P:carrageenan induced

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Pain Term
Category Other
Synonyms Carrageenan Induced Acute Paw, Carrageenan Induced Edema, Carrageenan Induced Hind Paw Edema, Carrageenan Induced Paw Edema, Carrageenan Paw Model, Carrageenin Induced, Carrageenin Induced Paw Edema
Pain Specific No
Documents 122
Hot Single Events 73
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for carrageenan induced. They are ordered first by their pain relevance and then by number of times they were reported for carrageenan induced. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT63521 Negative_regulation of Ptgs2 Negative_regulation of Gene_expression of Fos 1 0.66 0.1 0.12 86.52
2 INT190788 Adcy8 Positive_regulation of Adcy1 1 0.23 0.77 0.77 32.68
3 INT191762 FPR1 Positive_regulation of Gene_expression of IGKV1D-39 1 0.01 0.84 0.56 25.84
4 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83 25.00
5 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81 5.00
6 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75 5.00
7 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
8 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01 5.00
9 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97 5.00
10 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92 5.00
11 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8 5.00
12 INT182839 Camk4 Positive_regulation of Creb1 3 0.49 1.81 0.79 5.00
13 INT276865 Regulation of Trpv1 Regulation of Gene_expression of Gpr65 1 0.25 0.62 0.76 5.00
14 INT186160 Negative_regulation of Grin2b Negative_regulation of Grin1 1 0.37 0.5 0.72 5.00
15 INT186162 Phosphorylation of Prkaca Positive_regulation of Phosphorylation of Prkcg 1 0.04 0.22 0.7 5.00
16 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62 5.00
17 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55 5.00
18 INT14992 FPR1 Positive_regulation of Localization of MPO 2 0.56 1.1 0.49 5.00
19 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36 5.00
20 INT182837 Binding of Creb1 and Crebbp 1 0.12 0.57 0.32 5.00
21 INT339294 Il1 Positive_regulation of Gene_expression of Cxcl1 1 0.06 0.53 0.3 5.00
22 INT339287 Binding of Cxcr2 and Cxcl1 1 0.29 0.48 0.24 5.00
23 INT339292 Il1 Positive_regulation of Gene_expression of Ptger2 1 0.02 0.4 0.2 5.00
24 INT300469 Ros1 Regulation of Gene_expression of Fasl 1 0.03 0.88 0.2 5.00
25 INT191759 NFASC Negative_regulation of ELANE 1 0.00 0.98 0.11 5.00
26 INT191755 ROS1 Positive_regulation of JUN 1 0.00 0.54 0.08 5.00
27 INT191757 ROS1 Positive_regulation of TBK1 1 0.00 0.6 0.08 5.00
28 INT191758 ROS1 Positive_regulation of TFAP2A 1 0.01 0.54 0.08 5.00
29 INT191756 NFASC Positive_regulation of Gene_expression of IGKV1D-39 1 0.00 0.11 0.06 5.00
30 INT191760 NFASC Positive_regulation of Localization of MPO 1 0.00 0.55 0.04 5.00
31 INT191761 FPR1 Regulation of Localization of MPO 1 0.02 0.52 0.03 5.00
32 INT339288 Binding of Hprt1 and Il1 1 0.09 0.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for carrageenan induced. They are ordered first by their pain relevance and then by number of times they were reported in carrageenan induced. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 100.00
2 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
3 INT55633 Positive_regulation of Gene_expression of FLII 5 0.42 1.54 2.32 100.00
4 INT123816 Positive_regulation of Gene_expression of Parp1 9 0.50 6.64 1.04 100.00
5 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 99.90
6 INT123815 Gene_expression of Parp1 42 0.67 27.82 3.02 99.90
7 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.74
8 INT10555 Gene_expression of FLII 37 0.75 7.81 17.6 99.74
9 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 99.60
10 INT3928 Localization of Bdkrb1 15 0.75 4.06 7.23 98.36
11 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 98.04
12 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 97.88
13 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 97.84
14 INT133461 Phosphorylation of Grina 2 0.19 1.46 2.25 96.80
15 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 96.44
16 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 96.44
17 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 96.44
18 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77 96.44
19 INT35683 Gene_expression of Gsr 24 0.46 16.94 3.6 96.44
20 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 96.40
21 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55 96.40
22 INT101198 Regulation of Gene_expression of Grina 3 0.15 1.04 2.32 95.16
23 INT50419 Gene_expression of Grina 13 0.25 6.11 6.42 94.72
24 INT62254 Negative_regulation of FLII 20 0.48 4.11 9.44 94.68
25 INT66549 Negative_regulation of Positive_regulation of FLII 9 0.36 3.08 5.74 94.68
26 INT10929 Positive_regulation of FLII 46 0.67 13.17 24.63 93.88
27 INT169697 Negative_regulation of Ephx2 35 0.59 38.21 5.92 93.76
28 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 93.40
29 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 92.96
30 INT46118 Negative_regulation of Protein_catabolism of Alb 1 0.31 0.27 0.3 92.96
31 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 92.88
32 INT46117 Positive_regulation of Protein_catabolism of Alb 1 0.37 0.27 0.3 92.32
33 INT14103 Regulation of Hrh1 6 0.44 2.67 2.74 92.20
34 INT46116 Protein_catabolism of Alb 2 0.65 0.46 0.34 92.00
35 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 89.36
36 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 89.08
37 INT27415 Negative_regulation of Positive_regulation of Got1 15 0.51 10.99 5.14 89.00
38 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 87.76
39 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 87.36
40 INT87432 Regulation of Gene_expression of Il1rl1 6 0.58 4.5 6.62 87.36
41 INT158669 Negative_regulation of Camk4 43 0.58 26.82 5.04 87.20
42 INT20129 Regulation of Il1 53 0.53 44.14 19.89 87.04
43 INT66026 Gene_expression of Cxcl1 74 0.78 31.87 23.37 86.96
44 INT5649 Negative_regulation of Positive_regulation of Mpo 31 0.59 26.62 11.92 86.72
45 INT108780 Positive_regulation of Gene_expression of Ptger2 94 0.49 59.71 16.22 86.48
46 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 86.32
47 INT35803 Positive_regulation of Pla2g3 2 0.18 3.62 0.23 86.16
48 INT76542 Negative_regulation of Sgp2 2 0.00 0.23 0.23 85.96
49 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 85.84
50 INT81664 Positive_regulation of Gene_expression of Pnoc 12 0.68 2.51 9.75 85.64
51 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 85.52
52 INT68686 Gene_expression of Olr1869 5 0.39 2.3 3.21 85.52
53 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 85.16
54 INT3699 Gene_expression of H2-Ab1 24 0.74 12.06 11.82 85.16
55 INT146055 Gene_expression of Gpr68 3 0.63 8.12 6.99 85.04
56 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 84.44
57 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58 84.32
58 INT62253 Regulation of Gene_expression of FLII 3 0.60 0.98 1.73 84.16
59 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 83.88
60 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21 83.80
61 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35 83.80
62 INT39266 Negative_regulation of Localization of Neu1 6 0.30 4.66 2.6 83.16
63 INT1701 Localization of Neu1 11 0.69 6.36 4.18 82.56
64 INT120340 Negative_regulation of Abt1 2 0.10 1.27 1.45 82.56
65 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 81.40
66 INT65638 Negative_regulation of Gene_expression of Il1rl1 12 0.58 7.86 11.7 80.92
67 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71 80.88
68 INT258089 Gene_expression of Gpr4 8 0.56 6.17 5.12 80.76
69 INT276831 Negative_regulation of Gene_expression of Gpr4 1 0.43 2.52 2.57 80.76
70 INT68581 Transcription of Pnoc 4 0.70 1.21 3.54 80.56
71 INT96825 Positive_regulation of Transcription of Pnoc 1 0.49 0.41 0.47 80.56
72 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17 80.28
73 INT94004 Negative_regulation of Lox 31 0.59 13.76 10.45 80.28
74 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 79.08
75 INT115071 Positive_regulation of Accn3 14 0.70 16.56 14.24 77.48
76 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 76.24
77 INT276854 Negative_regulation of Gpr132 1 0.25 7.14 7.83 76.12
78 INT1491 Regulation of Rtcd1 33 0.53 5.17 13.4 74.44
79 INT190780 Regulation of Gene_expression of Rtcd1 2 0.19 0.93 0.68 74.44
80 INT12726 Gene_expression of Rtcd1 17 0.32 2.55 4.76 73.68
81 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13 72.64
82 INT145126 Positive_regulation of GLRX 5 0.12 4.55 2.53 72.52
83 INT70539 Negative_regulation of Cxcl1 13 0.57 7.15 4.58 72.08
84 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 71.28
85 INT100124 Gene_expression of Accn3 38 0.78 30.02 23.63 71.28
86 INT276840 Negative_regulation of Negative_regulation of Gpr4 1 0.31 2.34 2.62 70.56
87 INT276841 Negative_regulation of Gpr4 1 0.43 5.68 6.7 70.36
88 INT276845 Regulation of Gpr132 1 0.19 2.34 2.63 70.36
89 INT276829 Regulation of Gpr4 1 0.33 2.33 2.62 70.36
90 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 68.04
91 INT28096 Regulation of Wbc1 4 0.06 2.79 0.82 67.80
92 INT154773 Regulation of Accn3 7 0.62 7.09 6.63 66.40
93 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63 66.12
94 INT53574 Regulation of Tnf 45 0.62 40.68 19.71 66.12
95 INT51028 Regulation of Il1b 28 0.60 21.15 12.47 66.12
96 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05 66.12
97 INT83618 Regulation of Positive_regulation of Il1b 2 0.44 1.04 0.58 66.12
98 INT276826 Negative_regulation of Transcription of Gpr4 1 0.31 1.21 1.48 65.60
99 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 65.44
100 INT37139 Negative_regulation of Fdps 9 0.38 4.33 4.46 65.36
101 INT276859 Transcription of Gpr132 1 0.30 2.19 2.44 65.28
102 INT276832 Transcription of Gpr4 1 0.50 2.19 2.44 65.28
103 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 65.20
104 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 65.08
105 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 64.80
106 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 60.80
107 INT78354 Positive_regulation of Positive_regulation of CPOX 8 0.19 2.82 1.06 60.80
108 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68 59.96
109 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 58.56
110 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48 58.16
111 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 57.44
112 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29 55.04
113 INT68290 Gene_expression of Accn1 32 0.73 7.36 11.23 53.36
114 INT263204 Transcription of SERPINB1 4 0.11 3.09 0.45 52.72
115 INT300465 Positive_regulation of Lxl 1 0.45 0.47 0.2 52.16
116 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 51.32
117 INT276828 Gene_expression of Gpr132 1 0.33 6.26 5.29 49.56
118 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 48.20
119 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34 47.68
120 INT263205 Negative_regulation of Gene_expression of XDH 2 0.41 0.63 0.1 47.68
121 INT146053 Positive_regulation of Gpr65 2 0.61 12.11 13.38 45.92
122 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 45.88
123 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 45.68
124 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6 45.68
125 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 43.20
126 INT276855 Positive_regulation of Gene_expression of Gpr65 1 0.61 17.04 16.96 43.20
127 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 42.56
128 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 41.60
129 INT73608 Localization of Nos2 21 0.75 9.58 5.05 41.24
130 INT171820 Localization of Fig4 144 0.65 27.38 20.88 41.04
131 INT233457 Gene_expression of Gpr65 56 0.68 26.57 27.94 40.80
132 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 38.88
133 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 38.56
134 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 38.56
135 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67 36.80
136 INT276824 Negative_regulation of Plin1 1 0.13 1 1.09 35.80
137 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 33.60
138 INT113209 Localization of LOC100366216 2 0.08 0.91 2.56 31.60
139 INT146057 Positive_regulation of Gpr4 2 0.60 2.26 1.95 30.16
140 INT276851 Positive_regulation of Transcription of Gpr4 1 0.36 0.99 0.96 30.16
141 INT146058 Positive_regulation of Gpr132 2 0.48 2.26 1.95 29.92
142 INT276856 Positive_regulation of Transcription of Gpr132 1 0.21 0.99 0.96 29.92
143 INT276837 Positive_regulation of Transcription of Gpr65 1 0.61 1.76 1.62 29.56
144 INT276848 Transcription of Gpr65 1 0.63 1.75 1.61 29.56
145 INT2605 Regulation of ELANE 39 0.61 18.22 7.11 29.48
146 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85 29.36
147 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 26.44
148 INT34182 Regulation of Gene_expression of IGKV1D-39 2 0.22 0.33 0.22 26.24
149 INT191763 Regulation of IGKV1D-39 1 0.03 0.19 0.1 26.24
150 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 25.88
151 INT30294 Gene_expression of IGKV1D-39 30 0.62 8.66 5.26 25.84
152 INT19775 Localization of Il1 183 0.78 145.5 50.91 25.00
153 INT8248 Binding of Adra2a 43 0.48 6.72 22.17 25.00
154 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 17.84
155 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 17.84
156 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 17.84
157 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 17.84
158 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 17.84
159 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26 17.84
160 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64 17.84
161 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 17.76
162 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 10.48
163 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6 8.84
164 INT190782 Negative_regulation of Adcy8 3 0.58 4.37 1.84 8.84
165 INT64947 Positive_regulation of Gene_expression of IGKV1D-39 2 0.19 0.19 1.29 5.88
166 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 5.00
167 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
168 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
169 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
170 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
171 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
172 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
173 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
174 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
175 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 5.00
176 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
177 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
178 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
179 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
180 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
181 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
182 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
183 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
184 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57 5.00
185 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
186 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
187 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
188 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
189 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
190 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
191 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
192 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 5.00
193 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 5.00
194 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
195 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
196 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
197 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
198 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77 5.00
199 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 5.00
200 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
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