P:cINOD

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pChart

Pain Term
Category Drug class
Synonyms Anti-inflammatory Drugs, CINODS, Cyclooxygenase Inhibiting NO Donator, Cyclooxygenase Inhibiting NO Donators, Nonsteroidal Anti-inflammatory Drug, Nonsteroidal Anti-inflammatory Drugs, NSAID, NSAIDs
Pain Specific Yes
Documents 23345
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for cINOD. They are ordered first by their pain relevance and then by number of times they were reported for cINOD. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89 100.00
2 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87 100.00
3 INT91992 IGKV1-22 Negative_regulation of Sell 1 0.40 0.31 0.86 100.00
4 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86 100.00
5 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67 100.00
6 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99 100.00
7 INT159527 Binding of GDF15 and SLC17A5 1 0.14 1.15 0.51 100.00
8 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51 100.00
9 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51 100.00
10 INT97950 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of ST3GAL3 1 0.02 0.72 0.5 100.00
11 INT289658 Tnfrsf1a Positive_regulation of Mcpt1 1 0.02 0.76 0.81 100.00
12 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48 100.00
13 INT100597 Regulation of RPL21P132 Positive_regulation of IL6 1 0.01 0.45 0.53 100.00
14 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49 100.00
15 INT145433 Binding of CPOX and HMOX2 1 0.01 0.42 0.49 100.00
16 INT5388 PTGS1 Negative_regulation of APRT 1 0.21 0.4 0.34 100.00
17 INT64720 Regulation of IL1B Positive_regulation of IL6 1 0.36 0.65 0.5 100.00
18 INT107703 PPARG Regulation of Gene_expression of CPOX 1 0.16 0.15 0.41 100.00
19 INT107706 PPARA Positive_regulation of Gene_expression of CPOX 1 0.18 0.14 0.4 100.00
20 INT126006 Binding of ALB and IL8 1 0.41 0.28 0.28 100.00
21 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33 100.00
22 INT81479 Binding of Ptgs1 and ZNF398 1 0.00 0.17 0.28 100.00
23 INT117639 Serpini1 Negative_regulation of Cpox 1 0.00 0.64 0.72 100.00
24 INT65539 PTGS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.18 0.3 100.00
25 INT112659 Cpox Positive_regulation of Gene_expression of TNF 1 0.01 0.79 0.52 100.00
26 INT112661 Cpox Positive_regulation of Localization of TNF 1 0.01 0.79 0.52 100.00
27 INT147356 Egr1 Positive_regulation of Gene_expression of Btg1 1 0.14 1.56 0.28 100.00
28 INT147358 Egr1 Positive_regulation of Gene_expression of Gdf15 1 0.14 1.56 0.28 100.00
29 INT166840 Binding of Anxa1 and Nfkb1 1 0.26 0.82 0.56 100.00
30 INT24668 Binding of COL7A1 and EGF 1 0.14 0.25 0.16 100.00
31 INT24667 Binding of COL7A1 and FGF2 1 0.13 0.25 0.16 100.00
32 INT125515 SP1 Regulation of GDF15 1 0.14 0.47 0.26 100.00
33 INT125521 EGR1 Regulation of GDF15 1 0.13 0.47 0.26 100.00
34 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26 100.00
35 INT172895 Binding of Cpox and Selenbp2 1 0.00 0.64 0.2 100.00
36 INT115142 TGM7 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2 100.00
37 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15 100.00
38 INT87710 MYB Regulation of PTGS2 1 0.28 0.64 0.15 100.00
39 INT126005 Binding of IL8 and OXA1L 1 0.30 0.1 0.1 100.00
40 INT150787 ZNF398 Positive_regulation of Gene_expression of SPARC 1 0.13 1.02 1.05 99.98
41 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58 99.98
42 INT150921 ZNF398 Negative_regulation of Gene_expression of Mmp2 1 0.00 0.46 0.5 99.98
43 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85 99.96
44 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85 99.96
45 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 99.92
46 INT87922 Gm7869 Negative_regulation of Ptgs2 1 0.01 0.56 0.1 99.92
47 INT87921 Gm7869 Negative_regulation of Ptgs1 1 0.01 0.55 0.1 99.92
48 INT289659 Tnfrsf1b Negative_regulation of Mcpt3 1 0.02 0.82 1.13 99.90
49 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39 99.90
50 INT122000 Negative_regulation of PTGS1 Positive_regulation of Gene_expression of TNF 1 0.23 0.11 0.28 99.90
51 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2 99.88
52 INT67619 Inpp5k Negative_regulation of Ptgs1 1 0.03 0.5 0.13 99.88
53 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26 99.84
54 INT84885 APC Regulation of APC Regulation of PPARD 1 0.18 0.55 0.41 99.84
55 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26 99.84
56 INT312106 EGR1 Regulation of Gene_expression of PTGES 1 0.31 1.06 0.64 99.84
57 INT116926 Cpox Regulation of AKR1C3 1 0.01 0.28 0.45 99.80
58 INT249656 tm Positive_regulation of Il12a 1 0.07 1.17 0.84 99.80
59 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67 99.76
60 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89 99.76
61 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5 99.76
62 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5 99.76
63 INT80028 HIST2H2AA3 Positive_regulation of Binding of REL 1 0.02 0.94 0.3 99.70
64 INT80026 HIST2H2AA3 Positive_regulation of REL 1 0.02 0.93 0.29 99.70
65 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02 99.68
66 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34 99.68
67 INT134302 Cpox Negative_regulation of PTGS2 Negative_regulation of Gene_expression of Ptger2 1 0.00 0.78 0.34 99.68
68 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93 99.64
69 INT80027 TNF Positive_regulation of Binding of REL 1 0.15 0.94 0.3 99.60
70 INT159903 Binding of CYP2C8 and CYP2C9 1 0.42 0.22 0.35 99.56
71 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79 99.56
72 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58 99.54
73 INT217760 Il1f5 Positive_regulation of Gene_expression of Cpox 1 0.00 0.27 0.47 99.52
74 INT217759 Il1f5 Positive_regulation of Cpox 1 0.00 0.27 0.47 99.52
75 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62 99.48
76 INT65007 DAK Negative_regulation of CTSA 1 0.03 0.35 0.48 99.48
77 INT105918 Binding of FUT1 and SLC9A3R2 1 0.00 0.14 1.2 99.44
78 INT129943 Tnf Positive_regulation of Nfkb1 1 0.03 0.17 0.17 99.42
79 INT55672 Ptgs1 Positive_regulation of Gene_expression of Ik 1 0.03 0.75 0.61 99.38
80 INT142286 Binding of PLG and Plat 2 0.52 0.7 0.31 99.36
81 INT134301 Cpox Negative_regulation of Gene_expression of Ptger2 1 0.00 0.77 0.34 99.32
82 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69 99.28
83 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05 99.22
84 INT121000 Binding of PAG1 and Nrm 1 0.13 0.67 1.25 99.20
85 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45 99.16
86 INT148556 PPARG Regulation of Gene_expression of PPARA 1 0.30 1.2 0.31 99.12
87 INT64964 Binding of Alb and Cd24 1 0.02 0.2 0.2 99.08
88 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3 99.06
89 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3 99.06
90 INT220522 Ugt1a6b Positive_regulation of Sf3a3 1 0.00 0.92 0.18 99.06
91 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8 99.04
92 INT352196 Igkv12-66 Negative_regulation of Gm10404 1 0.00 1.62 1.34 99.02
93 INT41950 Ptger1 Positive_regulation of Localization of A2m 1 0.19 0.46 0.24 99.00
94 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64 98.96
95 INT134645 Binding of ORM1 and OXA1L 1 0.17 0.1 0.27 98.96
96 INT65006 DAK Negative_regulation of ELANE 1 0.05 0.35 0.47 98.92
97 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65 98.88
98 INT101806 Binding of NFE2L2 and KEAP1 Positive_regulation of Gene_expression of GCLC 1 0.55 0.1 0.19 98.84
99 INT101812 Binding of KEAP1 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19 98.84
100 INT101808 Binding of NFE2L2 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19 98.84
101 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19 98.82
102 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19 98.82
103 INT138305 Binding of PNN and Agtr2 1 0.01 0.73 0.15 98.80
104 INT220513 Ugt1a6b Positive_regulation of Ppara 1 0.01 0.98 0.18 98.78
105 INT80030 Binding of FAS and TNF 3 0.27 2.54 0.56 98.74
106 INT65015 IL6 Negative_regulation of Gene_expression of PTGER2 1 0.09 0.17 0.24 98.68
107 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03 98.64
108 INT101066 MAP3K15 Positive_regulation of CDCP1 1 0.03 0.46 1.03 98.64
109 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02 98.64
110 INT322543 Binding of FOXO3 and Cdkn1b 1 0.08 0.84 0.19 98.60
111 INT100596 RPL21P132 Positive_regulation of TNF 1 0.00 0.43 0.5 98.50
112 INT100595 RPL21P132 Positive_regulation of IL6 1 0.01 0.43 0.49 98.50
113 INT115811 Binding of Slc22a6 and Mtx1 1 0.02 0.17 0.65 98.48
114 INT115812 Binding of Slc22a8 and Mtx1 1 0.08 0.17 0.65 98.48
115 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 98.48
116 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 98.48
117 INT154533 Ifng Negative_regulation of Il4 1 0.11 0.62 0.6 98.44
118 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24 98.40
119 INT92580 IGF2 Positive_regulation of Gene_expression of PTGER2 1 0.07 0.43 0.15 98.40
120 INT94864 Regulation of Litaf Positive_regulation of Nos2 1 0.05 0.05 0.15 98.40
121 INT94865 Litaf Positive_regulation of Nos2 1 0.08 0.05 0.15 98.40
122 INT114967 ERI1 Negative_regulation of CPOX 1 0.00 0.25 0.14 98.40
123 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62 98.36
124 INT204792 Tnbs1 Positive_regulation of Transcription of Il10 1 0.09 1.2 0.32 98.36
125 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29 98.28
126 INT80031 FAS Positive_regulation of Positive_regulation of NFKB1 1 0.50 0.93 0.3 98.24
127 INT64967 Binding of AGFG1 and Alb 1 0.01 0.2 0.2 98.24
128 INT64966 Binding of AGFG1 and Cd24 1 0.00 0.1 0.1 98.24
129 INT153797 NUBPL Negative_regulation of PPARD 1 0.02 0.69 0.64 98.20
130 INT153796 NUBPL Negative_regulation of YWHAQ 1 0.02 0.69 0.64 98.20
131 INT12702 Regulation of Binding of FPR1 and GUSB 1 0.43 0.18 0.44 98.20
132 INT12703 Binding of FPR1 and GUSB 1 0.36 0.18 0.44 98.20
133 INT154530 Positive_regulation of Ifng Negative_regulation of Il10 1 0.33 0.63 0.61 98.20
134 INT154531 Ifng Negative_regulation of Il10 1 0.30 0.61 0.6 98.20
135 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76 98.16
136 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05 98.16
137 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8 98.04
138 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8 98.04
139 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46 98.04
140 INT92583 IGF2 Positive_regulation of Transcription of PTGER2 1 0.07 0.43 0.15 98.00
141 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15 98.00
142 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41 97.94
143 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41 97.94
144 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41 97.94
145 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41 97.94
146 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41 97.94
147 INT113235 Tacr1 Regulation of Gene_expression of Ifng 1 0.26 1 1.04 97.92
148 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19 97.92
149 INT41949 Ptger1 Positive_regulation of Gene_expression of A2m 1 0.19 0.46 0.24 97.92
150 INT146745 UGCG Positive_regulation of Gene_expression of PTGS2 1 0.23 0.1 0.16 97.88
151 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37 97.80
152 INT150243 POMC Positive_regulation of Mc3r 1 0.05 0.88 0.52 97.76
153 INT150244 POMC Positive_regulation of Mc3r Regulation of POMC 1 0.03 0.88 0.52 97.76
154 INT147359 Positive_regulation of Pik3cd Positive_regulation of Egr1 1 0.09 1.51 0.27 97.76
155 INT147360 Pik3cd Positive_regulation of Egr1 1 0.12 1.51 0.27 97.76
156 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88 97.56
157 INT122502 TNF Positive_regulation of Localization of CAPN2 1 0.24 0.18 0.38 97.48
158 INT177784 PDCD2 Positive_regulation of ASNS 1 0.04 0.76 0.46 97.48
159 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46 97.48
160 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14 97.44
161 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56 97.44
162 INT81916 HSF1 Positive_regulation of FOS 1 0.76 0.66 0.59 97.44
163 INT81918 HSF1 Negative_regulation of FOS 1 0.64 0.66 0.59 97.44
164 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39 97.44
165 INT103092 Binding of PPARA and ISYNA1 1 0.01 0.45 0.54 97.32
166 INT26497 TNF Positive_regulation of Gene_expression of MMP2 1 0.44 1.5 0.75 97.30
167 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54 97.28
168 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29 97.28
169 INT177791 PDCD2 Positive_regulation of ATF4 1 0.06 0.76 0.46 97.24
170 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46 97.24
171 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58 97.20
172 INT228055 WNT1 Positive_regulation of CTNND2 1 0.54 1.75 0.42 97.20
173 INT113237 Il10 Negative_regulation of Gene_expression of Tacr1 1 0.35 0.81 0.84 97.12
174 INT55679 IL1B Positive_regulation of MMP11 1 0.02 0.17 0.28 97.10
175 INT55684 IL1B Positive_regulation of Gene_expression of MMP11 1 0.04 0.17 0.28 97.10
176 INT55683 IL1B Positive_regulation of Gene_expression of TIMP1 1 0.64 0.17 0.28 97.10
177 INT55682 IL1B Positive_regulation of TIMP1 2 0.46 0.17 0.28 97.10
178 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56 97.08
179 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06 97.04
180 INT150782 ZNF398 Positive_regulation of THBS3 Negative_regulation of SPARC 1 0.05 0.51 0.54 97.04
181 INT150800 THBS3 Negative_regulation of SPARC 1 0.23 0.51 0.53 97.04
182 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23 97.04
183 INT56071 NFKB1 Positive_regulation of Gene_expression of IL1B 1 0.36 0.4 0.27 97.04
184 INT106809 ZNF398 Positive_regulation of Transcription of RECK 1 0.02 0.5 1.01 97.00
185 INT106810 ZNF398 Positive_regulation of RECK 1 0.02 0.5 1.01 97.00
186 INT81915 HSF1 Negative_regulation of IL1B 1 0.51 0.65 0.59 97.00
187 INT81917 HSF1 Positive_regulation of IL1B 1 0.41 0.65 0.59 97.00
188 INT79651 PTGS2 Positive_regulation of Phosphorylation of NR3C1 1 0.07 0.1 0.19 96.96
189 INT73331 PTAFR Positive_regulation of Transcription of PTGS2 1 0.13 0.54 0.18 96.96
190 INT177782 PDCD2 Positive_regulation of MTHFD2 1 0.06 0.76 0.46 96.88
191 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46 96.88
192 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54 96.80
193 INT66129 Binding of Tia1 and Olfr927-ps1 1 0.16 0.16 0.56 96.80
194 INT119264 Binding of RB1 and PPM1E 1 0.00 0.46 0.17 96.80
195 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31 96.80
196 INT48162 RIMS3 Regulation of Localization of LTC4S 1 0.10 2.14 3.25 96.72
197 INT117913 CREM Positive_regulation of Negative_regulation of BIRC2 1 0.15 0.81 0.14 96.64
198 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42 96.60
199 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42 96.60
200 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42 96.60

Single Events

The table below shows the top 200 pain related interactions that have been reported for cINOD. They are ordered first by their pain relevance and then by number of times they were reported in cINOD. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 100.00
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 100.00
3 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 100.00
4 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 100.00
5 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 100.00
6 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 100.00
7 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 100.00
8 INT94388 Gene_expression of GDF15 124 0.77 79.48 31.42 100.00
9 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 100.00
10 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 100.00
11 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 100.00
12 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 100.00
13 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 100.00
14 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 100.00
15 INT101988 Positive_regulation of GDF15 71 0.69 51.03 18.56 100.00
16 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 100.00
17 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 100.00
18 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 100.00
19 INT94390 Positive_regulation of Gene_expression of GDF15 67 0.69 45.5 14.74 100.00
20 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 100.00
21 INT546 Binding of ALB 311 0.48 85.98 60.14 100.00
22 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 100.00
23 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 100.00
24 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41 100.00
25 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 100.00
26 INT6852 Localization of TNF 883 0.81 705.95 270.84 100.00
27 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 100.00
28 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 100.00
29 INT81194 Binding of CPOX 40 0.29 23.7 18.95 100.00
30 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 100.00
31 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83 100.00
32 INT65502 Regulation of App 77 0.62 52.05 19.44 100.00
33 INT122041 Binding of Ppara 308 0.48 189.17 51.48 100.00
34 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
35 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 100.00
36 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 100.00
37 INT1850 Binding of OXA1L 77 0.48 7.61 15.22 100.00
38 INT49660 Positive_regulation of EGR1 54 0.69 32.17 9.89 100.00
39 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 100.00
40 INT234 Binding of Alb 151 0.48 52.34 32.97 100.00
41 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 100.00
42 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76 100.00
43 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
44 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 100.00
45 INT76427 Regulation of Negative_regulation of Cpox 17 0.31 6.75 7.93 100.00
46 INT4460 Regulation of Mpo 44 0.62 31.16 12.11 100.00
47 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 100.00
48 INT77427 Regulation of Negative_regulation of CPOX 17 0.26 10.03 6.15 100.00
49 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 100.00
50 INT67609 Binding of Pparg 17 0.46 9.53 6.06 100.00
51 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56 100.00
52 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48 100.00
53 INT71948 Negative_regulation of VN1R106P 1 0.01 0.79 4.43 100.00
54 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 100.00
55 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52 100.00
56 INT43356 Regulation of GDF15 13 0.59 8.27 3.63 100.00
57 INT102583 Gene_expression of Gdf15 26 0.77 15.33 4.52 100.00
58 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47 100.00
59 INT17444 Gene_expression of MTHFS 14 0.66 5.17 3.85 100.00
60 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44 100.00
61 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93 100.00
62 INT74272 Localization of CPOX 39 0.63 25.12 10.53 100.00
63 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 100.00
64 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97 100.00
65 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 100.00
66 INT96792 Regulation of Gene_expression of GDF15 10 0.61 5.74 3.21 100.00
67 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 100.00
68 INT106618 Positive_regulation of CIB1 9 0.63 3.38 3.63 100.00
69 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42 100.00
70 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6 100.00
71 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 100.00
72 INT108844 Positive_regulation of Positive_regulation of GDF15 11 0.68 7 2.74 100.00
73 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 100.00
74 INT138267 Positive_regulation of Positive_regulation of Keap1 1 0.12 0.96 2.29 100.00
75 INT9655 Regulation of Il6 98 0.62 70.92 31.95 100.00
76 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81 100.00
77 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 100.00
78 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86 100.00
79 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87 100.00
80 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 100.00
81 INT102585 Positive_regulation of Gdf15 19 0.69 14.78 3.21 100.00
82 INT75250 Negative_regulation of Positive_regulation of SGSM3 5 0.57 2.47 5.24 100.00
83 INT90097 Localization of PTGS2 15 0.69 6.14 6.63 100.00
84 INT82310 Binding of HADHA 1 0.39 1.16 2.05 100.00
85 INT62813 Negative_regulation of ZNF398 12 0.09 6.2 4.49 100.00
86 INT67580 Regulation of Gene_expression of Sell 5 0.51 1.86 2.8 100.00
87 INT101257 Negative_regulation of Positive_regulation of ALOX15 1 0.41 1.47 1.71 100.00
88 INT9210 Regulation of IL6 166 0.62 125.61 49.95 100.00
89 INT148804 Binding of Diablo 3 0.47 4.37 1.67 100.00
90 INT38366 Regulation of Cat 45 0.62 23.45 5.34 100.00
91 INT69966 Positive_regulation of Negative_regulation of CPOX 11 0.45 6.18 4.64 100.00
92 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 100.00
93 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 100.00
94 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5 100.00
95 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 100.00
96 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71 100.00
97 INT27964 Negative_regulation of CBR1 12 0.58 5.48 3.74 100.00
98 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 100.00
99 INT37104 Binding of GANAB 2 0.27 1.76 1.51 100.00
100 INT51683 Regulation of Gene_expression of PTAFR 11 0.60 5.06 2.59 100.00
101 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 100.00
102 INT105332 Regulation of Gene_expression of IFI27 14 0.45 8.39 2.02 100.00
103 INT194462 Localization of Ppara 94 0.78 68.33 12.09 100.00
104 INT6577 Regulation of Alox5 18 0.47 9.19 5.06 100.00
105 INT96694 Negative_regulation of Slc27a5 1 0.53 0.96 1.3 100.00
106 INT65538 Regulation of Positive_regulation of Nfkb1 17 0.51 8.31 6.5 100.00
107 INT18412 Binding of PLEK 49 0.47 17.82 10.72 100.00
108 INT73902 Regulation of Gene_expression of IL1RN 6 0.61 4.59 6.14 100.00
109 INT70538 Regulation of Localization of CSF2 4 0.54 3.08 1.9 100.00
110 INT82309 Positive_regulation of Binding of HADHA 1 0.35 0.87 1.38 100.00
111 INT138895 Positive_regulation of Negative_regulation of Hmox2 2 0.01 1.23 1.53 100.00
112 INT48404 Regulation of Gene_expression of Icam1 21 0.62 15.1 7.81 100.00
113 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41 100.00
114 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4 100.00
115 INT135919 Binding of SLC5A8 1 0.47 0 1.12 100.00
116 INT86437 Binding of IL6 154 0.48 121.22 29.3 100.00
117 INT32557 Negative_regulation of Negative_regulation of PTGS1 8 0.43 3.44 2.1 100.00
118 INT73260 Regulation of Positive_regulation of PTGS1 3 0.26 2.65 1.37 100.00
119 INT20462 Binding of ESR1 210 0.44 102.7 26.34 100.00
120 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47 100.00
121 INT35254 Negative_regulation of SERPINB1 22 0.48 11.42 4.7 100.00
122 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76 100.00
123 INT124623 Binding of GDF15 4 0.35 2.06 1.09 100.00
124 INT120869 Binding of SLC13A3 1 0.47 0.68 1.04 100.00
125 INT47303 Regulation of Ctsl 10 0.56 2.64 2.04 100.00
126 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49 100.00
127 INT178615 Binding of SOD2 12 0.48 6.93 1.51 100.00
128 INT860 Regulation of ALB 48 0.60 25.11 8.95 100.00
129 INT42335 Binding of CTSB 11 0.34 5.98 1.37 100.00
130 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 100.00
131 INT31134 Regulation of Binding of ALB 13 0.62 2.51 2.37 100.00
132 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 100.00
133 INT72684 Binding of Slc21a4 1 0.48 0.37 1.52 100.00
134 INT98634 Positive_regulation of Positive_regulation of EGR1 9 0.68 3.43 2.47 100.00
135 INT87360 Binding of ABCC1 6 0.47 1.71 2.38 100.00
136 INT29836 Regulation of MTHFS 6 0.33 1.43 1.67 100.00
137 INT51686 Regulation of Gene_expression of LTB4R 10 0.26 5.02 2.99 100.00
138 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 100.00
139 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
140 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 100.00
141 INT11364 Regulation of Gene_expression of PLAU 4 0.58 3.23 1.92 100.00
142 INT11354 Regulation of Gene_expression of SERPINE1 11 0.61 8.66 4.42 100.00
143 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56 100.00
144 INT156015 Negative_regulation of Protein_catabolism of BCL2L1 1 0.42 1.23 0.93 100.00
145 INT156014 Protein_catabolism of BCL2L1 1 0.64 1.23 0.93 100.00
146 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 100.00
147 INT11335 Regulation of Ptger2 46 0.51 22.3 15.42 100.00
148 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71 100.00
149 INT91176 Regulation of Localization of GSTA2 2 0.33 1.04 1.31 100.00
150 INT1851 Regulation of OXA1L 7 0.40 0.59 1.42 100.00
151 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 100.00
152 INT91276 Positive_regulation of Negative_regulation of Cpox 4 0.27 3.11 2.2 100.00
153 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63 100.00
154 INT34808 Binding of Ec 14 0.24 17.27 2.65 100.00
155 INT125591 Positive_regulation of Binding of GDF15 1 0.21 1.25 0.85 100.00
156 INT51684 Regulation of LTB4R 6 0.36 3.04 2.15 100.00
157 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 100.00
158 INT120598 Negative_regulation of ABCC4 4 0.59 0.49 1.6 100.00
159 INT2825 Regulation of Localization of Ptger3 3 0.23 0.3 1.29 100.00
160 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76 100.00
161 INT11154 Binding of EGFR 149 0.48 96.23 6.29 100.00
162 INT3437 Negative_regulation of Bad 5 0.48 1.66 2.99 100.00
163 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15 100.00
164 INT102070 Regulation of Gene_expression of Myc 4 0.60 2.68 0.96 100.00
165 INT113164 Regulation of Regulation of VEGFA 6 0.36 5.96 2.43 100.00
166 INT86625 Binding of Pla2g1b 8 0.24 2.52 2.43 100.00
167 INT106602 Positive_regulation of Gene_expression of CIB1 2 0.45 1 0.83 100.00
168 INT165538 Binding of Bmp7 5 0.37 1.87 1.39 100.00
169 INT53812 Regulation of Gene_expression of Ptgs1 5 0.38 0.89 1.78 100.00
170 INT145221 Binding of Tp53 10 0.37 8.59 1.37 100.00
171 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71 100.00
172 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88 100.00
173 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75 100.00
174 INT3598 Regulation of Pla2g1b 12 0.44 3.45 3.9 100.00
175 INT160011 Regulation of Gene_expression of CCND2 1 0.24 0.85 1.04 100.00
176 INT44254 Regulation of Gene_expression of ALOX5 12 0.43 7.06 3.65 100.00
177 INT55949 Regulation of Phosphorylation of CAMP 1 0.26 0.52 0.7 100.00
178 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04 100.00
179 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07 100.00
180 INT7743 Binding of Hrh2 19 0.47 7.75 7.11 100.00
181 INT81195 Binding of Bcmo1 17 0.33 1.28 2.45 100.00
182 INT115439 Regulation of Localization of Defb40 1 0.00 0.73 0.81 100.00
183 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41 100.00
184 INT143952 Regulation of Gene_expression of MMP9 14 0.53 10.16 2.73 100.00
185 INT64172 Regulation of Transcription of CPOX 1 0.19 0.31 0.75 100.00
186 INT58302 Regulation of Mpo 13 0.62 11.14 3.04 100.00
187 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19 100.00
188 INT9076 Regulation of Gene_expression of Tbxa2r 7 0.61 1.16 1.92 100.00
189 INT22944 Regulation of Grhpr 12 0.26 0.78 3 100.00
190 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 100.00
191 INT11350 Regulation of GTDC2 2 0.25 0.61 0.91 100.00
192 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84 100.00
193 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03 100.00
194 INT110038 Negative_regulation of Aco1 26 0.23 17.41 2.2 100.00
195 INT79051 Regulation of Localization of IGLL1 1 0.12 0.26 0.7 100.00
196 INT20480 Regulation of Localization of C6orf25 2 0.06 0.26 0.7 100.00
197 INT54020 Regulation of Binding of OXA1L 4 0.51 0.27 1.37 100.00
198 INT21168 Regulation of CYBB 14 0.53 1.99 1.45 100.00
199 INT123551 Regulation of Mmp2 17 0.57 11.6 6 100.00
200 INT126223 Binding of Nos2 17 0.37 6 3.22 100.00
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