P:antiarrhythmic agent

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Pain Term
Category Drug class
Synonyms Antiarrhythmic Agents
Pain Specific No
Documents 459
Hot Single Events 42
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for antiarrhythmic agent. They are ordered first by their pain relevance and then by number of times they were reported for antiarrhythmic agent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT55502 NDUFC1 Regulation of Nox1 1 0.00 0 0.08 93.40
2 INT55501 NDUFC1 Regulation of Coq10a 1 0.00 0 0.08 93.40
3 INT138469 Cpb2 Negative_regulation of Gene_expression of Ryr2 1 0.04 0.25 0.32 92.40
4 INT182816 EEF1A2 Negative_regulation of CRP 1 0.28 1.84 0.21 35.28
5 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
6 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
7 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 5.00
8 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 5.00
9 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
10 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
11 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 5.00
12 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 5.00
13 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
14 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 5.00
15 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
16 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
17 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
18 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
19 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
20 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
21 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28 5.00
22 INT210551 Binding of KCNH2 and KCNE2 1 0.08 0 0.19 5.00
23 INT205955 Gopc Regulation of Tdrd6 1 0.06 0.27 0.13 5.00
24 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11 5.00
25 INT352175 USE1 Regulation of NAGA 1 0.01 0.33 0 5.00
26 INT182818 EEF1A2 Negative_regulation of STAR 1 0.01 1.48 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for antiarrhythmic agent. They are ordered first by their pain relevance and then by number of times they were reported in antiarrhythmic agent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 100.00
2 INT59 Regulation of Adrb1 25 0.42 8.32 9.78 100.00
3 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73 99.64
4 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 99.30
5 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 99.24
6 INT84998 Positive_regulation of SLC10A1 1 0.69 0.16 0.45 98.70
7 INT6791 Binding of NA 55 0.46 5.36 17.59 98.60
8 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 98.36
9 INT7743 Binding of Hrh2 19 0.47 7.75 7.11 97.56
10 INT6163 Negative_regulation of INA 39 0.43 2.9 14.8 97.16
11 INT36930 Regulation of Positive_regulation of NA 2 0.22 1.1 1.39 96.64
12 INT1433 Regulation of MUC7 21 0.60 1.7 8.18 96.44
13 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 96.24
14 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 96.04
15 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 95.28
16 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 95.16
17 INT17561 Localization of Car2 303 0.79 60.95 44.52 94.80
18 INT41362 Binding of Actc1 1 0.31 0 0.18 94.76
19 INT5440 Negative_regulation of Ina 85 0.58 10.52 28.98 94.60
20 INT85001 Binding of SLC10A1 1 0.32 0.15 0.39 93.08
21 INT138468 Negative_regulation of Gene_expression of Ryr2 1 0.17 0.25 0.32 91.44
22 INT18578 Binding of Eef1a1 20 0.48 2.53 6.95 91.28
23 INT6843 Gene_expression of RPL7AP22 1 0.00 0 0.18 90.64
24 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 90.36
25 INT327526 Negative_regulation of Negative_regulation of SCD 1 0.15 1.35 0.07 90.36
26 INT6841 Gene_expression of C7orf23 1 0.00 0 0.18 90.16
27 INT23606 Regulation of Atp2b4 10 0.25 3.33 1.63 89.64
28 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 89.60
29 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 89.32
30 INT5536 Regulation of NA 74 0.59 16.61 15.36 88.96
31 INT138466 Regulation of Gene_expression of Ryr2 3 0.28 1.62 0.39 88.72
32 INT138467 Gene_expression of Ryr2 5 0.55 2.36 0.98 88.72
33 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 85.96
34 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 85.60
35 INT18577 Negative_regulation of Eef1a1 20 0.39 3.57 5.24 85.52
36 INT6842 Regulation of Positive_regulation of IGHVIV-44-1 1 0.00 0 0.17 83.92
37 INT3877 Negative_regulation of MUC7 30 0.57 1.62 12.89 83.76
38 INT6844 Positive_regulation of IGHVIV-44-1 1 0.00 0 0.17 83.08
39 INT55498 Negative_regulation of Ppp2r2b 1 0.16 0 0.15 82.36
40 INT55499 Localization of Ppp2r2b 1 0.26 0 0.15 81.80
41 INT4903 Regulation of Ina 23 0.50 3.03 9.46 81.76
42 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 80.72
43 INT55500 Localization of Coq10a 2 0.36 0.42 0.21 79.48
44 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 78.16
45 INT140199 Positive_regulation of Gene_expression of Cyp3a23/3a1 9 0.45 4.91 4.56 77.68
46 INT32706 Gene_expression of Cyp3a23/3a1 51 0.65 19.48 15.06 77.56
47 INT13287 Gene_expression of Cpb2 27 0.56 7.84 11.95 76.88
48 INT38254 Positive_regulation of Localization of Trib3 14 0.45 6.14 6.99 76.52
49 INT85002 Gene_expression of SLC10A1 1 0.67 0.35 0.76 76.32
50 INT48798 Positive_regulation of Aft 4 0.60 1.58 0.65 75.92
51 INT25606 Negative_regulation of Protein_catabolism of Ang 1 0.26 0 0.33 75.52
52 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 75.20
53 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01 75.00
54 INT6837 Positive_regulation of Binding of Atp2b4 1 0.00 0 0.14 75.00
55 INT6838 Binding of Atp2b4 4 0.08 0.8 0.18 75.00
56 INT55497 Negative_regulation of Phosphorylation of Ppp2r2b 1 0.16 0 0.16 75.00
57 INT55496 Phosphorylation of Ppp2r2b 1 0.23 0 0.16 75.00
58 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41 75.00
59 INT25605 Protein_catabolism of Ang 1 0.40 0 0.33 75.00
60 INT140538 Positive_regulation of Bwk1 2 0.37 0.7 0.28 75.00
61 INT168932 Negative_regulation of Bwk1 1 0.25 0.67 0.28 75.00
62 INT168931 Gene_expression of Bwk1 1 0.40 0.43 0.22 75.00
63 INT36622 Positive_regulation of Reb1 1 0.00 0.78 0.16 75.00
64 INT51734 Negative_regulation of Localization of Trib3 10 0.19 2.53 4.97 74.88
65 INT5232 Negative_regulation of Enpep 56 0.57 3.25 26.7 73.96
66 INT56386 Positive_regulation of UBXN11 6 0.49 2.79 1.05 73.88
67 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38 73.60
68 INT38253 Localization of Trib3 35 0.63 10.28 15.42 73.40
69 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 71.44
70 INT85000 Transcription of SLC10A1 1 0.53 0.36 0.76 70.48
71 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61 68.60
72 INT1031 Negative_regulation of B4galt6 2 0.23 0 0.41 68.32
73 INT2140 Regulation of REN 104 0.62 28.24 24.49 67.52
74 INT56385 Positive_regulation of Gk 11 0.22 15.07 1.28 67.08
75 INT4822 Localization of Ca2 417 0.80 99.57 96.45 65.52
76 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 65.40
77 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27 65.28
78 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 64.88
79 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75 64.88
80 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 64.40
81 INT68010 Positive_regulation of ANP32A 1 0.67 0.8 1.22 64.12
82 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 63.76
83 INT14282 Regulation of INA 5 0.23 0.87 2.42 62.68
84 INT51735 Negative_regulation of Regulation of MUC7 1 0.06 0.39 0.69 62.44
85 INT127144 Regulation of CD82 5 0.35 0.6 0.09 59.32
86 INT84999 Negative_regulation of SLC10A1 1 0.58 0.18 0.42 59.28
87 INT667 Negative_regulation of Hrh2 38 0.58 18.11 18.01 59.04
88 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 58.64
89 INT41751 Negative_regulation of PPA1 1 0.00 0.13 0.09 58.28
90 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 55.68
91 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 55.68
92 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 52.48
93 INT84997 Regulation of SLC10A2 1 0.20 0.13 0.37 51.04
94 INT42819 Positive_regulation of Negative_regulation of Ina 4 0.40 0.07 0.92 43.84
95 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18 40.72
96 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 38.56
97 INT166132 Positive_regulation of Dhrs4 2 0.54 1.95 0.65 30.24
98 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 28.80
99 INT387 Regulation of Ace 18 0.45 5.24 4.24 25.00
100 INT14954 Gene_expression of COLQ 7 0.52 2.59 1.39 25.00
101 INT62992 Regulation of COLQ 1 0.26 0.6 0.3 25.00
102 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 21.08
103 INT425 Localization of PRL 455 0.81 189.64 144.8 20.08
104 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 16.28
105 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 9.80
106 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 8.32
107 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
108 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
109 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
110 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
111 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
112 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
113 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
114 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
115 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
116 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 5.00
117 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
118 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 5.00
119 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
120 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
121 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
122 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
123 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
124 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
125 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
126 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
127 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
128 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
129 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
130 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
131 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
132 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
133 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
134 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
135 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
136 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
137 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
138 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
139 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
140 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
141 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 5.00
142 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
143 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
144 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
145 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
146 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
147 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
148 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
149 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
150 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
151 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
152 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 5.00
153 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
154 INT18621 Binding of ABAT 28 0.36 9.88 18.04 5.00
155 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 5.00
156 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
157 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
158 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
159 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
160 INT1416 Transcription of POMC 40 0.72 10.71 15.38 5.00
161 INT75908 Regulation of LEP 77 0.60 60.16 15.19 5.00
162 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
163 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
164 INT7587 Localization of GAL 27 0.78 4.79 14.29 5.00
165 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 5.00
166 INT13118 Positive_regulation of Ina 48 0.69 7.39 13.85 5.00
167 INT11996 Gene_expression of Ina 34 0.67 4.8 13.82 5.00
168 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
169 INT4931 Localization of IFNG 53 0.78 33.25 13.65 5.00
170 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
171 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
172 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
173 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 5.00
174 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
175 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
176 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 5.00
177 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
178 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
179 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
180 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
181 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 5.00
182 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14 5.00
183 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
184 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
185 INT10237 Binding of EDN1 40 0.48 16 8.48 5.00
186 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
187 INT51165 Binding of Gal 10 0.48 2.56 8.41 5.00
188 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 5.00
189 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 5.00
190 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
191 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 5.00
192 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 5.00
193 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 5.00
194 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 5.00
195 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 5.00
196 INT24191 Binding of VIP 14 0.40 2.16 6.2 5.00
197 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
198 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 5.00
199 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 5.00
200 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 5.00
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