P:ascending facilitation

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Pain Term
Category Process
Synonyms Descending Facilitation
Pain Specific No
Documents 80
Hot Single Events 48
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for ascending facilitation. They are ordered first by their pain relevance and then by number of times they were reported for ascending facilitation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04 29.20
2 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79 5.00
3 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57 5.00
4 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8 5.00
5 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2 5.00
6 INT193328 Grid1 Regulation of Positive_regulation of Prkcg 1 0.00 0.1 1.1 5.00
7 INT291966 Pag1 Positive_regulation of Gene_expression of Grin2b 1 0.19 1.91 1.06 5.00
8 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96 5.00
9 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96 5.00
10 INT291962 Pag1 Negative_regulation of Gene_expression of Grin2b 1 0.17 1.56 0.92 5.00
11 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82 5.00
12 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82 5.00
13 INT219274 Binding of Cx3cr1 and Cx3cl1 1 0.17 1.08 0.74 5.00
14 INT209593 Negative_regulation of Adcy1 Negative_regulation of Positive_regulation of Ltp 1 0.10 0 0.69 5.00
15 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61 5.00
16 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61 5.00
17 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61 5.00
18 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61 5.00
19 INT209591 Car2 Positive_regulation of Positive_regulation of Ltp 1 0.05 0 0.54 5.00
20 INT209592 Car2 Positive_regulation of Localization of Ltp 1 0.05 0 0.54 5.00
21 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52 5.00
22 INT291963 Phex Negative_regulation of Gene_expression of Grin1 1 0.06 0.81 0.43 5.00
23 INT291965 Phex Negative_regulation of Pag1 1 0.05 0.82 0.43 5.00
24 INT290821 CRX Positive_regulation of Cort 1 0.14 0.51 0.41 5.00
25 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13 5.00
26 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13 5.00
27 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for ascending facilitation. They are ordered first by their pain relevance and then by number of times they were reported in ascending facilitation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT161734 Positive_regulation of Positive_regulation of Rvm 2 0.44 3.21 2.24 99.96
2 INT18755 Positive_regulation of Rvm 79 0.60 60 92.93 99.80
3 INT7611 Positive_regulation of Cspg5 17 0.67 2.97 12.2 99.64
4 INT19199 Negative_regulation of Rvm 16 0.37 10.07 21.73 99.62
5 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 98.80
6 INT116347 Positive_regulation of Positive_regulation of GRIN1 12 0.49 3.63 11.44 98.80
7 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 98.68
8 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 98.68
9 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34 98.68
10 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 98.68
11 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 98.44
12 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 96.72
13 INT81419 Localization of PAG1 10 0.64 11.1 8.01 96.68
14 INT254569 Regulation of Localization of PAG1 2 0.20 3.08 1.23 96.68
15 INT29144 Gene_expression of Rvm 41 0.52 29.23 47.76 96.48
16 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 95.76
17 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16 94.80
18 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 94.56
19 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 94.32
20 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 94.16
21 INT17197 Gene_expression of Cspg5 9 0.78 1.21 8.85 93.44
22 INT17198 Negative_regulation of Negative_regulation of Cspg5 1 0.43 0.14 0.76 92.80
23 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 90.88
24 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 90.88
25 INT254567 Positive_regulation of Gene_expression of PAG1 10 0.39 31.15 24.26 90.88
26 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 90.24
27 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37 90.24
28 INT254566 Negative_regulation of Gene_expression of PAG1 7 0.33 9.51 9.91 90.24
29 INT254570 Regulation of Gene_expression of PAG1 3 0.35 6.72 5.76 90.24
30 INT7610 Localization of Srf 3 0.67 0.98 0.27 89.76
31 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 88.24
32 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 88.24
33 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 88.24
34 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95 88.24
35 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 87.88
36 INT17200 Negative_regulation of Gene_expression of Cspg5 3 0.56 0.27 2.23 87.60
37 INT17199 Negative_regulation of Cspg5 7 0.56 3.07 11.26 86.88
38 INT287 Localization of Cck 518 0.81 86.84 364.04 86.40
39 INT8153 Regulation of Localization of Cck 52 0.62 11.22 54.83 86.40
40 INT7612 Positive_regulation of Positive_regulation of Cspg5 3 0.50 0.83 0.83 86.16
41 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 85.80
42 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 84.32
43 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 83.84
44 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 82.60
45 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 82.60
46 INT62415 Binding of Htr7 6 0.47 1.76 2.26 81.76
47 INT9231 Binding of Htr3a 27 0.47 7.29 13.04 81.36
48 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 80.40
49 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 79.36
50 INT51062 Negative_regulation of Cckbr 7 0.59 1.98 7.68 79.24
51 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 78.72
52 INT219259 Binding of Nfib 1 0.36 1.46 1.46 78.72
53 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 78.36
54 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 77.92
55 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45 76.64
56 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 75.92
57 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 75.20
58 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45 75.04
59 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 75.00
60 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 75.00
61 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 75.00
62 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 75.00
63 INT3948 Regulation of Cck 291 0.62 58.07 255.88 75.00
64 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 75.00
65 INT112338 Localization of Rvm 11 0.31 9.51 17.61 75.00
66 INT136572 Localization of Ceacam3 3 0.75 1.83 2.2 71.52
67 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 70.96
68 INT7800 Localization of Pag1 51 0.56 33.06 53.74 70.72
69 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 70.00
70 INT7320 Positive_regulation of Tal2 9 0.58 2.05 4.94 68.00
71 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92 66.80
72 INT1562 Localization of Crh 499 0.81 126.74 236.68 66.28
73 INT53729 Localization of Cort 14 0.69 6.31 6.97 66.28
74 INT26008 Positive_regulation of Cckbr 5 0.65 1.47 5.01 66.00
75 INT130478 Localization of Grin2b 11 0.75 2.49 5.28 65.80
76 INT269144 Gene_expression of Mia1 8 0.59 11.84 6.16 63.56
77 INT101193 Regulation of Gene_expression of Pag1 13 0.22 8.62 6.77 62.96
78 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 62.36
79 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 62.24
80 INT170348 Regulation of Gene_expression of Grin2b 8 0.60 2.29 4.25 61.24
81 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88 60.80
82 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 60.68
83 INT269146 Localization of Mia1 1 0.51 0.84 0.85 59.96
84 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37 59.92
85 INT66868 Positive_regulation of Ceacam3 40 0.69 26.61 28.9 58.20
86 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 57.96
87 INT42459 Positive_regulation of Gene_expression of Pag1 19 0.25 13.49 12.22 57.96
88 INT152030 Gene_expression of Postn 10 0.55 8.09 7.08 57.44
89 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92 55.72
90 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7 55.68
91 INT63628 Positive_regulation of Htr7 3 0.67 1.07 2.68 55.68
92 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 55.20
93 INT92514 Regulation of Grin2b 22 0.50 11.07 16.92 55.12
94 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 50.00
95 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 50.00
96 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 50.00
97 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82 50.00
98 INT6053 Transcription of Fos 107 0.72 20.97 31.88 50.00
99 INT52657 Phosphorylation of Fos 20 0.80 6.36 10.64 50.00
100 INT56580 Positive_regulation of Htr1b 16 0.67 2.95 7.97 50.00
101 INT106142 Positive_regulation of Phosphorylation of Fos 4 0.49 0.71 1.4 50.00
102 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06 49.92
103 INT6926 Regulation of Pag1 72 0.39 55.79 65.09 49.04
104 INT108342 Negative_regulation of EPHB2 18 0.57 9.48 4.46 48.16
105 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 46.80
106 INT121987 Phosphorylation of Grin1 11 0.80 4.73 8.88 45.72
107 INT53063 Positive_regulation of Slc1a1 10 0.70 3.23 9.89 42.32
108 INT56439 Regulation of Positive_regulation of Slc1a1 3 0.32 1.65 1.47 42.32
109 INT192658 Negative_regulation of Acsf3 1 0.05 0.57 0.36 40.72
110 INT92513 Regulation of Grin1 26 0.59 9.12 13.94 37.68
111 INT135113 Localization of Grin1 18 0.73 3.73 7.69 37.68
112 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 35.20
113 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02 35.12
114 INT120296 Phosphorylation of Rvm 3 0.30 4.29 5.02 31.68
115 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 29.20
116 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24 29.20
117 INT192661 Positive_regulation of Acsf3 1 0.06 0.89 0.73 25.48
118 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 25.00
119 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 21.20
120 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 15.28
121 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 14.84
122 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43 14.84
123 INT168640 Positive_regulation of Gene_expression of Iba1 9 0.33 8.3 4.55 14.84
124 INT10520 Regulation of Rvm 20 0.24 10.15 20.52 14.48
125 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 14.44
126 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 14.44
127 INT168641 Gene_expression of Iba1 24 0.63 12.21 6.7 14.44
128 INT62725 Regulation of GRIN2D 6 0.45 2.98 5.68 7.20
129 INT9230 Gene_expression of Htr3a 43 0.78 10.54 18.81 7.12
130 INT282190 Regulation of Gene_expression of Htr3a 2 0.44 0.37 0.56 7.12
131 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
132 INT292 Localization of Penk 876 0.81 88.44 669.14 5.00
133 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 5.00
134 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 5.00
135 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
136 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 5.00
137 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
138 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
139 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
140 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
141 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
142 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
143 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
144 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
145 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 5.00
146 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 5.00
147 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
148 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
149 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
150 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
151 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 5.00
152 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
153 INT5587 Regulation of Fos 191 0.62 40.81 99.7 5.00
154 INT52651 Positive_regulation of Prkaca 136 0.67 40.82 99.16 5.00
155 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 5.00
156 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
157 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
158 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 5.00
159 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
160 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52 5.00
161 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 5.00
162 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
163 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
164 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
165 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
166 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
167 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 5.00
168 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13 5.00
169 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
170 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
171 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
172 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 5.00
173 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 5.00
174 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 5.00
175 INT13277 Regulation of Positive_regulation of Ltp 83 0.52 19.68 55.78 5.00
176 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11 5.00
177 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 5.00
178 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
179 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 5.00
180 INT12471 Regulation of Insrr 52 0.35 17.8 48.31 5.00
181 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
182 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 5.00
183 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
184 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 5.00
185 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 5.00
186 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
187 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
188 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 5.00
189 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
190 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25 5.00
191 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 5.00
192 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 5.00
193 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 5.00
194 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43 5.00
195 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05 5.00
196 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 5.00
197 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
198 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 5.00
199 INT12319 Positive_regulation of Cort 52 0.61 22.55 29.35 5.00
200 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
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