P:cOX1

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Pain Term
Category Molecule
Synonyms COX 1, Cyclooxygenase 1
Pain Specific No
Documents 960
Hot Single Events 200
Hot Interactions 25

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for cOX1. They are ordered first by their pain relevance and then by number of times they were reported for cOX1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT157150 Positive_regulation of PTGIR Negative_regulation of Gene_expression of TNF 1 0.12 0.97 0.34 100.00
2 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26 100.00
3 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23 100.00
4 INT336032 tf Positive_regulation of Gene_expression of Cpox 1 0.05 0.09 0.05 100.00
5 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54 99.98
6 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37 99.98
7 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62 99.94
8 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23 99.80
9 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23 99.80
10 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54 99.74
11 INT161250 Trib3 Regulation of Mapk14 1 0.04 0.81 0.54 99.74
12 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69 99.28
13 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79 99.22
14 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 99.20
15 INT336031 tf Positive_regulation of Gene_expression of PGE 1 0.12 0.09 0.05 98.64
16 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74 98.32
17 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24 98.00
18 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28 96.92
19 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03 96.36
20 INT108387 IL1B Positive_regulation of Localization of MMP1 1 0.27 0.3 0.57 90.20
21 INT136749 COX5A Positive_regulation of Gene_expression of SCARB1 1 0.52 0.36 0.45 87.20
22 INT196886 Ly6 Positive_regulation of Binding of Ly6 and Prkca 1 0.00 0.18 0.25 82.64
23 INT196880 Binding of Ly6 and Prkca 1 0.01 0.18 0.25 82.64
24 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42 81.36
25 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15 80.04
26 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78 77.12
27 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72 77.12
28 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71 77.12
29 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77 75.68
30 INT262566 Par2 Regulation of Trpv1 1 0.20 0.57 0.71 75.68
31 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22 75.52
32 INT136758 TNF Positive_regulation of Gene_expression of PTGES 1 0.05 0.52 0.55 75.00
33 INT136759 TNF Positive_regulation of PTGES 1 0.03 0.29 0.28 75.00
34 INT253475 Ncapg2 Positive_regulation of Gene_expression of Fpr3 1 0.21 3.11 0.47 72.96
35 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1 72.84
36 INT274471 IL12A Negative_regulation of Gene_expression of IL10 1 0.02 0.99 0.1 72.68
37 INT274470 Binding of IL12A and GOPC 1 0.02 0.6 0.09 70.36
38 INT253488 Ptger2 Positive_regulation of Ptger4 Positive_regulation of Positive_regulation of Pik3r1 1 0.06 1.2 0.13 59.08
39 INT253468 Ptger2 Positive_regulation of Ptger4 1 0.12 1.19 0.13 59.08
40 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52 46.80
41 INT274475 IL12A Regulation of Gene_expression of IL6 1 0.04 0.68 0 45.56
42 INT253474 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Bcl2 1 0.04 1.27 0 44.44
43 INT340292 Ea1 Positive_regulation of Ins1 1 0.04 0.6 0.43 43.04
44 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52 36.80
45 INT299368 Mkks Positive_regulation of Mapk8 1 0.41 0.17 0.03 35.28
46 INT340291 Ea1 Regulation of Gene_expression of Ins1 1 0.03 0.62 0.46 33.48
47 INT201740 Positive_regulation of Ngf Positive_regulation of Nfkb1 1 0.01 1.07 0.51 25.84
48 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7 25.00
49 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66 25.00
50 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 0.19 1.52 1.64 25.00
51 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55 25.00
52 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22 25.00
53 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14 25.00
54 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11 25.00
55 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09 25.00
56 INT157142 OPA1 Positive_regulation of Gene_expression of Camk2a 1 0.02 0.3 1.02 25.00
57 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97 25.00
58 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91 25.00
59 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9 25.00
60 INT75920 Slc8a1 Negative_regulation of Cpox 1 0.03 0.85 0.89 25.00
61 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 25.00
62 INT125234 Positive_regulation of Binding of BCR and CD40LG 1 0.31 0.76 0.86 25.00
63 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86 25.00
64 INT125233 Binding of BCR and CD40LG 1 0.23 0.75 0.85 25.00
65 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 25.00
66 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82 25.00
67 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8 25.00
68 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8 25.00
69 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79 25.00
70 INT150995 Sfpq Positive_regulation of Gene_expression of Il4 1 0.06 0.71 0.74 25.00
71 INT150997 Sfpq Positive_regulation of Gene_expression of Il10 1 0.09 0.71 0.74 25.00
72 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72 25.00
73 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72 25.00
74 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72 25.00
75 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72 25.00
76 INT150863 Grtp1 Negative_regulation of Gpt 1 0.09 0.58 0.71 25.00
77 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69 25.00
78 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69 25.00
79 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66 25.00
80 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6 25.00
81 INT151460 Olr1745 Positive_regulation of Il4 1 0.04 0.83 0.59 25.00
82 INT157141 Cpox Positive_regulation of Gene_expression of Camk2a 1 0.19 0.13 0.58 25.00
83 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58 25.00
84 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57 25.00
85 INT151461 Olr1745 Negative_regulation of Gene_expression of Il6 1 0.03 0.81 0.57 25.00
86 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54 25.00
87 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54 25.00
88 INT76200 CASP1 Positive_regulation of Gene_expression of PTGS1 1 0.05 0.16 0.54 25.00
89 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53 25.00
90 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52 25.00
91 INT129911 Skiv2l Negative_regulation of Localization of IL1A 1 0.01 0.74 0.48 25.00
92 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47 25.00
93 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47 25.00
94 INT103032 Calca Positive_regulation of Calca Positive_regulation of Nos3 1 0.24 0.41 0.46 25.00
95 INT103025 Calca Positive_regulation of Nos3 1 0.25 0.41 0.46 25.00
96 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46 25.00
97 INT103027 Ptgis Positive_regulation of Nos3 1 0.06 0.42 0.46 25.00
98 INT149690 M1 Negative_regulation of CYP2C8 1 0.19 0.05 0.46 25.00
99 INT103026 Ptgis Positive_regulation of Ptgs1 1 0.02 0.42 0.46 25.00
100 INT103029 Calca Positive_regulation of Positive_regulation of Ptgs1 1 0.12 0.41 0.46 25.00
101 INT103030 Calca Positive_regulation of Positive_regulation of Nos3 1 0.26 0.41 0.46 25.00
102 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45 25.00
103 INT103028 Calca Positive_regulation of Gene_expression of Ptgis 1 0.17 0.58 0.44 25.00
104 INT158267 Olr1745 Negative_regulation of Alox5 1 0.05 0.94 0.43 25.00
105 INT118519 Slc8a1 Negative_regulation of Positive_regulation of Nfkb1 1 0.16 0.59 0.42 25.00
106 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39 25.00
107 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37 25.00
108 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37 25.00
109 INT74938 Negative_regulation of IL1B Positive_regulation of PTGER2 1 0.07 0.23 0.36 25.00
110 INT157147 LSS Positive_regulation of PTGIR 1 0.09 0.96 0.36 25.00
111 INT157148 LSS Negative_regulation of TNF 1 0.25 0.74 0.35 25.00
112 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35 25.00
113 INT105437 IRF6 Positive_regulation of Localization of PTGER1 1 0.01 0.61 0.31 25.00
114 INT105433 CPOX Negative_regulation of IRF6 Positive_regulation of PTGER1 1 0.01 0.62 0.31 25.00
115 INT105438 IRF6 Positive_regulation of PTGER1 1 0.01 0.61 0.3 25.00
116 INT74940 HGF Positive_regulation of CPOX 1 0.13 0.25 0.3 25.00
117 INT93580 Hgf Positive_regulation of Cpox 1 0.19 2.2 0.29 25.00
118 INT74942 HGF Positive_regulation of PTGS1 1 0.11 0.25 0.29 25.00
119 INT100946 TNF Positive_regulation of Localization of NFIB 1 0.01 1.3 0.29 25.00
120 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29 25.00
121 INT93581 Hgf Positive_regulation of Hgf Positive_regulation of Cpox 1 0.14 2.21 0.29 25.00
122 INT100945 TNF Positive_regulation of NFIB 1 0.00 1.29 0.29 25.00
123 INT102335 DFP Negative_regulation of Ptgs1 1 0.04 0.31 0.28 25.00
124 INT158266 Olr1745 Negative_regulation of Ptgs1 1 0.01 0.52 0.27 25.00
125 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27 25.00
126 INT158265 Olr1745 Negative_regulation of Gene_expression of Ltb 1 0.01 0.52 0.27 25.00
127 INT156587 Hst1 Negative_regulation of Gene_expression of Cpox 1 0.15 0.82 0.26 25.00
128 INT156589 Hst1 Negative_regulation of Mpo 1 0.41 0.95 0.26 25.00
129 INT145660 Zfp329 Positive_regulation of Gene_expression of VEGFA 1 0.00 0.51 0.25 25.00
130 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25 25.00
131 INT80704 CAMP Positive_regulation of Gene_expression of HGF 1 0.50 0.46 0.22 25.00
132 INT80706 IL4I1 Positive_regulation of Gene_expression of HGF 1 0.06 0.43 0.22 25.00
133 INT80705 IL4I1 Positive_regulation of HGF 1 0.03 0.43 0.22 25.00
134 INT157146 LSS Negative_regulation of Positive_regulation of TNF 1 0.25 1.08 0.21 25.00
135 INT97472 CPOX Regulation of Gene_expression of MRXS5 1 0.02 0.16 0.21 25.00
136 INT90772 Binding of AKR1C4 and AKR1C1 1 0.39 0.08 0.2 25.00
137 INT114967 ERI1 Negative_regulation of CPOX 1 0.00 0.25 0.14 25.00
138 INT93579 Positive_regulation of Hgf Positive_regulation of Cpox 1 0.14 1.1 0.14 25.00
139 INT141001 Negative_regulation of CPOX Regulation of Localization of INS 1 0.17 0.07 0.14 25.00
140 INT67619 Inpp5k Negative_regulation of Ptgs1 1 0.03 0.5 0.13 25.00
141 INT105439 IL6 Positive_regulation of CPOX 1 0.11 0.75 0.12 25.00
142 INT105434 TNF Positive_regulation of CPOX 1 0.27 0.75 0.12 25.00
143 INT156588 Hst1 Positive_regulation of Gene_expression of Nos2 1 0.27 0.48 0.12 25.00
144 INT105436 IRF6 Positive_regulation of CPOX 1 0.08 0.74 0.11 25.00
145 INT142002 Trav9n-1 Negative_regulation of CDC42BPA 1 0.00 0 0.09 25.00
146 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09 25.00
147 INT169343 OXT Negative_regulation of Gene_expression of Txn1 1 0.00 0.58 0.08 25.00
148 INT141997 HEY1 Negative_regulation of CDC42BPA 1 0.00 0 0.08 25.00
149 INT152891 Ptger2 Positive_regulation of Positive_regulation of JUN 1 0.00 0.23 0.07 25.00
150 INT116388 Binding of Adm and Cpox 1 0.14 0.2 0.05 25.00
151 INT157151 LSS Positive_regulation of CPOX 1 0.17 0.89 0.05 25.00
152 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04 25.00
153 INT126110 Chrng Positive_regulation of Chrm1 1 0.00 0.1 0 25.00
154 INT126111 Chrm1 Positive_regulation of Chrng 1 0.00 0.1 0 25.00
155 INT196879 Cpox Negative_regulation of Gene_expression of Tbxa2r 1 0.04 0.8 0.56 24.88
156 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05 24.80
157 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49 23.56
158 INT201727 Ngf Positive_regulation of Nfkb1 1 0.01 1 0.48 22.48
159 INT338051 Ngf Positive_regulation of Localization of F2 1 0.11 0 0.32 14.36
160 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85 13.68
161 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 13.04
162 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58 10.00
163 INT149982 Negative_regulation of Cpox Negative_regulation of Gene_expression of FLII 1 0.01 0 0 10.00
164 INT141576 Slc6a14 Positive_regulation of Gene_expression of Tnf 1 0.05 0.07 0 10.00
165 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
166 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4 5.00
167 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81 5.00
168 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92 5.00
169 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9 5.00
170 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71 5.00
171 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44 5.00
172 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
173 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16 5.00
174 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02 5.00
175 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83 5.00
176 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81 5.00
177 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8 5.00
178 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8 5.00
179 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76 5.00
180 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76 5.00
181 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75 5.00
182 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75 5.00
183 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72 5.00
184 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71 5.00
185 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71 5.00
186 INT262571 Phosphorylation of Trpv1 Positive_regulation of Localization of Calca 1 0.17 0.71 0.7 5.00
187 INT262570 Binding of Pax3 and Trpv1 1 0.02 1.05 0.67 5.00
188 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67 5.00
189 INT262576 Binding of Calca and Trpv1 1 0.13 1.05 0.66 5.00
190 INT340298 Ea1 Positive_regulation of Ppargc1a 1 0.05 1.03 0.64 5.00
191 INT196877 Trpv1 Positive_regulation of Localization of Calca 1 0.11 0.41 0.62 5.00
192 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 5.00
193 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51 5.00
194 INT262565 Prkaca Regulation of Negative_regulation of Trpv1 1 0.05 0.21 0.5 5.00
195 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5 5.00
196 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46 5.00
197 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44 5.00
198 INT338059 Nrtn Positive_regulation of Gene_expression of F2r 1 0.12 0.45 0.41 5.00
199 INT340301 Ea1 Positive_regulation of Gene_expression of ACOX1 1 0.01 0.72 0.4 5.00
200 INT253482 H37 Positive_regulation of Gene_expression of Gopc 1 0.00 3.99 0.4 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for cOX1. They are ordered first by their pain relevance and then by number of times they were reported in cOX1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 100.00
2 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 100.00
3 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 100.00
4 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 100.00
5 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 100.00
6 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 100.00
7 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 100.00
8 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 100.00
9 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 100.00
10 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 100.00
11 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 100.00
12 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 100.00
13 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 100.00
14 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 100.00
15 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 100.00
16 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 100.00
17 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41 100.00
18 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49 100.00
19 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 100.00
20 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 100.00
21 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 100.00
22 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 100.00
23 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 100.00
24 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 100.00
25 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 100.00
26 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
27 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 100.00
28 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 100.00
29 INT64917 Regulation of DHRS9 2 0.28 0.25 0.88 100.00
30 INT64915 Regulation of Negative_regulation of PTGS1 4 0.20 1.81 1.76 100.00
31 INT55335 Binding of Cpox 49 0.34 15.48 18.46 100.00
32 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56 100.00
33 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4 100.00
34 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 100.00
35 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 100.00
36 INT81194 Binding of CPOX 40 0.29 23.7 18.95 100.00
37 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37 100.00
38 INT101744 Positive_regulation of COX1 4 0.67 1.16 1.83 100.00
39 INT20234 Regulation of Gene_expression of Ptgs1 11 0.44 6.55 7.72 100.00
40 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9 100.00
41 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39 100.00
42 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 100.00
43 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 100.00
44 INT130199 Negative_regulation of Binding of CPOX 4 0.30 1.89 2.1 100.00
45 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 100.00
46 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6 100.00
47 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29 100.00
48 INT53476 Positive_regulation of Localization of Ptgs1 6 0.49 2.88 2.35 100.00
49 INT128128 Negative_regulation of Cox4i2 1 0.42 0.2 0.88 100.00
50 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4 100.00
51 INT169435 Gene_expression of CHPT1 17 0.61 10.04 7.37 100.00
52 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 100.00
53 INT75918 Negative_regulation of Negative_regulation of Cpox 19 0.23 10.05 14.4 100.00
54 INT79685 Positive_regulation of Gene_expression of Pparg 17 0.70 14.63 11.03 100.00
55 INT74812 Negative_regulation of Positive_regulation of Cpox 17 0.34 10.1 9.94 100.00
56 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53 100.00
57 INT71381 Localization of Nos1 33 0.79 11.46 8.05 100.00
58 INT76427 Regulation of Negative_regulation of Cpox 17 0.31 6.75 7.93 100.00
59 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17 100.00
60 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86 100.00
61 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5 100.00
62 INT112070 Negative_regulation of Gene_expression of Pparg 6 0.59 3.72 3.96 100.00
63 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81 100.00
64 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94 100.00
65 INT92544 Localization of Hmox2 1 0.45 0.73 1.87 100.00
66 INT94934 Negative_regulation of COX1 3 0.57 3.27 1.75 100.00
67 INT98497 Regulation of PAPPA 5 0.44 3.18 1.74 100.00
68 INT29836 Regulation of MTHFS 6 0.33 1.43 1.67 100.00
69 INT119346 Positive_regulation of PTGIR 9 0.58 6.2 1.61 100.00
70 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 100.00
71 INT101026 Positive_regulation of Negative_regulation of Ptgs2 2 0.35 1.01 1.23 100.00
72 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05 100.00
73 INT99326 Negative_regulation of Pdha1 2 0.42 0.85 0.84 100.00
74 INT130508 Negative_regulation of Ptges2 1 0.02 0.8 0.75 100.00
75 INT157156 Negative_regulation of Positive_regulation of PTGIR 1 0.12 1.78 0.71 100.00
76 INT82544 Regulation of Positive_regulation of PTGS2 4 0.39 1.41 0.71 100.00
77 INT272291 Regulation of Binding of CPOX 1 0.11 0.37 0.67 100.00
78 INT142835 Regulation of Localization of Ptgs2 2 0.25 0.26 0.5 100.00
79 INT68509 Regulation of COX4I2 1 0.16 0.2 0.36 100.00
80 INT82545 Positive_regulation of Regulation of PTGS2 1 0.19 0.15 0.35 100.00
81 INT84143 Negative_regulation of Positive_regulation of Hmox2 2 0.03 0.17 0.35 100.00
82 INT101745 Positive_regulation of Positive_regulation of COX1 1 0.49 0 0.34 100.00
83 INT141727 Regulation of Binding of Ptgs1 1 0.11 0.33 0.28 100.00
84 INT141725 Regulation of Binding of Cpox 1 0.15 0.33 0.28 100.00
85 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47 99.98
86 INT267677 Negative_regulation of COX2 1 0.42 0.92 1.66 99.98
87 INT78353 Positive_regulation of Positive_regulation of PTGS1 4 0.27 0.95 1.06 99.92
88 INT320936 Gene_expression of ANGPT4 1 0.04 0 0.18 99.90
89 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 99.90
90 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 99.84
91 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 99.84
92 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12 99.84
93 INT74022 Regulation of Positive_regulation of Cpox 6 0.24 5.73 3.41 99.84
94 INT25601 Binding of IL36RN 5 0.35 1.93 2.9 99.84
95 INT787 Localization of Ptgs1 31 0.80 12.36 11.55 99.82
96 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 99.82
97 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9 99.82
98 INT90097 Localization of PTGS2 15 0.69 6.14 6.63 99.82
99 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 99.80
100 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 99.80
101 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53 99.80
102 INT91413 Negative_regulation of PTGES 35 0.58 17.94 12.03 99.80
103 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 99.80
104 INT145063 Negative_regulation of Selenbp2 1 0.04 0.05 0.98 99.80
105 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 99.76
106 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 99.76
107 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 99.76
108 INT39256 Localization of PTGS1 17 0.74 6.62 5.1 99.76
109 INT105445 Localization of HMOX1 5 0.71 3.11 0.98 99.76
110 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 99.74
111 INT78958 Regulation of Negative_regulation of Ptgs2 6 0.42 2.61 2.3 99.74
112 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 99.70
113 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 99.68
114 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23 99.68
115 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 99.68
116 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 99.66
117 INT92545 Regulation of Hmox2 1 0.15 1.09 2.5 99.66
118 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 99.64
119 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 99.64
120 INT91276 Positive_regulation of Negative_regulation of Cpox 4 0.27 3.11 2.2 99.64
121 INT79502 Gene_expression of Pvalb 26 0.78 2.83 7.46 99.60
122 INT104733 Positive_regulation of Gene_expression of Ren1 24 0.67 43.87 2.47 99.60
123 INT43091 Positive_regulation of Negative_regulation of Ace 3 0.30 1.51 0.48 99.60
124 INT18523 Negative_regulation of ALOX15 15 0.59 14.2 5.92 99.58
125 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 99.56
126 INT86516 Positive_regulation of Hmox2 6 0.69 3.22 4.39 99.56
127 INT1116 Regulation of Ren 103 0.62 27.66 33.26 99.54
128 INT78991 Regulation of Positive_regulation of Cpox 2 0.22 3.86 0.44 99.54
129 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78 99.46
130 INT148089 Gene_expression of Dock6 1 0.17 0.16 0.42 99.44
131 INT62500 Transcription of Ptgs1 10 0.56 4.54 4.52 99.42
132 INT44163 Gene_expression of Ren1 69 0.78 97.75 6.27 99.42
133 INT66237 Positive_regulation of Ptgis 5 0.33 1.49 1.96 99.42
134 INT103023 Positive_regulation of Positive_regulation of Ptgis 1 0.18 0.7 0.8 99.42
135 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 99.40
136 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 99.40
137 INT76405 Positive_regulation of Hmox2 21 0.43 12.77 8.99 99.32
138 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39 99.26
139 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13 99.24
140 INT94004 Negative_regulation of Lox 31 0.59 13.76 10.45 99.22
141 INT265338 Regulation of Eng 2 0.42 0.94 0.05 99.20
142 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 99.18
143 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82 99.16
144 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52 99.00
145 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44 99.00
146 INT61114 Gene_expression of Ppard 23 0.75 14.98 6.62 98.96
147 INT812 Localization of INS 1026 0.81 515.6 145.31 98.96
148 INT95056 Positive_regulation of Gene_expression of Ppard 5 0.52 3.84 1.6 98.96
149 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 98.92
150 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 98.92
151 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 98.90
152 INT94428 Negative_regulation of Gene_expression of NOS2 20 0.47 11.61 5.62 98.86
153 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 98.86
154 INT29745 Binding of APP 47 0.48 26.49 12.4 98.84
155 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17 98.82
156 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 98.78
157 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 98.74
158 INT64484 Binding of PNOC 12 0.33 5.51 10.86 98.70
159 INT86544 Positive_regulation of Camk2a 20 0.47 4.59 11.37 98.68
160 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 98.66
161 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 98.66
162 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.64
163 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 98.64
164 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 98.60
165 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 98.60
166 INT74946 Negative_regulation of Gene_expression of HGF 14 0.58 6.29 3.39 98.60
167 INT62813 Negative_regulation of ZNF398 12 0.09 6.2 4.49 98.60
168 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 98.56
169 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 98.44
170 INT66857 Regulation of CCL2 39 0.53 28.55 18.35 98.40
171 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 98.32
172 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83 98.32
173 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 98.30
174 INT5069 Negative_regulation of Mthfs 69 0.57 22.54 31.36 98.30
175 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 98.24
176 INT22764 Localization of Ptger2 81 0.64 24.38 26.77 98.12
177 INT136754 Gene_expression of SCARB1 64 0.77 43.28 4.82 98.12
178 INT136752 Positive_regulation of Gene_expression of SCARB1 5 0.69 10.63 1.76 98.12
179 INT78059 Regulation of Localization of Ptger2 4 0.12 0.79 1.59 98.12
180 INT136753 Regulation of Gene_expression of SCARB1 2 0.60 7.79 0.77 98.12
181 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 98.08
182 INT4528 Negative_regulation of Sell 12 0.58 4.76 4.22 98.06
183 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 97.90
184 INT117735 Positive_regulation of Regulation of Nfkb1 3 0.44 2.93 0.91 97.80
185 INT88640 Localization of TTR 5 0.75 1.71 0.3 97.76
186 INT320937 Negative_regulation of Gene_expression of ANGPT4 1 0.03 0 0.09 97.72
187 INT74944 Positive_regulation of Gene_expression of HGF 31 0.70 17.69 6.68 97.72
188 INT78404 Gene_expression of COX5A 24 0.75 9.73 7.07 97.68
189 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 97.68
190 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 97.56
191 INT86700 Regulation of Cav1 7 0.54 0.92 0.61 97.40
192 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 97.40
193 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5 97.40
194 INT14962 Gene_expression of Pf4 27 0.76 22.48 10.88 97.40
195 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.36
196 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 97.24
197 INT87361 Negative_regulation of TTR 25 0.57 5.74 1.51 97.16
198 INT95942 Gene_expression of LOC364790 1 0.02 0.91 0.54 97.14
199 INT65089 Positive_regulation of ACP5 4 0.50 1.67 0.57 97.00
200 INT310891 Gene_expression of 53T 28 0.50 35.4 7.17 96.80
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