P:anticonvulsant

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pChart

Pain Term
Category Drug class
Synonyms Anticonvulsants
Pain Specific No
Documents 2721
Hot Single Events 200
Hot Interactions 30

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for anticonvulsant. They are ordered first by their pain relevance and then by number of times they were reported for anticonvulsant. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95 99.92
2 INT81127 Binding of Gabrd and Abat 3 0.25 0 0.96 99.52
3 INT59925 Pdyn Regulation of Positive_regulation of Penk 1 0.10 0.09 0.59 99.52
4 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34 98.76
5 INT337692 Cyp2b2 Positive_regulation of Nr1i3 1 0.00 0.31 0.05 97.42
6 INT337693 Cyp3a62 Positive_regulation of Nr1i3 1 0.01 0.31 0.05 97.22
7 INT30575 SST Negative_regulation of Localization of Pomc 1 0.00 0.71 1.06 94.20
8 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 93.80
9 INT88555 Adora2a Negative_regulation of Vegfc 1 0.00 0.17 0.25 93.64
10 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 92.80
11 INT97207 Binding of Gabrg1 and Ptar1 1 0.00 0.07 0.55 92.72
12 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 88.60
13 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 88.04
14 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 87.48
15 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89 87.04
16 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89 87.04
17 INT58182 Fos Regulation of Egr1 1 0.49 0.09 0.27 86.08
18 INT58176 Junb Regulation of Egr1 1 0.46 0.09 0.27 86.08
19 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06 85.76
20 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88 85.76
21 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2 85.68
22 INT90561 Slc6a1 Negative_regulation of Abat 1 0.02 0.25 0.91 85.52
23 INT114230 NR1I2 Positive_regulation of Positive_regulation of CYP2C9 1 0.13 0.61 0.27 85.48
24 INT338893 TNFSF14 Positive_regulation of Gene_expression of Gria1 1 0.07 0.59 0.94 85.44
25 INT116815 Binding of Pias1 and Ppbp 1 0.36 0.86 1.92 85.36
26 INT162776 TYRP1 Regulation of Kcnq2 1 0.24 0.14 0.14 85.36
27 INT90559 Gm5114 Regulation of Abat 1 0.02 0.31 0.87 84.40
28 INT90560 Gm5114 Positive_regulation of Abat 1 0.03 0.25 0.86 84.40
29 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18 82.68
30 INT262336 Binding of Abat and Tmem132a 1 0.00 1.39 1.14 82.24
31 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27 79.64
32 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27 79.64
33 INT338892 TNFSF14 Regulation of Abat 1 0.00 0.61 1.01 79.40
34 INT338895 TNFSF14 Regulation of Regulation of Abat 1 0.00 0.62 1.01 79.40
35 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22 77.44
36 INT17850 Binding of PTGS2 and Ptgs2 1 0.00 0.08 0.04 75.68
37 INT17851 Negative_regulation of Binding of PTGS2 and Ptgs2 1 0.00 0.08 0.04 75.68
38 INT61033 Tmem132a Positive_regulation of Abat 1 0.22 0.07 0.82 75.00
39 INT58178 Gtf3a Positive_regulation of Egr1 1 0.07 0.09 0.19 75.00
40 INT58181 Gtf3a Positive_regulation of Gene_expression of Egr1 1 0.07 0.1 0.19 75.00
41 INT58177 Gtf3a Positive_regulation of Gene_expression of Junb 1 0.07 0.1 0.16 75.00
42 INT58179 Gtf3a Positive_regulation of Gene_expression of Homer1 1 0.07 0.1 0.16 75.00
43 INT58180 Gtf3a Positive_regulation of Gene_expression of Jun 1 0.05 0.1 0.16 75.00
44 INT58175 Gtf3a Positive_regulation of Gene_expression of Fos 1 0.07 0.1 0.16 75.00
45 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62 75.00
46 INT273233 Negative_regulation of Cdk5 Negative_regulation of Positive_regulation of Ltp 1 0.20 0.39 0.13 74.24
47 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04 68.24
48 INT296324 NFE2L2 Regulation of GSTK1 1 0.01 0.91 0.14 65.96
49 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26 64.96
50 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26 64.96
51 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 64.96
52 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 64.96
53 INT273239 Cdk5 Positive_regulation of Positive_regulation of GRIN1 1 0.51 0.37 0.12 64.20
54 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32 62.84
55 INT101813 KEAP1 Negative_regulation of NFE2L2 3 0.47 1.63 0.28 60.44
56 INT101810 Binding of NFE2L2 and KEAP1 7 0.53 4.12 0.29 58.12
57 INT187805 Ms18 Regulation of Positive_regulation of Slc1a3 1 0.26 0.87 1.12 50.48
58 INT261472 Binding of SPTBN1 and Gpi1 1 0.00 0.69 0.42 49.12
59 INT256706 Binding of Hsp90b1 and Wfs1 1 0.43 5.02 0.2 46.56
60 INT146518 Tmem132a Positive_regulation of Gene_expression of Fos 1 0.68 0.06 1.04 36.80
61 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 35.72
62 INT111078 Binding of Cnr1 and Cnr2 2 0.05 0 0.92 34.88
63 INT64789 ITIH4 Positive_regulation of Positive_regulation of Pla2g1b 1 0.19 0.55 0.24 33.84
64 INT69938 Cck Positive_regulation of Localization of Abat 2 0.29 0 3.78 31.56
65 INT69937 Cck Positive_regulation of Abat 2 0.31 0 2.88 31.24
66 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 26.72
67 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85 25.00
68 INT52294 Binding of Htr3a and Tcra-V11.1 1 0.27 0.37 0.14 25.00
69 INT241780 Binding of AVP and TRGV9 1 0.12 2.41 0.35 23.80
70 INT262219 Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 8.48
71 INT262143 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 8.48
72 INT195545 Rel Regulation of Gene_expression of Grm3 1 0.01 0.46 0.71 6.64
73 INT335307 SLC15A4 Regulation of TIMP1 1 0.01 0.69 0.29 6.40
74 INT311298 Binding of DMPK and Mbnl1 1 0.43 0.54 0 6.32
75 INT354923 Binding of VDR and Uvbs1 1 0.00 0.83 0 5.64
76 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
77 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
78 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
79 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
80 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
81 INT197379 Tbs1 Positive_regulation of Ltp 6 0.07 1.87 2.21 5.00
82 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92 5.00
83 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
84 INT195541 Lct Positive_regulation of Gene_expression of Grm2 1 0.02 0.4 1.27 5.00
85 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15 5.00
86 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92 5.00
87 INT261783 Bdnf Regulation of Gene_expression of Slc12a5 1 0.09 0 0.87 5.00
88 INT261786 Bdnf Negative_regulation of Slc12a5 1 0.14 0.05 0.85 5.00
89 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 5.00
90 INT271193 Creb1 Regulation of Bdnf 1 0.15 0.28 0.81 5.00
91 INT235604 Binding of Htr1a and Htr3a 1 0.01 0 0.74 5.00
92 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 5.00
93 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
94 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67 5.00
95 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
96 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00
97 INT271194 Binding of Bdnf and Gopc 1 0.03 0.49 0.6 5.00
98 INT271192 Binding of Gopc and Gtf3a 1 0.00 0.49 0.6 5.00
99 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57 5.00
100 INT203033 Cnr1 Regulation of Cnr2 1 0.15 0.29 0.56 5.00
101 INT335291 SLC15A4 Negative_regulation of NFATC1 1 0.01 0.45 0.51 5.00
102 INT271191 Bdnf Regulation of Slc6a4 1 0.03 0.29 0.51 5.00
103 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49 5.00
104 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49 5.00
105 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46 5.00
106 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46 5.00
107 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45 5.00
108 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45 5.00
109 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45 5.00
110 INT261782 Bdnf Positive_regulation of Gene_expression of Slc12a5 1 0.18 0 0.44 5.00
111 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44 5.00
112 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43 5.00
113 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43 5.00
114 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42 5.00
115 INT309199 Abat Positive_regulation of Adarb1 1 0.00 0 0.42 5.00
116 INT244280 Binding of Tspo and Ptz1a 1 0.02 0.49 0.41 5.00
117 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41 5.00
118 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4 5.00
119 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4 5.00
120 INT282505 Binding of ocd and Slc1a1 1 0.39 4.22 0.4 5.00
121 INT261788 Bdnf Regulation of Slc12a5 1 0.10 0.07 0.38 5.00
122 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38 5.00
123 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38 5.00
124 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36 5.00
125 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36 5.00
126 INT273234 Negative_regulation of Cdk5 Positive_regulation of Ptprs 1 0.14 1.26 0.34 5.00
127 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34 5.00
128 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34 5.00
129 INT187361 Binding of Gabrg1 and Kcnn3 1 0.36 0.13 0.3 5.00
130 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29 5.00
131 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27 5.00
132 INT264841 NAMPT Positive_regulation of GRM5 1 0.01 0.72 0.27 5.00
133 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 5.00
134 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
135 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26 5.00
136 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26 5.00
137 INT305686 Binding of Gfap and F2r 1 0.01 0 0.25 5.00
138 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25 5.00
139 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25 5.00
140 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25 5.00
141 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25 5.00
142 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25 5.00
143 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24 5.00
144 INT195544 Lct Positive_regulation of Transcription of Grm2 1 0.01 0.06 0.24 5.00
145 INT195547 Lct Positive_regulation of Transcription of Grm3 1 0.00 0.06 0.24 5.00
146 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24 5.00
147 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
148 INT195553 Lct Positive_regulation of Grm2 1 0.02 0.05 0.23 5.00
149 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
150 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23 5.00
151 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23 5.00
152 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23 5.00
153 INT195548 Lct Positive_regulation of Grm3 1 0.00 0.06 0.23 5.00
154 INT335346 SLC15A4 Negative_regulation of Gene_expression of Fos 1 0.02 0.23 0.23 5.00
155 INT262178 Binding of Nr1i2 and Abcb1b 1 0.07 1.68 0.21 5.00
156 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2 5.00
157 INT261787 Positive_regulation of Bdnf Positive_regulation of Fig4 1 0.02 0.77 0.2 5.00
158 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2 5.00
159 INT261784 Positive_regulation of Bdnf Positive_regulation of Slc12a5 1 0.15 0.77 0.2 5.00
160 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19 5.00
161 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19 5.00
162 INT335299 IRF6 Positive_regulation of TIMP1 1 0.03 0.21 0.19 5.00
163 INT335298 IRF6 Positive_regulation of MMP9 1 0.01 0.21 0.19 5.00
164 INT335311 Binding of IRF6 and SLC15A4 1 0.00 0.23 0.19 5.00
165 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19 5.00
166 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19 5.00
167 INT335306 IRF6 Positive_regulation of MMP3 1 0.03 0.21 0.18 5.00
168 INT287145 Binding of PNN and Shbg 1 0.07 0.14 0.18 5.00
169 INT197647 DPH1 Negative_regulation of VDR 1 0.02 0.58 0.18 5.00
170 INT335304 IRF6 Positive_regulation of Gene_expression of MMP1 1 0.01 0.21 0.18 5.00
171 INT335302 IRF6 Positive_regulation of MMP1 1 0.01 0.21 0.18 5.00
172 INT326460 NR1I2 Regulation of Cyp4f18 1 0.01 0.72 0.18 5.00
173 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18 5.00
174 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00
175 INT293361 Binding of CD80 and KLRD1 1 0.00 0.38 0.16 5.00
176 INT293359 Binding of CD86 and KLRD1 1 0.00 0.38 0.16 5.00
177 INT244116 ELAVL3 Negative_regulation of MUC1 1 0.09 3.41 0.15 5.00
178 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15 5.00
179 INT241772 AVP Positive_regulation of ADCY1 1 0.09 1.08 0.15 5.00
180 INT279829 Scn1a Regulation of Gene_expression of Scn9a 1 0.42 1.52 0.15 5.00
181 INT273238 Grin1 Positive_regulation of Ptprs 1 0.07 0.51 0.14 5.00
182 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14 5.00
183 INT197645 DPH1 Positive_regulation of SHBG 1 0.02 0.06 0.14 5.00
184 INT267799 Binding of RLS and ADHD1 1 0.00 4.84 0.14 5.00
185 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14 5.00
186 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13 5.00
187 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13 5.00
188 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13 5.00
189 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13 5.00
190 INT241777 Negative_regulation of Binding of AVP and TRGV9 1 0.10 0.75 0.13 5.00
191 INT335300 SLC15A4 Regulation of CA2 1 0.00 0.19 0.12 5.00
192 INT261789 PDGFA Positive_regulation of Slc12a5 1 0.07 0.15 0.12 5.00
193 INT262185 Positive_regulation of Binding of Ncoa1 and Nr1i2 1 0.04 0.56 0.12 5.00
194 INT261690 Binding of GSC and TCF23 1 0.10 0 0.12 5.00
195 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12 5.00
196 INT293312 CTLA4 Negative_regulation of Binding of CD28 and CD80 1 0.01 0.29 0.12 5.00
197 INT262148 Positive_regulation of Nr1i2 Positive_regulation of Abcb1b 1 0.09 0.69 0.12 5.00
198 INT262197 Nr1i2 Positive_regulation of Insig1 2 0.23 0 0.12 5.00
199 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12 5.00
200 INT212808 Rngtt Negative_regulation of Gene_expression of Ptger2 1 0.00 0.31 0.12 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for anticonvulsant. They are ordered first by their pain relevance and then by number of times they were reported in anticonvulsant. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5456 Binding of U 8 0.28 0.88 2.04 100.00
2 INT78797 Regulation of Tmem132a 8 0.45 3.61 12.73 100.00
3 INT24799 Regulation of Glul 22 0.45 8.3 8 100.00
4 INT50633 Regulation of Gene_expression of Glul 12 0.60 1.64 6.59 100.00
5 INT352654 Binding of BPTF 1 0.01 0.95 0.22 100.00
6 INT1154 Negative_regulation of CCK 24 0.59 9.3 15.32 99.98
7 INT949 Negative_regulation of TRH 12 0.43 3.06 3.4 99.98
8 INT25104 Regulation of Ptz1a 4 0.38 2.44 2 99.98
9 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65 99.96
10 INT1156 Binding of CCK 27 0.48 8.71 20.58 99.92
11 INT69554 Regulation of Slc7a11 4 0.12 1.02 3.68 99.92
12 INT93207 Negative_regulation of Cyp4a3 11 0.36 4.32 2.63 99.88
13 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 99.88
14 INT97876 Gene_expression of Pias1 4 0.59 1.62 2.18 99.82
15 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 99.82
16 INT111675 Regulation of TNFSF14 3 0.26 3.41 1.85 99.80
17 INT100520 Regulation of Grm1 8 0.44 1.3 4.48 99.80
18 INT34796 Positive_regulation of TNFSF14 7 0.67 4.16 2.26 99.80
19 INT100523 Regulation of GRM5 2 0.26 0.49 1.51 99.80
20 INT24526 Localization of Gal 13 0.75 3.54 5.5 99.78
21 INT100288 Negative_regulation of Localization of Gal 2 0.43 0.68 1.6 99.78
22 INT52876 Gene_expression of H3 16 0.77 6.87 1.36 99.78
23 INT169948 Gene_expression of H47 6 0.22 0.73 0.09 99.78
24 INT191142 Positive_regulation of Binding of H3 1 0.07 0.55 0.05 99.78
25 INT191149 Positive_regulation of Binding of H47 1 0.07 0.55 0.05 99.78
26 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35 99.76
27 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 99.76
28 INT13244 Binding of Helt 30 0.31 4.56 18.01 99.76
29 INT96071 Localization of PIAS1 6 0.71 4.44 3.79 99.74
30 INT96072 Regulation of Localization of PIAS1 1 0.14 0 0.66 99.74
31 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 99.70
32 INT261468 Binding of Snrpf 4 0.17 1.66 0.71 99.70
33 INT2910 Regulation of Abat 169 0.62 36.95 153.53 99.68
34 INT695 Binding of POMC 304 0.48 56.66 126.85 99.68
35 INT30683 Binding of TRH 4 0.36 0.96 1.55 99.68
36 INT94095 Negative_regulation of BCAT1 9 0.49 0.97 4.91 99.68
37 INT59559 Negative_regulation of Binding of Olr639 1 0.01 0 0.94 99.68
38 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 99.68
39 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49 99.68
40 INT73010 Gene_expression of Tmem132a 8 0.77 4.38 8.86 99.64
41 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 99.60
42 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 99.60
43 INT43443 Binding of H3 11 0.19 2.9 2.38 99.60
44 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 99.60
45 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 99.60
46 INT101414 Gene_expression of Phc1 27 0.60 9.55 7.58 99.60
47 INT21130 Positive_regulation of GABRB3 4 0.27 1.88 2.21 99.60
48 INT181323 Regulation of TNFAIP1 4 0.35 0.92 0.11 99.58
49 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 99.56
50 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 99.56
51 INT338858 Regulation of HADHA 1 0.03 0.61 0.72 99.54
52 INT338863 Positive_regulation of HADHA 1 0.03 0.61 0.72 99.54
53 INT19488 Localization of ABAT 56 0.69 21.51 50.56 99.52
54 INT30573 Regulation of Regulation of SST 2 0.18 1.55 1.69 99.52
55 INT64225 Positive_regulation of Localization of ABAT 15 0.60 4.46 11.28 99.52
56 INT58173 Negative_regulation of Homer1 5 0.43 1 2.79 99.50
57 INT191137 Binding of H47 4 0.19 1.22 0.13 99.46
58 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 99.44
59 INT164254 Gene_expression of Dnaja3 1 0.57 1.1 1.83 99.44
60 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 99.42
61 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6 99.42
62 INT3439 Localization of Abat 1017 0.78 112.39 727.06 99.40
63 INT76593 Negative_regulation of Bcat1 3 0.59 0 1.64 99.40
64 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84 99.36
65 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.36
66 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 99.34
67 INT17779 Negative_regulation of Got1 12 0.40 3.5 6.08 99.34
68 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 99.30
69 INT5923 Negative_regulation of Rtn4 50 0.36 24.19 27.2 99.30
70 INT3441 Regulation of Localization of Abat 117 0.38 8.67 87.59 99.28
71 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 99.28
72 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47 99.28
73 INT63840 Positive_regulation of Positive_regulation of Gabrg1 9 0.49 0.9 4.11 99.28
74 INT61925 Negative_regulation of Adk 53 0.59 22.46 40.38 99.24
75 INT165811 Binding of Phc1 13 0.15 5.99 3.09 99.24
76 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 99.20
77 INT2912 Positive_regulation of Positive_regulation of Abat 29 0.66 6.48 27.54 99.20
78 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 99.20
79 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78 99.20
80 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95 99.20
81 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27 99.20
82 INT196790 Localization of Cdk5 6 0.74 2.6 0.67 99.20
83 INT155989 Negative_regulation of Localization of ABAT 7 0.38 1.29 6.95 99.18
84 INT49813 Gene_expression of Ptz1a 5 0.49 2.8 2.39 99.16
85 INT244277 Negative_regulation of Gene_expression of Ptz1a 2 0.12 0.96 0.77 99.16
86 INT165655 Localization of Pias1 1 0.80 0.34 0.85 99.12
87 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 99.08
88 INT59560 Binding of Olr639 1 0.01 0 1.79 99.08
89 INT120365 Positive_regulation of KCNQ2 3 0.67 1.13 1.58 99.04
90 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93 99.04
91 INT5118 Regulation of SST 97 0.62 34.35 51.74 99.00
92 INT62014 Negative_regulation of Slc12a2 17 0.49 12.85 8.99 99.00
93 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 99.00
94 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41 99.00
95 INT5454 Localization of CRH 124 0.79 79.18 41.53 99.00
96 INT154358 Transcription of RLS 3 0.59 2.99 0.58 98.96
97 INT4207 Regulation of Avp 267 0.62 63.72 115.33 98.96
98 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 98.96
99 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 98.96
100 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07 98.96
101 INT3755 Positive_regulation of GBE1 29 0.40 8.99 8.91 98.92
102 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 98.90
103 INT7413 Positive_regulation of Localization of SST 37 0.69 5.64 13.94 98.90
104 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25 98.88
105 INT13176 Positive_regulation of Binding of Gabrd 3 0.38 0.73 1.55 98.88
106 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 98.88
107 INT14572 Binding of INS 205 0.48 175.43 13.38 98.88
108 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 98.86
109 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 98.84
110 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 98.80
111 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 98.80
112 INT2498 Positive_regulation of Mlst8 2 0.47 0.73 1.56 98.80
113 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 98.76
114 INT16051 Regulation of Tspo 6 0.45 2.81 4.95 98.76
115 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05 98.74
116 INT397 Localization of SST 232 0.81 58.05 101.19 98.74
117 INT121482 Negative_regulation of Cyp11b1 1 0.03 0.16 1.21 98.72
118 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 98.72
119 INT1352 Localization of Acot1 728 0.80 73.01 296.01 98.70
120 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14 98.68
121 INT29353 Positive_regulation of Negative_regulation of Oprd1 1 0.39 0.36 0.56 98.68
122 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6 98.68
123 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 98.64
124 INT76594 Negative_regulation of Bcat2 2 0.35 0 1.33 98.60
125 INT66193 Negative_regulation of Btd 3 0.59 3.39 0.32 98.60
126 INT103169 Negative_regulation of Slc12a5 38 0.58 27.75 20.81 98.56
127 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 98.56
128 INT5025 Positive_regulation of Gene_expression of Cck 63 0.70 10.96 47.11 98.56
129 INT53393 Positive_regulation of Cyp3a62 25 0.70 7.56 17.69 98.52
130 INT5340 Negative_regulation of Positive_regulation of Npy 12 0.55 3.83 8.23 98.52
131 INT61245 Positive_regulation of Cyp2b2 9 0.64 0.41 4.7 98.52
132 INT12444 Binding of Gabrd 26 0.48 4.7 11.23 98.48
133 INT136672 Positive_regulation of Cnga1 11 0.58 4.46 4.61 98.46
134 INT148862 Positive_regulation of Hcn4 3 0.47 1.4 1.73 98.46
135 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 98.44
136 INT47764 Binding of Jun 106 0.48 22.62 31.39 98.40
137 INT17029 Regulation of Scn7a 23 0.45 3.89 7.02 98.40
138 INT5743 Localization of NA 104 0.59 14.35 35.29 98.38
139 INT76757 Positive_regulation of SERPINA6 3 0.59 1.19 0.97 98.36
140 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 98.36
141 INT36887 Regulation of Hras 2 0.44 0.76 0.72 98.36
142 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 98.26
143 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 98.24
144 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2 98.24
145 INT191153 Negative_regulation of Negative_regulation of HDAC9 1 0.09 0.57 0.05 98.24
146 INT191140 Negative_regulation of Binding of H47 1 0.06 0.56 0.05 98.24
147 INT191138 Negative_regulation of Binding of H3 2 0.06 0.56 0.05 98.24
148 INT7346 Localization of Hrh2 15 0.69 5.78 4.79 98.20
149 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 98.16
150 INT44246 Positive_regulation of Sts 9 0.43 6.19 0.45 98.16
151 INT117731 Binding of MYP1 7 0.30 10.61 0.67 98.14
152 INT106581 Gene_expression of Bzrap1 1 0.78 0.68 2.09 98.12
153 INT306713 Regulation of Positive_regulation of Pgr 1 0.06 0.39 0.24 98.12
154 INT106578 Positive_regulation of Gene_expression of Bzrap1 1 0.70 0.53 1.69 98.12
155 INT106576 Transcription of Bzrap1 1 0.53 0.49 1.49 98.12
156 INT106580 Positive_regulation of Transcription of Bzrap1 1 0.47 0.34 1.1 98.12
157 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 98.04
158 INT2212 Binding of Abat 89 0.48 18.36 63.99 98.00
159 INT164762 Negative_regulation of Slc38a3 1 0.37 0.3 0.63 97.96
160 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 97.96
161 INT17276 Negative_regulation of Gene_expression of HIVEP1 27 0.42 26.85 2.61 97.96
162 INT101964 Regulation of Kcnj9 4 0.31 0.37 2.46 97.90
163 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 97.88
164 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 97.88
165 INT70410 Positive_regulation of AKAP13 2 0.49 0.77 0.96 97.84
166 INT19949 Regulation of Positive_regulation of Fos 36 0.60 6.11 22.05 97.84
167 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63 97.76
168 INT15552 Localization of Man2a2 10 0.69 0.49 5.71 97.76
169 INT145077 Regulation of SLC22A5 2 0.19 3 1.1 97.72
170 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 97.68
171 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 97.60
172 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 97.60
173 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 97.60
174 INT262343 Binding of Lgsn 6 0.32 10.1 1.65 97.56
175 INT17593 Regulation of Jun 37 0.60 5.5 14.35 97.52
176 INT106261 Negative_regulation of DPYD 16 0.59 15.02 1.19 97.52
177 INT155988 Regulation of Localization of ABAT 5 0.24 2.19 6.59 97.44
178 INT55917 Binding of Sigmar1 26 0.45 12.65 5.58 97.36
179 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 97.28
180 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 97.28
181 INT244600 Negative_regulation of POSTN 5 0.18 3.12 1.64 97.28
182 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 97.28
183 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 97.28
184 INT12924 Negative_regulation of Gene_expression of NA 25 0.30 6.59 6.71 97.28
185 INT321199 Binding of POSTN 2 0.31 1.94 0.62 97.28
186 INT345502 Positive_regulation of Binding of POSTN 1 0.07 0.93 0.62 97.28
187 INT797 Regulation of Penk 812 0.62 111.13 542.24 97.12
188 INT12598 Binding of DBP 20 0.48 13.11 3.62 97.08
189 INT96969 Positive_regulation of Positive_regulation of CNR1 9 0.48 1.27 7.19 97.04
190 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 97.04
191 INT149656 Negative_regulation of Gene_expression of Slc12a2 3 0.38 2.36 1.02 97.04
192 INT100115 Gene_expression of Slc12a2 34 0.76 39.15 15.69 97.04
193 INT6335 Binding of TSPO 39 0.44 10.88 7.66 97.00
194 INT37652 Positive_regulation of Pgr 29 0.59 9.09 4.67 96.96
195 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 96.94
196 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 96.92
197 INT81226 Gene_expression of Adk 9 0.64 9.28 4.81 96.92
198 INT124835 Positive_regulation of Nr1i3 7 0.28 2.87 1.23 96.86
199 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 96.84
200 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 96.84
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