P:Ziconotide

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 126
Hot Single Events 25
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ziconotide. They are ordered first by their pain relevance and then by number of times they were reported for Ziconotide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
2 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
3 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
4 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
5 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
6 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
7 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
8 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
9 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
10 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
11 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00
12 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
13 INT326809 Binding of Ankrd36 and SLC25A22 1 0.10 0.13 0 5.00
14 INT317843 Binding of TNC and TPSAB1 1 0.01 0.64 0 5.00
15 INT269140 Binding of Il6 and Rps7 1 0.02 0.85 0 5.00
16 INT326808 Binding of Ankrd36 and SLC25A18 1 0.12 0.13 0 5.00
17 INT269139 Binding of Csnk2a2 and Sub1 1 0.02 0.68 0 5.00
18 INT269138 Binding of Il6ra and Rps7 1 0.01 0.85 0 5.00
19 INT326793 FGFR1 Positive_regulation of Gene_expression of ST8SIA2 1 0.00 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ziconotide. They are ordered first by their pain relevance and then by number of times they were reported in Ziconotide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT158070 Localization of Aes 23 0.65 19.93 10.9 99.98
2 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 99.98
3 INT52180 Binding of Aes 38 0.42 23.16 6.7 99.98
4 INT275878 Positive_regulation of Gene_expression of Aes 4 0.23 4.54 3.39 99.84
5 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 99.80
6 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.80
7 INT5490 Binding of CA2 52 0.36 9.73 5.53 99.74
8 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 99.50
9 INT248325 Positive_regulation of Localization of Aes 4 0.26 1.88 2.07 99.28
10 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 99.26
11 INT149314 Negative_regulation of CAV2 5 0.42 1.21 2.76 98.72
12 INT275875 Negative_regulation of Localization of Aes 2 0.19 3.87 1.8 97.60
13 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 97.52
14 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 95.84
15 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 91.72
16 INT230715 Regulation of KCNB1 1 0.14 0.64 1.02 89.32
17 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 88.44
18 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 88.00
19 INT812 Localization of INS 1026 0.81 515.6 145.31 86.88
20 INT275876 Binding of Chkb 1 0.04 0.54 0.46 85.36
21 INT38255 Localization of Chkb 32 0.80 10.98 11.07 83.72
22 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 83.68
23 INT64280 Positive_regulation of Ptger1 22 0.67 14.9 7.49 81.60
24 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 81.56
25 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 81.00
26 INT275877 Positive_regulation of Positive_regulation of Chkb 1 0.07 0.35 0.68 79.24
27 INT262876 Localization of ST8SIA2 2 0.16 1.41 1.39 76.36
28 INT142488 Positive_regulation of Gene_expression of Chkb 7 0.23 4.09 4.54 76.08
29 INT20264 Gene_expression of Chkb 29 0.46 13.14 13.65 75.92
30 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 73.60
31 INT151878 Gene_expression of CAV2 18 0.66 9.26 2.17 70.04
32 INT151877 Positive_regulation of Gene_expression of CAV2 2 0.40 0.39 0.72 70.04
33 INT132453 Binding of TF 31 0.36 12.98 1.22 67.88
34 INT123419 Binding of NAV1 37 0.48 7.09 26.43 65.28
35 INT294980 Binding of BDP1 1 0.36 1.27 0.24 65.08
36 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 64.20
37 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 64.20
38 INT294979 Gene_expression of BDP1 1 0.58 2.22 0.18 62.72
39 INT309303 Positive_regulation of ST8SIA2 2 0.11 0.65 0.91 59.44
40 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 58.28
41 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 57.24
42 INT3568 Localization of Tf 4 0.62 1.27 1 54.52
43 INT294984 Localization of BDP1 1 0.52 1.2 0.11 54.52
44 INT92755 Regulation of MRGPRX1 26 0.27 3.63 7.37 53.76
45 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 50.36
46 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 50.00
47 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 50.00
48 INT59288 Negative_regulation of Map2 12 0.59 6.2 3.19 50.00
49 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36 48.44
50 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 47.40
51 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 46.92
52 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22 46.92
53 INT87287 Phosphorylation of CDCP1 20 0.04 5.62 2.43 45.36
54 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11 43.04
55 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 39.92
56 INT259746 Phosphorylation of CSNK1D 1 0.03 0.99 0.05 39.84
57 INT217905 Phosphorylation of CSNK1A1 3 0.54 2.14 0.05 39.84
58 INT259748 Phosphorylation of DYRK1A 1 0.33 0.53 0.05 39.84
59 INT100360 Negative_regulation of TF 19 0.42 10.43 2.68 37.44
60 INT164259 Gene_expression of H19 8 0.75 27.5 0.97 37.00
61 INT164258 Positive_regulation of Gene_expression of GLA 6 0.47 0.55 0.65 37.00
62 INT164260 Positive_regulation of Gene_expression of H19 2 0.67 4.29 0.43 37.00
63 INT57560 Positive_regulation of GLA 14 0.54 5.01 0.83 35.56
64 INT105698 Binding of KLK4 3 0.32 2.22 0.69 12.04
65 INT221973 Negative_regulation of CDK5 4 0.57 2.26 0.36 10.76
66 INT219355 Binding of CDK5 3 0.35 2.02 0.06 10.12
67 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
68 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 5.00
69 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
70 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
71 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
72 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 5.00
73 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
74 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
75 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
76 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
77 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
78 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
79 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
80 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
81 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
82 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
83 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
84 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
85 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
86 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
87 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
88 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
89 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
90 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
91 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
92 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
93 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
94 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
95 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
96 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
97 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
98 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
99 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
100 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
101 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
102 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
103 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
104 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
105 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
106 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
107 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
108 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
109 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
110 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
111 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
112 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 5.00
113 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 5.00
114 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 5.00
115 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
116 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
117 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
118 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
119 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 5.00
120 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
121 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
122 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86 5.00
123 INT136268 Localization of NAV1 22 0.75 2.84 26.23 5.00
124 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
125 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2 5.00
126 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92 5.00
127 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
128 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
129 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 5.00
130 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41 5.00
131 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
132 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 5.00
133 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
134 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45 5.00
135 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
136 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
137 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
138 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 5.00
139 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
140 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
141 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 5.00
142 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
143 INT20216 Localization of NGF 40 0.80 18.16 16.61 5.00
144 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 5.00
145 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 5.00
146 INT62629 Localization of CNR1 35 0.76 11.86 16.3 5.00
147 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 5.00
148 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82 5.00
149 INT71150 Binding of NGF 22 0.46 13.67 14.81 5.00
150 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 5.00
151 INT69311 Gene_expression of Scn10a 31 0.78 15.54 14.64 5.00
152 INT39046 Positive_regulation of PTGER1 28 0.69 18.18 13.21 5.00
153 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 5.00
154 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 5.00
155 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
156 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 5.00
157 INT83601 Binding of CNR2 30 0.47 7.79 12.37 5.00
158 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 5.00
159 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
160 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
161 INT72579 Localization of BDNF 56 0.80 14.84 10.65 5.00
162 INT9385 Localization of LDHA 74 0.81 31.67 10.5 5.00
163 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 5.00
164 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 5.00
165 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 5.00
166 INT13432 Positive_regulation of Klkb1 23 0.57 5.36 8.65 5.00
167 INT51922 Localization of Cpox 24 0.68 12.05 8.59 5.00
168 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 5.00
169 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 61 0.55 13.63 8.17 5.00
170 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58 5.00
171 INT75938 Regulation of TP53INP2 9 0.09 2.45 7.21 5.00
172 INT168399 Localization of Cnr2 12 0.81 4.37 6.77 5.00
173 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 5.00
174 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4 5.00
175 INT134585 Negative_regulation of Cnr2 10 0.43 3.98 6.16 5.00
176 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
177 INT33612 Binding of NTS 16 0.46 4.65 6 5.00
178 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95 5.00
179 INT68661 Positive_regulation of NTSR1 11 0.69 9.6 5.91 5.00
180 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 5.00
181 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 5.00
182 INT3731 Negative_regulation of Neu1 17 0.39 8.35 5.67 5.00
183 INT7126 Negative_regulation of PLA2G2A 26 0.58 12.97 5.64 5.00
184 INT64270 Gene_expression of GRM2 10 0.75 1.72 5.41 5.00
185 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 5.00
186 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 5.00
187 INT89304 Binding of ST8SIA2 12 0.35 0.93 5.23 5.00
188 INT7130 Localization of PLA2G2A 32 0.80 20.4 5.05 5.00
189 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02 5.00
190 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87 5.00
191 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 5.00
192 INT189842 Negative_regulation of Gene_expression of Cnr2 8 0.59 4.21 4.67 5.00
193 INT77429 Negative_regulation of Negative_regulation of CPOX 9 0.34 5.09 4.64 5.00
194 INT112040 Localization of P2RX2 6 0.73 4.69 4.3 5.00
195 INT77515 Positive_regulation of ASIC3 12 0.67 3.67 4.19 5.00
196 INT124622 Positive_regulation of ATF3 26 0.70 21.6 4.03 5.00
197 INT144051 Positive_regulation of Gene_expression of PTGER1 11 0.12 4.46 3.97 5.00
198 INT86293 Positive_regulation of Gene_expression of Mmp2 21 0.64 11.69 3.79 5.00
199 INT152743 Positive_regulation of Localization of BDNF 7 0.56 4.04 3.74 5.00
200 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74 5.00
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