P:Trigeminal neuralgia

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Pain Term
Category Disorder
Synonyms None
Pain Specific Yes
Documents 3390
Hot Single Events 104
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Trigeminal neuralgia. They are ordered first by their pain relevance and then by number of times they were reported for Trigeminal neuralgia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95 100.00
2 INT351245 Binding of TNC and OPN1LW 1 0.03 0.89 1.31 100.00
3 INT351246 Binding of OPN1LW and NNT 1 0.03 0.53 1.45 98.56
4 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13 71.68
5 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73 64.20
6 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67 63.00
7 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
8 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 5.00
9 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45 5.00
10 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
11 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
12 INT308172 Rvm Positive_regulation of Phosphorylation of GRIN1 1 0.50 0.68 1.14 5.00
13 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1 5.00
14 INT214875 Ap3d1 Negative_regulation of Gene_expression of Fos 1 0.00 0.39 1.04 5.00
15 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95 5.00
16 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83 5.00
17 INT214876 Ap3d1 Negative_regulation of Gria1 1 0.00 0.4 0.78 5.00
18 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
19 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75 5.00
20 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
21 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71 5.00
22 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
23 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
24 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
25 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61 5.00
26 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6 5.00
27 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
28 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56 5.00
29 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48 5.00
30 INT308170 Binding of thd and Tnfrsf14 1 0.00 1.84 0.46 5.00
31 INT308171 Binding of TNF and thd 1 0.00 1.84 0.45 5.00
32 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
33 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45 5.00
34 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
35 INT279961 CSF2 Negative_regulation of TTR 1 0.04 1.07 0.23 5.00
36 INT279964 STAT3 Regulation of Transcription of FGG 1 0.22 1.37 0.2 5.00
37 INT279965 STAT3 Regulation of Transcription of BCL2L1 1 0.10 2.31 0.19 5.00
38 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13 5.00
39 INT279962 Binding of A1BG and BCL2L1 1 0.13 1.11 0.1 5.00
40 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
41 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
42 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
43 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
44 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
45 INT306764 Binding of Aes and ZMYND10 1 0.04 0.21 0 5.00
46 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Trigeminal neuralgia. They are ordered first by their pain relevance and then by number of times they were reported in Trigeminal neuralgia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT163682 Phosphorylation of tn 1 0.09 4.25 3.96 100.00
2 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04 100.00
3 INT52115 Positive_regulation of tn 5 0.50 4.68 3.54 100.00
4 INT53460 Gene_expression of tn 13 0.66 7.97 5.2 100.00
5 INT79166 Regulation of TNC 12 0.44 9.42 8.13 100.00
6 INT79168 Binding of TNC 39 0.47 16.51 7.55 100.00
7 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61 100.00
8 INT53290 Gene_expression of OPN1LW 5 0.31 6.9 9.15 100.00
9 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 100.00
10 INT90210 Regulation of tn 1 0.23 1.93 1.46 100.00
11 INT79167 Localization of TNC 8 0.78 4.15 1.44 100.00
12 INT50669 Negative_regulation of Ptn 15 0.58 5.56 6.88 100.00
13 INT91265 Negative_regulation of Nr6a1 1 0.35 0.63 0.63 100.00
14 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 100.00
15 INT131044 Binding of tn 2 0.30 2.58 1.93 100.00
16 INT351254 Regulation of Regulation of TNC 1 0.14 0.55 1.4 100.00
17 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 99.84
18 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 99.84
19 INT17938 Binding of Cpe 28 0.48 11.17 13.62 99.80
20 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 99.76
21 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11 99.76
22 INT159361 Negative_regulation of Positive_regulation of SMG1 1 0.57 0.98 1.15 99.76
23 INT159360 Positive_regulation of SMG1 11 0.67 2.01 1.29 99.76
24 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 99.70
25 INT158541 Positive_regulation of Gene_expression of HTN1 3 0.40 5.88 0.97 99.68
26 INT158542 Gene_expression of HTN1 10 0.75 10.69 1.07 99.68
27 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 99.66
28 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 99.66
29 INT66246 Gene_expression of Mzb1 10 0.65 3.87 1.78 99.66
30 INT53288 Binding of OPN1LW 5 0.11 4.24 8.9 99.64
31 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 99.60
32 INT91266 Binding of Tpnr1 1 0.00 0.45 0.64 99.52
33 INT91264 Binding of Nr6a1 1 0.34 0.45 0.63 99.52
34 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4 99.40
35 INT52203 Negative_regulation of Positive_regulation of TCEA1 5 0.51 3.27 4.48 99.28
36 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 99.28
37 INT14916 Binding of RASA1 15 0.37 13.64 1.44 99.18
38 INT48643 Regulation of Positive_regulation of TCEA1 6 0.53 1.94 3.83 99.00
39 INT48642 Positive_regulation of TCEA1 92 0.70 24.59 53.64 98.84
40 INT42132 Negative_regulation of TCEA1 13 0.51 4.12 6.28 98.84
41 INT244256 Regulation of ckr 1 0.37 0.52 0.48 98.80
42 INT110269 Binding of Gabbr1 2 0.36 2.1 2.18 98.72
43 INT43900 Gene_expression of RASA1 13 0.58 12 2.03 98.24
44 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89 98.20
45 INT17271 Positive_regulation of CDNF 11 0.28 2.69 5.03 98.16
46 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 98.12
47 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 97.40
48 INT17993 Negative_regulation of RASA1 8 0.41 7.34 2.62 96.96
49 INT81262 Positive_regulation of Phlda2 9 0.43 3.76 2.47 96.64
50 INT81263 Positive_regulation of lla 1 0.01 0.36 0.22 96.64
51 INT84945 Transcription of BMP2 5 0.61 1.8 0.36 96.24
52 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 96.12
53 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 96.00
54 INT3794 Regulation of CDNF 16 0.16 2.99 5.59 96.00
55 INT904 Positive_regulation of Ptgfr 23 0.49 7.98 5.55 95.84
56 INT9895 Binding of GHR 18 0.36 4.8 5.65 94.84
57 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1 94.84
58 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 94.36
59 INT105021 Binding of GOPC 187 0.40 60.39 20.38 93.92
60 INT85623 Gene_expression of ATXN1 6 0.58 5.14 0.9 92.92
61 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 92.72
62 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 92.52
63 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 91.88
64 INT3051 Binding of PRX 1 0.25 0.25 0.36 91.84
65 INT221513 Regulation of TRGV9 5 0.39 3.26 2.26 91.44
66 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 91.12
67 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 90.76
68 INT59 Regulation of Adrb1 25 0.42 8.32 9.78 89.72
69 INT47514 Localization of Avpr2 7 0.61 4.43 1.24 89.72
70 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 89.56
71 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63 89.40
72 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 89.32
73 INT7552 Negative_regulation of IL1RL1 12 0.42 1.68 0.87 89.28
74 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 89.12
75 INT69572 Localization of Prnp 96 0.81 38.11 5.45 89.12
76 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 88.96
77 INT7044 Positive_regulation of Positive_regulation of Htr1a 17 0.67 3.5 10 88.04
78 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 87.80
79 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 87.60
80 INT8787 Negative_regulation of WAS 4 0.42 2.42 1.81 87.56
81 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 87.48
82 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 87.48
83 INT58700 Binding of Slc16a11 11 0.42 1.17 6.38 87.32
84 INT105214 Binding of Mzb1 2 0.26 0.46 0.47 86.28
85 INT7040 Binding of Vip 43 0.48 4.57 15.05 85.88
86 INT160170 Gene_expression of Pde11a 1 0.75 8.65 7.74 85.52
87 INT195203 Binding of Tenc1 14 0.32 13.97 8.28 84.88
88 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94 84.56
89 INT160169 Gene_expression of Pde9a 1 0.75 8.67 7.75 83.92
90 INT121596 Localization of Abpa 1 0.59 0.24 0.43 83.44
91 INT351255 Transcription of OPN1LW 1 0.16 1.15 1.27 83.40
92 INT397 Localization of SST 232 0.81 58.05 101.19 83.28
93 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 83.28
94 INT7413 Positive_regulation of Localization of SST 37 0.69 5.64 13.94 83.28
95 INT133572 Positive_regulation of Gene_expression of Slc16a11 1 0.60 0.43 0.6 82.84
96 INT133571 Gene_expression of Slc16a11 3 0.67 0.88 2.58 82.84
97 INT91209 Binding of VIM 15 0.36 12.02 0.53 82.40
98 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 81.36
99 INT53291 Negative_regulation of Binding of OPN1LW 2 0.10 0.67 1.02 81.28
100 INT8388 Positive_regulation of Vip 142 0.70 39.72 67.61 80.64
101 INT76265 Positive_regulation of Mzb1 7 0.49 2.27 1.68 80.64
102 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 80.32
103 INT297117 Gene_expression of TSSK1B 1 0.65 1.59 1.69 80.32
104 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 80.08
105 INT167018 Negative_regulation of POR 3 0.37 1.9 0.11 79.96
106 INT477 Localization of Avp 813 0.81 131.58 300.4 79.88
107 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 79.64
108 INT81188 Gene_expression of Vipr2 16 0.78 4.38 3.7 79.44
109 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 78.64
110 INT104756 Gene_expression of ACSM3 8 0.58 8.76 1.83 78.24
111 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 77.12
112 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 76.00
113 INT94545 Positive_regulation of C7orf49 37 0.69 12.91 11.19 75.00
114 INT131199 Positive_regulation of Positive_regulation of C7orf49 7 0.08 4.98 4.65 75.00
115 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47 75.00
116 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 75.00
117 INT68649 Gene_expression of IL24 9 0.72 6.7 1.7 75.00
118 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 75.00
119 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39 75.00
120 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 5 0.45 1.62 3.33 75.00
121 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97 75.00
122 INT128779 Localization of Tg 3 0.35 0.16 0.29 75.00
123 INT72884 Positive_regulation of Tenc1 13 0.42 14.01 7.67 74.16
124 INT160166 Localization of Pde9a 2 0.78 1.26 0.98 73.92
125 INT160167 Localization of Pde11a 2 0.77 1.26 0.95 73.92
126 INT160171 Localization of Pde10a 2 0.77 1.26 0.95 73.92
127 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 73.20
128 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 71.68
129 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 71.68
130 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 71.52
131 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 71.44
132 INT626 Localization of CALCA 289 0.81 125.39 221.15 71.00
133 INT142084 Positive_regulation of Kdm5d 22 0.29 5.88 3.17 69.68
134 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 69.36
135 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 69.08
136 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 68.80
137 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 67.04
138 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 67.00
139 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 66.32
140 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 66.00
141 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 65.76
142 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22 64.32
143 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 63.92
144 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 63.80
145 INT20470 Positive_regulation of Acsl1 5 0.40 3.76 1.03 63.36
146 INT95585 Negative_regulation of Pde12 18 0.43 8.32 11.23 62.04
147 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 61.16
148 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 61.12
149 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 61.12
150 INT41722 Positive_regulation of Negative_regulation of MTOR 1 0.45 0.73 0.28 61.12
151 INT41720 Positive_regulation of Gene_expression of MTOR 2 0.49 1.54 0.28 61.12
152 INT23609 Negative_regulation of Acp5 5 0.33 1.69 1.65 60.64
153 INT23610 Gene_expression of Acp5 4 0.51 0.96 1.23 60.64
154 INT41718 Positive_regulation of Gene_expression of Acp5 1 0.38 0.73 0.28 60.64
155 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 59.92
156 INT139646 Positive_regulation of Positive_regulation of Grin2b 4 0.42 3.89 3.74 59.92
157 INT100328 Gene_expression of AQP2 6 0.75 2.41 1.21 59.28
158 INT241788 Positive_regulation of Gene_expression of AQP2 3 0.67 1.26 0.7 59.28
159 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 57.24
160 INT351256 Regulation of OPN1LW 1 0.10 0.55 1.17 56.48
161 INT44608 Gene_expression of C2 45 0.75 15.84 5.05 55.08
162 INT58172 Gene_expression of Oog1 2 0.60 0.44 0.51 55.08
163 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 55.04
164 INT4207 Regulation of Avp 267 0.62 63.72 115.33 52.88
165 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 50.00
166 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 50.00
167 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 50.00
168 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 50.00
169 INT97649 Gene_expression of Dlat 48 0.66 13.77 8.94 50.00
170 INT15887 Gene_expression of Nbr1 39 0.77 23.91 7.34 50.00
171 INT37215 Positive_regulation of SMN1 18 0.45 8.99 4.87 50.00
172 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 50.00
173 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 50.00
174 INT33951 Regulation of TXNRD1 18 0.51 6.97 4.02 50.00
175 INT57957 Localization of TXNRD1 14 0.64 4.01 2.7 50.00
176 INT15654 Gene_expression of Tg 22 0.66 12.2 2.36 50.00
177 INT114330 Binding of MPZ 21 0.32 25.58 2.14 50.00
178 INT139738 Gene_expression of Ptcra 9 0.63 2.75 1.14 50.00
179 INT221514 Positive_regulation of Positive_regulation of SMN1 1 0.17 0.74 0.42 50.00
180 INT163397 Regulation of CCR6 4 0.44 3.15 0.32 50.00
181 INT173042 Regulation of EME1 1 0.06 0.32 0.3 50.00
182 INT173041 Binding of EME1 1 0.05 0.3 0.29 50.00
183 INT148819 Positive_regulation of Positive_regulation of TNC 4 0.45 0.53 0.05 50.00
184 INT163968 Negative_regulation of tn 1 0.06 0.07 0 50.00
185 INT135267 Regulation of IGKV2D-26 1 0.44 0.19 0 50.00
186 INT91263 Positive_regulation of Nr6a1 1 0.38 0.19 0 50.00
187 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 49.56
188 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12 49.56
189 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 49.44
190 INT69570 Binding of Prnp 75 0.48 44.26 4.37 49.36
191 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 49.20
192 INT119855 Localization of Gabbr1 21 0.79 3.15 2.7 48.80
193 INT9864 Positive_regulation of B3gat3 2 0.11 0.37 1.49 48.64
194 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 47.72
195 INT15508 Negative_regulation of nt 8 0.36 3.4 2.26 46.88
196 INT264765 Positive_regulation of Gene_expression of Gabbr1 2 0.70 4.88 5.07 45.44
197 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 45.28
198 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 43.48
199 INT174785 Localization of Hspg2 2 0.06 2.18 1.24 42.72
200 INT180497 Binding of MRI1 45 0.42 28.35 14.77 41.88
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