P:Ultiva

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Pain Term
Category Drug
Synonyms Remifentanil
Pain Specific Yes
Documents 1979
Hot Single Events 178
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ultiva. They are ordered first by their pain relevance and then by number of times they were reported for Ultiva. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06 99.48
2 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39 85.12
3 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08 75.00
4 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09 75.00
5 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08 75.00
6 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 50.00
7 INT273120 NOVA2 Regulation of Gene_expression of MET 1 0.23 1.17 2.11 5.00
8 INT326471 Binding of ATP6V0A1 and IGKV2D-29 1 0.00 0.09 0.62 5.00
9 INT326473 Positive_regulation of PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.41 5.00
10 INT326470 PGAP1 Positive_regulation of ROS1 1 0.00 0.07 0.4 5.00
11 INT326472 AGXT Negative_regulation of PGAP1 1 0.00 0.05 0.39 5.00
12 INT201227 C2 Regulation of CEBPZ 2 0.06 1.19 0.07 5.00
13 INT249131 Positive_regulation of C2 Positive_regulation of CEBPZ 1 0.05 0.43 0.07 5.00
14 INT203009 Binding of Cpb1 and Dob2 1 0.02 0.77 0 5.00
15 INT247660 PER1 Positive_regulation of TNNI3 1 0.01 0.35 0 5.00
16 INT249129 C2 Positive_regulation of CEBPZ 1 0.05 0.25 0 5.00
17 INT249130 Positive_regulation of C2 Positive_regulation of CEBPZ 1 0.05 0.25 0 5.00
18 INT247661 PER1 Positive_regulation of Positive_regulation of TNNI3 1 0.01 0.41 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ultiva. They are ordered first by their pain relevance and then by number of times they were reported in Ultiva. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08 100.00
2 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84 100.00
3 INT73265 Regulation of NRF1 3 0.10 0.33 1.32 100.00
4 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 100.00
5 INT2330 Regulation of CB 78 0.10 20.46 32.6 100.00
6 INT12464 Binding of MET 38 0.47 10.3 13.15 100.00
7 INT162970 Regulation of Gene_expression of Mpo 8 0.41 9.1 1.21 100.00
8 INT12112 Regulation of ICK 5 0.14 0.76 2.26 100.00
9 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 100.00
10 INT10754 Positive_regulation of Gene_expression of PCa 18 0.41 21.81 4.17 100.00
11 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 100.00
12 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 100.00
13 INT139010 Regulation of Gfm1 16 0.32 5.02 3.27 99.98
14 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33 99.98
15 INT158832 Regulation of Phosphorylation of Gfm1 2 0.32 0.61 0.9 99.98
16 INT158833 Regulation of Gene_expression of Gfm1 3 0.32 1.34 1.04 99.98
17 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 99.92
18 INT101038 Positive_regulation of CHSY1 4 0.36 0.36 2.31 99.92
19 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.92
20 INT159414 Positive_regulation of Cobra1 1 0.33 0 0.29 99.92
21 INT7464 Regulation of Mbp 25 0.62 6.62 6.43 99.86
22 INT27864 Regulation of Sysbp1 9 0.22 3.76 3.42 99.86
23 INT159242 Gene_expression of Slep1 1 0.28 0 1.8 99.84
24 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 99.82
25 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 99.80
26 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92 99.80
27 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.74
28 INT109633 Negative_regulation of TP53INP2 5 0.15 2.29 6.46 99.74
29 INT156507 Negative_regulation of Transcription of TP53INP2 1 0.08 0.97 1.72 99.74
30 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48 99.70
31 INT222660 Phosphorylation of Tyr 2 0.06 5.31 12.33 99.70
32 INT30755 Regulation of Bsp 5 0.54 0.18 5.68 99.70
33 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51 99.66
34 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13 99.66
35 INT30011 Negative_regulation of Sepp1 18 0.54 4.65 3.54 99.56
36 INT53014 Transcription of TP53INP2 2 0.41 1.05 2.91 99.54
37 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 99.52
38 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.50
39 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 99.48
40 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 99.48
41 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 99.48
42 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 99.44
43 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36 99.40
44 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 99.40
45 INT75938 Regulation of TP53INP2 9 0.09 2.45 7.21 99.36
46 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 99.32
47 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.28
48 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 99.22
49 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 99.14
50 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 99.14
51 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.14
52 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 99.14
53 INT139008 Positive_regulation of Gfm1 21 0.35 7.79 2.34 99.12
54 INT156794 Gene_expression of CISH 41 0.58 23.09 5.03 99.10
55 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 99.10
56 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07 99.04
57 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 99.02
58 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6 99.00
59 INT11673 Positive_regulation of ECT 43 0.59 13.93 11.25 98.96
60 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 98.94
61 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 98.92
62 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78 98.92
63 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 98.84
64 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 98.80
65 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17 98.72
66 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85 98.68
67 INT6437 Binding of YY1 154 0.47 26.3 90.46 98.64
68 INT158831 Phosphorylation of Gfm1 10 0.58 5.99 1.19 98.56
69 INT7607 Localization of Nacc1 7 0.81 0 7.09 98.56
70 INT9547 Regulation of TNNI3 25 0.56 14.22 2.22 98.56
71 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 98.52
72 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 98.48
73 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64 98.44
74 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 98.36
75 INT50873 Regulation of Tnni3 4 0.13 2.36 1.22 98.32
76 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 98.30
77 INT62350 Binding of RGD1563334 1 0.02 0.07 0.36 98.30
78 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55 98.28
79 INT147966 Regulation of CHSY1 2 0.24 0.2 1.09 98.24
80 INT53015 Gene_expression of TP53INP2 50 0.78 9.05 26.23 98.20
81 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 98.12
82 INT79505 Binding of Grin2b 9 0.36 1.43 4.61 98.08
83 INT10228 Positive_regulation of PCS 49 0.67 28.72 7 97.96
84 INT10694 Binding of Bche 19 0.48 8.03 4.85 97.94
85 INT78479 Negative_regulation of Localization of PENK 2 0.43 1.9 1.81 97.92
86 INT58341 Positive_regulation of Positive_regulation of ECT 2 0.43 0.73 0.98 97.84
87 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 97.82
88 INT2260 Gene_expression of Tyr 30 0.49 7.05 11.31 97.76
89 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 97.72
90 INT106646 Gene_expression of Socs3 15 0.69 6.19 4.31 97.72
91 INT1664 Gene_expression of Kitl 30 0.65 13.63 7.47 97.72
92 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 97.68
93 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 97.64
94 INT92541 Localization of Grin2b 11 0.75 2.85 5.14 97.56
95 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 97.52
96 INT127353 Regulation of Phosphorylation of Grin2b 5 0.45 1.6 5.29 97.52
97 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 97.52
98 INT1242 Negative_regulation of Slc17a5 14 0.42 4.06 5.78 97.52
99 INT154115 Positive_regulation of Localization of PENK 5 0.49 3.15 6.93 97.20
100 INT4862 Localization of PENK 62 0.81 11.57 40.28 97.20
101 INT31395 Negative_regulation of Lor 7 0.51 1.04 1.57 97.08
102 INT277196 Gene_expression of CHI3L2 1 0.01 0.22 1.06 96.92
103 INT4652 Gene_expression of CB 13 0.32 7.41 5.57 96.72
104 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 96.40
105 INT4805 Positive_regulation of Localization of TPSAB1 9 0.55 0.32 5.38 96.28
106 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35 96.20
107 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73 96.20
108 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 96.16
109 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 96.16
110 INT70529 Positive_regulation of Cish 16 0.59 14.43 3.8 96.16
111 INT70528 Protein_catabolism of Cish 1 0.00 0 0.22 96.16
112 INT70527 Positive_regulation of Protein_catabolism of Cish 1 0.00 0 0.22 96.16
113 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 96.12
114 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88 96.12
115 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 96.12
116 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25 96.12
117 INT164381 Regulation of Positive_regulation of MAPK3 2 0.60 1.49 1.03 96.12
118 INT7644 Positive_regulation of Gene_expression of PDYN 27 0.69 10.19 17.47 96.12
119 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 96.12
120 INT73264 Gene_expression of NRF1 2 0.70 0.52 0.48 96.08
121 INT101140 Negative_regulation of Tap1 7 0.50 9.08 17.46 95.80
122 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 95.66
123 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 95.56
124 INT143839 Negative_regulation of TCN1 2 0.27 0.28 0.33 95.52
125 INT114746 Gene_expression of Sepp1 15 0.60 3.33 1.86 95.40
126 INT71807 Negative_regulation of Cp 18 0.58 8.9 1.88 95.24
127 INT654 Localization of REN 250 0.81 75.12 47.86 95.12
128 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 95.12
129 INT157382 Gene_expression of Csi 17 0.58 3.93 0.82 95.04
130 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 94.88
131 INT100589 Binding of FBXW11 1 0.31 0.8 0.45 94.84
132 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52 94.76
133 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 94.68
134 INT136001 Positive_regulation of Positive_regulation of Nacc1 1 0.38 0 0.96 94.64
135 INT1261 Localization of Adh1 63 0.81 19.36 16.09 94.32
136 INT4261 Positive_regulation of Localization of Adh1 11 0.61 2.04 3.49 94.32
137 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 94.28
138 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 94.20
139 INT68304 Positive_regulation of Nacc1 11 0.70 0.76 6.45 94.12
140 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 93.84
141 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 93.64
142 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 93.32
143 INT74286 Regulation of Il10 42 0.44 28.06 19.44 93.24
144 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 93.00
145 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 93.00
146 INT12232 Regulation of Gene_expression of PDYN 21 0.60 9.91 12.18 93.00
147 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 93.00
148 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 92.88
149 INT47769 Phosphorylation of Fos 20 0.61 3.03 8.68 92.24
150 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73 92.24
151 INT99059 Positive_regulation of Cpb1 16 0.45 3.12 4.09 91.96
152 INT135629 Binding of COMT 33 0.48 16.68 19.37 91.60
153 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 91.24
154 INT18460 Positive_regulation of Transcription of PDYN 11 0.67 2.14 6.61 90.92
155 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21 90.80
156 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 90.64
157 INT8531 Transcription of PDYN 56 0.72 19.51 30.99 90.44
158 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 90.32
159 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 90.08
160 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49 89.96
161 INT38493 Positive_regulation of LOC246267 2 0.00 0.95 0.43 88.96
162 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 88.80
163 INT163872 Negative_regulation of TSHR 4 0.42 3.52 0.49 88.16
164 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 87.64
165 INT232176 Regulation of Slc43a1 2 0.11 1.51 1.22 86.84
166 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 86.52
167 INT107407 Regulation of KCNE1 3 0.39 2.18 0.88 86.44
168 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 85.96
169 INT5412 Regulation of G6pd 9 0.62 1.64 2.87 84.00
170 INT235399 Positive_regulation of Binding of PTGDR 2 0.15 1.08 2.33 83.12
171 INT103878 Binding of PTGDR 9 0.48 6.22 7.23 83.12
172 INT49564 Positive_regulation of PTGDR 8 0.70 3.28 4.62 82.48
173 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 82.40
174 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 81.84
175 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 81.36
176 INT113909 Positive_regulation of SOX18 2 0.19 0.19 1.51 80.72
177 INT3954 Regulation of Fabp6 33 0.52 15.64 9.27 80.56
178 INT232180 Positive_regulation of Slc43a1 2 0.09 1.79 0.98 80.24
179 INT189092 Gene_expression of Tap1 56 0.76 14.09 1.33 79.96
180 INT28110 Transcription of MET 9 0.67 9.43 1.15 79.88
181 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 79.80
182 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 79.52
183 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 79.24
184 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 78.96
185 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 78.96
186 INT153959 Phosphorylation of GRIN1 8 0.80 4.07 6.18 78.88
187 INT14586 Gene_expression of Cpb1 23 0.58 6.18 1.99 78.88
188 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 78.68
189 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 78.64
190 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 78.24
191 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74 77.60
192 INT9397 Regulation of MET 17 0.60 8.36 7.04 77.20
193 INT137593 Regulation of Gene_expression of SLC6A4 7 0.60 2.59 5.23 76.88
194 INT138660 Positive_regulation of Regulation of Grin1 2 0.24 1.59 1.71 75.04
195 INT159241 Positive_regulation of Gene_expression of Slep1 1 0.18 0 0.88 75.00
196 INT159243 Negative_regulation of Slep1 1 0.16 0 0.87 75.00
197 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32 74.96
198 INT15470 Regulation of CPP 42 0.48 26.1 18.25 74.72
199 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 74.20
200 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 73.60
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