 0.1 55.64
22 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1 55.64
23 INT172821 Crp Positive_regulation of Negative_regulation of Nos3 1 0.06 0.84 0.1 55.64
24 INT293899 UPF1 Positive_regulation of Gene_expression of APOB 1 0.01 0 0.04 35.48
25 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07 19.64
26 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
27 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
28 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 5.00
29 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
30 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 5.00
31 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79 5.00
32 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77 5.00
33 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
34 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64 5.00
35 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62 5.00
36 INT284791 Binding of Trpv1 and DRGX 1 0.02 0.66 0.6 5.00
37 INT284792 Binding of Trpa1 and DRGX 1 0.02 0.66 0.6 5.00
38 INT284790 Trpa1 Positive_regulation of Regulation of Napa 1 0.19 0 0.59 5.00
39 INT284784 Trpv1 Positive_regulation of Regulation of Napa 1 0.20 0 0.59 5.00
40 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58 5.00
41 INT236489 Gtf3a Regulation of Pain1 1 0.00 0.52 0.56 5.00
42 INT236492 Gtf3a Regulation of SNRNP70 1 0.00 0.52 0.56 5.00
43 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46 5.00
44 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43 5.00
45 INT313455 Binding of Ppp2ca and Syp 1 0.45 0.68 0.4 5.00
46 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37 5.00
47 INT284788 Napa Positive_regulation of Trpv1 1 0.31 0 0.35 5.00
48 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 5.00
49 INT198642 GPI Positive_regulation of TNF 1 0.03 0.98 0.33 5.00
50 INT344036 Binding of NOS1 and SPTB 1 0.01 0.31 0.32 5.00
51 INT172822 Binding of Fga and T2dm2 1 0.01 2.24 0.31 5.00
52 INT198640 TNF Positive_regulation of ISYNA1 1 0.04 1.07 0.29 5.00
53 INT182771 ROS1 Positive_regulation of NFKB1 Positive_regulation of CRP 1 0.00 3.83 0.28 5.00
54 INT213029 Positive_regulation of Binding of Apoa1 and Scarb1 1 0.09 3.38 0.27 5.00
55 INT313446 Syp Regulation of Ppp2ca 1 0.58 0.62 0.26 5.00
56 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25 5.00
57 INT284783 Napa Positive_regulation of Positive_regulation of Trpa1 1 0.20 0 0.25 5.00
58 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24 5.00
59 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24 5.00
60 INT175910 SERPINE1 Negative_regulation of PLAU 1 0.06 1.01 0.22 5.00
61 INT312517 Rapgef1 Negative_regulation of Rbp4 1 0.01 0.9 0.22 5.00
62 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22 5.00
63 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22 5.00
64 INT284787 Napa Positive_regulation of Binding of Trpa1 1 0.22 0 0.2 5.00
65 INT284789 Napa Positive_regulation of Binding of Trpv1 1 0.22 0 0.2 5.00
66 INT284782 Napa Positive_regulation of Trpa1 1 0.30 0 0.2 5.00
67 INT175909 Binding of ROS1 and CNBP 1 0.01 1.78 0.19 5.00
68 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19 5.00
69 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18 5.00
70 INT313453 Siglec1 Regulation of Th 1 0.02 0.61 0.17 5.00
71 INT213041 Hdl1 Negative_regulation of Gene_expression of Vcam1 1 0.14 0.9 0.17 5.00
72 INT313449 Siglec1 Regulation of Ppp2ca 1 0.03 0.61 0.17 5.00
73 INT172829 Binding of Nfkb1 and ISYNA1 1 0.00 2.06 0.17 5.00
74 INT172820 Binding of Nfkb1 and T2dm2 1 0.00 2.14 0.17 5.00
75 INT172827 ROS1 Positive_regulation of Tnf 1 0.01 2.1 0.16 5.00
76 INT172837 ROS1 Positive_regulation of Nfkb1 1 0.00 2.11 0.16 5.00
77 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 0.03 1.44 0.15 5.00
78 INT213010 Hdl1 Negative_regulation of Gene_expression of Icam1 1 0.15 1.01 0.15 5.00
79 INT213005 Hdl1 Positive_regulation of Akt1 3 0.19 3.81 0.14 5.00
80 INT182772 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL1B 1 0.00 1.89 0.14 5.00
81 INT182773 ROS1 Positive_regulation of NFKB1 Positive_regulation of IL6 1 0.00 1.9 0.14 5.00
82 INT182780 NFKB1 Positive_regulation of IL1B 1 0.00 1.8 0.14 5.00
83 INT182782 NFKB1 Positive_regulation of IL6 1 0.00 1.8 0.14 5.00
84 INT313441 Th Regulation of Siglec1 1 0.02 0.22 0.13 5.00
85 INT313439 Syp Negative_regulation of Th 1 0.30 0.14 0.13 5.00
86 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 5.00
87 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12 5.00
88 INT213058 Binding of Apoa1 and Scarb1 Positive_regulation of Positive_regulation of Hdl1 1 0.05 1.15 0.12 5.00
89 INT313466 Syp Negative_regulation of Siglec1 1 0.05 0.24 0.12 5.00
90 INT172824 Positive_regulation of Binding of Tnfsf4 and T2dm2 1 0.00 2.97 0.12 5.00
91 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11 5.00
92 INT313454 Negative_regulation of Syp Negative_regulation of Th 1 0.30 0.14 0.1 5.00
93 INT172818 Binding of T2dm2 and Hypism 1 0.00 3.62 0.1 5.00
94 INT213053 Hdl1 Negative_regulation of Gene_expression of Adamts1 1 0.07 0.88 0.1 5.00
95 INT213023 Hdl1 Regulation of Nos3 2 0.09 4.06 0.09 5.00
96 INT213006 Olr1 Positive_regulation of Gene_expression of Mmp9 1 0.11 0.81 0.09 5.00
97 INT313430 Syp Positive_regulation of Ppp2ca 1 0.66 0.08 0.09 5.00
98 INT213051 Hdl1 Positive_regulation of Pik3r1 1 0.13 1.93 0.09 5.00
99 INT213018 Hdl1 Negative_regulation of Gene_expression of Mmp9 1 0.10 0.81 0.09 5.00
100 INT172836 Binding of INS and T2dm2 1 0.00 1.65 0.08 5.00
101 INT313442 Th Regulation of Phosphorylation of Syp 1 0.32 0 0.08 5.00
102 INT313447 Ppp2ca Regulation of Phosphorylation of Syp 1 0.43 0 0.08 5.00
103 INT313459 Gene_expression of Syp Negative_regulation of Th 1 0.30 0.49 0.08 5.00
104 INT313437 Th Regulation of Phosphorylation of Siglec1 1 0.04 0 0.08 5.00
105 INT313469 Ppp2ca Regulation of Phosphorylation of Siglec1 1 0.06 0 0.08 5.00
106 INT213019 Hdl1 Positive_regulation of Tgoln1 1 0.03 1.01 0.07 5.00
107 INT284786 Trpv1 Positive_regulation of Gene_expression of Trpa1 1 0.45 0.36 0.07 5.00
108 INT353489 Negative_regulation of Aldh2 Negative_regulation of Prkag1 1 0.00 0.84 0.07 5.00
109 INT313450 Th Regulation of Syp 1 0.32 0.6 0.06 5.00
110 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06 5.00
111 INT213001 Hdl1 Positive_regulation of Trib3 1 0.00 2 0.06 5.00
112 INT313463 Ppp2ca Regulation of Syp 1 0.43 0.6 0.06 5.00
113 INT213060 Hdl1 Negative_regulation of Gene_expression of PLEK 1 0.25 1.33 0.05 5.00
114 INT213014 Regulation of Hdl1 Positive_regulation of Akt1 1 0.12 0.97 0.05 5.00
115 INT213016 Regulation of Hdl1 Positive_regulation of Pik3r1 1 0.09 0.97 0.05 5.00
116 INT323056 LDLR Regulation of HSD11B1 1 0.01 1.2 0.05 5.00
117 INT182775 Binding of PTH and ROS1 1 0.04 1.73 0.04 5.00
118 INT213047 Hdl1 Positive_regulation of Gene_expression of Nos3 1 0.14 0.94 0.04 5.00
119 INT198639 S100A12 Positive_regulation of TNF 1 0.15 1.49 0.04 5.00
120 INT296113 Fig4 Negative_regulation of Gene_expression of Csf2 1 0.01 0.91 0.04 5.00
121 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04 5.00
122 INT213037 Hdl1 Positive_regulation of Gene_expression of Serpine1 1 0.19 1.19 0.04 5.00
123 INT198646 S100A12 Positive_regulation of IL1B 1 0.01 1.49 0.04 5.00
124 INT323286 CYP4A11 Positive_regulation of Kcnma1 1 0.01 0.45 0.04 5.00
125 INT313462 Syp Positive_regulation of Binding of Ppp2ca 1 0.47 0 0.04 5.00
126 INT213052 Hdl1 Negative_regulation of Gene_expression of Vwf 1 0.19 1.23 0.04 5.00
127 INT198651 Positive_regulation of S100A12 Positive_regulation of TNF 1 0.15 1.5 0.04 5.00
128 INT296115 Fig4 Negative_regulation of Csf2 1 0.01 0.91 0.04 5.00
129 INT198650 Positive_regulation of S100A12 Positive_regulation of IL1B 1 0.01 1.5 0.04 5.00
130 INT213002 Binding of Scarb1 and Trib3 1 0.00 1.02 0.03 5.00
131 INT213050 Hdl1 Regulation of Bgn 1 0.00 0.79 0.03 5.00
132 INT313433 53T Regulation of Th 1 0.00 0 0.03 5.00
133 INT313464 Negative_regulation of Ppp2ca Positive_regulation of Phosphorylation of Mapk1 1 0.09 0 0.03 5.00
134 INT172832 Binding of ROS1 and Renbp 1 0.00 0.83 0.03 5.00
135 INT213011 Binding of Scarb1 and Hdl1 1 0.13 0.96 0.03 5.00
136 INT313445 53T Regulation of Ppp2ca 1 0.00 0 0.03 5.00
137 INT213059 Hdl1 Regulation of BGN 1 0.16 0.79 0.03 5.00
138 INT212938 Binding of Scarb1 and Hdl1 Positive_regulation of Trib3 1 0.00 1.02 0.03 5.00
139 INT213036 Hdl1 Positive_regulation of Phosphorylation of Mapk14 1 0.22 0.78 0.03 5.00
140 INT213004 Hdl1 Positive_regulation of Mapk14 1 0.22 0.97 0.03 5.00
141 INT313448 Gene_expression of Syp Positive_regulation of Th 1 0.28 0 0.03 5.00
142 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03 5.00
143 INT313468 Negative_regulation of Syp Regulation of Th 1 0.30 0.3 0.03 5.00
144 INT313451 Gene_expression of Syp Negative_regulation of Mapk1 1 0.09 0 0.03 5.00
145 INT213039 Hdl1 Positive_regulation of Prkca 1 0.10 0.98 0.03 5.00
146 INT213057 Hdl1 Positive_regulation of Binding of Scarb1 and Hdl1 1 0.08 0.96 0.03 5.00
147 INT213030 Hdl1 Regulation of Gene_expression of Edn1 1 0.06 0.88 0 5.00
148 INT313443 Syp Positive_regulation of Binding of Th 1 0.35 0.31 0 5.00
149 INT213024 Cd320 Positive_regulation of Localization of F3 1 0.12 1.16 0 5.00
150 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0 5.00
151 INT313461 Gopc Regulation of Th 1 0.07 0 0 5.00
152 INT172759 INS Positive_regulation of Localization of REN 1 0.03 0.64 0 5.00
153 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 5.00
154 INT213045 Cd320 Positive_regulation of Gene_expression of tf 1 0.16 1.17 0 5.00
155 INT182804 Binding of ETV3 and T2DM 1 0.10 2.62 0 5.00
156 INT213048 Cog1 Positive_regulation of Localization of tf 1 0.03 2.38 0 5.00
157 INT213055 Cd320 Positive_regulation of Positive_regulation of Tfpi 1 0.06 1.18 0 5.00
158 INT213056 Hdl1 Positive_regulation of Vtn Positive_regulation of Apc 1 0.00 1.21 0 5.00
159 INT213017 Apoa1 Negative_regulation of Positive_regulation of Gtf3a 1 0.00 1.16 0 5.00
160 INT213038 Hdl1 Positive_regulation of Localization of tf 1 0.12 1.11 0 5.00
161 INT172838 Binding of ISL1 and T2dm2 1 0.00 2.41 0 5.00
162 INT313429 Syp Regulation of Phosphorylation of Siglec1 1 0.04 0.57 0 5.00
163 INT313457 Ppp2ca Regulation of Th 1 0.36 0 0 5.00
164 INT213040 Tfpi Positive_regulation of Positive_regulation of Gtf3a 1 0.00 1.12 0 5.00
165 INT213012 Cog1 Positive_regulation of Localization of F3 1 0.02 1.17 0 5.00
166 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0 5.00
167 INT172831 Binding of INS and Tnfsf4 1 0.02 1.07 0 5.00
168 INT213020 Cd320 Positive_regulation of Localization of tf 1 0.16 2.36 0 5.00
169 INT213044 Cog1 Positive_regulation of Positive_regulation of Tfpi 1 0.01 1.19 0 5.00
170 INT313465 Syp Regulation of Regulation of Ppp2ca 1 0.26 0.56 0 5.00
171 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 5.00
172 INT172830 INS Positive_regulation of Agtrap 1 0.01 1.17 0 5.00
173 INT313426 Positive_regulation of Ppp2ca Positive_regulation of Bax 1 0.46 0.36 0 5.00
174 INT213049 Hdl1 Regulation of Gene_expression of Nppc 1 0.09 1 0 5.00
175 INT183462 Agt Positive_regulation of Ros1 1 0.02 0.11 0 5.00
176 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0 5.00
177 INT172839 Binding of ANGPT2 and T2dm2 1 0.00 1.72 0 5.00
178 INT273495 GBP4 Negative_regulation of IMPDH1 1 0.03 0.2 0 5.00
179 INT213015 Binding of S1pr1 and S1pr3 1 0.16 1.17 0 5.00
180 INT182774 Binding of ETV3 and SAE1 1 0.00 1.17 0 5.00
181 INT213043 Regulation of Binding of Apoa1 and Scarb1 1 0.05 1.12 0 5.00
182 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 5.00
183 INT313452 Phosphorylation of Siglec1 Regulation of Syp 1 0.06 0.1 0 5.00
184 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0 5.00
185 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 5.00
186 INT213046 Hdl1 Negative_regulation of Gene_expression of tf 1 0.07 2.36 0 5.00
187 INT313438 Mapk1 Regulation of Th 1 0.06 0 0 5.00
188 INT313431 Positive_regulation of Binding of Ppp2ca and Gopc 1 0.11 0.34 0 5.00
189 INT172828 Iapp Positive_regulation of Localization of REN 1 0.02 0.64 0 5.00
190 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0 5.00
191 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0 5.00
192 INT313456 Binding of Ppp2ca and Gopc 1 0.08 0.68 0 5.00
193 INT172835 Binding of AGT and T2dm2 1 0.00 1.73 0 5.00
194 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 5.00
195 INT172833 Binding of FFAR1 and T2dm2 1 0.00 1.55 0 5.00
196 INT213008 Hdl1 Positive_regulation of Gene_expression of Edn1 1 0.10 0.85 0 5.00
197 INT313428 Binding of Syp and Th 1 0.25 0.31 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tetrahydrobiopterin. They are ordered first by their pain relevance and then by number of times they were reported in Tetrahydrobiopterin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT65480 Gene_expression of Pts 15 0.66 7.53 6.46 100.00
2 INT139440 Gene_expression of Blmh 3 0.04 2.86 3.37 100.00
3 INT65481 Positive_regulation of Gene_expression of Pts 5 0.48 0.57 2.85 100.00
4 INT139442 Negative_regulation of Gene_expression of Blmh 2 0.03 2.19 2.53 100.00
5 INT165432 Negative_regulation of BLMH 3 0.13 1.62 1.37 100.00
6 INT165433 Gene_expression of BLMH 1 0.20 1.06 1.52 100.00
7 INT48635 Negative_regulation of Pts 15 0.49 15.38 2.43 100.00
8 INT65475 Gene_expression of Sept4 2 0.01 0 1.25 100.00
9 INT139441 Positive_regulation of Blmh 1 0.03 0.98 1.19 100.00
10 INT48944 Binding of Pts 8 0.41 3.23 1.03 100.00
11 INT65477 Positive_regulation of Gene_expression of Sept4 1 0.01 0 0.51 100.00
12 INT165435 Negative_regulation of Positive_regulation of BLMH 1 0.13 0.52 0.79 100.00
13 INT165431 Positive_regulation of BLMH 1 0.15 0.52 0.79 100.00
14 INT45175 Gene_expression of PTS 5 0.56 1.46 1.24 100.00
15 INT65478 Binding of Sept4 1 0.01 0 0.5 100.00
16 INT65479 Positive_regulation of Negative_regulation of Pts 1 0.32 0 0.43 100.00
17 INT65476 Negative_regulation of Sept4 1 0.01 0 0.4 100.00
18 INT172795 Negative_regulation of Tbca 1 0.00 0.83 0.17 100.00
19 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 100.00
20 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57 100.00
21 INT164779 Negative_regulation of Gene_expression of Pts 2 0.01 0.71 1.01 100.00
22 INT173213 Regulation of PTS 2 0.38 2.18 0.31 100.00
23 INT28505 Positive_regulation of P4hb 1 0.41 0.18 0.09 100.00
24 INT28506 Positive_regulation of Pts 1 0.07 0 0.09 100.00
25 INT150928 Gene_expression of Bh4p 3 0.02 1.97 2.18 100.00
26 INT167894 Negative_regulation of PTS 3 0.14 3.96 1.54 100.00
27 INT122893 Gene_expression of Pts 4 0.10 0.97 0.61 100.00
28 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56 100.00
29 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53 99.98
30 INT163776 Regulation of GCH1 7 0.27 4.58 6.16 99.98
31 INT86632 Gene_expression of 5,6,7,8 1 0.00 0 0.19 99.96
32 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27 99.84
33 INT283972 Localization of GCH1 1 0.67 0.99 1.13 99.84
34 INT102515 Binding of Nos3 19 0.45 9.41 4.01 99.74
35 INT48118 Gene_expression of KIAA0101 5 0.65 2.2 2.24 99.72
36 INT323258 Positive_regulation of Dhfr 1 0.20 0.66 0.49 99.66
37 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 99.60
38 INT68591 Regulation of TYRP1 14 0.44 3.93 5.05 99.58
39 INT293908 Regulation of IGKC 1 0.18 0 0.1 99.58
40 INT83991 Regulation of Nos3 25 0.44 9.89 4.06 99.56
41 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22 99.56
42 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 99.50
43 INT69499 Binding of Nos1 15 0.36 2.56 6.23 99.48
44 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47 99.40
45 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 99.32
46 INT49020 Negative_regulation of TYR 11 0.58 1.97 2.68 99.30
47 INT89131 Negative_regulation of NOS2 20 0.58 9.68 6.56 99.20
48 INT325218 Negative_regulation of Positive_regulation of Gch1 2 0.14 1.51 0.27 99.16
49 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14 99.14
50 INT73809 Regulation of Nos3 18 0.45 10.05 2.27 99.14
51 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 99.08
52 INT282983 Positive_regulation of Igkv1-131 2 0.10 1.13 0.38 98.92
53 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 98.88
54 INT80469 Negative_regulation of Spr 2 0.30 1.62 1.61 98.78
55 INT325216 Positive_regulation of Gch1 2 0.23 1.5 0.27 98.74
56 INT165434 Regulation of SPR 4 0.24 2.14 2.33 98.72
57 INT283973 Transcription of GCH1 1 0.61 1.99 2.33 98.60
58 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13 98.60
59 INT165430 Gene_expression of SPR 2 0.59 1.27 0.75 98.26
60 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 98.24
61 INT282979 Negative_regulation of Igkv1-131 2 0.08 1.36 0.45 98.16
62 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 97.44
63 INT212933 Regulation of Binding of Nos3 2 0.34 0.88 0.24 97.36
64 INT288522 Positive_regulation of Transcription of Gch1 1 0.64 1.06 1.42 97.36
65 INT288525 Transcription of Gch1 1 0.66 1.06 1.41 97.36
66 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 97.20
67 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 97.20
68 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 96.88
69 INT76532 Binding of Nos3 13 0.37 9.32 1.87 96.48
70 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 96.32
71 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 96.32
72 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77 96.32
73 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 96.12
74 INT18677 Gene_expression of F3 50 0.65 30.86 5.86 95.92
75 INT174798 Negative_regulation of Gene_expression of F3 3 0.01 2.09 0.26 95.92
76 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 95.88
77 INT122890 Regulation of Gene_expression of Rbm39 5 0.13 1.96 2.17 95.88
78 INT173208 Binding of CNBP 9 0.25 11.01 1.23 95.28
79 INT69142 Positive_regulation of Atxn3 3 0.50 1.52 0.53 95.04
80 INT20873 Negative_regulation of MTG1 6 0.42 1.23 2.34 95.04
81 INT122891 Negative_regulation of Gch1 4 0.16 1.83 1.15 95.04
82 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 94.88
83 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 94.48
84 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 94.32
85 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 94.26
86 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 94.12
87 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 94.00
88 INT116431 Negative_regulation of Gene_expression of CYBB 11 0.39 7.88 1.72 94.00
89 INT166274 Gene_expression of EPHB1 14 0.55 8.2 1.19 93.36
90 INT89132 Regulation of NOS2 9 0.61 7.34 4.95 93.12
91 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 92.88
92 INT173209 Regulation of DDAH1 1 0.13 0.16 0.24 92.72
93 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56 92.16
94 INT219 Negative_regulation of Th 55 0.59 20.88 17.09 92.00
95 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78 91.92
96 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 91.80
97 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09 91.80
98 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 91.64
99 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 91.04
100 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 90.84
101 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 90.76
102 INT1352 Localization of Acot1 728 0.80 73.01 296.01 90.72
103 INT61949 Regulation of Nos2 74 0.58 34.08 16.7 89.76
104 INT212996 Negative_regulation of Positive_regulation of Nos3 3 0.35 2.11 0.12 88.40
105 INT48911 Binding of NOS1 24 0.40 11.21 5.89 88.16
106 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 88.00
107 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 87.72
108 INT182791 Binding of CPLX1 1 0.04 2.85 0.3 87.60
109 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73 87.44
110 INT162102 Gene_expression of Gch1 3 0.72 23.65 27.96 87.08
111 INT65246 Negative_regulation of Nos3 36 0.50 25.65 7.62 86.80
112 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 86.76
113 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05 86.56
114 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78 86.56
115 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 86.24
116 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13 85.76
117 INT159346 Gene_expression of Zfp956 1 0.05 0.18 0.14 85.52
118 INT323260 Gene_expression of Ddah2 1 0.10 0.66 0.23 85.16
119 INT78733 Gene_expression of Iapp 20 0.78 12.99 3.33 84.92
120 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 84.76
121 INT288515 Negative_regulation of Gene_expression of Gch1 1 0.47 9.26 10.41 84.72
122 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 84.72
123 INT255702 Positive_regulation of TPH2 4 0.50 1.43 1.37 84.28
124 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 83.80
125 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 83.80
126 INT67724 Regulation of Gene_expression of ISYNA1 14 0.51 5.99 3.62 83.08
127 INT93844 Gene_expression of Ptgir 19 0.77 12.12 7.66 82.64
128 INT9126 Negative_regulation of Xdh 20 0.58 8.58 3.28 82.40
129 INT172796 Regulation of Negative_regulation of Nos3 1 0.16 1.4 0.23 82.28
130 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77 82.24
131 INT152347 Binding of GCH1 8 0.37 6.13 7.36 82.04
132 INT138671 Gene_expression of TPH2 35 0.78 7.34 6.03 80.80
133 INT293909 Positive_regulation of Gene_expression of TPH2 1 0.50 0.62 0.34 80.80
134 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 80.16
135 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 80.16
136 INT288521 Protein_catabolism of Gch1 1 0.61 1.17 1.3 80.00
137 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 79.72
138 INT142082 Positive_regulation of IDO1 17 0.60 9.46 6.33 79.60
139 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81 79.60
140 INT198666 Regulation of Gene_expression of IDO1 1 0.05 1.77 0.26 79.60
141 INT288520 Negative_regulation of Positive_regulation of Gch1 1 0.40 0.67 1.02 79.44
142 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71 79.28
143 INT164010 Gene_expression of CNBP 7 0.53 9.13 1.71 79.28
144 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 79.20
145 INT288514 Positive_regulation of Gch1 1 0.43 1.91 2.35 79.12
146 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 79.08
147 INT30040 Negative_regulation of TYRP1 11 0.51 2.72 2.54 79.08
148 INT605 Regulation of Acot1 61 0.62 10.7 26.34 78.92
149 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 78.56
150 INT4723 Transcription of Tac1 26 0.71 8.33 11.18 78.56
151 INT48908 Transcription of NOS1 27 0.55 13.46 8.39 78.56
152 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13 78.56
153 INT8530 Transcription of Penk 48 0.70 11.67 16.34 78.56
154 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91 78.56
155 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 78.56
156 INT95759 Gene_expression of DIO3 5 0.51 2.55 5.28 78.56
157 INT90981 Transcription of Dio1 2 0.42 1.44 2.85 78.56
158 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 78.56
159 INT122892 Transcription of Rbm39 1 0.02 0.71 1.25 78.56
160 INT122894 Transcription of DIO3 1 0.52 0.71 1.19 78.56
161 INT80251 Binding of Nos1 21 0.30 8.24 11.31 78.32
162 INT76092 Localization of ISYNA1 10 0.66 7.72 3.11 76.96
163 INT11437 Positive_regulation of IGKC 3 0.20 0.5 0.59 76.72
164 INT18073 Positive_regulation of TYRP1 11 0.67 1.98 3.36 76.60
165 INT2383 Positive_regulation of CP 33 0.67 25.41 15.38 76.36
166 INT288526 Negative_regulation of Gch1 1 0.54 8.59 9.6 76.20
167 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 76.16
168 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18 75.04
169 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 75.04
170 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68 75.04
171 INT89133 Transcription of NOS2 13 0.71 6.84 2.93 75.04
172 INT89130 Positive_regulation of Transcription of NOS2 7 0.50 3.32 2.14 75.04
173 INT217 Negative_regulation of Th 134 0.59 26.83 62.63 75.00
174 INT288517 Regulation of Gch1 1 0.50 2.96 3.19 71.44
175 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 71.36
176 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 70.48
177 INT63423 Negative_regulation of Gene_expression of SELP 13 0.55 1.98 0.57 70.48
178 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 69.20
179 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12 69.20
180 INT172815 Gene_expression of Cand1 4 0.65 1.86 0.12 68.72
181 INT74688 Regulation of Nos1 55 0.62 22.16 25.3 68.40
182 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 68.16
183 INT62821 Negative_regulation of Gene_expression of VCAM1 21 0.54 12.24 4.41 68.16
184 INT130603 Binding of Timp1 9 0.35 8.52 3.04 67.84
185 INT172814 Localization of Cand1 2 0.73 0.96 0.03 67.84
186 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05 67.76
187 INT293911 Negative_regulation of TPH2 1 0.59 0.64 0.56 67.52
188 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75 66.08
189 INT21610 Positive_regulation of ANGPT2 23 0.41 13.28 3.03 65.84
190 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18 65.68
191 INT32165 Binding of CALM1 92 0.48 24.19 29.57 65.48
192 INT57059 Negative_regulation of IGKC 4 0.24 1.34 0.86 65.00
193 INT236488 Regulation of Regulation of Pain1 1 0.01 0.76 1.23 64.04
194 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 63.64
195 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 63.64
196 INT156818 Gene_expression of Coq10a 8 0.33 3.93 0.76 63.52
197 INT236485 Negative_regulation of Regulation of Pain1 1 0.01 0.76 1.23 63.48
198 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 63.24
199 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 63.08
200 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 62.96
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