P:chronic pain

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Pain Term
Category Disorder
Synonyms Lasting Pain, Persistent Pain
Pain Specific Yes
Documents 15745
Hot Single Events 200
Hot Interactions 167

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for chronic pain. They are ordered first by their pain relevance and then by number of times they were reported for chronic pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66 100.00
2 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66 100.00
3 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 99.96
4 INT287096 Binding of Bdnf and FL 1 0.16 1.15 0.6 99.96
5 INT287101 Binding of Bdnf and Mutyh 1 0.04 0.58 0.24 99.96
6 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9 99.92
7 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81 99.92
8 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8 99.92
9 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8 99.92
10 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72 99.92
11 INT334928 Binding of pr and Aes 1 0.00 1.49 3.38 99.76
12 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82 99.48
13 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36 99.44
14 INT87169 Creb1 Positive_regulation of Gene_expression of Nkx1-1 1 0.11 0.17 0.21 99.28
15 INT113611 Binding of Pick1 and Grip2 1 0.31 0.6 0.63 98.92
16 INT113610 Binding of Nsf and Grip2 1 0.24 0.6 0.63 98.92
17 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61 98.72
18 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88 98.68
19 INT254004 Cxcl12 Positive_regulation of Cxcr4 1 0.47 1.29 0.86 98.68
20 INT340117 Binding of Bdnf and Pain1 1 0.01 2.48 2.55 98.54
21 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21 98.52
22 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2 98.52
23 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12 98.52
24 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4 98.40
25 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 98.36
26 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62 98.16
27 INT118653 Binding of Bdnf and Creb1 1 0.39 0.19 0.3 98.04
28 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66 97.64
29 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78 97.56
30 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29 97.56
31 INT91393 Crh Positive_regulation of SST 1 0.01 0.73 0.58 97.52
32 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8 97.36
33 INT142868 YY1 Positive_regulation of Oprd1 1 0.01 0.1 0.55 97.28
34 INT208946 Positive_regulation of Tacr1 Positive_regulation of Gene_expression of S100a8 1 0.02 1.11 0.8 97.24
35 INT249537 Binding of Ephb1 and Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.68 0.71 97.20
36 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37 97.08
37 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 0.29 0.32 0.69 97.08
38 INT82020 Negative_regulation of Binding of Trib3 and Ngf 1 0.07 0.31 0.68 97.08
39 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11 97.04
40 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85 96.88
41 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02 96.80
42 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16 96.72
43 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14 96.60
44 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92 96.56
45 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05 96.56
46 INT82022 Binding of Trib3 and Ngf 1 0.08 0.31 0.68 96.56
47 INT75247 Abat Regulation of Gene_expression of Tacr1 1 0.23 0.41 1.03 96.52
48 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62 96.28
49 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 96.28
50 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 96.28
51 INT120999 Binding of Oprm1 and Ifng 1 0.22 0.57 0.84 96.28
52 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79 96.24
53 INT282139 Grm1 Regulation of Grip2 1 0.00 0.62 0.69 96.20
54 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 96.12
55 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 96.12
56 INT133653 Epo Regulation of Transcription of TNF 1 0.22 1.09 0.33 95.96
57 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24 95.80
58 INT282141 Grm5 Regulation of Grip2 1 0.00 0.61 0.69 95.76
59 INT119457 Binding of Pts and Del(7)Tyr<c-23DVT>-p 1 0.01 1.34 0.1 95.76
60 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 95.56
61 INT340118 Binding of Sugt1 and Pain1 1 0.00 3.53 3.44 95.12
62 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59 95.08
63 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72 95.08
64 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15 95.08
65 INT166303 Adrbk1 Positive_regulation of Binding of Mapk14 and Gpbar1 1 0.22 0.65 0.65 95.08
66 INT166300 Adrbk1 Positive_regulation of Negative_regulation of Gpbar1 1 0.39 0.63 0.58 95.08
67 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82 95.04
68 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28 94.92
69 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98 94.80
70 INT118157 Binding of Prkca and Prkcz Positive_regulation of Binding of Prkca Prkcz 1 0.02 0.58 1.55 94.80
71 INT118159 Binding of Prkca and Prkcz Positive_regulation of Prkcz 1 0.02 0.58 1.54 94.80
72 INT118160 Binding of Prkca and Prkcz Positive_regulation of Prkca 1 0.11 0.58 1.54 94.80
73 INT100559 Binding of Grin1 and LOC502940 1 0.13 0.61 0.8 94.08
74 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95 94.00
75 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7 93.96
76 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7 93.96
77 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7 93.96
78 INT110407 Htr1a Positive_regulation of Gene_expression of Fos 1 0.50 0.52 0.66 93.60
79 INT155663 Positive_regulation of P2rx4 Positive_regulation of Localization of Bdnf 1 0.42 0.84 1.25 93.52
80 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8 93.48
81 INT133651 Epo Regulation of TNF 1 0.50 1.25 0.38 93.32
82 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79 93.04
83 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95 93.04
84 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84 92.88
85 INT305034 Adcy8 Regulation of Localization of Adcy1 1 0.35 1.51 0.77 92.60
86 INT305033 Adcy1 Regulation of Localization of Adcy8 1 0.35 1.51 0.77 92.60
87 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69 92.56
88 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64 92.48
89 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29 92.36
90 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83 92.36
91 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95 92.08
92 INT166299 Binding of Mapk14 and Gpbar1 1 0.13 0.64 0.65 92.08
93 INT166302 Negative_regulation of Binding of Mapk14 and Gpbar1 1 0.12 0.64 0.65 92.08
94 INT296463 Binding of Gria1 and Pick1 1 0.16 0.32 0.59 92.08
95 INT82306 Bdnf Positive_regulation of Gene_expression of Fos 1 0.68 0.64 0.65 91.92
96 INT197239 Grik1 Regulation of Localization of Gabrg1 1 0.10 0.56 0.61 91.84
97 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31 91.36
98 INT249494 Binding of Ephb1 and Efnb1 1 0.01 1.34 1.4 91.28
99 INT192134 Ngf Positive_regulation of Trpv1 1 0.18 1.22 0.79 90.88
100 INT287102 FL Positive_regulation of Bdnf 1 0.20 0.61 0.2 90.72
101 INT287100 FL Positive_regulation of Ntrk2 1 0.30 0.61 0.2 90.72
102 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79 90.64
103 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66 90.56
104 INT296486 Binding of Pick1 and GRIP1 1 0.03 0.32 0.59 90.48
105 INT113743 Mc3r Regulation of Gene_expression of Agrp 1 0.05 0.9 0.98 90.20
106 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66 90.20
107 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89 89.88
108 INT352462 Gse1 Positive_regulation of Gene_expression of Tnc 1 0.05 0.75 0.64 89.80
109 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3 89.72
110 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 89.72
111 INT92205 Crh Positive_regulation of Localization of SST 1 0.30 0.87 0.21 89.56
112 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83 89.44
113 INT197234 Grik1 Positive_regulation of Localization of Gabrg1 1 0.15 0.82 0.71 89.36
114 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61 89.36
115 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83 89.12
116 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46 88.88
117 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5 88.80
118 INT159386 Positive_regulation of TRPV1 Positive_regulation of Localization of Calca 1 0.05 0.44 0.69 88.68
119 INT107951 Pax3 Positive_regulation of Tac1 1 0.11 1.21 0.95 88.40
120 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14 88.16
121 INT287097 T Positive_regulation of Ntrk2 1 0.21 0.6 0.19 87.56
122 INT192132 Ngf Positive_regulation of P2rx3 1 0.18 0.59 0.38 87.52
123 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54 87.00
124 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26 86.96
125 INT287099 Binding of Bdnf and T 1 0.10 1.1 0.69 86.76
126 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54 86.44
127 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54 86.44
128 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89 86.40
129 INT156508 Nfkb1 Regulation of Positive_regulation of Grin1 1 0.22 0.98 0.98 86.40
130 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58 86.40
131 INT150455 Binding of Prss12 and Nts 3 0.24 1.42 2.66 86.32
132 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44 86.24
133 INT250054 Positive_regulation of Binding of Gpr143 and Spdya 1 0.04 0.52 0.59 85.84
134 INT250053 Binding of Gpr143 and Spdya 1 0.03 0.51 0.59 85.84
135 INT132585 GABBR1 Positive_regulation of Binding of Gabbr1 1 0.01 0.6 0.3 85.76
136 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64 85.64
137 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42 85.64
138 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11 85.52
139 INT156510 Nfkb1 Regulation of Positive_regulation of Grin1 1 0.03 0.98 0.98 85.52
140 INT114635 Hmox2 Positive_regulation of Gene_expression of Fos 1 0.47 0.88 1.26 85.48
141 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18 84.76
142 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2 84.68
143 INT112107 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2a 1 0.40 0.49 0.57 84.68
144 INT112106 Negative_regulation of Dlg2 Negative_regulation of Grin2a 1 0.40 0.48 0.56 84.68
145 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66 84.60
146 INT105668 Binding of AAVS1 and BDNF 1 0.08 0.94 0.95 84.56
147 INT341897 Positive_regulation of NT5C3 Positive_regulation of Positive_regulation of Oxt 1 0.32 0.42 1.07 84.44
148 INT214876 Ap3d1 Negative_regulation of Gria1 1 0.00 0.4 0.78 84.28
149 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78 84.24
150 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01 83.84
151 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93 82.96
152 INT77218 Binding of NFKBIL1 and NKIRAS2 1 0.00 0.27 0.51 82.96
153 INT118655 Bdnf Positive_regulation of Phosphorylation of Creb1 1 0.44 0.16 0.3 82.76
154 INT156608 Trpv1 Regulation of Nav1 1 0.51 0.52 0.95 82.68
155 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86 82.20
156 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86 82.20
157 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43 82.16
158 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11 82.16
159 INT251148 Negative_regulation of Binding of Grin2a and Dlg2 1 0.37 0.45 0.32 82.16
160 INT151768 Ngf Positive_regulation of P2rx6 1 0.00 0.81 1.01 82.08
161 INT151772 Ngf Positive_regulation of Ngf Positive_regulation of P2rx6 1 0.00 0.81 1.01 82.08
162 INT151765 Ngf Positive_regulation of Positive_regulation of P2rx6 1 0.00 0.81 1.01 82.08
163 INT140140 Adcy1 Regulation of Regulation of Atf6b 1 0.14 0.34 0.41 81.52
164 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12 81.12
165 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55 80.48
166 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55 80.48
167 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42 80.16
168 INT339318 Ngf Positive_regulation of Pik3cg 1 0.02 0.69 0.87 79.76
169 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53 78.28
170 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43 78.24
171 INT127398 Negative_regulation of Mdk Negative_regulation of Gene_expression of Tacr1 1 0.01 0.71 0.45 77.52
172 INT127395 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Tacr1 1 0.07 0.71 0.45 77.52
173 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 77.44
174 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75 77.36
175 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17 76.88
176 INT164790 Cdk5r1 Positive_regulation of Trib3 1 0.02 0.25 0.17 76.88
177 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87 76.80
178 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45 76.72
179 INT127396 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin2a 1 0.00 0.71 0.45 76.72
180 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34 76.32
181 INT127392 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin1 1 0.08 0.71 0.45 76.16
182 INT127397 Negative_regulation of Mdk Negative_regulation of Gene_expression of Grin1 1 0.01 0.71 0.45 76.16
183 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03 76.08
184 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92 76.08
185 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91 76.08
186 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 75.96
187 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1 75.96
188 INT296485 Negative_regulation of Binding of Gria2 and GRIP1 1 0.05 0.3 0.54 75.72
189 INT238009 Binding of Cxcr3 and Cxcl9 3 0.40 4.01 1.37 75.60
190 INT237999 Binding of Cxcr3 and Cxcl11 2 0.45 3.49 1.11 75.60
191 INT127400 Negative_regulation of Mdk Negative_regulation of Gene_expression of Elk1 1 0.01 0.71 0.45 75.60
192 INT127391 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Elk1 1 0.08 0.71 0.45 75.60
193 INT102283 Binding of Grin2d and Nr2c2 1 0.03 0.08 0.24 75.44
194 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99 75.24
195 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11 75.12
196 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66 75.12
197 INT116771 Binding of MAVS and MRGPRX1 1 0.00 0.51 0.89 75.04
198 INT114036 Binding of Grin1 and Psd 1 0.24 0.45 0.68 75.00
199 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54 75.00
200 INT150069 Cnr1 Regulation of Cnr2 2 0.50 0.83 1.42 75.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for chronic pain. They are ordered first by their pain relevance and then by number of times they were reported in chronic pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 100.00
2 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 100.00
3 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 100.00
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 100.00
5 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11 100.00
6 INT193663 Binding of Pain1 9 0.36 8.84 8.04 100.00
7 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05 100.00
8 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6 100.00
9 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 100.00
10 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 100.00
11 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 100.00
12 INT69951 Binding of Cgnz1 3 0.25 1.82 1.64 100.00
13 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 100.00
14 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 100.00
15 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 100.00
16 INT95318 Binding of Pain1 17 0.22 21.26 20.14 100.00
17 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81 100.00
18 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 100.00
19 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2 100.00
20 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 100.00
21 INT112536 Regulation of Regulation of Mrpl40 1 0.00 1.58 1.3 100.00
22 INT112537 Regulation of Mrpl40 1 0.00 1.58 1.3 100.00
23 INT62132 Regulation of Gene_expression of Ifng 12 0.62 1.28 4.77 100.00
24 INT27687 Regulation of Cp 20 0.53 9.75 10.8 100.00
25 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 100.00
26 INT302434 Regulation of Transcription of Prf1 2 0.05 1.11 1.22 100.00
27 INT151111 Gene_expression of Pain1 33 0.40 33.6 30.73 100.00
28 INT18480 Positive_regulation of ANPEP 9 0.59 5.18 2.13 100.00
29 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 100.00
30 INT173272 Phosphorylation of Fig4 45 0.48 13.85 11.42 100.00
31 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 100.00
32 INT173273 Positive_regulation of Phosphorylation of Fig4 16 0.30 7.3 4.62 100.00
33 INT78719 Binding of Ucp1 8 0.41 8.93 4.5 100.00
34 INT195203 Binding of Tenc1 14 0.32 13.97 8.28 100.00
35 INT169594 Binding of Cpd 1 0.41 2.79 0.17 100.00
36 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 100.00
37 INT10808 Negative_regulation of Negative_regulation of Fos 3 0.57 1.08 3.92 100.00
38 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48 99.98
39 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.98
40 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.98
41 INT771 Regulation of Nts 93 0.61 13.13 53.57 99.98
42 INT60618 Regulation of Positive_regulation of Nts 1 0.44 2.63 2.62 99.98
43 INT8391 Positive_regulation of Gene_expression of Nts 23 0.67 5.05 14.59 99.98
44 INT3521 Regulation of Csf2 38 0.54 11.09 12.73 99.98
45 INT14500 Positive_regulation of Gene_expression of CST3 9 0.67 7.46 1.87 99.98
46 INT71101 Positive_regulation of Positive_regulation of Grip2 3 0.50 0.53 1.27 99.98
47 INT51912 Positive_regulation of Transcription of Nts 4 0.45 1.42 1.48 99.98
48 INT297507 Positive_regulation of Phosphorylation of Oprk1 1 0.50 0.63 2.26 99.98
49 INT3524 Regulation of Defb22 3 0.02 0.6 1.16 99.98
50 INT109603 Positive_regulation of Localization of CST3 1 0.45 0.61 0.67 99.98
51 INT4867 Positive_regulation of Gene_expression of GAL 17 0.70 6.65 8.28 99.96
52 INT101056 Positive_regulation of GRIN2B 1 0.23 0.32 0.9 99.96
53 INT41635 Positive_regulation of Negative_regulation of Gabrg1 2 0.45 0.28 4.18 99.96
54 INT11787 Positive_regulation of Positive_regulation of NA 14 0.21 2.97 2.46 99.96
55 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 99.92
56 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 99.92
57 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.92
58 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 99.92
59 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.92
60 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 99.92
61 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75 99.92
62 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 99.92
63 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 99.92
64 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 99.92
65 INT47674 Positive_regulation of Myoz1 21 0.54 4.37 3.57 99.92
66 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 99.90
67 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24 99.90
68 INT281138 Regulation of Binding of Ccl2 1 0.07 0.92 0.47 99.88
69 INT281140 Regulation of Binding of Cxcl12 1 0.28 0.93 0.47 99.88
70 INT281147 Regulation of Binding of Ccr2 1 0.39 0.86 0.46 99.88
71 INT281150 Regulation of Binding of Cxcr4 1 0.38 0.86 0.46 99.88
72 INT214577 Positive_regulation of Gene_expression of PCS 4 0.29 2.07 1.56 99.86
73 INT116705 Positive_regulation of Positive_regulation of P2rx2 13 0.49 9.44 9.47 99.86
74 INT122054 Positive_regulation of Positive_regulation of P2rx4 3 0.49 2.85 2.65 99.86
75 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 99.84
76 INT12232 Regulation of Gene_expression of PDYN 21 0.60 9.91 12.18 99.84
77 INT2649 Regulation of Calca 433 0.62 146.05 330.95 99.84
78 INT274527 Regulation of SYNM 3 0.20 2.68 2.7 99.84
79 INT6361 Localization of Edn1 30 0.81 19.09 9.7 99.84
80 INT112431 Positive_regulation of Positive_regulation of P2rx4 2 0.49 3.52 2.81 99.84
81 INT81596 Positive_regulation of Gene_expression of Npff 6 0.69 3.41 6.1 99.84
82 INT51837 Negative_regulation of TACR1 17 0.43 6.5 9.12 99.84
83 INT332472 Regulation of Localization of ipv 1 0.37 3.15 0.41 99.84
84 INT17386 Positive_regulation of Aia1 24 0.38 30.89 20.18 99.84
85 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62 99.84
86 INT109661 Positive_regulation of Gene_expression of Npvf 1 0.42 0.65 0.85 99.84
87 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.82
88 INT47540 Binding of Cp 20 0.41 15.54 7.01 99.82
89 INT24989 Positive_regulation of Cfp 125 0.61 29.55 64.9 99.80
90 INT17736 Gene_expression of Cfp 111 0.65 40.68 36.61 99.80
91 INT53311 Positive_regulation of Gene_expression of Cfp 20 0.42 4.39 6.62 99.80
92 INT156850 Binding of VDR 40 0.47 24.86 4.87 99.80
93 INT106330 Regulation of Positive_regulation of Creb1 11 0.56 5.57 7.06 99.80
94 INT160280 Positive_regulation of ipv 14 0.44 15.73 1.02 99.80
95 INT105746 Regulation of ECT 22 0.39 7.6 7.47 99.80
96 INT291828 Positive_regulation of Gene_expression of ipv 3 0.44 7.4 0.89 99.78
97 INT290523 Phosphorylation of Oprk1 3 0.81 3.1 6.34 99.78
98 INT322091 Negative_regulation of Cd244 1 0.18 0.49 0.16 99.78
99 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 99.76
100 INT181922 Binding of RENBP 16 0.36 13.92 3.71 99.76
101 INT143276 Phosphorylation of Gria2 42 0.80 16.07 15.2 99.76
102 INT182976 Negative_regulation of KCNIP3 2 0.51 8.49 7.67 99.76
103 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 99.76
104 INT117674 Regulation of Gene_expression of Nav1 16 0.62 11.5 22.01 99.76
105 INT97366 Regulation of Nav1 38 0.62 23.63 38.17 99.76
106 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 99.74
107 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 99.74
108 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 99.74
109 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13 99.74
110 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 99.74
111 INT47909 Binding of CPP 32 0.48 24.9 13.79 99.74
112 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 99.72
113 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 99.72
114 INT3948 Regulation of Cck 291 0.62 58.07 255.88 99.72
115 INT151156 Binding of PANX2 1 0.36 1 1.45 99.72
116 INT104394 Positive_regulation of Gene_expression of Cxcl10 28 0.65 25.64 8.79 99.72
117 INT159405 Negative_regulation of Transcription of Hmox2 1 0.02 0.55 0.62 99.72
118 INT159404 Transcription of Hmox2 1 0.04 0.55 0.62 99.72
119 INT102638 Regulation of VDR 21 0.44 9.92 2.54 99.70
120 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 99.70
121 INT5587 Regulation of Fos 191 0.62 40.81 99.7 99.70
122 INT13145 Positive_regulation of Car1 60 0.70 16.32 23.23 99.70
123 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 99.68
124 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 99.68
125 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 99.68
126 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 99.68
127 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 99.68
128 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7 99.68
129 INT166818 Positive_regulation of Gene_expression of IMPA1 3 0.36 0.99 1.06 99.68
130 INT34141 Positive_regulation of IMPA1 8 0.50 2.38 1.12 99.68
131 INT244418 Regulation of Negative_regulation of Ctsa 1 0.11 1.63 1.2 99.68
132 INT36835 Regulation of Ctsa 5 0.27 3.85 2.87 99.68
133 INT63628 Positive_regulation of Htr7 3 0.67 1.07 2.68 99.68
134 INT195817 Gene_expression of ipv 28 0.58 31.04 1.86 99.66
135 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97 99.66
136 INT149229 Localization of ipv 8 0.65 10.34 1.06 99.66
137 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02 99.66
138 INT12638 Positive_regulation of Gnai2 5 0.52 1.16 2.91 99.66
139 INT169482 Negative_regulation of Positive_regulation of Sema6a 1 0.42 0.2 1.32 99.66
140 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 99.66
141 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 99.64
142 INT5993 Positive_regulation of Nts 122 0.70 26.82 70.45 99.64
143 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 99.64
144 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 99.64
145 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 99.64
146 INT43707 Positive_regulation of CCBE1 11 0.07 8.22 4.86 99.64
147 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 99.62
148 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4 99.62
149 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 99.62
150 INT112427 Positive_regulation of P2rx4 27 0.68 26.29 21.31 99.62
151 INT122053 Positive_regulation of P2rx4 16 0.69 13.02 11.98 99.62
152 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 99.62
153 INT26229 Positive_regulation of ATP8A2 6 0.67 2.1 4.48 99.62
154 INT14388 Regulation of TACR1 12 0.45 3.1 5.58 99.60
155 INT103289 Binding of Il10 15 0.35 13.67 7.42 99.60
156 INT91158 Regulation of Ros1 26 0.25 17 4.23 99.60
157 INT72073 Positive_regulation of Gene_expression of NPFF 2 0.60 1.25 1.77 99.58
158 INT28852 Negative_regulation of OFC1 11 0.42 4.23 3.24 99.58
159 INT222241 Binding of Ccr2 5 0.42 4.09 3.71 99.58
160 INT183668 Binding of SGCA 15 0.36 9.86 2.42 99.58
161 INT250050 Gene_expression of Gpr143 1 0.48 5.76 6.53 99.56
162 INT85048 Regulation of NGF 19 0.62 11.61 10.5 99.56
163 INT28336 Positive_regulation of Pax3 37 0.33 20.94 25.66 99.56
164 INT9397 Regulation of MET 17 0.60 8.36 7.04 99.56
165 INT340119 Regulation of Regulation of MET 1 0.10 0.93 0.93 99.56
166 INT288523 Regulation of Binding of Gch1 1 0.36 0.91 1.27 99.56
167 INT121224 Positive_regulation of Positive_regulation of Pax3 5 0.14 2.32 2.4 99.56
168 INT149456 Regulation of OR13C5 1 0.30 0.1 0.1 99.56
169 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 99.54
170 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 99.54
171 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 99.54
172 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 99.52
173 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 99.52
174 INT316829 Negative_regulation of SYNM 4 0.54 3.31 3.32 99.52
175 INT21047 Transcription of Nts 20 0.69 4.55 8.5 99.52
176 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 99.52
177 INT249506 Regulation of Phosphorylation of Src 1 0.13 0.48 0.77 99.50
178 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1 99.50
179 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 99.48
180 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 99.48
181 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94 99.48
182 INT101121 Regulation of Comt 19 0.53 10.66 7.22 99.48
183 INT115890 Gene_expression of Nefh 28 0.68 11.55 3.84 99.48
184 INT149788 Binding of Reln 4 0.37 1.41 0.6 99.48
185 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 99.46
186 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 99.46
187 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08 99.46
188 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 99.46
189 INT60975 Localization of CST3 6 0.78 2.4 1.58 99.46
190 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.44
191 INT89046 Positive_regulation of P2RX2 15 0.67 7.25 7.52 99.44
192 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57 99.44
193 INT112041 Regulation of Positive_regulation of P2RX2 3 0.44 2.37 1.75 99.44
194 INT18460 Positive_regulation of Transcription of PDYN 11 0.67 2.14 6.61 99.44
195 INT78233 Positive_regulation of P2rx3 36 0.56 21.49 17.25 99.44
196 INT17233 Positive_regulation of Localization of PDYN 9 0.69 2.84 10.06 99.44
197 INT93195 Negative_regulation of Accn2 14 0.59 7.23 6.31 99.44
198 INT274740 Localization of Sez6l 1 0.01 0.2 0.25 99.44
199 INT443 Localization of POMC 1020 0.81 284.52 443.17 99.42
200 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 99.42
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