P:colic

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pChart

Pain Term
Category Disorder
Synonyms Abdominal Cramp, Abdominal Cramps, Colic Infantile, Colicky Pain, Cramp Abdominal, Cramps Abdominal, Infantile Colic, Pain Colicky
Pain Specific No
Documents 1953
Hot Single Events 77
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for colic. They are ordered first by their pain relevance and then by number of times they were reported for colic. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3 59.40
2 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18 55.28
3 INT215904 IL36B Regulation of PRL 1 0.01 0.22 0.03 31.52
4 INT27932 Binding of CCK and NCOR2 1 0.01 0.91 1.47 25.00
5 INT7656 Binding of SST and Gs 1 0.02 0.27 0.46 25.00
6 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 13.08
7 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33 5.00
8 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31 5.00
9 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86 5.00
10 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
11 INT313778 Gene_expression of Crhq1 Negative_regulation of Localization of Crh 1 0.05 0.66 0.71 5.00
12 INT278077 Binding of BPHL and AURKC 1 0.16 4.29 0.69 5.00
13 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 5.00
14 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
15 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34 5.00
16 INT300727 IL25 Positive_regulation of IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
17 INT300732 IL33 Positive_regulation of IL13 1 0.00 0 0.34 5.00
18 INT300728 IL33 Positive_regulation of IL4 1 0.00 0 0.33 5.00
19 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33 5.00
20 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3 5.00
21 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3 5.00
22 INT277705 SMAP2 Regulation of TNF 1 0.01 1.23 0.25 5.00
23 INT348637 Binding of TLE4 and OLFM1 1 0.01 1.67 0.24 5.00
24 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2 5.00
25 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2 5.00
26 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2 5.00
27 INT191241 SST Regulation of SAE1 1 0.05 0.89 0.18 5.00
28 INT300753 Binding of Cd28 and Positive_regulation of Transcription of IL13 1 0.00 0 0.17 5.00
29 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
30 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14 5.00
31 INT310412 Binding of CP and TF 1 0.14 1.66 0.13 5.00
32 INT300731 IL10 Negative_regulation of Gene_expression of IGHE 1 0.03 0.23 0.13 5.00
33 INT172568 Gene_expression of GNRH1 Regulation of Localization of CGA 1 0.05 0.66 0.08 5.00
34 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08 5.00
35 INT214437 NCAM1 Regulation of CHGA 1 0.05 1.21 0.07 5.00
36 INT288099 Binding of APP and App 1 0.01 1.04 0.05 5.00
37 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05 5.00
38 INT339778 Binding of EDNRA and PTH 1 0.12 0.35 0.05 5.00
39 INT198620 CRH Negative_regulation of GH1 1 0.05 0.47 0.05 5.00
40 INT198619 CRH Negative_regulation of TRH 1 0.18 0.47 0.05 5.00
41 INT198618 CRH Negative_regulation of Localization of SST 1 0.07 0.53 0.05 5.00
42 INT355906 MAPK1 Positive_regulation of Localization of IL8 1 0.02 0.67 0.05 5.00
43 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0 5.00
44 INT234612 Binding of KIT and STIP1 1 0.04 1 0 5.00
45 INT271101 PIK3CB Regulation of Akt1 1 0.01 0.72 0 5.00
46 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0 5.00
47 INT271096 Pcna Positive_regulation of Akt1 1 0.00 0.34 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for colic. They are ordered first by their pain relevance and then by number of times they were reported in colic. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 100.00
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.86
3 INT73992 Gene_expression of Hspa1b 41 0.78 37.26 6.88 99.86
4 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.80
5 INT180034 Transcription of Large 1 0.57 0.42 1.22 99.76
6 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 99.58
7 INT4715 Positive_regulation of Xdh 20 0.69 6.57 2.28 99.54
8 INT817 Negative_regulation of Abp1 15 0.49 4.25 3.56 99.52
9 INT74977 Binding of FGFR1 6 0.41 4.66 1.02 99.48
10 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 98.96
11 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 98.68
12 INT46152 Positive_regulation of CYP4F22 7 0.46 4.05 5.56 98.60
13 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 98.56
14 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69 98.40
15 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 98.12
16 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 97.88
17 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 97.52
18 INT96542 Negative_regulation of SMN1 14 0.51 10.72 3.11 97.44
19 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 97.36
20 INT65642 Binding of Dync1h1 27 0.41 15.83 2.68 97.12
21 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 96.96
22 INT93911 Regulation of COX5A 11 0.60 4.94 4.05 96.80
23 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 96.80
24 INT22455 Binding of Nbr1 8 0.21 10.57 0.93 95.56
25 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 95.24
26 INT125226 Binding of Nf2 7 0.48 5.94 2.02 95.12
27 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27 94.96
28 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 94.32
29 INT7653 Regulation of Gs 3 0.21 1.87 0.87 93.08
30 INT46383 Negative_regulation of TRGC1 42 0.55 44.03 6.2 92.80
31 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 92.64
32 INT20253 Regulation of CBR1 1 0.44 0.09 0.26 91.60
33 INT5587 Regulation of Fos 191 0.62 40.81 99.7 91.20
34 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 91.16
35 INT2884 Positive_regulation of CCK 66 0.69 25.25 30.6 91.12
36 INT94004 Negative_regulation of Lox 31 0.59 13.76 10.45 90.76
37 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 90.64
38 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 90.40
39 INT12339 Localization of IL8 437 0.81 251.87 117.39 89.92
40 INT74423 Localization of IL10 91 0.80 61.6 22.95 89.92
41 INT233330 Localization of LEFTY2 4 0.15 4.46 0.99 89.92
42 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 89.80
43 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 89.80
44 INT134909 Positive_regulation of TRIM21 1 0.67 0.95 0.16 89.80
45 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 89.52
46 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 89.28
47 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 89.28
48 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 89.28
49 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 89.12
50 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 88.72
51 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73 88.48
52 INT140394 Regulation of Dync1h1 7 0.39 2.59 1.25 88.16
53 INT146792 Negative_regulation of Nf2 2 0.59 3.49 0.3 87.64
54 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 87.52
55 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 87.52
56 INT182806 Binding of Cuzd1 3 0.24 1.45 0.53 86.84
57 INT8775 Binding of IGHE 167 0.48 102.61 23.54 86.60
58 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 85.92
59 INT2406 Gene_expression of CCK 85 0.78 28.04 46.67 85.68
60 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.20
61 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 84.96
62 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 84.24
63 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 84.00
64 INT16165 Regulation of DMD 114 0.60 35.13 3.64 83.56
65 INT154732 Positive_regulation of Pip 7 0.41 5.93 0.6 83.28
66 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 82.80
67 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 82.80
68 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 82.56
69 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 82.40
70 INT122860 Negative_regulation of HGD 3 0.57 2.03 0.42 82.40
71 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 82.36
72 INT105781 Positive_regulation of Krt7 4 0.04 3.34 0.3 82.08
73 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 81.88
74 INT249 Localization of GHRH 215 0.80 78.02 51.87 81.40
75 INT19433 Gene_expression of FCGR2A 4 0.57 2.04 0.72 80.64
76 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 80.04
77 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 80.04
78 INT40189 Localization of IFNA2 6 0.74 7.7 1.04 79.84
79 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 79.12
80 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6 79.12
81 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 77.96
82 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 77.68
83 INT96499 Gene_expression of FES 5 0.65 2.26 0.48 77.36
84 INT96498 Negative_regulation of Gene_expression of FES 1 0.41 0.5 0.18 77.36
85 INT96500 Negative_regulation of FES 1 0.42 0.5 0.18 77.36
86 INT110816 Gene_expression of Mefv 2 0.07 2.98 0.31 77.08
87 INT397 Localization of SST 232 0.81 58.05 101.19 76.80
88 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 76.56
89 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 76.36
90 INT19639 Negative_regulation of Gene_expression of Tbxa2r 17 0.55 7.69 5.01 76.12
91 INT153015 Positive_regulation of Gene_expression of nct 3 0.24 0.9 0.74 76.04
92 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 75.84
93 INT104442 Transcription of ATF1 5 0.06 4.96 0.65 75.76
94 INT7654 Binding of Gs 3 0.10 1.62 2.16 75.76
95 INT153016 Gene_expression of nct 4 0.32 0.97 0.89 75.60
96 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 75.00
97 INT355463 Gene_expression of SPRED1 1 0.56 6.96 0.24 74.64
98 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 74.56
99 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84 74.08
100 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 73.44
101 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 73.04
102 INT183207 Negative_regulation of USE1 14 0.18 10.97 4 72.60
103 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 72.24
104 INT76999 Regulation of Fbp1 1 0.17 0.58 0.34 71.84
105 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 70.76
106 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 70.72
107 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 70.08
108 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 69.52
109 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 69.00
110 INT178048 Gene_expression of NOV 5 0.63 1.13 0.1 68.40
111 INT153371 Binding of Cfp 27 0.47 7.33 7.48 67.96
112 INT268240 Positive_regulation of Gene_expression of CDAN1 1 0.10 1.16 0.09 66.88
113 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 66.64
114 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 66.64
115 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 66.64
116 INT159494 Gene_expression of CDAN1 8 0.65 4.55 0.58 66.32
117 INT48513 Positive_regulation of MMEL1 2 0.38 0.6 0.15 65.80
118 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 65.44
119 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 64.68
120 INT27455 Positive_regulation of C2 18 0.60 4.3 3.93 64.64
121 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 64.64
122 INT92486 Positive_regulation of Gene_expression of P2RX3 5 0.49 1.56 1.82 64.56
123 INT87939 Gene_expression of P2RX3 23 0.75 6.15 6.62 64.56
124 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 64.32
125 INT77000 Protein_catabolism of Fgg 5 0.04 3.57 0.64 64.32
126 INT147464 Binding of Ptprc 13 0.36 15.18 0.98 64.24
127 INT95475 Positive_regulation of P2RX3 13 0.67 6.28 5.82 63.92
128 INT101412 Negative_regulation of CDAN1 16 0.57 6.41 1.61 63.76
129 INT1156 Binding of CCK 27 0.48 8.71 20.58 63.36
130 INT143489 Gene_expression of Ggt6 3 0.24 1.67 0.28 63.36
131 INT812 Localization of INS 1026 0.81 515.6 145.31 63.16
132 INT14572 Binding of INS 205 0.48 175.43 13.38 62.80
133 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 62.68
134 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 62.68
135 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 62.68
136 INT271098 Negative_regulation of Positive_regulation of JUND 1 0.01 1.69 0.16 62.68
137 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 62.52
138 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 62.20
139 INT75133 Positive_regulation of JUND 15 0.51 6.69 3.26 62.20
140 INT341865 Negative_regulation of Nhlrc1 1 0.09 0.54 0.32 60.72
141 INT341866 Negative_regulation of Positive_regulation of Nhlrc1 1 0.09 0.54 0.32 60.72
142 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 60.56
143 INT118102 Positive_regulation of Nhlrc1 4 0.40 1.19 1.21 60.48
144 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 59.88
145 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 59.80
146 INT217253 Positive_regulation of Positive_regulation of PPIG 2 0.08 0.55 2.33 59.80
147 INT60196 Binding of FOS 33 0.47 13.11 6.95 59.68
148 INT29421 Positive_regulation of CDS1 7 0.46 3.16 1.47 58.72
149 INT87938 Regulation of P2RX3 5 0.43 2.37 2.32 57.68
150 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 57.68
151 INT195060 Gene_expression of ALPL 9 0.73 4.82 1.3 57.36
152 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 56.80
153 INT10763 Localization of IL2 157 0.80 81.11 33.21 56.56
154 INT4931 Localization of IFNG 53 0.78 33.25 13.65 56.56
155 INT68725 Regulation of Cyp11a1 6 0.19 2.62 0.44 56.56
156 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 56.08
157 INT4494 Regulation of GCG 41 0.45 18.38 9.68 55.48
158 INT355462 Negative_regulation of SPRED1 1 0.36 1.34 0.16 55.44
159 INT339786 Gene_expression of FSD1L 1 0.03 0.41 0.03 54.88
160 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 54.72
161 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 54.16
162 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 53.60
163 INT93169 Binding of Ttf1 3 0.30 2.04 0.03 50.80
164 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 50.76
165 INT264580 Binding of Grhl2 1 0.05 0.35 0.08 50.24
166 INT4207 Regulation of Avp 267 0.62 63.72 115.33 50.00
167 INT894 Binding of Avp 84 0.48 29.16 29.63 50.00
168 INT62850 Negative_regulation of COP 8 0.37 0.18 0.38 50.00
169 INT355461 Localization of SPRED1 1 0.63 3.48 0.04 48.40
170 INT25353 Negative_regulation of F8 22 0.59 18.51 1.4 47.52
171 INT2408 Regulation of CCK 37 0.61 10.01 26.66 46.32
172 INT191243 Binding of SAE1 4 0.35 2.88 0.29 44.44
173 INT74446 Positive_regulation of Dync1h1 25 0.59 13 2.38 44.08
174 INT206532 Localization of mc 3 0.20 0.93 0.73 43.76
175 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 43.40
176 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 43.40
177 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 43.40
178 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 43.40
179 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 43.12
180 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56 42.72
181 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 42.04
182 INT19590 Localization of cod 2 0.17 0.27 0.09 41.92
183 INT223064 Binding of RBT 1 0.21 0.2 0 41.76
184 INT223063 Positive_regulation of Binding of 1 0.28 0.2 0 41.76
185 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 41.36
186 INT96447 Regulation of SMN1 4 0.17 2.59 0.57 41.20
187 INT230 Positive_regulation of GGTLC1 14 0.68 11.78 1.55 40.96
188 INT336003 Binding of HADH 1 0.07 0.35 0 40.72
189 INT41314 Gene_expression of GGTLC1 9 0.59 5.61 1.79 40.60
190 INT70622 Binding of Hypism 9 0.04 14.9 0.59 39.36
191 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68 38.80
192 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26 37.12
193 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 36.88
194 INT165213 Regulation of Gene_expression of Cd4 12 0.40 9.14 1.57 36.88
195 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 36.40
196 INT302707 Phosphorylation of Spnb4 1 0.28 3.13 0 36.12
197 INT546 Binding of ALB 311 0.48 85.98 60.14 33.68
198 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 33.12
199 INT107400 Localization of Das 4 0.28 2.95 1 33.12
200 INT182621 Localization of MLH1 9 0.64 9.31 0.12 30.68
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