P:addiction

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pChart

Pain Term
Category Condition
Synonyms Dependence
Pain Specific No
Documents 12588
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for addiction. They are ordered first by their pain relevance and then by number of times they were reported for addiction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46 100.00
2 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53 100.00
3 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47 100.00
4 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77 100.00
5 INT142128 Nrgn Regulation of Creb1 1 0.38 0.25 0.89 100.00
6 INT142129 Nrgn Regulation of Camk2a 1 0.48 0.25 0.89 100.00
7 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58 100.00
8 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57 100.00
9 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57 100.00
10 INT185191 Binding of Car9 and Pif 1 0.01 2.33 0.45 100.00
11 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1 100.00
12 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 0.10 0 0.62 100.00
13 INT303759 IGHG3 Regulation of Localization of ROS1 1 0.07 0 0.09 100.00
14 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 100.00
15 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32 100.00
16 INT68614 Positive_regulation of GNRH1 Positive_regulation of Gh 1 0.01 0 0.28 100.00
17 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09 100.00
18 INT251293 Regulation of Binding of ITIH4 and ERVW-1 1 0.27 0.07 0.08 100.00
19 INT208363 Binding of Apoc3 and Positive_regulation of Binding of Apoe Apoe 1 0.02 0.72 0.05 100.00
20 INT107933 Oprm1 Positive_regulation of Gene_expression of Mastl 1 0.33 0.61 0.71 99.96
21 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47 99.92
22 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47 99.92
23 INT244452 CS Positive_regulation of Phosphorylation of EIF2S2 1 0.21 2.07 0.09 99.92
24 INT313635 MUC7 Negative_regulation of Rbm39 1 0.00 0 0.48 99.92
25 INT115272 Neu1 Positive_regulation of Coq10a 1 0.43 0.41 1.35 99.92
26 INT68613 GNRH1 Positive_regulation of Gh 1 0.01 0 0.28 99.92
27 INT145058 Nr1i3 Regulation of Transcription of Ppara 1 0.28 0.23 0.13 99.92
28 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8 99.88
29 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75 99.82
30 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22 99.76
31 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08 99.76
32 INT254460 Binding of Calm2 and Ca2 5 0.03 0.48 0.43 99.72
33 INT44338 Binding of Penk and RGD1304827 1 0.02 0.2 0.38 99.64
34 INT44337 Penk Negative_regulation of RGD1304827 1 0.02 0.2 0.38 99.64
35 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35 99.60
36 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21 99.56
37 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19 99.52
38 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05 99.52
39 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09 99.40
40 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7 99.36
41 INT132839 TPT1 Regulation of Mapk1 1 0.01 0.07 0.25 99.36
42 INT115271 Neu1 Positive_regulation of Coq10a 1 0.01 0.41 1.35 99.32
43 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75 99.26
44 INT135586 CSF2 Regulation of ICAM1 1 0.13 1.3 0.49 99.24
45 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71 99.18
46 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14 99.18
47 INT354210 Binding of Igfbp7 and Accn3 1 0.27 3.91 1.64 99.16
48 INT139189 Binding of Daxx and Fadd 1 0.03 0.27 0.57 99.10
49 INT38905 Ptgfr Regulation of Ptgds 1 0.20 0 0.63 99.08
50 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42 98.92
51 INT139488 Oprm1 Positive_regulation of Cnr1 1 0.17 0.1 0.42 98.92
52 INT139489 Oprm1 Positive_regulation of Penk 1 0.23 0.1 0.42 98.92
53 INT139486 Oprm1 Positive_regulation of Crh 1 0.27 0.1 0.42 98.92
54 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42 98.82
55 INT339516 Binding of Eif2ak2 and TIRAP 1 0.25 0.19 0.23 98.80
56 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67 98.74
57 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19 98.72
58 INT166863 Kcnj9 Regulation of Kcnj6 1 0.20 0 0.56 98.68
59 INT147229 Positive_regulation of Ccdc80 Negative_regulation of Faah 1 0.02 0.06 0.16 98.60
60 INT147230 Ccdc80 Negative_regulation of Faah 1 0.02 0.06 0.16 98.60
61 INT332538 Binding of AD5 and Cxadr 1 0.08 0.98 0.76 98.56
62 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68 98.56
63 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24 98.44
64 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49 98.40
65 INT25399 Il2 Positive_regulation of Gene_expression of Csf2 1 0.41 0.07 0.05 98.40
66 INT339501 Binding of Eif2ak2 and Tlr4 1 0.14 0.19 0.23 98.24
67 INT268023 Binding of Abcc8 and Slc25a25 1 0.00 0 0.05 98.24
68 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7 98.12
69 INT254459 Ca2 Positive_regulation of Calm2 1 0.03 0 0.08 98.08
70 INT95457 Nka1 Positive_regulation of Tacr1 1 0.63 0.29 1.3 98.04
71 INT135589 CSF2 Regulation of IL6 1 0.08 1.27 0.48 98.04
72 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9 98.00
73 INT135591 CSF2 Regulation of IL8 1 0.09 1.27 0.48 97.92
74 INT139893 Binding of Alb and Alms1 1 0.04 0.48 0.75 97.68
75 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17 97.60
76 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89 97.56
77 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15 97.56
78 INT208763 Binding of CSF2 and TPH1 1 0.07 0.65 0.19 97.56
79 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 97.52
80 INT251292 Binding of ITIH4 and ERVW-1 1 0.22 0.07 0.08 97.52
81 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65 97.40
82 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71 97.22
83 INT222787 Binding of HLA-DQB3 and FCRL4 1 0.00 1.18 0.22 97.20
84 INT342466 Binding of FFAR1 and MAFD1 1 0.03 0.87 0.05 97.04
85 INT356324 ORF61 Regulation of Localization of Gabrg1 1 0.00 0.19 0.76 96.96
86 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05 96.88
87 INT135585 CSF2 Regulation of CCL2 1 0.13 2.51 0.95 96.80
88 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05 96.76
89 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76 96.16
90 INT36171 Ptger2 Positive_regulation of Localization of Gnrh1 1 0.10 0 0.25 96.12
91 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24 96.12
92 INT356313 Crh Positive_regulation of Localization of Helt 1 0.02 0 2.11 96.08
93 INT356327 Crh Positive_regulation of Localization of Gabrg1 1 0.17 0 1.58 96.08
94 INT356316 Crh Positive_regulation of Localization of Cea 1 0.34 0 1.06 96.08
95 INT50793 Oprd1 Regulation of Phosphorylation of Oprd1 1 0.00 0 0.8 96.08
96 INT171186 Binding of PPFIA4 and ACOT1 1 0.00 0.37 0.42 96.00
97 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56 95.96
98 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42 95.92
99 INT265603 Msc Positive_regulation of Gene_expression of Il6 1 0.16 1.79 0.2 95.84
100 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91 95.84
101 INT356330 ORF61 Regulation of ORF61 Regulation of Crh 1 0.00 0.1 0.38 95.84
102 INT356319 ORF61 Regulation of Crh 1 0.00 0.1 0.38 95.84
103 INT272774 Binding of Mc4r and Fto 1 0.30 0.66 0.08 95.68
104 INT322019 CASP8 Regulation of Gene_expression of IL1B 1 0.02 0 0.1 95.60
105 INT171185 Binding of NEUROD1 and ACOT1 1 0.01 0.37 0.42 95.36
106 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3 95.32
107 INT177589 Binding of HBG1 and C7orf49 1 0.00 0 0.12 95.28
108 INT261629 Binding of CPD and TRPC5 1 0.04 0.52 0.32 95.24
109 INT312662 Binding of CSTF2 and DSE 1 0.06 0.1 0.53 95.12
110 INT93234 Negative_regulation of Pde4b Negative_regulation of Gene_expression of Fos 1 0.41 0.1 0.96 95.00
111 INT171183 Binding of BHLHE23 and ACOT1 1 0.01 0.36 0.42 94.96
112 INT153897 Binding of KCNJ3 and Snx27 1 0.03 0.28 0.5 94.92
113 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05 94.88
114 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05 94.88
115 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 0.02 0.18 1.24 94.64
116 INT136257 Tff3 Regulation of SGCG 1 0.00 0.18 1.24 94.64
117 INT136255 Tff3 Regulation of GRIA1 1 0.00 0.18 1.24 94.64
118 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23 94.64
119 INT310066 Negative_regulation of Pain1 Positive_regulation of Faah 1 0.03 1.32 1.23 94.64
120 INT310069 Negative_regulation of Pain1 Positive_regulation of Mgll 1 0.02 1.32 1.23 94.64
121 INT310068 Pain1 Positive_regulation of Faah 1 0.03 1.3 1.22 94.64
122 INT310067 Pain1 Positive_regulation of Mgll 1 0.02 1.29 1.21 94.64
123 INT270948 Cpe Regulation of Regulation of Slc6a3 1 0.14 0.28 0.23 94.64
124 INT350700 Binding of Bcl6 and thd 1 0.00 0.21 0.08 94.56
125 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08 94.56
126 INT350720 Binding of Bcl6 and TBX21 1 0.07 0.22 0.08 94.56
127 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16 94.48
128 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13 94.48
129 INT159454 Binding of Inadl2 and Ppidl1 1 0.03 1.08 0.7 94.36
130 INT64259 Binding of Gtpbp4 and Ptprg 1 0.06 0 1.1 94.04
131 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79 94.00
132 INT25400 Binding of Ptger1 and Ptger2 2 0.11 1.02 0.15 94.00
133 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88 93.92
134 INT136256 Creb1 Regulation of SGCG 1 0.26 0.18 1.23 93.92
135 INT136258 Creb1 Regulation of GRIA1 1 0.26 0.18 1.23 93.92
136 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92 93.84
137 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3 93.72
138 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67 93.72
139 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17 93.68
140 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17 93.68
141 INT182705 NPFF Regulation of Localization of PRL 1 0.03 0 0.48 93.64
142 INT150755 GTS Negative_regulation of Phosphorylation of Atf6b 1 0.13 0.08 0.64 93.60
143 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2 93.56
144 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11 93.40
145 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42 93.40
146 INT316248 ESR1 Regulation of Gene_expression of TRPM8 1 0.34 0.17 0.05 93.36
147 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05 93.24
148 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05 93.24
149 INT112153 Regulation of Binding of Oprm1 and Rtcd1 1 0.00 0.09 0.87 93.20
150 INT350721 Binding of Hand1 and TBX21 1 0.13 0.22 0.08 93.12
151 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62 93.04
152 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61 93.04
153 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95 92.80
154 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22 92.76
155 INT112154 Binding of Oprm1 and Rtcd1 1 0.00 0.09 0.81 92.72
156 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85 92.52
157 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25 92.52
158 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57 92.40
159 INT127738 Binding of Crygb and Pnoc 2 0.49 0.1 0.99 92.40
160 INT317640 Slc3a1 Positive_regulation of Creb1 1 0.12 0.58 0.46 92.36
161 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45 92.32
162 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41 92.20
163 INT117199 Rgs1 Regulation of Rgs19 1 0.02 0.16 0.56 92.16
164 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 0.00 0 2.64 92.12
165 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 0.01 0 2.64 92.12
166 INT274872 Positive_regulation of Cbr2 Positive_regulation of Dusp6 1 0.02 0.63 0.32 92.04
167 INT324583 Hspg2 Positive_regulation of Trpm5 1 0.19 0 0.09 91.88
168 INT153896 Snx27 Regulation of KCNJ3 1 0.04 0.17 0.33 91.84
169 INT222781 Positive_regulation of Binding of HLA-DQB3 and FCRL4 1 0.00 0.32 0.08 91.84
170 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 91.68
171 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4 91.64
172 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43 91.52
173 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22 91.32
174 INT317636 Creb1 Positive_regulation of Phosphorylation of Hmmr 1 0.04 0.55 0.45 91.32
175 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05 91.28
176 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28 91.24
177 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32 91.12
178 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24 91.04
179 INT231027 LOC100366054 Negative_regulation of Gene_expression of Pgr 1 0.02 0 0.62 90.84
180 INT26197 Qrfp Regulation of Localization of Crh 1 0.02 0 0.36 90.76
181 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1 90.72
182 INT207434 LPA Regulation of Gene_expression of PLA2G7 1 0.11 0.73 0.31 90.44
183 INT232619 Binding of Gria1 and Grid2ip 1 0.23 0.51 0.48 90.00
184 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33 89.92
185 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85 89.84
186 INT251296 Binding of CCR5 and ITIH4 1 0.16 0.08 0.04 89.60
187 INT245348 Binding of Abat and Vta1 1 0.03 0.53 2.01 89.52
188 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18 89.52
189 INT259209 Binding of Glul and Flna 1 0.03 0 4.2 89.44
190 INT328378 GH1 Regulation of Gene_expression of Ghrl 1 0.02 0.39 0.25 89.44
191 INT188006 NLRP3 Regulation of Gene_expression of TP53BP1 1 0.28 0.36 0.04 89.44
192 INT317635 Positive_regulation of Drd1a Positive_regulation of Phosphorylation of Gtf3a 1 0.01 0.53 0.43 89.20
193 INT73381 Npy5r Positive_regulation of Positive_regulation of Npy 1 0.12 0 0.63 89.12
194 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76 88.80
195 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75 88.80
196 INT250392 Binding of TRPV1 and TBA 1 0.01 0 0.12 88.80
197 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63 88.64
198 INT150754 GTS Negative_regulation of Gene_expression of Prkaca 1 0.32 0.08 0.65 88.48
199 INT245349 Binding of Abat and Gpr156 1 0.02 0.26 1 88.32
200 INT20035 Il1b Negative_regulation of Gene_expression of LH 1 0.28 0.2 0.22 88.28

Single Events

The table below shows the top 200 pain related interactions that have been reported for addiction. They are ordered first by their pain relevance and then by number of times they were reported in addiction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 100.00
2 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 100.00
3 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 100.00
4 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 100.00
5 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 100.00
6 INT12484 Binding of Drd2 45 0.48 15.17 24.72 100.00
7 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
8 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 100.00
9 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 100.00
10 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 100.00
11 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
12 INT272768 Gene_expression of Nrxn3 5 0.78 4.73 3.31 100.00
13 INT1562 Localization of Crh 499 0.81 126.74 236.68 100.00
14 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 100.00
15 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 100.00
16 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 100.00
17 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
18 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
19 INT21566 Regulation of Oprk1 10 0.62 3.4 8.63 100.00
20 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 100.00
21 INT4822 Localization of Ca2 417 0.80 99.57 96.45 100.00
22 INT3948 Regulation of Cck 291 0.62 58.07 255.88 100.00
23 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 100.00
24 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 100.00
25 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 100.00
26 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46 100.00
27 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39 100.00
28 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
29 INT5490 Binding of CA2 52 0.36 9.73 5.53 100.00
30 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 100.00
31 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 100.00
32 INT251 Regulation of INS 398 0.62 232.47 55.04 100.00
33 INT212819 Regulation of Chrm5 2 0.44 1.64 2.22 100.00
34 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 100.00
35 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 100.00
36 INT847 Regulation of Lhb 131 0.61 22.08 46.54 100.00
37 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 100.00
38 INT109150 Negative_regulation of Tubgcp2 4 0.38 2.04 5.12 100.00
39 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 100.00
40 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 100.00
41 INT170511 Regulation of Localization of Car2 11 0.21 2.18 1.09 100.00
42 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83 100.00
43 INT138917 Positive_regulation of Gene_expression of Stat1 63 0.69 36.76 1.71 100.00
44 INT48832 Positive_regulation of Grip2 48 0.69 12.13 25.99 100.00
45 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72 100.00
46 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 100.00
47 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 100.00
48 INT150698 Regulation of PTPRB 1 0.45 1.52 0.89 100.00
49 INT1530 Regulation of Gh 382 0.61 115.96 112.47 100.00
50 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 100.00
51 INT87794 Positive_regulation of Mors1 19 0.38 4.74 20.23 100.00
52 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 100.00
53 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66 100.00
54 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 100.00
55 INT315006 Regulation of Localization of Tmie 2 0.04 0.26 0.37 100.00
56 INT3546 Binding of Oxt 54 0.48 9.75 10.81 100.00
57 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 100.00
58 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 100.00
59 INT52166 Positive_regulation of Positive_regulation of OPRK1 2 0.57 0.48 2.74 100.00
60 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 100.00
61 INT11788 Positive_regulation of Rrsv 36 0.46 10.08 9.68 100.00
62 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71 100.00
63 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 100.00
64 INT5476 Regulation of Gabbr1 21 0.45 4.01 10.26 100.00
65 INT7286 Regulation of Transcription of Penk 81 0.62 9.25 33.45 100.00
66 INT96904 Regulation of Prkaca 33 0.44 10.86 24.51 100.00
67 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 100.00
68 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
69 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56 100.00
70 INT212817 Regulation of Regulation of Chrm5 1 0.44 0.13 0.81 100.00
71 INT290728 Gene_expression of Depmq1 1 0.01 0.79 0.92 100.00
72 INT2213 Regulation of EP300 10 0.54 4.72 4.5 100.00
73 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 100.00
74 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 100.00
75 INT135120 Phosphorylation of Atf6b 13 0.61 4.01 8.03 100.00
76 INT6229 Positive_regulation of Gene_expression of Sult1b1 18 0.22 2.21 6.04 100.00
77 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 100.00
78 INT310381 Positive_regulation of Gene_expression of Nrxn3 1 0.03 1.19 1 100.00
79 INT339 Regulation of Trh 156 0.62 39.27 83.55 100.00
80 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 100.00
81 INT29558 Positive_regulation of Positive_regulation of CYBB 16 0.32 2.33 1.25 100.00
82 INT9782 Binding of HTR1B 43 0.47 12.08 19.83 100.00
83 INT12231 Positive_regulation of Localization of Nts 17 0.70 4.54 13.85 100.00
84 INT5939 Regulation of Gene_expression of Oxt 27 0.51 2.84 9.1 100.00
85 INT70377 Regulation of Transcription of Oprm1 3 0.47 0.93 2.78 100.00
86 INT16256 Regulation of Ntf3 15 0.49 9.75 13.07 100.00
87 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 100.00
88 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 100.00
89 INT1376 Binding of Trh 121 0.48 20 69.86 100.00
90 INT1433 Regulation of MUC7 21 0.60 1.7 8.18 100.00
91 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78 100.00
92 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46 100.00
93 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18 100.00
94 INT251196 Regulation of Cora1 1 0.00 0 0.15 100.00
95 INT290729 Positive_regulation of Depmq1 1 0.00 0.29 0.15 100.00
96 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 100.00
97 INT2502 Regulation of Gene_expression of Sult1b1 5 0.11 0.92 2.8 100.00
98 INT207454 Regulation of PLA2G7 5 0.49 3.55 1.12 100.00
99 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 100.00
100 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38 100.00
101 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91 100.00
102 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97 100.00
103 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 100.00
104 INT130466 Regulation of Negative_regulation of Tubgcp2 2 0.30 0.55 1.24 100.00
105 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 100.00
106 INT98871 Regulation of Psd 8 0.42 4.55 2.57 100.00
107 INT81868 Positive_regulation of Aldh2 14 0.69 6.61 0.97 100.00
108 INT129742 Regulation of Positive_regulation of Rtn4 2 0.05 2.51 2.33 100.00
109 INT111069 Regulation of Psen1 19 0.44 7.78 5.87 100.00
110 INT129665 Regulation of Nrcam 1 0.54 1.13 0.63 100.00
111 INT110233 Regulation of Gene_expression of CCR5 6 0.34 7.14 2.76 100.00
112 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 100.00
113 INT8361 Regulation of Localization of Nts 9 0.46 0.54 3.39 100.00
114 INT309772 Regulation of Snord22 1 0.00 1.75 0.12 100.00
115 INT53319 Regulation of Negative_regulation of Kcnn4 1 0.39 0.2 0.25 100.00
116 INT129666 Gene_expression of Nrcam 5 0.78 3.97 1.01 100.00
117 INT170351 Positive_regulation of Gene_expression of Gria2 13 0.67 3.67 3.27 100.00
118 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
119 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26 100.00
120 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 100.00
121 INT24820 Positive_regulation of Binding of POMC 9 0.67 2.98 4.6 100.00
122 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33 100.00
123 INT207450 Regulation of Gene_expression of PLA2G7 1 0.49 2.18 0.85 100.00
124 INT94690 Gene_expression of DPYD 12 0.75 4.6 1.07 100.00
125 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75 100.00
126 INT988 Positive_regulation of Negative_regulation of Trh 3 0.50 0 2.39 100.00
127 INT342408 Positive_regulation of Binding of Atp9a 1 0.49 0 0.1 100.00
128 INT209935 Regulation of Regulation of PPARA 4 0.44 1.56 0.69 100.00
129 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96 100.00
130 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 100.00
131 INT22946 Gene_expression of MBD2 4 0.25 0.26 0.98 100.00
132 INT64807 Positive_regulation of Positive_regulation of CA2 10 0.41 1.21 1.7 100.00
133 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14 100.00
134 INT80385 Binding of GP9 4 0.35 0.26 0.89 100.00
135 INT91946 Regulation of Prkce 6 0.44 4.13 5.46 100.00
136 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35 100.00
137 INT771 Regulation of Nts 93 0.61 13.13 53.57 100.00
138 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09 100.00
139 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54 100.00
140 INT224812 Protein_catabolism of CCT6A 1 0.05 0.1 0.09 100.00
141 INT5324 Binding of Htr2a 23 0.47 7.14 14.66 100.00
142 INT218036 Positive_regulation of NYS3 3 0.11 0.93 0.61 100.00
143 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77 100.00
144 INT127718 Regulation of Gene_expression of TRPM8 8 0.62 10.43 2.07 100.00
145 INT134874 Regulation of Dlg4 3 0.58 0.28 2.12 100.00
146 INT306082 Regulation of ADH5 1 0.08 0.46 0.08 100.00
147 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 100.00
148 INT51947 Regulation of Transcription of Egr1 2 0.59 0.15 0.96 100.00
149 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 100.00
150 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 100.00
151 INT44280 Regulation of Glra1 2 0.02 0 0.18 100.00
152 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 100.00
153 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 100.00
154 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 100.00
155 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 100.00
156 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 100.00
157 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 100.00
158 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 100.00
159 INT18884 Regulation of RYBP 25 0.38 11.43 23.2 100.00
160 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 100.00
161 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38 100.00
162 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 100.00
163 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 100.00
164 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37 100.00
165 INT65964 Regulation of Adcyap1 13 0.45 10.1 7.54 100.00
166 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94 100.00
167 INT49506 Regulation of Ptger2 29 0.44 17.38 6.75 100.00
168 INT65772 Positive_regulation of Positive_regulation of Bdkrb1 6 0.49 8.34 6.54 100.00
169 INT35248 Gene_expression of Gpi 14 0.51 2.38 5.49 100.00
170 INT20200 Positive_regulation of Serpinc1 25 0.68 17.08 4.98 100.00
171 INT83991 Regulation of Nos3 25 0.44 9.89 4.06 100.00
172 INT49712 Regulation of Nr3c1 10 0.28 5.65 4.06 100.00
173 INT28062 Regulation of Negative_regulation of Gabrg1 3 0.47 0 3.87 100.00
174 INT3889 Regulation of Serpinc1 13 0.61 8.6 3.46 100.00
175 INT62957 Positive_regulation of CXCL5 13 0.50 8.53 3.28 100.00
176 INT139010 Regulation of Gfm1 16 0.32 5.02 3.27 100.00
177 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14 100.00
178 INT170343 Positive_regulation of Gene_expression of Gria1 10 0.61 2.77 3.09 100.00
179 INT30645 Regulation of Localization of RYBP 4 0.36 0 3.07 100.00
180 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66 100.00
181 INT51683 Regulation of Gene_expression of PTAFR 11 0.60 5.06 2.59 100.00
182 INT98607 Regulation of Regulation of TNF 8 0.44 6.95 2.56 100.00
183 INT102638 Regulation of VDR 21 0.44 9.92 2.54 100.00
184 INT93341 Localization of Prkaca 7 0.59 2.04 2.28 100.00
185 INT68277 Positive_regulation of CXCL1 6 0.56 6.98 2.14 100.00
186 INT239025 Regulation of Gene_expression of Il17a 9 0.42 7.18 2.09 100.00
187 INT51000 Positive_regulation of Atp9a 12 0.49 5.63 1.93 100.00
188 INT94892 Regulation of NOSTRIN 7 0.31 2.99 1.72 100.00
189 INT13144 Regulation of Positive_regulation of Ina 5 0.22 0.4 1.67 100.00
190 INT97560 Regulation of Transcription of Fos 6 0.44 2.71 1.46 100.00
191 INT19619 Positive_regulation of SHMT2 6 0.08 1.05 1.35 100.00
192 INT233970 Regulation of Myd88 7 0.45 5.2 1.28 100.00
193 INT293709 Regulation of Gene_expression of Gpi 2 0.10 0.23 1.24 100.00
194 INT148946 Negative_regulation of CCT6A 2 0.02 0 1.21 100.00
195 INT57494 Positive_regulation of Positive_regulation of Serpinc1 3 0.26 1.67 1.19 100.00
196 INT135615 Positive_regulation of IKBKB 3 0.59 6.16 1.1 100.00
197 INT129910 Positive_regulation of Inhbe 2 0.05 3.84 1.07 100.00
198 INT92623 Regulation of Positive_regulation of Ntf3 2 0.09 1 0.83 100.00
199 INT88283 Positive_regulation of Gene_expression of Hmmr 2 0.06 0.78 0.81 100.00
200 INT135931 Regulation of Regulation of Pde4a 1 0.44 0 0.81 100.00
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