P:chronic pain syndrome

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pChart

Pain Term
Category Disorder
Synonyms None
Pain Specific Yes
Documents 372
Hot Single Events 31
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for chronic pain syndrome. They are ordered first by their pain relevance and then by number of times they were reported for chronic pain syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88 81.00
2 INT37489 Binding of ADRA1D and Alb 1 0.34 0.84 0.11 74.88
3 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
4 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02 5.00
5 INT202160 Binding of ARSD and CSF1R 1 0.16 1.69 0.59 5.00
6 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54 5.00
7 INT177440 Binding of HPSE and Gnrh1 1 0.00 1.82 0.45 5.00
8 INT311587 CXCL10 Regulation of Gene_expression of VEGFA 1 0.23 0.45 0.43 5.00
9 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43 5.00
10 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43 5.00
11 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43 5.00
12 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
13 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for chronic pain syndrome. They are ordered first by their pain relevance and then by number of times they were reported in chronic pain syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 99.90
2 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 97.96
3 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74 97.96
4 INT175482 Positive_regulation of Gene_expression of CALM1 12 0.44 3.47 6.54 96.32
5 INT93007 Regulation of Gene_expression of CALM1 7 0.41 3.47 6.08 96.08
6 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 95.80
7 INT738 Regulation of POMC 459 0.62 111.19 243.74 94.04
8 INT236872 Regulation of BPHL 6 0.16 6.52 1.14 93.84
9 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 92.28
10 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 92.28
11 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 92.04
12 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31 92.00
13 INT79709 Regulation of M1 13 0.24 4.8 4.9 90.76
14 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 89.80
15 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 89.76
16 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 89.76
17 INT131877 Negative_regulation of Nps 12 0.39 8.19 3.56 88.80
18 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 87.28
19 INT57637 Localization of M1 6 0.24 2.3 0.69 86.56
20 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 85.68
21 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 85.24
22 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 84.64
23 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 84.20
24 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 83.64
25 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 83.44
26 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 82.12
27 INT135629 Binding of COMT 33 0.48 16.68 19.37 81.00
28 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36 80.48
29 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 80.24
30 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 80.24
31 INT7527 Gene_expression of SLTM 12 0.25 2.9 6.07 80.04
32 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 79.96
33 INT26546 Positive_regulation of Gene_expression of Hras1 35 0.70 16.59 4.54 79.96
34 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 79.84
35 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36 79.84
36 INT180907 Positive_regulation of COQ10A 21 0.60 3.26 1.88 79.28
37 INT229892 Positive_regulation of Gene_expression of COQ10A 2 0.43 1.11 0.4 79.28
38 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 78.56
39 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 78.56
40 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 77.16
41 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 75.92
42 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77 75.76
43 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 74.36
44 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 72.00
45 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 72.00
46 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 69.88
47 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 69.36
48 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 67.68
49 INT113021 Gene_expression of ADAM18 2 0.37 2.94 4.49 67.60
50 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 66.80
51 INT234 Binding of Alb 151 0.48 52.34 32.97 65.84
52 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05 64.88
53 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 63.44
54 INT145993 Positive_regulation of Xiap 4 0.67 4.4 1.16 62.16
55 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 60.40
56 INT6484 Binding of IL1B 122 0.47 75.84 35.07 59.28
57 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 58.88
58 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 57.44
59 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 57.44
60 INT9660 Regulation of TNF 363 0.62 312.94 139.99 57.44
61 INT73155 Positive_regulation of Positive_regulation of Ngf 11 0.70 5.11 6.7 57.12
62 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 55.36
63 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 55.36
64 INT10834 Binding of IL8 65 0.48 41.66 16.53 52.84
65 INT87844 Binding of IL1RN 40 0.41 24.37 11.92 52.84
66 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32 52.36
67 INT311593 Localization of Cx3cl1 3 0.49 1.99 1.69 52.36
68 INT12082 Localization of IL6 365 0.81 241.78 105.78 52.04
69 INT12339 Localization of IL8 437 0.81 251.87 117.39 51.80
70 INT312039 Positive_regulation of Binding of UQCRC2 1 0.02 0.78 0.28 51.72
71 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 51.64
72 INT312040 Negative_regulation of Binding of UQCRC2 1 0.02 0.68 0.23 51.40
73 INT72565 Localization of IL1RN 45 0.80 23.59 13.17 51.32
74 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81 51.04
75 INT312034 Binding of UQCRC2 2 0.15 1.36 0.6 51.00
76 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 50.84
77 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 50.84
78 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 48.08
79 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 45.92
80 INT205592 Negative_regulation of Gene_expression of COQ10A 7 0.37 5.98 1.54 45.44
81 INT312036 Negative_regulation of Negative_regulation of COQ10A 1 0.23 2.23 0.64 45.44
82 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 44.64
83 INT199570 Negative_regulation of Tks 7 0.26 4.41 0.59 42.56
84 INT27785 Regulation of HTR2A 11 0.44 8 8.18 33.28
85 INT29556 Negative_regulation of CALM1 26 0.57 9.08 6.04 32.64
86 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 27.44
87 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 12.32
88 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 11.24
89 INT921 Regulation of GH1 172 0.60 52.88 51.04 10.88
90 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87 10.32
91 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
92 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
93 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
94 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
95 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
96 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
97 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
98 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
99 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
100 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
101 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
102 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
103 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
104 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
105 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
106 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
107 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
108 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
109 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
110 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 5.00
111 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
112 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
113 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
114 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
115 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 5.00
116 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 5.00
117 INT920 Localization of PLOD1 223 0.81 42.25 78.7 5.00
118 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
119 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
120 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
121 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
122 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
123 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
124 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
125 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
126 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
127 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
128 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 5.00
129 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
130 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
131 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
132 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 5.00
133 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
134 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
135 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
136 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
137 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
138 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
139 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
140 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
141 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
142 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 5.00
143 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
144 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07 5.00
145 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 5.00
146 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 5.00
147 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 5.00
148 INT32165 Binding of CALM1 92 0.48 24.19 29.57 5.00
149 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
150 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
151 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02 5.00
152 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
153 INT54467 Localization of Ltp 41 0.58 8.86 26.88 5.00
154 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
155 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
156 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 5.00
157 INT5966 Localization of Il1a 50 0.78 22.91 26.54 5.00
158 INT123419 Binding of NAV1 37 0.48 7.09 26.43 5.00
159 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
160 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 5.00
161 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 5.00
162 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
163 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 5.00
164 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 5.00
165 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
166 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 5.00
167 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 5.00
168 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
169 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
170 INT74286 Regulation of Il10 42 0.44 28.06 19.44 5.00
171 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
172 INT5372 Localization of LHB 55 0.68 9.47 19 5.00
173 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
174 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 5.00
175 INT1642 Negative_regulation of Localization of PLOD1 40 0.58 10.67 17.95 5.00
176 INT61626 Transcription of IL6 73 0.72 42.04 17.86 5.00
177 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 5.00
178 INT72564 Localization of Il10 41 0.78 28.62 17.6 5.00
179 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 5.00
180 INT75585 Negative_regulation of Negative_regulation of Ltp 18 0.37 9.81 16.63 5.00
181 INT139128 Positive_regulation of Negative_regulation of Ltp 12 0.42 4.94 15.52 5.00
182 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 5.00
183 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
184 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 5.00
185 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
186 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 5.00
187 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
188 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74 5.00
189 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35 5.00
190 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
191 INT21937 Positive_regulation of Scly 16 0.39 22.34 13.76 5.00
192 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
193 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68 5.00
194 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 5.00
195 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
196 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 5.00
197 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
198 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
199 INT120828 Localization of CXCL10 29 0.68 18.01 12.17 5.00
200 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31 5.00
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