P:adjuvant analgesic

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pChart

Pain Term
Category Drug class
Synonyms Adjuvant Analgesics
Pain Specific Yes
Documents 202
Hot Single Events 18
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for adjuvant analgesic. They are ordered first by their pain relevance and then by number of times they were reported for adjuvant analgesic. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13 5.00
2 INT351246 Binding of OPN1LW and NNT 1 0.03 0.53 1.45 5.00
3 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37 5.00
4 INT351245 Binding of TNC and OPN1LW 1 0.03 0.89 1.31 5.00
5 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98 5.00
6 INT344381 Olfr360 Negative_regulation of Gene_expression of Grin2b 1 0.01 1.17 0.93 5.00
7 INT344390 Olfr360 Negative_regulation of Phosphorylation of Grin2b 1 0.01 1.17 0.93 5.00
8 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92 5.00
9 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9 5.00
10 INT344383 Olfr360 Regulation of Gene_expression of Efnb1 1 0.01 1.27 0.74 5.00
11 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 1 0.01 1.05 0.66 5.00
12 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for adjuvant analgesic. They are ordered first by their pain relevance and then by number of times they were reported in adjuvant analgesic. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 97.92
2 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 95.36
3 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 95.36
4 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 93.92
5 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 93.60
6 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61 91.36
7 INT7561 Positive_regulation of gr 70 0.57 31.92 20.22 91.16
8 INT131884 Positive_regulation of Positive_regulation of gr 3 0.03 2.31 6.03 91.16
9 INT7573 Positive_regulation of Nr3c2 38 0.67 20 21.84 91.16
10 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 91.00
11 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 90.56
12 INT344377 Negative_regulation of Cckbr 1 0.33 3.94 3.67 89.28
13 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 88.72
14 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 88.64
15 INT79166 Regulation of TNC 12 0.44 9.42 8.13 86.40
16 INT168399 Localization of Cnr2 12 0.81 4.37 6.77 86.28
17 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 83.76
18 INT73599 Negative_regulation of Gene_expression of Cpox 47 0.55 19.89 17.26 83.76
19 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 80.00
20 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 78.56
21 INT1005 Localization of Sst 385 0.81 26.31 244.56 78.56
22 INT12319 Positive_regulation of Cort 52 0.61 22.55 29.35 78.56
23 INT879 Localization of Fdft1 16 0.59 1.11 12.59 78.56
24 INT18591 Positive_regulation of Localization of Fdft1 4 0.12 0.73 3.48 78.56
25 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 77.20
26 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 76.00
27 INT4631 Positive_regulation of Sst 127 0.70 17.37 83.29 75.36
28 INT7695 Positive_regulation of Fdft1 13 0.30 1.51 6.51 74.80
29 INT134585 Negative_regulation of Cnr2 10 0.43 3.98 6.16 73.76
30 INT189842 Negative_regulation of Gene_expression of Cnr2 8 0.59 4.21 4.67 73.76
31 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 73.52
32 INT351302 Regulation of Regulation of Cnr1 1 0.10 0.78 1.39 72.48
33 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 71.12
34 INT351303 Regulation of Binding of Cnr2 1 0.10 0.66 1.39 71.12
35 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 69.68
36 INT53288 Binding of OPN1LW 5 0.11 4.24 8.9 56.48
37 INT12321 Binding of Nr3c2 19 0.46 5.44 13.46 47.36
38 INT12316 Negative_regulation of Cort 10 0.38 5.89 6.08 39.68
39 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7 29.08
40 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 28.88
41 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 28.48
42 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9 28.48
43 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14 27.08
44 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39 26.36
45 INT2649 Regulation of Calca 433 0.62 146.05 330.95 25.00
46 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 25.00
47 INT22499 Regulation of Calca 42 0.62 17.32 28.02 25.00
48 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 25.00
49 INT2490 Regulation of Sct 44 0.62 9.45 13.11 25.00
50 INT76198 Positive_regulation of ADORA3 3 0.45 1.53 1.7 25.00
51 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 23.88
52 INT345985 Positive_regulation of Gene_expression of SLC1A1 1 0.01 0.35 2.2 23.80
53 INT76430 Gene_expression of SLC1A1 2 0.03 0.77 3.15 23.40
54 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
55 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
56 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
57 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 5.00
58 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
59 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 5.00
60 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 5.00
61 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
62 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 5.00
63 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 5.00
64 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
65 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
66 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
67 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
68 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 5.00
69 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 5.00
70 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 5.00
71 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
72 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
73 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
74 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
75 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
76 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3 5.00
77 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
78 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
79 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
80 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
81 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
82 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
83 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
84 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97 5.00
85 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
86 INT7833 Positive_regulation of Cck 33 0.70 8.54 34.21 5.00
87 INT9796 Gene_expression of Cck 63 0.78 11.44 32.09 5.00
88 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
89 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32 5.00
90 INT32794 Gene_expression of Grin2d 81 0.68 20.87 26.99 5.00
91 INT256285 Gene_expression of Efnb1 32 0.70 36.25 24.73 5.00
92 INT12441 Positive_regulation of Gpr156 29 0.67 5.7 24.44 5.00
93 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 5.00
94 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 5.00
95 INT26116 Gene_expression of Gpr156 31 0.78 13.97 20.59 5.00
96 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
97 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24 5.00
98 INT67975 Gene_expression of Bdkrb2 38 0.68 21.69 17.94 5.00
99 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 5.00
100 INT256282 Gene_expression of Efnb2 3 0.76 17.61 16.41 5.00
101 INT18191 Negative_regulation of Cyp3a23/3a1 48 0.57 10.21 13.38 5.00
102 INT344368 Positive_regulation of Gene_expression of Efnb1 13 0.63 18.39 13.31 5.00
103 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 5.00
104 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 5.00
105 INT50580 Binding of PPIG 39 0.36 11.17 12.34 5.00
106 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 5.00
107 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
108 INT130475 Positive_regulation of Phosphorylation of Grin2b 8 0.47 11.52 10.96 5.00
109 INT53290 Gene_expression of OPN1LW 5 0.31 6.9 9.15 5.00
110 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 5.00
111 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 5.00
112 INT250978 Binding of FMOD 4 0.16 12.32 8.75 5.00
113 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 5.00
114 INT79168 Binding of TNC 39 0.47 16.51 7.55 5.00
115 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49 5.00
116 INT14029 Regulation of Fdft1 9 0.19 0.68 7.4 5.00
117 INT53729 Localization of Cort 14 0.69 6.31 6.97 5.00
118 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 5.00
119 INT250982 Positive_regulation of FMOD 7 0.24 8.65 6.09 5.00
120 INT103918 Phosphorylation of Tyr 12 0.47 10.12 5.96 5.00
121 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 5.00
122 INT130472 Negative_regulation of Phosphorylation of Grin2b 4 0.40 4.4 5.78 5.00
123 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77 5.00
124 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 5.00
125 INT137886 Gene_expression of Bcl2a1a 17 0.55 8.58 5.44 5.00
126 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 5.00
127 INT351278 Regulation of FMOD 1 0.09 6.45 5.16 5.00
128 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 5.00
129 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 5.00
130 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 5.00
131 INT250981 Gene_expression of FMOD 2 0.20 7.3 4.47 5.00
132 INT85843 Negative_regulation of BPI 5 0.35 5.13 3.77 5.00
133 INT11107 Binding of Lbp 12 0.42 4.42 3.41 5.00
134 INT344366 Negative_regulation of Gene_expression of Efnb1 1 0.53 5.02 3.29 5.00
135 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 5.00
136 INT26641 Gene_expression of Fdft1 4 0.20 1.61 3.15 5.00
137 INT9794 Regulation of Gene_expression of Cck 5 0.43 1.49 3.1 5.00
138 INT137907 Phosphorylation of Ephb2 2 0.61 2.78 2.96 5.00
139 INT275367 Positive_regulation of Gene_expression of Gpr156 3 0.26 2.15 2.85 5.00
140 INT344371 Phosphorylation of Efnb1 1 0.57 3.35 2.81 5.00
141 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 5.00
142 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 5.00
143 INT203154 Positive_regulation of Gene_expression of Lts1 6 0.17 3.68 2.67 5.00
144 INT75450 Gene_expression of Ugt2a2 2 0.01 3.71 2.35 5.00
145 INT64567 Negative_regulation of Positive_regulation of Gpr156 4 0.36 0.63 2.34 5.00
146 INT250980 Negative_regulation of FMOD 2 0.14 2.67 2.31 5.00
147 INT351277 Positive_regulation of Gene_expression of FMOD 1 0.10 5.79 2.25 5.00
148 INT344367 Regulation of Gene_expression of Efnb1 1 0.41 4.64 2.24 5.00
149 INT250983 Regulation of Gene_expression of FMOD 2 0.09 2.62 2.18 5.00
150 INT183159 Gene_expression of Epha1 3 0.25 3.15 2.17 5.00
151 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17 5.00
152 INT118918 Negative_regulation of SBDS 4 0.16 2.05 2.05 5.00
153 INT113439 Positive_regulation of OPN1LW 2 0.11 0.84 2.01 5.00
154 INT135692 Localization of Nr3c2 7 0.77 4.14 1.98 5.00
155 INT232662 Localization of MS 1 0.03 0.57 1.95 5.00
156 INT232666 Negative_regulation of AK1 1 0.02 2.52 1.88 5.00
157 INT135009 Positive_regulation of BPI 8 0.54 3.8 1.59 5.00
158 INT351254 Regulation of Regulation of TNC 1 0.14 0.55 1.4 5.00
159 INT351255 Transcription of OPN1LW 1 0.16 1.15 1.27 5.00
160 INT245636 Regulation of Positive_regulation of Nr3c2 2 0.59 1.55 1.25 5.00
161 INT344370 Phosphorylation of Ephb6 1 0.31 1.67 1.25 5.00
162 INT232661 Negative_regulation of Gene_expression of GPM6A 1 0.02 0.81 1.2 5.00
163 INT311511 Phosphorylation of Grin2d 2 0.36 1.33 1.18 5.00
164 INT351256 Regulation of OPN1LW 1 0.10 0.55 1.17 5.00
165 INT232665 Gene_expression of WIPF3 1 0.06 1.85 1.14 5.00
166 INT216858 Negative_regulation of PID1 4 0.35 6.3 1.11 5.00
167 INT9551 Regulation of AK1 2 0.03 1.38 1.03 5.00
168 INT53291 Negative_regulation of Binding of OPN1LW 2 0.10 0.67 1.02 5.00
169 INT232664 Regulation of Positive_regulation of AK1 1 0.02 0.91 0.95 5.00
170 INT46369 Positive_regulation of AK1 3 0.09 1.24 0.94 5.00
171 INT344365 Phosphorylation of Il1a 1 0.61 1.01 0.92 5.00
172 INT344376 Positive_regulation of Gene_expression of Ugt2a2 1 0.01 1.4 0.81 5.00
173 INT344373 Phosphorylation of Olfr360 1 0.02 1.15 0.74 5.00
174 INT270304 Localization of FMOD 3 0.15 2.15 0.73 5.00
175 INT276424 Negative_regulation of IMPACT 4 0.32 2.6 0.72 5.00
176 INT351279 Positive_regulation of Localization of FMOD 1 0.10 1.79 0.71 5.00
177 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69 5.00
178 INT318841 Binding of BPI 2 0.29 0.46 0.53 5.00
179 INT333283 Positive_regulation of Gene_expression of Ephb1 3 0.32 1.17 0.47 5.00
180 INT344378 Gene_expression of Olfr360 1 0.02 0.69 0.45 5.00
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