P:butorphanol

From wiki-pain
Jump to: navigation, search

pChart

Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 931
Hot Single Events 146
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for butorphanol. They are ordered first by their pain relevance and then by number of times they were reported for butorphanol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 98.86
2 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34 98.00
3 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07 96.08
4 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27 96.08
5 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29 90.68
6 INT134324 Gh Regulation of Gene_expression of F8a 1 0.07 0 0.33 81.92
7 INT55564 Binding of Oprk1 and Pde6b 1 0.01 0 0.92 65.04
8 INT229497 Binding of Vim and Ndel1 1 0.33 3.5 2.81 5.00
9 INT229496 Binding of Ndel1 and Gopc 1 0.08 2.05 1.36 5.00
10 INT229507 Binding of Nefl and Ndel1 1 0.09 2.01 0.43 5.00
11 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32 5.00
12 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32 5.00
13 INT229502 Binding of Vim and Gopc 1 0.05 0.42 0.23 5.00
14 INT229513 Positive_regulation of Binding of Ndel1 and Gopc 1 0.09 0.2 0.2 5.00
15 INT229514 Positive_regulation of Ndel1 Positive_regulation of Binding of Vim and Ndel1 1 0.34 0 0.14 5.00
16 INT229506 Negative_regulation of Binding of Ndel1 and Gopc 1 0.08 0.35 0.09 5.00
17 INT229504 Negative_regulation of Binding of Nefl and Ndel1 1 0.08 0.33 0.09 5.00
18 INT229512 Binding of Nefl and Gopc 1 0.01 0.35 0.09 5.00
19 INT229495 Negative_regulation of Binding of Nefl and Gopc 1 0.02 0.35 0.09 5.00
20 INT229501 Binding of Nefl and Vim 1 0.05 0.32 0.08 5.00
21 INT229500 Binding of Vim and Nde1 1 0.00 0.79 0.07 5.00
22 INT229493 Binding of Ndel1 and Disc1 1 0.13 0.68 0.06 5.00
23 INT229490 Binding of Vim and Kpna4 1 0.02 0.21 0.04 5.00
24 INT229499 Nde1 Regulation of Vim 1 0.00 0.35 0.04 5.00
25 INT229505 Ndel1 Negative_regulation of Vim 1 0.29 0.14 0.04 5.00
26 INT229494 Binding of Ndel1 and Tsp1 1 0.03 0.24 0.04 5.00
27 INT229498 Binding of Vim and Mapk1 1 0.03 0.21 0.04 5.00
28 INT229508 Binding of Fez1 and Disc1 1 0.03 0.34 0.03 5.00
29 INT229503 Binding of Ndel1 and Fez1 1 0.15 0.34 0.03 5.00
30 INT229511 Ndel1 Regulation of Binding of Nefl 1 0.09 0.31 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for butorphanol. They are ordered first by their pain relevance and then by number of times they were reported in butorphanol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 100.00
2 INT16887 Binding of Maoa 10 0.41 2.32 4.49 100.00
3 INT114992 Regulation of Regulation of S100a1 1 0.11 0 1.24 100.00
4 INT4629 Regulation of Fshb 12 0.49 1.93 5.95 100.00
5 INT20117 Regulation of Imacq 2 0.14 0 1 100.00
6 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 100.00
7 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 100.00
8 INT12315 Gene_expression of Nr3c2 37 0.75 19.28 11.97 100.00
9 INT58626 Positive_regulation of Gene_expression of Ugt2b1 3 0.50 0.07 1.45 100.00
10 INT4438 Negative_regulation of Localization of Adh1 18 0.59 6.23 6.95 99.98
11 INT4598 Negative_regulation of Adh1 15 0.54 4.69 5.33 99.98
12 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 99.98
13 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 99.96
14 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 99.92
15 INT32910 Positive_regulation of Gene_expression of Oprl1 22 0.70 7.07 19.03 99.92
16 INT214 Localization of AVP 370 0.81 208.51 91.09 99.90
17 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 99.90
18 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66 99.86
19 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 99.84
20 INT92667 Gene_expression of ACP1 4 0.01 2.49 1.81 99.84
21 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 99.84
22 INT114989 Regulation of S100a1 1 0.11 0 1.23 99.84
23 INT93031 Regulation of Grina 3 0.30 0.4 2.01 99.84
24 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.84
25 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6 99.84
26 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 99.74
27 INT58625 Gene_expression of Ugt2b1 19 0.77 1.95 7.05 99.72
28 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.68
29 INT52166 Positive_regulation of Positive_regulation of OPRK1 2 0.57 0.48 2.74 99.68
30 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 99.66
31 INT12424 Binding of Npy 48 0.48 8.23 24.26 99.64
32 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 99.62
33 INT114991 Regulation of Ccdc88a 2 0.10 0.07 2.4 99.56
34 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 99.52
35 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 99.46
36 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 99.46
37 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49 99.40
38 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.36
39 INT1616 Regulation of Gad1 46 0.61 10.2 28.64 99.32
40 INT2649 Regulation of Calca 433 0.62 146.05 330.95 99.32
41 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54 99.28
42 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08 99.22
43 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 99.16
44 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28 99.16
45 INT93032 Regulation of Nr2c2 2 0.06 0.05 2.17 99.16
46 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 99.16
47 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92 99.12
48 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 99.12
49 INT10070 Negative_regulation of Fshb 13 0.42 3.48 2.5 99.08
50 INT1261 Localization of Adh1 63 0.81 19.36 16.09 98.94
51 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 98.92
52 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 98.92
53 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 98.86
54 INT114988 Negative_regulation of Ccdc88a 3 0.22 0.14 4.29 98.84
55 INT892 Regulation of TRH 23 0.60 8.46 8.54 98.84
56 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 98.70
57 INT51624 Gene_expression of Nr2c2 10 0.20 3.39 3.47 98.70
58 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 98.68
59 INT94927 Transcription of Gria1 12 0.69 3.14 5.94 98.64
60 INT6437 Binding of YY1 154 0.47 26.3 90.46 98.64
61 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5 98.64
62 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78 98.56
63 INT74593 Transcription of Grin2b 10 0.66 1.21 5.98 98.44
64 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 98.44
65 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 98.36
66 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 98.28
67 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84 98.20
68 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 98.20
69 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44 98.16
70 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 98.04
71 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 98.04
72 INT44425 Regulation of Localization of BRD2 1 0.37 0 0.82 98.04
73 INT44424 Regulation of BRD2 5 0.58 1.7 2.75 98.04
74 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 98.04
75 INT921 Regulation of GH1 172 0.60 52.88 51.04 98.04
76 INT74182 Positive_regulation of Binding of OPRK1 8 0.49 1.39 5.25 97.94
77 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63 97.84
78 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 97.84
79 INT93034 Positive_regulation of Grina 2 0.24 0.66 2.22 97.84
80 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 97.84
81 INT252 Localization of GH1 529 0.80 227.4 122.05 97.84
82 INT920 Localization of PLOD1 223 0.81 42.25 78.7 97.76
83 INT44426 Localization of BRD2 6 0.78 4.02 2.59 97.68
84 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 97.60
85 INT4053 Regulation of GRP 27 0.58 5.57 13.76 97.60
86 INT114990 Positive_regulation of S100a1 2 0.29 0.15 2.51 97.56
87 INT76470 Binding of Grina 2 0.18 0.1 1.97 97.40
88 INT93035 Negative_regulation of Transcription of Grin1 6 0.41 2.29 4.39 97.36
89 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 97.36
90 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 97.28
91 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32 97.24
92 INT3699 Gene_expression of H2-Ab1 24 0.74 12.06 11.82 97.16
93 INT61044 Negative_regulation of Gene_expression of Slc9a2 1 0.06 0.3 1.64 96.92
94 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 96.92
95 INT21185 Binding of Ptprg 213 0.47 13.49 157.75 96.88
96 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 96.80
97 INT11246 Binding of Grin1 65 0.48 14.53 36.93 96.72
98 INT67693 Binding of Grin2a 9 0.38 1.74 5.68 96.72
99 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78 96.68
100 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 96.60
101 INT58044 Gene_expression of Slc9a2 3 0.77 0.55 3.01 96.40
102 INT61043 Positive_regulation of Gene_expression of Slc9a2 1 0.07 0.3 1.63 96.40
103 INT5345 Positive_regulation of BRD2 14 0.67 6.72 3.43 96.32
104 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 96.28
105 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 96.28
106 INT12717 Binding of Pck1 85 0.47 12.49 54.81 96.24
107 INT12029 Gene_expression of Car1 143 0.67 29.69 36.39 96.12
108 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 96.12
109 INT50420 Transcription of Grin1 30 0.71 13.21 18.28 96.04
110 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 96.00
111 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 95.96
112 INT131973 Positive_regulation of Transcription of Gria1 3 0.49 0.35 2.62 95.88
113 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 95.88
114 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 95.76
115 INT28510 Positive_regulation of Gpi 21 0.68 6.75 14.27 95.28
116 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06 95.12
117 INT153044 Negative_regulation of Gene_expression of Marcks 2 0.37 0 1.84 94.80
118 INT153045 Negative_regulation of Negative_regulation of Marcks 1 0.37 0 1.54 94.80
119 INT107555 Gene_expression of Marcks 8 0.58 1.22 3.56 94.80
120 INT92355 Negative_regulation of Marcks 4 0.48 0 3.07 94.80
121 INT25647 Negative_regulation of Binding of YY1 10 0.57 1.47 6.77 94.48
122 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 93.64
123 INT860 Regulation of ALB 48 0.60 25.11 8.95 93.16
124 INT19537 Negative_regulation of Binding of ALB 6 0.43 3.32 2.26 92.56
125 INT546 Binding of ALB 311 0.48 85.98 60.14 92.16
126 INT56972 Regulation of ANGPT2 6 0.44 3.48 0.86 91.84
127 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95 91.76
128 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36 91.76
129 INT2758 Binding of Dbp 36 0.44 8.3 14.47 91.20
130 INT24813 Negative_regulation of Positive_regulation of Trib3 10 0.16 1.3 4.48 90.64
131 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 90.08
132 INT72126 Positive_regulation of HIST2H2AA3 16 0.38 3.94 2.89 88.64
133 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 88.56
134 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 87.88
135 INT20556 Negative_regulation of Slc9a2 6 0.58 1.24 3.8 87.84
136 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17 87.80
137 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 85.96
138 INT7375 Negative_regulation of Positive_regulation of AVP 6 0.43 0.37 1.97 85.96
139 INT53536 Gene_expression of Bw86 8 0.30 0.89 5.21 85.68
140 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78 85.12
141 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 84.56
142 INT134321 Regulation of Gene_expression of F8a 1 0.11 0 0.33 81.92
143 INT134322 Gene_expression of F8a 2 0.19 0.51 0.33 81.92
144 INT134323 Positive_regulation of Gene_expression of F8a 1 0.11 0 0.33 81.92
145 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 81.84
146 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 81.84
147 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 79.60
148 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49 77.92
149 INT64748 Regulation of Binding of Pck1 4 0.44 0.45 3.15 76.96
150 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 76.08
151 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32 75.00
152 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87 73.48
153 INT40572 Regulation of Localization of PTHLH 1 0.04 0 0.49 73.48
154 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 73.04
155 INT37363 Localization of PTHLH 14 0.68 13.23 2.92 72.92
156 INT71952 Regulation of Negative_regulation of Oprm1 3 0.43 0.09 2.18 72.84
157 INT29142 Positive_regulation of Binding of Pck1 10 0.67 1.48 7.6 71.04
158 INT3948 Regulation of Cck 291 0.62 58.07 255.88 64.52
159 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 63.32
160 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 60.32
161 INT21610 Positive_regulation of ANGPT2 23 0.41 13.28 3.03 60.32
162 INT58765 Positive_regulation of Gene_expression of ANGPT2 11 0.38 8.2 0.81 60.32
163 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 59.68
164 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 59.68
165 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 59.68
166 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28 59.36
167 INT661 Gene_expression of REN 100 0.78 48.21 11.36 58.40
168 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11 58.40
169 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 57.84
170 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 57.68
171 INT193399 Localization of SEA 4 0.54 0.6 0.2 55.12
172 INT232492 Gene_expression of MROS 5 0.57 4.13 1.02 53.44
173 INT72011 Positive_regulation of Binding of Ptprg 42 0.50 2.72 39.89 52.40
174 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 52.24
175 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 50.00
176 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 50.00
177 INT18853 Negative_regulation of APCS 13 0.57 4.51 2.3 50.00
178 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 32.88
179 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 32.00
180 INT308499 Positive_regulation of Gv2 1 0.03 0.53 0.18 28.36
181 INT229741 Phosphorylation of AOC2 1 0.09 0.57 0.07 12.64
182 INT79558 Binding of Aqp2 2 0.31 0.25 0.33 12.24
183 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
184 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
185 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
186 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
187 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
188 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
189 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
190 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 5.00
191 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
192 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
193 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
194 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
195 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
196 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
197 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
198 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
199 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
200 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox