P:algil

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pChart

Pain Term
Category Drug
Synonyms Alodan, Centralgin, Demerol, Dispadol, Dolantin, Dolestine, Dolosal, Dolsin, Isonipecaine, Mefedina, Meperidine Hydrochloride, Mialgin, Pethanol, Pethidine, Petidin Dolargan, Piridosal
Pain Specific Yes
Documents 2029
Hot Single Events 98
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for algil. They are ordered first by their pain relevance and then by number of times they were reported for algil. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT21534 Binding of Oprd1 and Il1 1 0.00 0 0.84 98.00
2 INT21536 Binding of Il2 and Il1 1 0.28 0 1.47 94.84
3 INT21535 Binding of Il2 and Il1f5 1 0.13 0 0.73 94.60
4 INT144598 Hrh2 Positive_regulation of IL2 1 0.01 0.08 0.56 80.08
5 INT65677 Binding of CGA and FSHR 2 0.25 0.29 0.16 52.88
6 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 25.00
7 INT211860 PLOD1 Regulation of AGRP 1 0.07 0.15 0.14 5.00
8 INT292363 Rbmy1a1 Positive_regulation of Bhr1 1 0.05 1.04 0.12 5.00
9 INT277745 Trib3 Regulation of Ccnd1 1 0.00 0.41 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for algil. They are ordered first by their pain relevance and then by number of times they were reported in algil. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT40453 Regulation of ODC1 7 0.45 1.08 1.58 100.00
2 INT5402 Regulation of Bdh2 3 0.01 1.04 0.86 100.00
3 INT41703 Regulation of HBD 1 0.03 0.32 0.44 100.00
4 INT7468 Negative_regulation of Localization of Oxt 109 0.59 9.46 66.79 99.98
5 INT2148 Negative_regulation of Oxt 105 0.59 11.42 57 99.98
6 INT5337 Negative_regulation of Npy 87 0.59 19.6 46.75 99.98
7 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49 99.98
8 INT275 Regulation of Tns1 2 0.28 0.47 1.37 99.92
9 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 99.90
10 INT27803 Regulation of ACOT1 16 0.38 5.94 4.64 99.86
11 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57 99.84
12 INT53392 Positive_regulation of Cyp2b1 8 0.68 0.68 2.13 99.84
13 INT5340 Negative_regulation of Positive_regulation of Npy 12 0.55 3.83 8.23 99.84
14 INT53395 Positive_regulation of Cyp2c6 6 0.70 0.07 3.73 99.84
15 INT53389 Positive_regulation of Cyp2c7 1 0.44 0 0.78 99.84
16 INT53393 Positive_regulation of Cyp3a62 25 0.70 7.56 17.69 99.84
17 INT29694 Positive_regulation of CYP4A1 3 0.67 0.47 1 99.84
18 INT3579 Localization of Oxt 555 0.81 43.35 292.44 99.80
19 INT3840 Negative_regulation of FCGR3B 18 0.59 8.9 5.97 99.76
20 INT3837 Negative_regulation of su 5 0.40 3.39 1.36 99.76
21 INT17879 Positive_regulation of Ppap2a 17 0.53 9.72 3.8 99.56
22 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.48
23 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7 99.44
24 INT46201 Gene_expression of KLKB1 21 0.53 3.01 2.87 99.00
25 INT46202 Positive_regulation of Gene_expression of KLKB1 2 0.04 0 0.68 99.00
26 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17 98.96
27 INT63 Regulation of Me2 1 0.16 0 0.4 98.96
28 INT3830 Positive_regulation of FCGR3B 27 0.67 15.18 10.49 98.94
29 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2 98.84
30 INT4727 Regulation of TAC1 60 0.47 6.74 32.83 98.74
31 INT7553 Negative_regulation of Pih1d2 1 0.15 1.67 2.68 98.62
32 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 98.26
33 INT12360 Regulation of Tac1 31 0.61 5.9 18 98.20
34 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59 98.04
35 INT30850 Gene_expression of MORF4 3 0.65 1.08 0.78 97.72
36 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66 97.40
37 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 97.28
38 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12 97.12
39 INT30849 Gene_expression of Sle1a 1 0.00 0.73 0.66 97.12
40 INT5533 Binding of Oxt 43 0.48 8.69 18.35 96.98
41 INT5338 Regulation of Npy 92 0.62 25.54 51.24 96.56
42 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 96.48
43 INT214 Localization of AVP 370 0.81 208.51 91.09 96.16
44 INT71417 Binding of CES2 6 0.47 0.23 1.31 96.12
45 INT7090 Gene_expression of pcp 50 0.66 13.54 8.96 95.36
46 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 94.92
47 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 94.84
48 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 94.64
49 INT16887 Binding of Maoa 10 0.41 2.32 4.49 94.20
50 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 93.84
51 INT112689 Protein_catabolism of Ptpn2 1 0.59 1.45 0.44 93.64
52 INT21533 Positive_regulation of Il1f5 7 0.25 4.78 2.77 93.60
53 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 93.20
54 INT316 Regulation of Cebpz 105 0.00 27.21 35.41 91.92
55 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 91.84
56 INT156198 Negative_regulation of Vas1 3 0.30 0.97 1.65 91.60
57 INT30209 Localization of SCN5A 24 0.72 7.95 5.35 91.36
58 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 91.20
59 INT11307 Negative_regulation of pcp 30 0.48 7.86 11.53 90.80
60 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 89.80
61 INT5339 Positive_regulation of Positive_regulation of Npy 13 0.68 4.5 8.15 89.60
62 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 89.28
63 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 89.28
64 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 89.28
65 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 89.28
66 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4 89.04
67 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 88.80
68 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 88.68
69 INT142806 Negative_regulation of CECR 4 0.36 0.13 0.32 88.08
70 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 87.88
71 INT61949 Regulation of Nos2 74 0.58 34.08 16.7 87.76
72 INT162 Regulation of Prl 794 0.62 165.01 322.24 87.68
73 INT2140 Regulation of REN 104 0.62 28.24 24.49 87.36
74 INT67183 Binding of Serpinb1a 4 0.37 4 1.77 87.16
75 INT416 Regulation of LH 253 0.62 31.48 125.55 86.92
76 INT20722 Regulation of Localization of ACOT1 5 0.27 1.43 2.86 86.84
77 INT46038 Positive_regulation of ALAS1 3 0.60 0.9 1 86.72
78 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 86.52
79 INT20721 Localization of ACOT1 47 0.80 11.37 10.95 86.40
80 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 86.40
81 INT20586 Regulation of Gfra1 20 0.51 9.43 3.41 86.40
82 INT5561 Negative_regulation of GRIN2D 10 0.50 2.46 4.88 86.28
83 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 86.08
84 INT3117 Regulation of Oxt 103 0.61 17.93 32.28 85.92
85 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 85.44
86 INT157774 Negative_regulation of Depmq1 1 0.02 0.2 0.35 85.20
87 INT25134 Positive_regulation of CD9 3 0.49 3.38 0.66 84.64
88 INT234 Binding of Alb 151 0.48 52.34 32.97 84.12
89 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 84.12
90 INT44972 Negative_regulation of Gfra1 16 0.58 10.17 0.93 83.36
91 INT3835 Positive_regulation of su 10 0.62 4.04 6.19 82.40
92 INT3048 Negative_regulation of Regulation of VSX1 1 0.09 0 0.16 81.96
93 INT11807 Gene_expression of Il2 266 0.78 112 64.97 81.76
94 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 81.76
95 INT2117 Regulation of VSX1 15 0.30 3.38 3.38 81.16
96 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 80.88
97 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 80.68
98 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 80.08
99 INT3841 Gene_expression of FCGR3B 117 0.75 58.99 28.87 79.36
100 INT3836 Gene_expression of su 8 0.46 2.8 2.32 79.36
101 INT3839 Positive_regulation of Gene_expression of FCGR3B 10 0.67 13.58 6.25 79.36
102 INT3833 Positive_regulation of Gene_expression of su 2 0.13 0.83 0.8 79.36
103 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 78.32
104 INT5412 Regulation of G6pd 9 0.62 1.64 2.87 78.00
105 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 77.56
106 INT22782 Localization of PRSS1 25 0.81 14.44 7.34 77.00
107 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 76.72
108 INT58744 Regulation of Negative_regulation of MAOB 1 0.43 0.26 0.29 76.72
109 INT2243 Localization of GAST 67 0.81 34.54 16.19 76.52
110 INT66492 Negative_regulation of CES2 8 0.42 0.73 0.96 75.56
111 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49 75.00
112 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03 75.00
113 INT53387 Negative_regulation of Positive_regulation of Cyp2e1 3 0.42 1.28 1.98 75.00
114 INT53391 Negative_regulation of Positive_regulation of Cyp2b1 2 0.41 0.24 0.61 75.00
115 INT46797 Negative_regulation of Cyp3a62 27 0.59 7.06 13.97 75.00
116 INT53388 Negative_regulation of Cyp2c11 18 0.53 2.66 3.11 75.00
117 INT53386 Negative_regulation of Cyp4a10 7 0.32 4.13 0.7 75.00
118 INT53285 Gene_expression of Cyp2c11 20 0.76 5.43 1.17 75.00
119 INT53394 Negative_regulation of Gene_expression of Cyp2c11 5 0.55 1.13 0.64 75.00
120 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06 75.00
121 INT53396 Regulation of Gene_expression of Cyp3a23/3a1 7 0.38 3.04 0.63 75.00
122 INT3359 Regulation of YY1 32 0.60 8.19 19.2 74.96
123 INT44479 Negative_regulation of NDUFS1 1 0.07 0 0.14 72.52
124 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 72.28
125 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 72.28
126 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 71.28
127 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76 71.20
128 INT165899 Gene_expression of TNIP3 1 0.03 0 0.18 71.20
129 INT38043 Gene_expression of Cps1 6 0.56 0.82 1.46 70.24
130 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 67.72
131 INT3834 Regulation of su 3 0.18 1.85 1.16 67.28
132 INT3838 Regulation of FCGR3B 16 0.60 6.67 5.53 67.04
133 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 66.80
134 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 66.80
135 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 64.80
136 INT22831 Negative_regulation of Positive_regulation of IL2 7 0.55 1.7 2.62 63.68
137 INT4494 Regulation of GCG 41 0.45 18.38 9.68 63.48
138 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 63.12
139 INT35744 Binding of MAOB 13 0.46 7.52 4.26 62.64
140 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 62.60
141 INT2442 Localization of Mb 38 0.80 24.74 6.33 61.84
142 INT11365 Positive_regulation of Localization of Mb 5 0.38 3.78 1.54 61.84
143 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 60.96
144 INT7691 Negative_regulation of Rnase1 7 0.43 0.41 0.38 58.16
145 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 56.64
146 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 55.60
147 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 55.60
148 INT78955 Regulation of Gene_expression of Ptgs2 12 0.62 7.22 6.02 55.60
149 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 55.16
150 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 55.16
151 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 54.40
152 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 53.60
153 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18 51.84
154 INT180379 Gene_expression of Olr1 31 0.36 36.46 4.84 51.28
155 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 50.72
156 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 50.08
157 INT14599 Localization of Tpsab1 36 0.79 14.58 7.18 50.00
158 INT4464 Localization of CEL 21 0.80 8.09 3.88 50.00
159 INT61042 Localization of SPG21 5 0.78 1.42 0.89 50.00
160 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 50.00
161 INT61041 Positive_regulation of Localization of Tpsab1 4 0.63 0.39 0.26 50.00
162 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 49.52
163 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 47.40
164 INT38573 Positive_regulation of Gene_expression of Mb 10 0.46 2.11 0.54 46.72
165 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 46.32
166 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 46.32
167 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 45.56
168 INT325077 Positive_regulation of OR4G3P 1 0.29 0.96 0.27 44.24
169 INT85563 Positive_regulation of KCNJ6 6 0.50 0.4 5.89 39.56
170 INT177992 Positive_regulation of SNRNP70 28 0.49 16.14 4.28 39.56
171 INT156180 Positive_regulation of Gene_expression of SNRNP70 14 0.49 4.54 2.13 39.56
172 INT229242 Positive_regulation of Gene_expression of KCNJ6 2 0.50 1.47 2.03 39.56
173 INT281851 Positive_regulation of Binding of KCNJ6 1 0.50 0.4 1.82 39.56
174 INT74446 Positive_regulation of Dync1h1 25 0.59 13 2.38 39.20
175 INT90184 Gene_expression of KCNJ6 7 0.67 4.14 12.57 39.04
176 INT281850 Binding of KCNJ6 1 0.37 0.93 4.57 39.04
177 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 38.64
178 INT211863 Gene_expression of VPS13B 2 0.13 0.65 0.03 38.40
179 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 37.76
180 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 37.76
181 INT24297 Regulation of CYP21A2 3 0.05 1.29 1.09 37.20
182 INT46036 Regulation of ALAS1 2 0.39 0.23 0.72 30.40
183 INT179798 Regulation of Gene_expression of Col3a1 2 0.22 0.57 0.25 30.32
184 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 27.68
185 INT6481 Binding of TNF 624 0.48 510.2 214.82 26.96
186 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 25.00
187 INT920 Localization of PLOD1 223 0.81 42.25 78.7 25.00
188 INT249 Localization of GHRH 215 0.80 78.02 51.87 25.00
189 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 25.00
190 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 25.00
191 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 25.00
192 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 25.00
193 INT912 Localization of FSHR 91 0.79 23.61 15.58 25.00
194 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 25.00
195 INT3682 Binding of Ppr1 10 0.42 1.87 2.96 25.00
196 INT105466 Binding of HM13 1 0.36 1.13 0.09 25.00
197 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 17.92
198 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 5.00
199 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 5.00
200 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 5.00
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