P:anti-cytokine treatment

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Pain Term
Category Treatment
Synonyms None
Pain Specific No
Documents 5
Hot Single Events 3
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for anti-cytokine treatment. They are ordered first by their pain relevance and then by number of times they were reported for anti-cytokine treatment. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
2 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7 5.00
3 INT171896 Binding of Ifnar1 and Il1rn 1 0.00 0.81 0.54 5.00
4 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
5 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52 5.00
6 INT171899 Binding of Ifnar1 and Il1 1 0.01 0.75 0.52 5.00
7 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 5.00
8 INT171898 Il1rn Regulation of Gene_expression of Il1 1 0.02 0.92 0.4 5.00
9 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3 5.00
10 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 5.00
11 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 5.00
12 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 5.00
13 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 5.00
14 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 5.00
15 INT171903 Binding of TNF and Lifr 1 0.01 0.35 0.22 5.00
16 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18 5.00
17 INT171902 TNF Positive_regulation of Il1f5 1 0.05 0.52 0.14 5.00
18 INT171904 TNF Positive_regulation of Il1 1 0.35 0.52 0.14 5.00
19 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14 5.00
20 INT272867 Binding of NLRP1 and COPD 1 0.00 1.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for anti-cytokine treatment. They are ordered first by their pain relevance and then by number of times they were reported in anti-cytokine treatment. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9660 Regulation of TNF 363 0.62 312.94 139.99 85.00
2 INT171891 Regulation of Il15 3 0.18 3.78 2.02 83.28
3 INT141015 Regulation of Il18 14 0.59 6.3 3.73 82.88
4 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 76.36
5 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14 67.80
6 INT112003 Localization of ROS1 94 0.73 66.32 12.16 67.40
7 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39 52.96
8 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 46.80
9 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 19.84
10 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 9.96
11 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
12 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
13 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
14 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
15 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
16 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
17 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
18 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
19 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
20 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
21 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
22 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
23 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
24 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
25 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
26 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
27 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
28 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
29 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
30 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
31 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
32 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
33 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
34 INT117598 Regulation of ACR 118 0.26 41.25 48.01 5.00
35 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
36 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
37 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
38 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
39 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
40 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
41 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
42 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
43 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
44 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 5.00
45 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
46 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
47 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
48 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
49 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
50 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
51 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 5.00
52 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
53 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
54 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
55 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
56 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
57 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
58 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
59 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
60 INT25607 Binding of Il1 82 0.47 64.4 23.9 5.00
61 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
62 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 5.00
63 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
64 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
65 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 5.00
66 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8 5.00
67 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
68 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81 5.00
69 INT138696 Positive_regulation of Ccl2 57 0.67 59.57 19.58 5.00
70 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
71 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
72 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 5.00
73 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78 5.00
74 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
75 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
76 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
77 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
78 INT10834 Binding of IL8 65 0.48 41.66 16.53 5.00
79 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
80 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
81 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
82 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
83 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
84 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
85 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 5.00
86 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
87 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 5.00
88 INT37618 Gene_expression of Col2a1 50 0.70 33.88 11.58 5.00
89 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
90 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 5.00
91 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
92 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 5.00
93 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
94 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 5.00
95 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
96 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89 5.00
97 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
98 INT150867 Regulation of COPD 54 0.48 71.38 8.8 5.00
99 INT59165 Binding of fc 67 0.36 37.51 8.68 5.00
100 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 5.00
101 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
102 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
103 INT83954 Binding of Cxcr2 21 0.37 17.27 7.65 5.00
104 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 5.00
105 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32 5.00
106 INT147793 Localization of COPD 70 0.64 89.01 7.3 5.00
107 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24 5.00
108 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22 5.00
109 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 5.00
110 INT81880 Positive_regulation of Gene_expression of Sele 30 0.48 27.54 7.05 5.00
111 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
112 INT23782 Positive_regulation of Spna1 58 0.50 35.41 6.94 5.00
113 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 5.00
114 INT61258 Transcription of Nfkb1 24 0.67 10.89 6.32 5.00
115 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
116 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
117 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28 5.00
118 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 5.00
119 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25 5.00
120 INT116420 Localization of Elane 16 0.14 7.8 6 5.00
121 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84 5.00
122 INT179810 Protein_catabolism of Ecm1 30 0.11 18.28 5.75 5.00
123 INT150853 Negative_regulation of Cxcl1 22 0.49 12.61 5.72 5.00
124 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 5.00
125 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 5.00
126 INT176524 Binding of Mapk14 19 0.43 12.54 5.21 5.00
127 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97 5.00
128 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 5.00
129 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 5.00
130 INT134968 Localization of Ecm1 20 0.32 27.27 4.31 5.00
131 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21 5.00
132 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 5.00
133 INT62545 Regulation of Gene_expression of Icam1 17 0.49 14.26 4.06 5.00
134 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99 5.00
135 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86 5.00
136 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 5.00
137 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 5.00
138 INT140337 Negative_regulation of Cd8a 42 0.50 25.4 3.66 5.00
139 INT179656 Gene_expression of Elane 12 0.32 9.44 3.53 5.00
140 INT219695 Positive_regulation of Gene_expression of COPD 24 0.40 33.04 3.42 5.00
141 INT171233 Binding of Ecm1 25 0.07 12.41 3.36 5.00
142 INT171888 Binding of Il1rn 13 0.38 5.53 3.13 5.00
143 INT135409 Transcription of Ccl2 13 0.62 10.59 3.06 5.00
144 INT105985 Transcription of Mmp9 11 0.66 8.55 3.02 5.00
145 INT171884 Positive_regulation of Gene_expression of Col2a1 11 0.23 8.04 3.02 5.00
146 INT28731 Negative_regulation of Elane 14 0.14 8.97 3.01 5.00
147 INT165915 Regulation of Negative_regulation of Pde4a 5 0.29 6.72 2.91 5.00
148 INT234716 Negative_regulation of Gene_expression of Cxcl1 10 0.48 9.31 2.86 5.00
149 INT220858 Positive_regulation of Mmp1a 15 0.38 9.11 2.77 5.00
150 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
151 INT65258 Regulation of Gene_expression of Col7a1 17 0.55 8.26 2.57 5.00
152 INT153492 Gene_expression of Gmcl1 44 0.65 15.77 2.56 5.00
153 INT103603 Negative_regulation of Gene_expression of Mmp2 16 0.51 12.29 2.47 5.00
154 INT73671 Regulation of Gene_expression of Sele 8 0.45 7.01 2.39 5.00
155 INT134964 Regulation of Ecm1 13 0.10 7.45 2.37 5.00
156 INT79228 Binding of Ltbr 8 0.10 7.2 2.33 5.00
157 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 5.00
158 INT135925 Regulation of Pde4b 5 0.41 1.58 2.24 5.00
159 INT100256 Positive_regulation of Transcription of Nfkb1 8 0.49 3.41 2.2 5.00
160 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
161 INT161382 Localization of KRT20 25 0.61 12.97 2.13 5.00
162 INT172554 Positive_regulation of Gene_expression of Mmp1a 7 0.16 4.48 2.05 5.00
163 INT178339 Binding of Cxcl1 17 0.36 5.14 2.04 5.00
164 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83 5.00
165 INT83358 Positive_regulation of Elane 8 0.21 8.14 1.83 5.00
166 INT171894 Localization of fc 6 0.22 4.42 1.8 5.00
167 INT181341 Binding of Ccr2 8 0.32 6.47 1.77 5.00
168 INT73674 Regulation of Gene_expression of Vcam1 9 0.33 11.23 1.64 5.00
169 INT25384 Positive_regulation of Localization of Csf2 11 0.66 7.81 1.62 5.00
170 INT33381 Binding of NPL 4 0.23 1.76 1.56 5.00
171 INT164410 Negative_regulation of Col2a1 4 0.39 3.75 1.53 5.00
172 INT269828 Transcription of Timp1 3 0.38 5.2 1.53 5.00
173 INT179663 Localization of Mmp12 8 0.51 4.97 1.53 5.00
174 INT91900 Localization of Sod1 12 0.77 6.62 1.51 5.00
175 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48 5.00
176 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35 5.00
177 INT99788 Regulation of Cxcr2 3 0.41 2.25 1.27 5.00
178 INT202365 Regulation of Gene_expression of Mapk14 6 0.45 4.89 1.26 5.00
179 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25 5.00
180 INT116242 Negative_regulation of Cybb 11 0.57 8.57 1.24 5.00
181 INT139261 Positive_regulation of Gene_expression of Mtpn 8 0.05 5.95 1.22 5.00
182 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17 5.00
183 INT250322 Negative_regulation of Binding of Ltbr 2 0.06 0.89 1.11 5.00
184 INT150854 Negative_regulation of Cxcr2 7 0.54 4.12 1.06 5.00
185 INT259601 Positive_regulation of Mmp12 8 0.48 5.67 1.03 5.00
186 INT183686 Binding of Cxcr1 5 0.35 1.8 0.98 5.00
187 INT272918 Positive_regulation of Positive_regulation of SELE 2 0.03 2.24 0.96 5.00
188 INT29379 Negative_regulation of gp 3 0.03 0.56 0.91 5.00
189 INT171889 Negative_regulation of Gene_expression of Il1rn 3 0.08 2.31 0.9 5.00
190 INT112783 Regulation of Gene_expression of SELE 6 0.40 6.82 0.87 5.00
191 INT179814 Positive_regulation of Protein_catabolism of Ecm1 5 0.06 3.38 0.85 5.00
192 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 5.00
193 INT174416 Negative_regulation of Gene_expression of Cxcr2 2 0.33 2.06 0.82 5.00
194 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82 5.00
195 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8 5.00
196 INT200250 Binding of Hdac2 6 0.22 2.97 0.76 5.00
197 INT221384 Positive_regulation of Localization of COPD 6 0.29 9.13 0.75 5.00
198 INT52196 Negative_regulation of Regulation of Il6 3 0.42 3.42 0.74 5.00
199 INT272878 Negative_regulation of Smad7 4 0.41 3.86 0.72 5.00
200 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7 5.00
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