P:abatacept

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 365
Hot Single Events 200
Hot Interactions 31

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for abatacept. They are ordered first by their pain relevance and then by number of times they were reported for abatacept. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT265213 Binding of Ctla4 and Cd86 2 0.13 1.93 1.31 100.00
2 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93 100.00
3 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7 99.96
4 INT157657 Binding of CTLA4 and FCGR1A 1 0.01 0.07 0.4 99.96
5 INT139068 Binding of CTLA4 and Cd80 1 0.00 0.33 0.33 99.96
6 INT220051 Fcgr4 Positive_regulation of Gene_expression of Ido1 1 0.01 1.24 0.55 99.96
7 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18 99.92
8 INT157656 Binding of RUNX1 and FCGR1A 1 0.02 0.07 0.4 99.84
9 INT157658 Binding of FCGR1A and SGCG 1 0.07 0.07 0.4 99.84
10 INT288006 Binding of CD28 and LRRC23 1 0.02 0.54 0.19 99.84
11 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 99.56
12 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05 99.30
13 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 99.04
14 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 99.04
15 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 98.24
16 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 96.96
17 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 96.96
18 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 96.80
19 INT149121 Binding of CD80 and Cd28 2 0.04 0.95 0.46 95.48
20 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32 95.12
21 INT158400 Binding of CD80 and CD86 3 0.36 0.76 0.48 93.12
22 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55 92.88
23 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63 92.56
24 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63 92.56
25 INT252367 Binding of RUNX1 and CTLA4 1 0.02 0.48 0.18 92.52
26 INT252366 Binding of RUNX1 and CD80 1 0.01 0.54 0.2 92.08
27 INT209957 Binding of CD8A and RDBP Positive_regulation of CD8A 1 0.01 0.3 0.71 88.96
28 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49 88.52
29 INT209956 Binding of CD8A and RDBP 1 0.01 0.3 0.7 88.12
30 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62 87.40
31 INT329297 Binding of Cd226 and Aff3 1 0.18 1.54 0.64 84.96
32 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28 79.84
33 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 77.28
34 INT299766 APCS Positive_regulation of Gene_expression of Cd80 1 0.04 0.86 0.5 76.44
35 INT299767 APCS Positive_regulation of Gene_expression of Cd86 1 0.07 0.86 0.5 76.44
36 INT299764 APCS Positive_regulation of Cd86 1 0.02 0.86 0.5 76.44
37 INT299765 APCS Positive_regulation of Cd80 1 0.04 0.85 0.49 76.44
38 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34 75.92
39 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 68.72
40 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57 68.72
41 INT265215 Cd28 Regulation of Transcription of thd 1 0.00 0 0.15 66.88
42 INT289953 Binding of CD80 and KLF1 1 0.00 0.21 0.23 64.44
43 INT289955 Binding of APCS and KLF1 1 0.00 0.21 0.23 64.44
44 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7 64.40
45 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23 53.72
46 INT299780 Binding of Cd28 and Cd80 1 0.21 1.36 0.34 50.00
47 INT299782 Cd28 Regulation of Gene_expression of Il2 1 0.01 0.43 0.11 50.00
48 INT299781 Cd80 Regulation of Gene_expression of Il2 1 0.01 0.43 0.11 50.00
49 INT211191 CD28 Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.03 50.00
50 INT265212 Cd28 Negative_regulation of Gene_expression of Il17a 1 0.10 0 0.09 49.68
51 INT299763 Binding of APC and CTLA4 Positive_regulation of Ido1 1 0.11 0.31 0.14 48.64
52 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11 48.64
53 INT345924 IL6 Regulation of Gene_expression of SPHAR 1 0.00 0.21 0.18 33.04
54 INT265222 Binding of Cd28 and Gopc 1 0.04 0 0.08 32.12
55 INT277808 Binding of APCS and CD80 1 0.11 0.07 0 28.84
56 INT149120 Binding of CTLA4 and Cd28 1 0.03 0.14 0 26.00
57 INT288007 Binding of CD28 and CD40 1 0.05 0.51 0.03 20.00
58 INT288008 Binding of CD40 and LRRC23 1 0.02 0.45 0 17.20
59 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48 16.76
60 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 16.76
61 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 16.76
62 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 14.88
63 INT321842 Binding of Ros1 and SCFV 1 0.01 1.34 0.54 13.84
64 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 13.52
65 INT194621 TNF Positive_regulation of Gene_expression of Klrk1 1 0.05 0.5 0.32 7.76
66 INT194614 Il15 Positive_regulation of Gene_expression of Klrk1 1 0.04 0.5 0.32 7.76
67 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
68 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
69 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 5.00
70 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
71 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
72 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25 5.00
73 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
74 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22 5.00
75 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2 5.00
76 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
77 INT103928 Binding of Cd28 and Trav6-3 3 0.03 0.55 0.98 5.00
78 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91 5.00
79 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85 5.00
80 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79 5.00
81 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77 5.00
82 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77 5.00
83 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71 5.00
84 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7 5.00
85 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7 5.00
86 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 5.00
87 INT194618 Il17a Positive_regulation of Gene_expression of IL8 2 0.01 1.94 0.67 5.00
88 INT252293 Binding of TNF and Positive_regulation of Gene_expression of Ccl20 1 0.04 0.54 0.66 5.00
89 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66 5.00
90 INT252288 Binding of Il1 and Positive_regulation of Gene_expression of Ccl20 1 0.06 0.54 0.66 5.00
91 INT252290 Binding of Il17a and Positive_regulation of Gene_expression of Ccl20 1 0.06 0.54 0.66 5.00
92 INT254230 Ik Negative_regulation of Gene_expression of TNF 1 0.00 1.29 0.65 5.00
93 INT254199 Il10 Positive_regulation of Gene_expression of Socs3 2 0.06 0.75 0.63 5.00
94 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
95 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59 5.00
96 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57 5.00
97 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56 5.00
98 INT260830 Binding of NRP2 and Flt1 Positive_regulation of Gene_expression of TNF 1 0.01 1.5 0.56 5.00
99 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 0.36 1.5 0.56 5.00
100 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56 5.00
101 INT306935 Tnfsf12 Positive_regulation of Gene_expression of Cxcl10 1 0.03 3.55 0.55 5.00
102 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55 5.00
103 INT302834 Cd4 Positive_regulation of Gene_expression of Il7 1 0.05 1.02 0.54 5.00
104 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52 5.00
105 INT220054 Regulation of IFN1@ Negative_regulation of Cia1 1 0.18 1.19 0.52 5.00
106 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51 5.00
107 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51 5.00
108 INT302838 TNF Positive_regulation of Sox18 1 0.00 0.71 0.5 5.00
109 INT302845 Il7 Positive_regulation of Gene_expression of TNF 1 0.01 0.98 0.49 5.00
110 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49 5.00
111 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49 5.00
112 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49 5.00
113 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49 5.00
114 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49 5.00
115 INT220055 IFN1@ Negative_regulation of Cia1 1 0.24 1.12 0.48 5.00
116 INT172096 Binding of HLA-E and Il27ra 2 0.01 1.32 0.48 5.00
117 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47 5.00
118 INT260839 Hivep3 Positive_regulation of Gene_expression of TNF 1 0.01 1.21 0.47 5.00
119 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46 5.00
120 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46 5.00
121 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46 5.00
122 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46 5.00
123 INT306936 Binding of Tnfsf12 and Tnfrsf12a 1 0.05 4.84 0.45 5.00
124 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
125 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43 5.00
126 INT239042 Il17a Negative_regulation of Gene_expression of Il6 1 0.03 0.82 0.42 5.00
127 INT299789 IL4 Negative_regulation of Gene_expression of RAE1 1 0.00 0.84 0.41 5.00
128 INT302824 Mapkapk5 Positive_regulation of Phosphorylation of Hspb2 1 0.11 0.64 0.4 5.00
129 INT299786 IL4 Negative_regulation of Gene_expression of CD5 1 0.07 0.82 0.4 5.00
130 INT302825 Binding of Creb1 and Xpnpep1 1 0.00 0.64 0.39 5.00
131 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39 5.00
132 INT302836 Negative_regulation of Mapk8 Negative_regulation of TNF Positive_regulation of Mir155 1 0.00 0.48 0.39 5.00
133 INT220052 Binding of Col7a1 and Cia1 1 0.01 1.11 0.38 5.00
134 INT220050 Ctla4 Positive_regulation of Ido1 1 0.31 1.45 0.38 5.00
135 INT302815 TNF Positive_regulation of TNF Positive_regulation of Mir155 1 0.00 0.47 0.38 5.00
136 INT302840 Positive_regulation of TNF Positive_regulation of Mir155 1 0.01 0.47 0.38 5.00
137 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 5.00
138 INT302821 Mdk Negative_regulation of Il1 1 0.02 0.91 0.38 5.00
139 INT302843 TNF Positive_regulation of Mir155 1 0.01 0.47 0.38 5.00
140 INT299790 IL4 Negative_regulation of Gene_expression of NPEPPS 1 0.00 0.86 0.37 5.00
141 INT299788 INCENP Negative_regulation of Gene_expression of NPEPPS 1 0.00 0.86 0.37 5.00
142 INT252289 Il17a Positive_regulation of Gene_expression of Il1 1 0.02 0.75 0.34 5.00
143 INT252295 Il17a Positive_regulation of Gene_expression of TNF 1 0.03 0.75 0.34 5.00
144 INT254213 Binding of Jak1 and Tyk2 1 0.09 0.84 0.33 5.00
145 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33 5.00
146 INT302830 Mapk14 Regulation of Mapkapk5 1 0.12 0.53 0.33 5.00
147 INT254217 Tyk2 Positive_regulation of Stat3 1 0.23 0.83 0.33 5.00
148 INT254209 Jak1 Positive_regulation of Stat3 1 0.18 0.84 0.33 5.00
149 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33 5.00
150 INT302841 Mdk Positive_regulation of Positive_regulation of TNF 1 0.01 0.35 0.33 5.00
151 INT254218 Binding of Il10 and Il10rb 1 0.00 0.87 0.32 5.00
152 INT254226 Binding of Il10 and Il10ra 1 0.00 0.87 0.32 5.00
153 INT302842 Binding of S1PR1 and S1pr1 1 0.24 0.92 0.32 5.00
154 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29 5.00
155 INT254206 Il10 Negative_regulation of Chuk 1 0.05 0.59 0.29 5.00
156 INT260831 Pgf Positive_regulation of TNF 1 0.60 0.75 0.29 5.00
157 INT254208 Il10 Negative_regulation of Regulation of Chuk 1 0.05 0.59 0.29 5.00
158 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28 5.00
159 INT260828 Pgf Positive_regulation of Gene_expression of Gtf3a 1 0.01 0.73 0.28 5.00
160 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28 5.00
161 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28 5.00
162 INT306941 Tnfsf12 Positive_regulation of Gene_expression of CCL2 1 0.03 1.65 0.27 5.00
163 INT239041 Binding of Sqle and Gtf3a 1 0.00 1.08 0.27 5.00
164 INT306937 Tnfsf12 Positive_regulation of Gene_expression of Vcam1 1 0.05 1.79 0.27 5.00
165 INT254212 Binding of Il17rc and Hrec 1 0.00 0.19 0.27 5.00
166 INT306942 Tnfsf12 Positive_regulation of Gene_expression of ICAM1 1 0.04 1.78 0.27 5.00
167 INT254221 Binding of Il17a and Il17ra 1 0.00 0.18 0.26 5.00
168 INT254203 Binding of Il17a and Hrec 1 0.00 0.19 0.26 5.00
169 INT254196 Binding of Il17a and Il17rc 1 0.01 0.18 0.26 5.00
170 INT254211 Binding of Il17ra and Hrec 1 0.00 0.19 0.26 5.00
171 INT252347 Cd70 Positive_regulation of Cd27 1 0.20 1.06 0.25 5.00
172 INT254224 Binding of Ltbr and Tnfrsf11a 1 0.01 0.59 0.25 5.00
173 INT252349 Binding of Cd70 and Mthfd1 Positive_regulation of Cd27 1 0.03 1.07 0.25 5.00
174 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24 5.00
175 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24 5.00
176 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24 5.00
177 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24 5.00
178 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24 5.00
179 INT252340 Binding of Cd70 and Mthfd1 1 0.03 1.05 0.24 5.00
180 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23 5.00
181 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23 5.00
182 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23 5.00
183 INT289246 Il6 Positive_regulation of Gopc 1 0.06 1 0.22 5.00
184 INT302819 Regulation of S1pr1 Positive_regulation of Ptger2 1 0.02 0.35 0.22 5.00
185 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22 5.00
186 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 5.00
187 INT302822 Tnfsf10 Positive_regulation of Protein_catabolism of Psmd9 1 0.03 0.78 0.21 5.00
188 INT299787 Binding of IL2 and ISG20 1 0.04 0.82 0.21 5.00
189 INT276968 Il6 Positive_regulation of Gene_expression of Stat3 2 0.20 1.54 0.21 5.00
190 INT311987 Binding of Cd40 and Negative_regulation of Regulation of Hand1 1 0.28 0.27 0.21 5.00
191 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21 5.00
192 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2 5.00
193 INT260827 Binding of Flt1 and Pgf 1 0.27 0.6 0.2 5.00
194 INT302835 S1pr1 Positive_regulation of Ptger2 1 0.03 0.3 0.2 5.00
195 INT220053 Il10 Positive_regulation of Ido1 1 0.14 0.74 0.19 5.00
196 INT252330 Binding of Cd36 and Cd47 2 0.10 0.72 0.19 5.00
197 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18 5.00
198 INT289241 Cish Regulation of Il6 1 0.03 0.85 0.18 5.00
199 INT302846 Negative_regulation of Binding of S1PR1 and S1pr1 1 0.28 0.41 0.18 5.00
200 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for abatacept. They are ordered first by their pain relevance and then by number of times they were reported in abatacept. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 100.00
2 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
3 INT97261 Negative_regulation of Regulation of IL2 2 0.26 1.04 1.17 100.00
4 INT15803 Regulation of IFNG 21 0.44 12.57 5.98 100.00
5 INT15796 Regulation of IL2 66 0.61 25.43 20.62 100.00
6 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17 100.00
7 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 100.00
8 INT49770 Binding of FCAR 7 0.26 0.86 0.62 100.00
9 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 100.00
10 INT132178 Binding of CD80 41 0.47 15.55 12.98 99.98
11 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.98
12 INT19620 Binding of CD86 30 0.47 12.01 9.89 99.98
13 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 99.98
14 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 99.98
15 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 99.98
16 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41 99.98
17 INT162380 Negative_regulation of CXCR2 11 0.57 6.98 2.76 99.98
18 INT124355 Negative_regulation of BEST1 11 0.19 6.13 2.04 99.98
19 INT138544 Negative_regulation of Cd86 2 0.41 0.87 0.72 99.98
20 INT138545 Negative_regulation of Cd80 1 0.08 0.5 0.72 99.98
21 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 99.98
22 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 99.98
23 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 99.98
24 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12 99.98
25 INT140338 Negative_regulation of Gene_expression of Il17a 34 0.46 23.82 9.87 99.98
26 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 99.98
27 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19 99.98
28 INT31940 Binding of FCGR1A 6 0.35 2.16 3.1 99.98
29 INT44015 Binding of Cd86 16 0.31 5.92 3.58 99.96
30 INT227772 Binding of Cd80 11 0.29 7.85 2.2 99.96
31 INT145986 Positive_regulation of CTLA4 8 0.56 2.66 0.82 99.94
32 INT142082 Positive_regulation of IDO1 17 0.60 9.46 6.33 99.92
33 INT149700 Binding of Cd86 1 0.33 0.69 0.53 99.92
34 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 99.84
35 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 99.84
36 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 99.84
37 INT174557 Negative_regulation of Gene_expression of Cd28 7 0.43 4.42 1.2 99.84
38 INT22285 Negative_regulation of Mtx1 16 0.49 7.84 8.98 99.80
39 INT139064 Binding of Cd80 3 0.35 1.64 1.07 99.76
40 INT139065 Negative_regulation of Binding of Cd80 1 0.11 0.33 0.33 99.76
41 INT75685 Regulation of CD86 12 0.58 3.55 2.66 99.74
42 INT147636 Regulation of CD80 3 0.60 1.27 1.73 99.74
43 INT147635 Regulation of Positive_regulation of CD80 1 0.44 0.38 0.53 99.74
44 INT147634 Regulation of Cd28 2 0.44 3.23 0.82 99.74
45 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 99.72
46 INT182013 Regulation of Acr 5 0.06 1.92 4.58 99.68
47 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 99.68
48 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 99.68
49 INT117598 Regulation of ACR 118 0.26 41.25 48.01 99.66
50 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26 99.64
51 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 99.56
52 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 99.56
53 INT288015 Regulation of SLC44A4 1 0.10 0.59 0.19 99.50
54 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 99.48
55 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.46
56 INT93912 Positive_regulation of CD80 11 0.56 7.01 1.88 99.46
57 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.44
58 INT279357 Regulation of Binding of CD28 1 0.18 0.3 0.72 99.42
59 INT266746 Binding of ACR 8 0.23 3.44 5.26 99.40
60 INT19621 Positive_regulation of CD86 23 0.69 14 2.58 99.36
61 INT25607 Binding of Il1 82 0.47 64.4 23.9 99.36
62 INT332988 Negative_regulation of Sle1 1 0.03 0.71 0.53 99.32
63 INT46162 Regulation of C6orf25 12 0.39 5.42 1.61 99.32
64 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.30
65 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.30
66 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75 99.24
67 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 99.24
68 INT73504 Binding of CD28 35 0.45 15.99 10.04 99.22
69 INT209959 Negative_regulation of Binding of CD80 3 0.42 0.9 1.52 99.20
70 INT209958 Negative_regulation of Binding of CD86 1 0.40 0.28 0.85 99.20
71 INT102694 Localization of CREM 4 0.27 1.6 1.8 99.18
72 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 99.18
73 INT97134 Negative_regulation of CD80 8 0.57 5.09 2.11 99.08
74 INT19617 Negative_regulation of CD86 12 0.42 3.68 1.77 99.08
75 INT147456 Negative_regulation of Positive_regulation of CD80 2 0.41 1.32 0.5 99.08
76 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 99.04
77 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61 98.96
78 INT96157 Gene_expression of Cd80 74 0.77 31.19 9.78 98.92
79 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 98.84
80 INT211192 Localization of ACR 8 0.73 3.04 3.03 98.80
81 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 98.76
82 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 98.74
83 INT138543 Negative_regulation of Cd28 3 0.11 2.1 1.01 98.72
84 INT132177 Binding of CD27 3 0.19 1.84 1 98.72
85 INT38672 Binding of KRT20 69 0.39 48.01 6.31 98.68
86 INT129164 Binding of Cd22 6 0.19 4.46 0.57 98.68
87 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98 98.62
88 INT158573 Negative_regulation of Jak3 3 0.43 8.2 3.99 98.56
89 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 98.46
90 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 98.42
91 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 98.34
92 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28 98.32
93 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 98.22
94 INT226175 Regulation of thd 8 0.14 6.8 1.42 98.20
95 INT157491 Negative_regulation of Ctla4 5 0.31 2.68 0.63 98.12
96 INT6852 Localization of TNF 883 0.81 705.95 270.84 98.12
97 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 98.02
98 INT209961 Binding of GAGE4 3 0.03 1.8 1.16 98.00
99 INT149698 Negative_regulation of Binding of Cd28 2 0.15 1.21 0.75 97.96
100 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 97.84
101 INT149697 Binding of Cd28 2 0.12 1.16 0.74 97.78
102 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.72
103 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 97.60
104 INT4528 Negative_regulation of Sell 12 0.58 4.76 4.22 97.52
105 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 97.36
106 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 97.36
107 INT165066 Gene_expression of GAGE4 3 0.09 2.82 0.57 97.32
108 INT133422 Binding of IL6ST 10 0.40 4.9 1.49 97.24
109 INT143083 Regulation of CTLA4 4 0.25 1.06 1.36 97.00
110 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 96.88
111 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 96.88
112 INT169221 Negative_regulation of Positive_regulation of Tnfrsf4 1 0.31 0.6 0.76 96.80
113 INT169222 Negative_regulation of Positive_regulation of Cd69 2 0.42 0.97 0.76 96.80
114 INT19854 Binding of IGKV2-18 2 0.36 1.07 0.44 96.32
115 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34 96.08
116 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 96.04
117 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 95.96
118 INT220045 Regulation of Regulation of Cia1 1 0.09 1.27 0.55 95.96
119 INT155485 Regulation of Gene_expression of CD86 7 0.61 3.73 0.6 95.92
120 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86 95.92
121 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 95.68
122 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 95.56
123 INT258404 Positive_regulation of Gene_expression of ACR 4 0.28 1.08 2.24 95.32
124 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 95.28
125 INT204550 Regulation of Cia1 6 0.23 9.7 4.23 94.60
126 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 94.48
127 INT170315 Positive_regulation of Gene_expression of Ido1 50 0.67 25.39 6.06 94.48
128 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 94.24
129 INT20129 Regulation of Il1 53 0.53 44.14 19.89 94.16
130 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 93.84
131 INT53574 Regulation of Tnf 45 0.62 40.68 19.71 93.80
132 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 93.76
133 INT352167 Negative_regulation of Positive_regulation of CEL 1 0.04 1.07 0.31 93.76
134 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 93.44
135 INT38674 Regulation of KRT20 32 0.44 19 2.15 93.44
136 INT187168 Binding of Cd74 13 0.27 11.2 3.44 93.28
137 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 93.12
138 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 92.96
139 INT204549 Negative_regulation of Positive_regulation of Cia1 5 0.16 7.49 3.72 92.96
140 INT163359 Gene_expression of RFC1 9 0.65 3.34 2.64 92.96
141 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 92.88
142 INT161595 Positive_regulation of Tnfrsf4 4 0.51 2.73 1.08 92.88
143 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 92.88
144 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76 92.88
145 INT14238 Positive_regulation of Cd69 19 0.60 17.75 6.07 92.84
146 INT170323 Regulation of Gene_expression of Ido1 11 0.60 8.74 2.33 92.72
147 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65 92.56
148 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 92.08
149 INT88184 Gene_expression of ENDO1 5 0.16 0.54 1.69 91.42
150 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75 91.20
151 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 91.20
152 INT44602 Gene_expression of TNFSF13B 37 0.75 30.98 9.96 91.12
153 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 91.00
154 INT89660 Positive_regulation of Gene_expression of Hrec 15 0.17 12.06 7.37 91.00
155 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 90.80
156 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 90.56
157 INT153260 Gene_expression of CD22 19 0.70 8.35 0.39 90.40
158 INT194591 Negative_regulation of Gene_expression of ACR 2 0.07 0.33 1.23 89.88
159 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07 89.60
160 INT158070 Localization of Aes 23 0.65 19.93 10.9 89.20
161 INT621 Positive_regulation of SERPINH1 19 0.57 21.52 8.44 89.20
162 INT23105 Gene_expression of MS4A1 5 0.75 5.17 0.95 89.16
163 INT209963 Positive_regulation of Binding of RDBP 1 0.07 0.3 0.71 88.96
164 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 88.96
165 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 88.80
166 INT94437 Positive_regulation of Gene_expression of OLR1 17 0.70 16.04 2.8 88.80
167 INT306748 Gene_expression of Stil 1 0.58 1.47 0.84 88.80
168 INT149119 Binding of CFLAR 3 0.17 0.51 0.42 88.80
169 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 88.40
170 INT188355 Binding of Cd28 25 0.34 8.29 3.38 88.20
171 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72 87.88
172 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 87.84
173 INT131155 Regulation of Cd200 2 0.04 0.34 0.27 87.52
174 INT133156 Binding of Cd40 77 0.48 45.92 13.77 87.40
175 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 87.40
176 INT133568 Regulation of TNFRSF1B 1 0.01 0.54 0.37 87.28
177 INT209962 Binding of RDBP 4 0.11 2.93 1.27 87.20
178 INT196393 Negative_regulation of Cd86 9 0.22 4.24 1.17 87.20
179 INT299760 Negative_regulation of Cd80 2 0.16 1.06 0.55 87.20
180 INT100582 Positive_regulation of Stil 2 0.49 1.69 1.33 87.16
181 INT29898 Negative_regulation of C6orf25 16 0.29 9.58 1.33 86.68
182 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 86.20
183 INT85965 Binding of Cd40lg 26 0.45 16.76 4.52 85.40
184 INT265207 Positive_regulation of Gene_expression of Cd28 3 0.43 1.47 0.66 85.28
185 INT60745 Gene_expression of Ltbr 10 0.61 7.86 3.21 85.12
186 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 85.12
187 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 85.12
188 INT108427 Gene_expression of Il15 9 0.76 5.13 4.63 85.12
189 INT36751 Gene_expression of ZMYND10 7 0.75 3.92 0.32 84.88
190 INT94833 Gene_expression of FGF1 4 0.53 2.01 0.81 84.80
191 INT154825 Gene_expression of HBXIP 1 0.09 0.2 0.25 84.80
192 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 84.00
193 INT117080 Localization of Csrp1 6 0.42 7.23 3.09 83.72
194 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 83.52
195 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 83.40
196 INT23148 Gene_expression of RUNX1 10 0.10 6.58 1.71 83.32
197 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 82.00
198 INT133549 Gene_expression of Il15 42 0.69 27.84 14.74 81.08
199 INT170295 Positive_regulation of Ido1 40 0.67 28.89 7.61 81.08
200 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 81.08
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