P:anakinra

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 194
Hot Single Events 134
Hot Interactions 13

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for anakinra. They are ordered first by their pain relevance and then by number of times they were reported for anakinra. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 100.00
2 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01 99.36
3 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 94.16
4 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31 91.04
5 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45 89.68
6 INT219151 IL18 Positive_regulation of CASP1 1 0.01 1.05 0.3 88.40
7 INT279398 Binding of IL1RN and Il1rn 1 0.00 0.51 0.63 85.20
8 INT219156 NLRP3 Positive_regulation of IL1B 1 0.01 1.03 0.27 84.80
9 INT219194 Nlrp3 Positive_regulation of IL1B 1 0.04 1.03 0.26 84.80
10 INT219193 Nlrp3 Positive_regulation of Positive_regulation of NLRP3 1 0.24 1.03 0.26 84.40
11 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 83.16
12 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96 82.68
13 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64 81.76
14 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5 79.28
15 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5 79.28
16 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68 77.52
17 INT224584 Binding of IL1RN and SIGMAR1 1 0.00 0.73 0.36 75.28
18 INT320153 Negative_regulation of Binding of IL6 and IL6R 1 0.02 0.37 0.24 72.40
19 INT209918 Positive_regulation of Nlrp3 Positive_regulation of Localization of Il1 1 0.42 1.06 0.4 71.84
20 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 71.68
21 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26 71.44
22 INT229087 IL1R1 Negative_regulation of ACCS 1 0.03 0.86 0.33 70.48
23 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 69.44
24 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61 68.80
25 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28 67.44
26 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 66.32
27 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 66.32
28 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 64.80
29 INT346196 AMELX Negative_regulation of CRP 1 0.04 0.36 0.26 62.88
30 INT346195 AMELX Negative_regulation of ESR1 1 0.02 0.36 0.26 62.16
31 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 59.80
32 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65 58.16
33 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59 57.92
34 INT219152 NLRP3 Positive_regulation of Positive_regulation of CASP1 1 0.02 0.83 0.1 50.00
35 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23 47.12
36 INT345924 IL6 Regulation of Gene_expression of SPHAR 1 0.00 0.21 0.18 46.64
37 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63 43.20
38 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7 38.40
39 INT188432 Negative_regulation of Binding of ABCA1 and IL6 1 0.02 0.47 0.05 38.08
40 INT188431 Binding of ABCA1 and IL6 1 0.02 0.47 0.05 38.08
41 INT149121 Binding of CD80 and Cd28 2 0.04 0.95 0.46 34.48
42 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 24.72
43 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 24.00
44 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48 17.32
45 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 17.32
46 INT260838 Il17a Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47 17.32
47 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3 14.64
48 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27 13.84
49 INT229088 IL1R1 Positive_regulation of Gene_expression of IL6 1 0.04 0.45 0.14 10.00
50 INT229089 IL1R1 Positive_regulation of IL6 1 0.03 0.45 0.12 9.12
51 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
52 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
53 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
54 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
55 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
56 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
57 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
58 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
59 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
60 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 5.00
61 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
62 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22 5.00
63 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14 5.00
64 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
65 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
66 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
67 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 5.00
68 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
69 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
70 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89 5.00
71 INT224583 CSF2 Positive_regulation of IL1RN 1 0.02 1.3 0.88 5.00
72 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
73 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
74 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87 5.00
75 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85 5.00
76 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72 5.00
77 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72 5.00
78 INT275554 Binding of CXCL10 and Cxcr3 1 0.03 2.18 0.71 5.00
79 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7 5.00
80 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69 5.00
81 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69 5.00
82 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68 5.00
83 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68 5.00
84 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
85 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67 5.00
86 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66 5.00
87 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
88 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 5.00
89 INT260821 NRP2 Positive_regulation of Gene_expression of TNF 1 0.01 1.48 0.56 5.00
90 INT260830 Binding of NRP2 and Flt1 Positive_regulation of Gene_expression of TNF 1 0.01 1.5 0.56 5.00
91 INT260845 Binding of Flt1 and Positive_regulation of Gene_expression of TNF 1 0.36 1.5 0.56 5.00
92 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55 5.00
93 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55 5.00
94 INT106744 Binding of CRP and EGFL7 2 0.07 2.35 0.51 5.00
95 INT271874 IL10 Negative_regulation of TNF 1 0.07 0.78 0.5 5.00
96 INT271873 IL10 Regulation of Gene_expression of IK 1 0.00 0.81 0.47 5.00
97 INT271872 IL10 Regulation of IK 1 0.00 0.81 0.47 5.00
98 INT260839 Hivep3 Positive_regulation of Gene_expression of TNF 1 0.01 1.21 0.47 5.00
99 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46 5.00
100 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46 5.00
101 INT279392 SFTPA1 Positive_regulation of IL1RN 1 0.00 0.19 0.4 5.00
102 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
103 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
104 INT224582 Binding of IL1B and Positive_regulation of Gene_expression of TNF 1 0.05 1.33 0.37 5.00
105 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
106 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
107 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35 5.00
108 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35 5.00
109 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
110 INT275557 Negative_regulation of Binding of CXCL10 and Cxcr3 1 0.04 1.09 0.35 5.00
111 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34 5.00
112 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
113 INT254391 Binding of F13A1 and GSN 1 0.00 1.08 0.34 5.00
114 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34 5.00
115 INT254393 Binding of FN1 and GSN 1 0.01 1.08 0.34 5.00
116 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
117 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
118 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
119 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
120 INT194859 IL1B Positive_regulation of Gene_expression of MMP13 2 0.52 0.86 0.33 5.00
121 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 5.00
122 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31 5.00
123 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31 5.00
124 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31 5.00
125 INT229600 Tlr4 Positive_regulation of Il1a 1 0.00 0.41 0.3 5.00
126 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3 5.00
127 INT275555 Binding of Ltb4r1 and COPD 1 0.01 1.02 0.3 5.00
128 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29 5.00
129 INT260831 Pgf Positive_regulation of TNF 1 0.60 0.75 0.29 5.00
130 INT260828 Pgf Positive_regulation of Gene_expression of Gtf3a 1 0.01 0.73 0.28 5.00
131 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28 5.00
132 INT275548 Il10 Regulation of Mmp9 1 0.00 0.86 0.28 5.00
133 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28 5.00
134 INT275556 Il10 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
135 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28 5.00
136 INT275553 Negative_regulation of Binding of Ccr5 and Ccl3 1 0.05 0.73 0.26 5.00
137 INT323612 Negative_regulation of Tlr4 Positive_regulation of Hmgb1 1 0.23 0.2 0.25 5.00
138 INT323610 Tlr4 Positive_regulation of Hmgb1 1 0.25 0.2 0.25 5.00
139 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24 5.00
140 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23 5.00
141 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22 5.00
142 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22 5.00
143 INT219153 IL6 Positive_regulation of IL23A 1 0.02 0.45 0.21 5.00
144 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 5.00
145 INT260827 Binding of Flt1 and Pgf 1 0.27 0.6 0.2 5.00
146 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19 5.00
147 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17 5.00
148 INT254392 Binding of CRP and GSN 1 0.12 0.33 0.16 5.00
149 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14 5.00
150 INT260834 Negative_regulation of Binding of VEGFA and Flt1 1 0.15 0.5 0.13 5.00
151 INT220115 Mefv Regulation of Gene_expression of Il1 1 0.01 1.85 0.13 5.00
152 INT300570 Binding of IL1RN and SUGT1P2 1 0.01 0.43 0.12 5.00
153 INT219157 Binding of KLRB1 and CLEC2D 1 0.02 0.41 0.12 5.00
154 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1 5.00
155 INT219155 Binding of HLA-G and LILRB2 1 0.15 0.23 0.1 5.00
156 INT220116 Tnfrsf1a Negative_regulation of TNF 1 0.06 0.56 0.09 5.00
157 INT219150 Binding of CXCL11 and CXCR7 1 0.09 1.77 0.09 5.00
158 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06 5.00
159 INT219149 FBXO8 Positive_regulation of Localization of IL10 1 0.01 0.14 0.05 5.00
160 INT219195 Binding of PDC and fc 1 0.01 0.24 0.04 5.00
161 INT211191 CD28 Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.03 5.00
162 INT336296 Il1 Positive_regulation of Gene_expression of INS 1 0.05 0.14 0 5.00
163 INT279268 CARD8 Positive_regulation of CASP1 1 0.32 0.3 0 5.00
164 INT240124 Binding of IL1B and MIR885 1 0.00 0.09 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for anakinra. They are ordered first by their pain relevance and then by number of times they were reported in anakinra. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT87844 Binding of IL1RN 40 0.41 24.37 11.92 100.00
2 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29 100.00
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
4 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
5 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31 100.00
6 INT14258 Regulation of TSPO 32 0.60 10.16 6.24 100.00
7 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82 100.00
8 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 100.00
9 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 100.00
10 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71 100.00
11 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 99.92
12 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 99.92
13 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 99.90
14 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 99.90
15 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 99.84
16 INT6484 Binding of IL1B 122 0.47 75.84 35.07 99.82
17 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.80
18 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 99.80
19 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 99.70
20 INT165401 Phosphorylation of IL1RN 2 0.09 1.51 0.91 99.68
21 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.60
22 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 99.60
23 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.52
24 INT126966 Positive_regulation of IL1R1 8 0.67 6.93 2.84 99.48
25 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09 99.48
26 INT125530 Negative_regulation of Gene_expression of IL1RAP 1 0.12 1.13 0.57 99.48
27 INT125531 Negative_regulation of IL1RAP 1 0.12 1.13 0.57 99.48
28 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 99.26
29 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 99.22
30 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 99.16
31 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 99.12
32 INT191589 Gene_expression of Msu 9 0.46 7.08 1.33 98.86
33 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 98.80
34 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78 98.46
35 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 98.40
36 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 98.38
37 INT19775 Localization of Il1 183 0.78 145.5 50.91 98.38
38 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 98.08
39 INT38674 Regulation of KRT20 32 0.44 19 2.15 98.08
40 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 97.52
41 INT25264 Regulation of Negative_regulation of IL1B 3 0.27 1.17 1.02 97.20
42 INT6849 Localization of IL1B 229 0.81 112.56 69.63 97.04
43 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 96.80
44 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 96.80
45 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 96.80
46 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 96.72
47 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68 96.56
48 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 96.56
49 INT155822 Localization of ADH1A 3 0.78 3.74 0.32 96.56
50 INT20129 Regulation of Il1 53 0.53 44.14 19.89 96.32
51 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 95.96
52 INT48081 Localization of Il1b 46 0.80 21.59 22.4 95.48
53 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 95.36
54 INT117598 Regulation of ACR 118 0.26 41.25 48.01 94.56
55 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 94.28
56 INT73850 Transcription of TSPO 6 0.59 0.83 0.61 94.08
57 INT205265 Regulation of Transcription of TSPO 1 0.21 0.13 0.49 94.08
58 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02 93.72
59 INT9660 Regulation of TNF 363 0.62 312.94 139.99 93.60
60 INT191311 Binding of Das 3 0.03 2.56 0.99 93.20
61 INT96073 Localization of Casp1 11 0.78 4.91 1.29 93.20
62 INT6852 Localization of TNF 883 0.81 705.95 270.84 92.64
63 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 92.64
64 INT25607 Binding of Il1 82 0.47 64.4 23.9 92.60
65 INT100861 Binding of CRP 179 0.48 175.2 26.45 92.36
66 INT20462 Binding of ESR1 210 0.44 102.7 26.34 92.36
67 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 91.64
68 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45 90.96
69 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 90.80
70 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99 90.52
71 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 90.20
72 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16 90.20
73 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 89.88
74 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 89.60
75 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02 89.60
76 INT219695 Positive_regulation of Gene_expression of COPD 24 0.40 33.04 3.42 89.56
77 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 89.08
78 INT179688 Negative_regulation of Gene_expression of COPD 13 0.35 16.06 0.97 89.08
79 INT19430 Positive_regulation of IGHA1 10 0.67 6.42 2.58 88.92
80 INT236278 Negative_regulation of CADPS 4 0.36 2.16 0.22 88.64
81 INT81049 Positive_regulation of CASP1 44 0.67 19.97 5.69 88.40
82 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 88.40
83 INT209913 Regulation of Msu 2 0.32 2.42 0.64 88.32
84 INT81485 Negative_regulation of IL1RN 19 0.57 8.3 4.69 87.20
85 INT192791 Negative_regulation of MVK 3 0.16 5.64 0.25 87.20
86 INT121985 Positive_regulation of SLEB1 10 0.29 10.52 0.64 87.12
87 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 86.56
88 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 86.56
89 INT94437 Positive_regulation of Gene_expression of OLR1 17 0.70 16.04 2.8 86.56
90 INT306748 Gene_expression of Stil 1 0.58 1.47 0.84 86.56
91 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 86.52
92 INT35175 Localization of IL18 18 0.80 12.96 3.83 86.48
93 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41 86.40
94 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 86.16
95 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 85.76
96 INT39406 Positive_regulation of OLR1 45 0.70 37.8 7.72 85.64
97 INT99020 Gene_expression of Nlrp3 23 0.75 18.86 4.4 85.60
98 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 85.40
99 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 85.20
100 INT100582 Positive_regulation of Stil 2 0.49 1.69 1.33 84.92
101 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 84.28
102 INT117080 Localization of Csrp1 6 0.42 7.23 3.09 84.20
103 INT171888 Binding of Il1rn 13 0.38 5.53 3.13 84.08
104 INT181596 Binding of IL1R1 9 0.36 7.99 4.32 83.76
105 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 83.50
106 INT146829 Negative_regulation of Mefv 2 0.39 5.73 0.95 83.44
107 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 83.12
108 INT219136 Positive_regulation of Positive_regulation of Nlrp3 3 0.49 2.61 0.58 83.12
109 INT126759 Negative_regulation of Nlrp3 5 0.41 2.95 1.58 83.12
110 INT219135 Positive_regulation of Gene_expression of Nlrp3 4 0.49 3.52 0.93 83.12
111 INT219134 Negative_regulation of Positive_regulation of Nlrp3 2 0.41 1.42 0.3 83.12
112 INT219133 Negative_regulation of Gene_expression of Nlrp3 1 0.41 1.02 0.26 83.12
113 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 82.60
114 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 82.40
115 INT191527 Positive_regulation of Gene_expression of NLRP3 6 0.50 8.65 1.15 82.40
116 INT219173 Negative_regulation of Gene_expression of NLRP3 1 0.19 1.02 0.26 82.40
117 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 82.32
118 INT23171 Negative_regulation of NLRP3 7 0.37 4.15 1.53 82.32
119 INT15981 Positive_regulation of Positive_regulation of NLRP3 2 0.44 1.02 0.62 82.32
120 INT219174 Negative_regulation of Positive_regulation of NLRP3 1 0.19 1.02 0.26 82.32
121 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 81.92
122 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 81.92
123 INT183809 Regulation of IL17A 11 0.25 6.6 2.37 80.80
124 INT181720 Regulation of IL15 9 0.20 3.65 1.79 80.80
125 INT174230 Positive_regulation of Gene_expression of IL12B 6 0.49 3.2 1.56 80.80
126 INT236329 Regulation of IL12B 3 0.02 0.78 1.2 80.80
127 INT345936 Regulation of JAK3 1 0.02 0.41 0.46 80.80
128 INT345935 Regulation of ZAP70 1 0.01 0.41 0.45 80.80
129 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 80.56
130 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 80.52
131 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 80.12
132 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 80.12
133 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 80.12
134 INT108427 Gene_expression of Il15 9 0.76 5.13 4.63 80.12
135 INT191534 Negative_regulation of EGFL7 10 0.06 7.52 1.98 79.20
136 INT254317 Negative_regulation of Pycard 5 0.42 3.13 0.45 78.88
137 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77 78.76
138 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 78.68
139 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 78.44
140 INT81075 Negative_regulation of Atp9b 7 0.57 1.39 0.64 78.16
141 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89 77.56
142 INT278975 Gene_expression of JAK3 3 0.52 1.03 0.97 77.36
143 INT318784 Gene_expression of ZAP70 2 0.13 1.33 0.44 77.36
144 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 76.64
145 INT192784 Positive_regulation of Gene_expression of Myo5a 2 0.45 3.39 0.04 75.64
146 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49 75.28
147 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 75.28
148 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 75.24
149 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 75.08
150 INT173927 Positive_regulation of Negative_regulation of Il1 2 0.35 1.13 0.34 75.00
151 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 74.32
152 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77 74.16
153 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 73.24
154 INT188434 Positive_regulation of IL6R 2 0.02 2.17 0.49 72.52
155 INT144689 Regulation of RCT 49 0.53 25.91 9.6 71.92
156 INT86437 Binding of IL6 154 0.48 121.22 29.3 71.68
157 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 71.60
158 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 71.60
159 INT174816 Binding of IL6R 14 0.09 11.26 3.63 71.48
160 INT132178 Binding of CD80 41 0.47 15.55 12.98 70.64
161 INT19620 Binding of CD86 30 0.47 12.01 9.89 70.64
162 INT92199 Negative_regulation of Gene_expression of IL1RN 14 0.58 10.11 4.71 70.28
163 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 69.80
164 INT201091 Regulation of HLA-DOA 5 0.20 3.6 0.44 69.72
165 INT344831 Gene_expression of Gm11428 1 0.01 0.62 0.37 69.60
166 INT61626 Transcription of IL6 73 0.72 42.04 17.86 68.96
167 INT95338 Positive_regulation of Positive_regulation of CASP1 9 0.49 4.61 1.43 68.72
168 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 68.68
169 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 68.56
170 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28 68.56
171 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64 68.56
172 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 68.40
173 INT73504 Binding of CD28 35 0.45 15.99 10.04 68.04
174 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12 67.44
175 INT188230 Negative_regulation of IL6ST 3 0.33 0.49 0.45 67.40
176 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83 67.12
177 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 66.84
178 INT258404 Positive_regulation of Gene_expression of ACR 4 0.28 1.08 2.24 66.76
179 INT171562 Regulation of IL4 19 0.36 12.12 5.33 66.60
180 INT85130 Regulation of IL5 14 0.27 8.37 3.55 66.60
181 INT73500 Regulation of IL13 12 0.36 10.37 3.53 66.60
182 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 66.40
183 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 66.40
184 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 66.04
185 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 66.00
186 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 66.00
187 INT72455 Transcription of S100A8 3 0.69 1.66 0.36 66.00
188 INT334889 Positive_regulation of Transcription of MRPL14 1 0.07 0.79 0.21 66.00
189 INT334883 Positive_regulation of Transcription of CBFA2T2 1 0.03 0.79 0.21 66.00
190 INT334884 Transcription of CBFA2T2 1 0.04 0.78 0.21 66.00
191 INT334887 Positive_regulation of Gene_expression of CBFA2T2 1 0.03 0.79 0.21 66.00
192 INT334888 Gene_expression of CBFA2T2 1 0.05 0.78 0.21 66.00
193 INT334885 Transcription of MRPL14 1 0.10 0.79 0.21 66.00
194 INT334886 Gene_expression of MRPL14 1 0.11 0.79 0.21 66.00
195 INT334890 Positive_regulation of Gene_expression of MRPL14 1 0.07 0.79 0.21 66.00
196 INT334891 Positive_regulation of Transcription of S100A8 1 0.06 0.79 0.21 66.00
197 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 64.76
198 INT23257 Regulation of CRP 127 0.62 100.05 21.87 64.64
199 INT219165 Localization of TSLP 1 0.21 1.11 0.52 64.24
200 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14 64.16
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