P:antinociception

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pChart

Pain Term
Category Pain type
Synonyms None
Pain Specific Yes
Documents 4370
Hot Single Events 200
Hot Interactions 165

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for antinociception. They are ordered first by their pain relevance and then by number of times they were reported for antinociception. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49 100.00
2 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46 100.00
3 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35 100.00
4 INT46022 tp Positive_regulation of SERPINB1 1 0.04 0 1.26 100.00
5 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28 100.00
6 INT149844 Negative_regulation of Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.26 100.00
7 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58 100.00
8 INT75399 Regulation of Binding of Dll1 and Oprd1 1 0.08 0 0.74 100.00
9 INT75398 Binding of Dll1 and Oprd1 1 0.11 0 0.74 100.00
10 INT116628 St13 Regulation of Positive_regulation of P9Ehs1 1 0.00 0 1.25 100.00
11 INT22109 Positive_regulation of Pomc Positive_regulation of Penk 1 0.35 0 0.99 100.00
12 INT66569 Pomc Positive_regulation of Atxn2l 1 0.03 0 1.36 99.98
13 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01 99.92
14 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01 99.92
15 INT199497 Pdyn Negative_regulation of Il1 1 0.00 0.14 1.67 99.92
16 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24 99.84
17 INT11392 Cck Positive_regulation of Cckbr 1 0.52 0 0.96 99.60
18 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41 99.48
19 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94 99.48
20 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35 99.44
21 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49 99.18
22 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48 99.18
23 INT73710 Mastl Positive_regulation of Localization of Oprl1 1 0.02 0 1.26 99.16
24 INT59482 Cpe Positive_regulation of Rbm39 1 0.02 0 0.89 99.04
25 INT149845 Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.24 99.00
26 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6 98.96
27 INT104710 Em Positive_regulation of Rbm39 1 0.02 0.07 1.76 98.92
28 INT104709 Msh3 Positive_regulation of Rbm39 1 0.01 0.07 1.76 98.92
29 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19 98.88
30 INT172511 Mir343 Positive_regulation of ECT 1 0.04 0.08 0.6 98.88
31 INT48790 Negative_regulation of Rtcd1 Negative_regulation of Pax3 1 0.02 0 1.59 98.84
32 INT46021 tp Positive_regulation of Oprl1 1 0.22 0 1.26 98.68
33 INT159839 Binding of HTR1A and HTR7 1 0.39 0.38 0.62 98.68
34 INT159840 Binding of HTR1A and HTR6 1 0.39 0.38 0.62 98.68
35 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 0.24 0 1.11 98.48
36 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21 98.38
37 INT150455 Binding of Prss12 and Nts 3 0.24 1.42 2.66 98.34
38 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64 98.34
39 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29 98.32
40 INT71395 Ugt2a2 Regulation of Bcl2a1a 1 0.00 0.1 1.32 98.28
41 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12 98.24
42 INT96260 Pik3cd Regulation of Plcg2 1 0.02 0 0.92 98.16
43 INT75370 Positive_regulation of Binding of Hrh1 and RGD735065 1 0.00 0.56 1.41 97.96
44 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82 97.92
45 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 0.21 0 1.43 97.80
46 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67 97.80
47 INT75371 Binding of Hrh1 and RGD735065 1 0.00 0.55 1.4 97.68
48 INT96307 Binding of Pnoc and Adarb1 1 0.12 0.37 0.77 97.66
49 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69 97.64
50 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22 97.60
51 INT172515 Mir343 Positive_regulation of Positive_regulation of ECT 1 0.03 0.09 0.42 97.56
52 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14 97.52
53 INT46246 Tpsg1 Regulation of Ache 1 0.15 0.06 0.76 97.52
54 INT46247 Tpsg1 Regulation of Binding of Ache 1 0.15 0.06 0.76 97.52
55 INT65361 Binding of Oprk1 and Ceacam1 1 0.00 0 0.42 97.12
56 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2 96.96
57 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67 96.96
58 INT172508 Binding of Cnnm1 and Mir343 1 0.01 0.15 1.08 96.88
59 INT57509 Trh Negative_regulation of Adarb1 1 0.02 0.22 1.05 96.80
60 INT57508 Pomc Negative_regulation of Adarb1 1 0.01 0.22 1.05 96.80
61 INT104320 Binding of Adk and Ado 1 0.33 0.3 1.12 96.72
62 INT165450 Gal Regulation of Ceacam3 1 0.41 0.06 1.47 96.56
63 INT130607 Hcrt Positive_regulation of H1 1 0.59 0.39 1.02 96.32
64 INT341897 Positive_regulation of NT5C3 Positive_regulation of Positive_regulation of Oxt 1 0.32 0.42 1.07 96.12
65 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01 96.04
66 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96 95.84
67 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53 95.68
68 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78 95.52
69 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33 95.52
70 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63 95.44
71 INT125301 Nts Positive_regulation of Unc5c 1 0.00 0 1.03 95.12
72 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7 94.84
73 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61 94.80
74 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14 94.56
75 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19 94.44
76 INT106838 Lyar Regulation of Oprm1 1 0.04 0.28 0.8 94.44
77 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82 93.68
78 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6 93.60
79 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 1 0.03 0.28 1.8 93.48
80 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6 93.44
81 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16 93.16
82 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15 92.80
83 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69 92.72
84 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64 92.72
85 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52 92.72
86 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2 92.64
87 INT51705 Binding of Penk and Naga 1 0.19 0.08 0.69 92.48
88 INT134584 Arrb2 Regulation of Arrb2 Regulation of Oprm1 1 0.19 0.62 1.07 92.32
89 INT21858 Maoa Regulation of Gene_expression of Spna1 1 0.12 0.18 1.24 92.08
90 INT21857 Maoa Regulation of Ap3d1 1 0.12 0.18 1.23 92.08
91 INT21859 Maoa Regulation of Spna1 1 0.12 0.18 1.23 92.08
92 INT13349 Binding of Gabrg1 and Mastl 1 0.08 0.24 0.54 92.08
93 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39 91.92
94 INT125300 Nts Positive_regulation of Ntsr1 1 0.04 0 0.99 91.92
95 INT138961 Dbi Positive_regulation of Chkb 1 0.00 3.05 3.99 91.88
96 INT138959 Dbi Positive_regulation of Penk 1 0.01 3.05 3.99 91.88
97 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2 91.88
98 INT138960 Dbi Positive_regulation of Avp 1 0.02 1.53 2 91.88
99 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 0.02 1.53 2 91.88
100 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68 91.60
101 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68 91.60
102 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63 91.60
103 INT150069 Cnr1 Regulation of Cnr2 2 0.50 0.83 1.42 91.28
104 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28 91.20
105 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 0.01 0 2.44 91.12
106 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1 91.12
107 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08 91.12
108 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45 90.80
109 INT166414 Gprasp1 Regulation of Negative_regulation of Cnr1 1 0.37 0.3 0.75 90.56
110 INT165284 Positive_regulation of Nts Positive_regulation of Crh 1 0.40 1.86 1.93 90.48
111 INT21331 Binding of Adarb1 and Gm5195 1 0.00 0.26 1.08 90.00
112 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98 90.00
113 INT98245 Binding of Oprm1 and Rbm39 1 0.01 0 0.57 89.84
114 INT165285 Nts Positive_regulation of Crh 1 0.40 1.84 1.91 89.48
115 INT119598 H2-Ab1 Regulation of Scn4a 1 0.00 0.09 0.46 89.28
116 INT119596 H2-Ab1 Regulation of H2-Ab1 Regulation of Scn4a 1 0.00 0.09 0.46 89.28
117 INT159837 Trim2 Negative_regulation of Transcription of Fos 1 0.10 1.92 1.22 89.20
118 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96 88.52
119 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48 88.48
120 INT172512 Mir343 Regulation of ECT 1 0.03 0.08 0.45 88.32
121 INT66488 Binding of Oprl1 and Cbm4 1 0.01 0 1.17 88.08
122 INT117269 Binding of Avp and Prl 1 0.25 0.47 1.8 87.08
123 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58 86.76
124 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58 86.76
125 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48 86.64
126 INT58678 Binding of Penk and Abat 2 0.40 1.39 1.97 86.48
127 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53 86.24
128 INT135378 Binding of Cfb and Oprk1 1 0.01 0.31 0.49 86.16
129 INT82754 Cck Positive_regulation of Positive_regulation of Pomc 1 0.39 0.3 1.21 86.08
130 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41 86.08
131 INT112032 Positive_regulation of Oprm1 Positive_regulation of Pdia3 1 0.44 0.13 0.62 85.84
132 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68 85.60
133 INT21329 Binding of Man2a2 and Gm5195 1 0.00 0.26 1.06 85.52
134 INT26222 Calca Positive_regulation of Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02 85.44
135 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02 85.44
136 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28 85.20
137 INT106374 Olr833 Negative_regulation of Abcb1a 1 0.00 0 0.56 85.20
138 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59 85.04
139 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23 85.04
140 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79 84.96
141 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84 84.68
142 INT80415 Binding of Csf2 and Gnptab 1 0.02 0 0.43 84.60
143 INT137246 Slc6a14 Negative_regulation of Gene_expression of Fos 1 0.10 1.24 0.54 84.56
144 INT119918 Zfp821 Positive_regulation of Binding of ACAA1 1 0.00 0 1.64 84.32
145 INT182704 Binding of NPFF and TP53INP2 1 0.01 0.73 3.28 84.20
146 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1 84.08
147 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67 83.76
148 INT211744 Binding of Gopc and Mors1 1 0.10 0.2 1.48 83.64
149 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08 83.16
150 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07 83.16
151 INT135868 Zfp821 Positive_regulation of Binding of ACAA1 1 0.00 0 2.11 83.04
152 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9 82.96
153 INT21330 Binding of Htr1f and Gm5195 1 0.00 0.26 0.99 82.56
154 INT348403 FDPS Negative_regulation of FDPS Negative_regulation of Fdps 1 0.03 0.79 0.71 82.40
155 INT29554 Ebp Positive_regulation of LH 2 0.40 0.12 1.41 82.24
156 INT126831 Binding of Oprk1 and Rbm39 1 0.05 0.88 1.33 81.76
157 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 81.60
158 INT80751 Negative_regulation of Binding of Il1b and El4 1 0.60 0.08 0.54 81.32
159 INT84414 Folr2 Regulation of Binding of Oprd1 1 0.03 0.18 0.84 81.12
160 INT80752 Binding of Il1b and El4 1 0.49 0.08 0.54 81.00
161 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89 80.56
162 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92 80.48
163 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92 80.48
164 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01 80.28
165 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82 80.08
166 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98 79.28
167 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63 78.64
168 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59 78.24
169 INT112218 Ntsr2 Positive_regulation of H2-Ab1 1 0.06 0 0.64 78.24
170 INT31861 Cd79b Regulation of Sst 1 0.49 0.31 0.56 77.60
171 INT31862 Pdyn Regulation of Sst 1 0.45 0.31 0.56 77.60
172 INT172513 ECT Negative_regulation of Mir343 1 0.02 0.24 0.47 77.00
173 INT14827 Binding of Gabrd and Pag1 1 0.07 0.95 1.33 76.88
174 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17 76.72
175 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56 76.44
176 INT92293 Tacr1 Regulation of Tac2 1 0.17 0.07 0.79 76.40
177 INT93781 Racgap1 Positive_regulation of Positive_regulation of Gnptab 1 0.02 0.07 1.49 76.28
178 INT93782 Racgap1 Positive_regulation of Rgs9 1 0.55 0.07 1.49 76.28
179 INT93783 Racgap1 Positive_regulation of Gnptab 1 0.02 0.07 1.49 76.28
180 INT54199 Binding of Pag1 and Agp2 1 0.04 0.18 0.91 75.68
181 INT54198 Agp2 Negative_regulation of Pag1 1 0.05 0.18 0.91 75.68
182 INT54188 Agp2 Negative_regulation of Binding of Oprd1 and Pag1 1 0.00 0.18 0.91 75.68
183 INT54202 Gnai1 Negative_regulation of Binding of Pag1 and Agp2 1 0.01 0.18 0.91 75.68
184 INT54200 Gnai1 Negative_regulation of Pag1 1 0.05 0.18 0.9 75.68
185 INT54197 Binding of Gnai1 and Pag1 1 0.04 0.18 0.9 75.68
186 INT54187 Gnai1 Negative_regulation of Binding of Oprd1 and Pag1 1 0.00 0.18 0.9 75.68
187 INT54194 Binding of Oprd1 and Pag1 1 0.01 0.18 0.89 75.68
188 INT54196 Binding of Oprd1 and Agp2 1 0.00 0.18 0.91 75.12
189 INT107933 Oprm1 Positive_regulation of Gene_expression of Mastl 1 0.33 0.61 0.71 75.04
190 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57 75.00
191 INT96496 Binding of Oprk1 and Cq1 1 0.01 0.27 0.64 75.00
192 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67 75.00
193 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28 75.00
194 INT87646 Dbi Regulation of Olfr1507 1 0.00 0.69 0.72 75.00
195 INT6077 Cck Negative_regulation of Localization of Penk 1 0.06 0 0.99 75.00
196 INT90045 Oprd1 Positive_regulation of P9Ehs1 1 0.19 0.92 0.64 75.00
197 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63 75.00
198 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91 75.00
199 INT6976 Helt Regulation of Gene_expression of St8sia1 1 0.00 0.07 1.45 75.00
200 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29 75.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for antinociception. They are ordered first by their pain relevance and then by number of times they were reported in antinociception. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 100.00
2 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 100.00
3 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 100.00
4 INT5033 Negative_regulation of tf 39 0.54 13.37 48.62 100.00
5 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 100.00
6 INT1308 Localization of Pomc 457 0.81 66.83 217.5 100.00
7 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 100.00
8 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7 100.00
9 INT4153 Binding of Insrr 109 0.40 17.99 72.15 100.00
10 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
11 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 100.00
12 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 100.00
13 INT2555 Positive_regulation of Localization of Penk 116 0.70 24.35 119.73 100.00
14 INT6969 Negative_regulation of St8sia1 12 0.42 6.36 12.96 100.00
15 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 100.00
16 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
17 INT6970 Gene_expression of St8sia1 13 0.52 4.94 9.27 100.00
18 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68 100.00
19 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 100.00
20 INT84769 Positive_regulation of St8sia1 10 0.41 7.56 9.86 100.00
21 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86 100.00
22 INT53631 Positive_regulation of Morph1 6 0.03 1 8.32 100.00
23 INT104707 Gene_expression of Em 16 0.65 3.95 22.19 100.00
24 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95 100.00
25 INT1295 Binding of Pomc 85 0.48 12.92 42.8 100.00
26 INT21482 Gene_expression of Morph1 3 0.12 0.35 4.19 100.00
27 INT148534 Gene_expression of Olr594 2 0.26 1.09 4.72 100.00
28 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31 100.00
29 INT5771 Binding of Oprd1 37 0.48 2.6 27.54 100.00
30 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 100.00
31 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 100.00
32 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 100.00
33 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 100.00
34 INT33308 Gene_expression of Ap1m2 5 0.15 0.44 5.08 100.00
35 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
36 INT1396 Binding of Penk 355 0.48 22.79 269.65 100.00
37 INT38375 Gene_expression of Siafq1 4 0.51 1.5 3.98 100.00
38 INT4554 Negative_regulation of Otor 5 0.35 2.04 3.5 100.00
39 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 100.00
40 INT85616 Negative_regulation of Positive_regulation of P9Ehs1 8 0.37 4.17 8.11 100.00
41 INT65277 Negative_regulation of Fst 20 0.43 4.61 11.83 100.00
42 INT129585 Gene_expression of St13 17 0.59 4.46 9.3 100.00
43 INT12269 Gene_expression of Chrna9 39 0.73 6.98 18.44 100.00
44 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 100.00
45 INT3276 Binding of LH 16 0.37 4.76 5.94 100.00
46 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13 100.00
47 INT695 Binding of POMC 304 0.48 56.66 126.85 100.00
48 INT32007 Gene_expression of ECT 56 0.62 18.94 11.13 100.00
49 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15 100.00
50 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 100.00
51 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 100.00
52 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95 100.00
53 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 100.00
54 INT63171 Positive_regulation of Mapkap1 1 0.44 0 0.8 100.00
55 INT90155 Negative_regulation of Positive_regulation of St8sia1 1 0.38 0.58 1.15 100.00
56 INT53630 Regulation of Positive_regulation of Morph1 1 0.00 0.08 1.43 100.00
57 INT3387 Negative_regulation of Gene_expression of LH 23 0.43 3.14 12.37 100.00
58 INT52795 Regulation of Btg3 3 0.38 1.58 1.77 100.00
59 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 100.00
60 INT77877 Regulation of P9Ehs1 13 0.38 3.31 10.04 100.00
61 INT254145 Gene_expression of Ppap2a 9 0.10 2.66 4.33 100.00
62 INT113713 Positive_regulation of Gene_expression of Em 2 0.33 0.78 4.43 100.00
63 INT339 Regulation of Trh 156 0.62 39.27 83.55 100.00
64 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 100.00
65 INT20450 Regulation of Binding of Penk 11 0.60 0.47 11.92 100.00
66 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24 100.00
67 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 100.00
68 INT84796 Positive_regulation of Binding of 2 0.46 0.66 1.39 100.00
69 INT55800 Negative_regulation of Binding of 2 0.37 0.65 1.26 100.00
70 INT33313 Gene_expression of Ap1m1 4 0.41 0.44 4.04 100.00
71 INT58774 Negative_regulation of G2e3 8 0.38 0.22 7.75 100.00
72 INT140151 Gene_expression of Tens1 9 0.67 5.84 13.68 100.00
73 INT21572 Gene_expression of Pebp1 9 0.71 2.52 3.3 100.00
74 INT18788 Regulation of ANC 6 0.60 0.15 1.12 100.00
75 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76 100.00
76 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 100.00
77 INT113712 Positive_regulation of Gene_expression of Msh3 2 0.43 0 1.04 100.00
78 INT68139 Gene_expression of D5Ucla2 1 0.08 0 1.21 100.00
79 INT149843 Negative_regulation of C19orf10 1 0.41 0.45 1.25 100.00
80 INT258162 Positive_regulation of Gene_expression of Ppap2a 3 0.09 1.4 1.88 100.00
81 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 100.00
82 INT13484 Negative_regulation of Morph1 2 0.31 0 2.17 100.00
83 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13 100.00
84 INT80697 Regulation of Positive_regulation of Thpo 2 0.44 0.17 1.11 100.00
85 INT21849 Regulation of Artmd1 3 0.03 1.13 2.48 100.00
86 INT110200 Negative_regulation of Positive_regulation of Sbp 1 0.30 0 0.42 100.00
87 INT159523 Positive_regulation of Gene_expression of ECT 9 0.42 2.1 2.91 100.00
88 INT53605 Regulation of Binding of Oprd1 2 0.42 0 2.26 100.00
89 INT52796 Regulation of Guca2a 2 0.44 0 1.12 100.00
90 INT111422 Positive_regulation of Regulation of CNR1 3 0.03 0.56 2.76 100.00
91 INT69763 Positive_regulation of Positive_regulation of Cnr1 12 0.50 9.05 12.46 100.00
92 INT31648 Binding of Trh 11 0.48 2.09 5.48 100.00
93 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32 100.00
94 INT101193 Regulation of Gene_expression of Pag1 13 0.22 8.62 6.77 100.00
95 INT64192 Regulation of Gtf2a2 3 0.19 0.87 6.36 100.00
96 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 100.00
97 INT21325 Regulation of Gm5195 1 0.07 0.23 1.09 100.00
98 INT143233 Positive_regulation of Binding of Dio1 1 0.21 0 1.36 100.00
99 INT55999 Gene_expression of 20T 1 0.09 0.1 0.96 100.00
100 INT128977 Positive_regulation of Positive_regulation of Cnr2 4 0.47 0.86 3.51 100.00
101 INT12270 Gene_expression of Chrna2 11 0.67 5.47 3.06 100.00
102 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 100.00
103 INT159835 Negative_regulation of Trim2 1 0.09 1.81 1.14 100.00
104 INT110352 Transcription of Gm8813 1 0.09 0 0.97 100.00
105 INT258161 Negative_regulation of Negative_regulation of Ppap2a 1 0.05 0.35 0.75 100.00
106 INT90090 Gene_expression of ADO 4 0.58 1.41 0.42 100.00
107 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 99.98
108 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 99.98
109 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 99.98
110 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 99.98
111 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 99.98
112 INT8048 Gene_expression of Nts 45 0.74 8.9 21.84 99.98
113 INT13498 Gene_expression of Atxn2l 16 0.52 1.24 13.73 99.98
114 INT9796 Gene_expression of Cck 63 0.78 11.44 32.09 99.98
115 INT26218 Gene_expression of Gt(pU21)50Imeg 3 0.02 0.26 4.63 99.98
116 INT88255 Regulation of Positive_regulation of Kitl 2 0.00 1.72 3.47 99.98
117 INT25613 Gene_expression of Il1f5 32 0.77 13.29 10.44 99.98
118 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 99.98
119 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.98
120 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75 99.98
121 INT84701 Binding of HSP90B2P 8 0.47 7.37 1.29 99.98
122 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 99.98
123 INT80696 Positive_regulation of Thpo 16 0.70 13.75 4.49 99.98
124 INT55235 Regulation of Positive_regulation of Pag1 2 0.09 1.34 1.22 99.98
125 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46 99.98
126 INT22066 Gene_expression of Phax 40 0.78 22.51 25.91 99.98
127 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16 99.98
128 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 99.96
129 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.96
130 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 99.96
131 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 99.96
132 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 99.96
133 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 99.96
134 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 99.96
135 INT70557 Negative_regulation of Localization of Pax3 1 0.36 1.15 17.32 99.96
136 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 99.96
137 INT56884 Gene_expression of Dll1 9 0.48 1.15 8.98 99.96
138 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 99.96
139 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 99.96
140 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 99.96
141 INT46020 Binding of tp 1 0.35 0 2.53 99.96
142 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 99.96
143 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32 99.96
144 INT18616 Positive_regulation of Positive_regulation of Adarb1 18 0.33 2.04 13.18 99.96
145 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27 99.96
146 INT5988 Localization of Dbi 74 0.81 17.52 24.09 99.96
147 INT8160 Gene_expression of Prss12 20 0.67 4.83 8.17 99.96
148 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 99.96
149 INT7039 Regulation of Nkx1-1 22 0.44 10.51 20.89 99.96
150 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 99.96
151 INT104708 Gene_expression of Msh3 6 0.72 0.07 3.17 99.96
152 INT57512 Negative_regulation of Gm9007 1 0.06 0 4.06 99.96
153 INT790 Gene_expression of Mastl 22 0.68 4.56 10.23 99.96
154 INT56014 Gene_expression of Pzp 4 0.52 0.22 1.61 99.96
155 INT49001 Regulation of Gria1 51 0.56 18.28 31.22 99.96
156 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 99.96
157 INT65460 Positive_regulation of Gene_expression of Oprd1 8 0.69 1.87 3.87 99.96
158 INT69329 Gene_expression of Musd2 3 0.27 2.54 1.15 99.96
159 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 99.96
160 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 99.96
161 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03 99.96
162 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 99.96
163 INT30181 Gene_expression of Adra2b 10 0.62 1.89 3.48 99.96
164 INT90818 Gene_expression of Cckar 1 0.77 0 2.93 99.96
165 INT56019 Gene_expression of Dll1 11 0.78 3.38 8.71 99.96
166 INT57510 Regulation of Notch2 1 0.05 0 0.73 99.96
167 INT35095 Negative_regulation of Notch2 3 0.36 0.06 1.15 99.96
168 INT27805 Regulation of Avpr1a 5 0.60 3.11 5.19 99.96
169 INT39374 Gene_expression of Sct 5 0.68 1.42 3.89 99.96
170 INT66407 Positive_regulation of Gt(pU21)50Imeg 1 0.04 0 1.37 99.96
171 INT26696 Gene_expression of Hils1 4 0.21 1.18 2.38 99.96
172 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 99.96
173 INT38130 Negative_regulation of Gene_expression of Pag1 8 0.28 6.16 7.99 99.96
174 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 99.96
175 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 99.96
176 INT5675 Gene_expression of Adra2c 7 0.75 1.25 4.58 99.96
177 INT57511 Positive_regulation of Negative_regulation of Gm9007 1 0.05 0 1.38 99.96
178 INT13610 Regulation of Acyp2-ps1 10 0.62 3.29 9.4 99.96
179 INT86790 Gene_expression of P2rx6 34 0.74 14.04 15.92 99.96
180 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 99.96
181 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 99.96
182 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 99.96
183 INT23178 Gene_expression of H1 38 0.68 13.37 9.09 99.96
184 INT95039 Gene_expression of Gm9409 1 0.18 0.5 3.21 99.96
185 INT150938 Regulation of Nisch 2 0.45 0.8 1.05 99.96
186 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58 99.96
187 INT82350 Gene_expression of Hm 5 0.15 0.64 0.92 99.96
188 INT67132 Gene_expression of Gtf2a2 1 0.05 0 1.63 99.96
189 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 99.96
190 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 99.96
191 INT95040 Regulation of Gm9409 1 0.12 0.27 1.98 99.96
192 INT28042 Gene_expression of Tsc22d3 14 0.77 6.54 6.4 99.96
193 INT28044 Regulation of Gene_expression of Tsc22d3 2 0.61 0 1.26 99.96
194 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 99.96
195 INT169555 Gene_expression of Acpp 8 0.68 5.55 4.01 99.96
196 INT82984 Gene_expression of Cartpt 27 0.78 3.93 11.55 99.96
197 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86 99.96
198 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69 99.96
199 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55 99.96
200 INT29929 Gene_expression of Rb1 20 0.69 5.81 3.1 99.96
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