P:Triptan

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pChart

Pain Term
Category Drug class
Synonyms Triptans
Pain Specific Yes
Documents 994
Hot Single Events 121
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Triptan. They are ordered first by their pain relevance and then by number of times they were reported for Triptan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT169346 Nxn Negative_regulation of Dynll1 1 0.06 1.22 1.87 99.36
2 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 0.02 2.15 3.12 93.44
3 INT94205 TACR1 Regulation of Gene_expression of SP5 1 0.04 0.72 1.06 93.44
4 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98 93.44
5 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72 91.84
6 INT253895 Binding of Htr1b and Htr1d 1 0.40 0.52 1.74 77.56
7 INT191480 Htr3a Positive_regulation of Ca2 1 0.02 0.12 0.23 51.04
8 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01 5.00
9 INT253897 Binding of Htr1d and Pag1 1 0.30 0.29 0.52 5.00
10 INT253896 Binding of Htr1a and Pag1 1 0.30 0.29 0.49 5.00
11 INT208763 Binding of CSF2 and TPH1 1 0.07 0.65 0.19 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Triptan. They are ordered first by their pain relevance and then by number of times they were reported in Triptan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT626 Localization of CALCA 289 0.81 125.39 221.15 100.00
2 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 100.00
3 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94 100.00
4 INT57176 Positive_regulation of Dynll1 9 0.49 4.76 7.71 99.98
5 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 99.98
6 INT79198 Positive_regulation of Positive_regulation of Dynll1 2 0.42 0.99 1.99 99.98
7 INT9357 Positive_regulation of Positive_regulation of HTR1B 5 0.49 0.88 2.47 99.98
8 INT9782 Binding of HTR1B 43 0.47 12.08 19.83 99.90
9 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 99.90
10 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51 99.86
11 INT2649 Regulation of Calca 433 0.62 146.05 330.95 99.84
12 INT216065 Localization of C4B 2 0.21 2.86 2.01 99.84
13 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 99.80
14 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 99.80
15 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 99.80
16 INT29047 Negative_regulation of Etf1 18 0.08 9.6 11.12 99.80
17 INT25772 Regulation of HTR1B 15 0.60 3.8 7.17 99.76
18 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.68
19 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 99.68
20 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 99.66
21 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.64
22 INT79822 Gene_expression of Htr1b 10 0.65 2.92 6.27 99.64
23 INT27170 Gene_expression of Maoa 13 0.67 3.88 7.5 99.64
24 INT264641 Binding of AES 25 0.42 18.56 6.98 99.60
25 INT169344 Positive_regulation of Gene_expression of Dynll1 3 0.49 2.34 3.48 99.58
26 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94 99.38
27 INT13041 Binding of Htr1b 14 0.47 4.92 7.95 99.38
28 INT169345 Negative_regulation of Nxn 1 0.07 1.16 1.85 99.36
29 INT74393 Gene_expression of Dynll1 8 0.65 2.64 4.39 99.20
30 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 99.20
31 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 99.20
32 INT96510 Localization of Htr1b 6 0.78 2.31 5.51 99.16
33 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2 99.16
34 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 99.16
35 INT74099 Negative_regulation of Dynll1 8 0.56 3.43 7.25 99.02
36 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 98.88
37 INT32579 Binding of C4B 14 0.36 14.99 7.79 98.84
38 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 98.80
39 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 98.76
40 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 98.64
41 INT2415 Binding of MAOA 26 0.47 13.26 11.86 98.60
42 INT75684 Regulation of Aif1 32 0.47 8.03 7.89 98.44
43 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 98.40
44 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 98.40
45 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03 98.30
46 INT191478 Negative_regulation of Positive_regulation of Aif1 2 0.25 0.31 0.95 98.30
47 INT84965 Gene_expression of MAOA 15 0.75 6.9 6.06 98.20
48 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 98.16
49 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73 98.00
50 INT2541 Binding of Calca 200 0.48 67.14 134.62 97.98
51 INT24445 Gene_expression of FBF1 2 0.35 2.73 3.63 97.92
52 INT6270 Binding of HTR1D 55 0.47 9.54 22.86 97.54
53 INT54363 Gene_expression of Htr1d 13 0.75 3.8 7.59 97.40
54 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 97.40
55 INT83313 Gene_expression of Htr1b 4 0.75 5.1 5.73 97.24
56 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 97.20
57 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13 97.16
58 INT22187 Localization of HTR1D 6 0.78 5.26 5.97 97.16
59 INT180497 Binding of MRI1 45 0.42 28.35 14.77 97.04
60 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 96.64
61 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95 96.64
62 INT94207 Positive_regulation of SP5 1 0.22 1.24 1.61 96.64
63 INT54473 Binding of ABCB1 30 0.48 8.65 10.38 96.48
64 INT9012 Localization of Vip 283 0.81 31.71 106.16 96.40
65 INT30011 Negative_regulation of Sepp1 18 0.54 4.65 3.54 96.40
66 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 96.08
67 INT5432 Regulation of Atp7b 7 0.36 0.87 2.65 96.04
68 INT139613 Binding of pr 16 0.47 5.52 8.46 95.84
69 INT23021 Gene_expression of SP5 2 0.65 1.82 2.1 95.84
70 INT50580 Binding of PPIG 39 0.36 11.17 12.34 95.52
71 INT118115 Regulation of Gene_expression of Sstr4 1 0.61 0.32 0.83 95.52
72 INT106023 Localization of PPIG 8 0.57 4.08 0.96 95.26
73 INT53866 Gene_expression of Sstr4 17 0.77 6.67 11.83 95.20
74 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26 95.08
75 INT27785 Regulation of HTR2A 11 0.44 8 8.18 94.96
76 INT60813 Regulation of HTR1D 10 0.60 3.4 4.67 94.96
77 INT191477 Positive_regulation of Htr1d 3 0.45 1.98 4.23 94.76
78 INT142623 Regulation of Gnb3 2 0.42 0.56 1.4 94.20
79 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 94.20
80 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 94.12
81 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 93.56
82 INT86082 Localization of Htr1b 4 0.73 2.77 3.46 92.64
83 INT24441 Positive_regulation of FBF1 13 0.39 6.52 4.29 92.60
84 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16 92.48
85 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 92.40
86 INT21934 Negative_regulation of Negative_regulation of Pag1 11 0.39 7.91 11.37 92.04
87 INT165057 Binding of MID1 7 0.32 4.13 3.12 92.00
88 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 91.92
89 INT50657 Positive_regulation of HTR2B 8 0.67 3.95 4.71 91.92
90 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 91.84
91 INT7383 Localization of VIP 53 0.81 17.7 22.65 91.76
92 INT79767 Negative_regulation of Aif1 30 0.42 5.14 4.73 91.48
93 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 91.44
94 INT46168 Positive_regulation of Sepp1 12 0.50 8.02 7.47 91.08
95 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 90.96
96 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 90.76
97 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 90.44
98 INT267677 Negative_regulation of COX2 1 0.42 0.92 1.66 90.24
99 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 90.12
100 INT62835 Binding of HTR1F 12 0.47 2 5.43 89.52
101 INT135630 Negative_regulation of GON4L 1 0.51 1.67 1.82 89.36
102 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 88.56
103 INT116220 Localization of HTR1B 5 0.78 1.86 3.75 88.12
104 INT67710 Binding of Sepp1 3 0.41 1.77 1.83 87.96
105 INT6761 Binding of CALCA 100 0.48 26.71 62.05 87.76
106 INT69742 Positive_regulation of Gene_expression of Hmox2 12 0.69 8.29 8.08 87.44
107 INT69743 Gene_expression of Hmox2 36 0.78 20.77 14.26 86.80
108 INT166828 Gene_expression of Sap30bp 1 0.43 0.54 0.95 86.68
109 INT356350 Positive_regulation of Snf8 1 0.02 4.31 4.23 86.64
110 INT76405 Positive_regulation of Hmox2 21 0.43 12.77 8.99 86.24
111 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 85.20
112 INT105540 Binding of FMO1 1 0.33 0.47 0.73 84.48
113 INT17938 Binding of Cpe 28 0.48 11.17 13.62 84.44
114 INT109833 Binding of GNB3 7 0.48 8.83 2.84 83.84
115 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 82.52
116 INT165058 Negative_regulation of MID1 14 0.37 10.82 4.67 82.52
117 INT165059 Gene_expression of MID1 11 0.58 3.68 2.31 82.52
118 INT165056 Regulation of Gene_expression of MID1 2 0.39 0.93 1.1 82.52
119 INT96403 Transcription of Htr1b 2 0.67 0.81 2.14 81.24
120 INT96404 Transcription of Olr1746 2 0.69 0.25 0.9 81.24
121 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 80.16
122 INT49774 Binding of DRD2 48 0.48 17.42 20.73 78.68
123 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81 77.56
124 INT24442 Negative_regulation of FBF1 5 0.36 3.38 3.17 77.20
125 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 77.12
126 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 76.56
127 INT56580 Positive_regulation of Htr1b 16 0.67 2.95 7.97 76.40
128 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 75.40
129 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 75.00
130 INT62240 Localization of Htr1d 3 0.78 0.91 2.83 75.00
131 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 73.80
132 INT66646 Regulation of Chdh 13 0.44 16.24 8.84 72.56
133 INT270 Regulation of MAOA 17 0.60 2.58 6.84 71.96
134 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 71.56
135 INT167836 Binding of CD200R1 1 0.36 0.84 0.88 71.52
136 INT167837 Binding of ADH7 1 0.36 0.84 0.88 71.52
137 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 71.08
138 INT34106 Negative_regulation of Htr1a 14 0.57 4.72 8.73 70.84
139 INT6884 Negative_regulation of pr 20 0.42 13.18 7.97 70.16
140 INT24444 Regulation of FBF1 2 0.12 5.55 5.06 70.04
141 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 69.36
142 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 69.36
143 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 68.40
144 INT152120 Gene_expression of Sp5 3 0.09 0.71 1.65 67.76
145 INT132279 Binding of Hcrtr2 4 0.48 2.48 2.28 67.76
146 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88 67.44
147 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 67.32
148 INT194421 Gene_expression of DCLK3 27 0.40 1.26 13.94 66.56
149 INT102448 Gene_expression of RAMP1 23 0.75 4.62 10.9 66.56
150 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 66.36
151 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 66.24
152 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 65.84
153 INT7487 Gene_expression of Htr1a 36 0.75 11.08 20.05 65.48
154 INT11668 Gene_expression of Htr1f 3 0.58 1.57 2.02 65.48
155 INT7894 Negative_regulation of Vip 59 0.59 11.76 27.36 65.36
156 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 64.20
157 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77 63.92
158 INT141967 Gene_expression of RAMP3 4 0.69 3.35 1.69 63.92
159 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68 63.84
160 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 63.76
161 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36 63.56
162 INT191481 Negative_regulation of Positive_regulation of HTR1B 1 0.41 0.07 0.23 63.32
163 INT5358 Positive_regulation of Protein_catabolism of Abat 2 0.38 1.28 1.89 62.44
164 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 62.16
165 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 61.56
166 INT3164 Positive_regulation of GUSB 4 0.49 2.67 1.47 61.44
167 INT57504 Positive_regulation of Positive_regulation of GUSB 2 0.33 1.25 1.16 61.44
168 INT24684 Localization of PLAT 30 0.78 26.21 13.56 61.16
169 INT37350 Negative_regulation of ENPEP 7 0.42 1.15 1.7 60.76
170 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14 60.16
171 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 58.84
172 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 58.52
173 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 58.08
174 INT144388 Positive_regulation of Negative_regulation of CYP3A 1 0.40 0.24 0.18 58.08
175 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 57.52
176 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 57.20
177 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4 57.20
178 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 56.56
179 INT144389 Positive_regulation of Negative_regulation of CYP2C19 2 0.43 0.37 0.17 56.56
180 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 56.44
181 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 56.24
182 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 55.84
183 INT144390 Positive_regulation of Negative_regulation of CYP2C9 4 0.49 2.03 0.72 55.84
184 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 55.60
185 INT15610 Localization of GOPC 223 0.65 68.26 28.7 55.60
186 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 55.60
187 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 55.20
188 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28 55.20
189 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 55.04
190 INT200373 Binding of Omd 7 0.34 7.03 0.34 54.72
191 INT264642 Gene_expression of SEC14L2 1 0.35 0.46 1 54.40
192 INT253894 Regulation of Localization of Htr1b 1 0.44 0.61 1.82 52.48
193 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 52.00
194 INT64378 Gene_expression of DMRT1 9 0.54 1.72 1.71 51.52
195 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 50.88
196 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 50.00
197 INT47628 Regulation of CEL 9 0.60 4.5 1.85 50.00
198 INT151950 Localization of Mphosph9 1 0.01 0 0 50.00
199 INT253890 Regulation of Binding of Pag1 1 0.30 1.22 2.02 48.72
200 INT4721 Negative_regulation of Nka1 17 0.59 2.08 9.57 47.84
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