P:complementary and alternative medicine

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Pain Term
Category Other
Synonyms None
Pain Specific No
Documents 419
Hot Single Events 78
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for complementary and alternative medicine. They are ordered first by their pain relevance and then by number of times they were reported for complementary and alternative medicine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT209409 Binding of CALM1 and NHS 2 0.27 0.58 1.32 100.00
2 INT356351 Binding of CALM1 and TNC 1 0.02 0 0.52 100.00
3 INT336021 EBM Regulation of Regulation of CALM1 1 0.18 0 0.32 100.00
4 INT294487 Binding of Calm1 and Tcm 1 0.00 0.81 0.23 100.00
5 INT213749 NHS Positive_regulation of Localization of CALM1 1 0.28 0.58 0.14 100.00
6 INT279799 ATP6V0A2 Regulation of ERBB3 1 0.00 1.77 0.12 47.60
7 INT279804 ATP6V0A2 Regulation of MCF2 1 0.00 1.76 0.12 47.60
8 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 14.08
9 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
10 INT188336 IL6 Positive_regulation of Localization of POMC 1 0.01 0.83 0.4 5.00
11 INT245343 Prkd1 Regulation of Slc3a1 1 0.29 0.47 0.36 5.00
12 INT219206 CD19 Positive_regulation of Positive_regulation of NCAM1 1 0.30 0 0.29 5.00
13 INT219208 CD19 Positive_regulation of Positive_regulation of FCGR3B 1 0.24 0 0.29 5.00
14 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
15 INT219207 Binding of FCGR3B and NCAM1 1 0.17 0 0.17 5.00
16 INT310263 Rb1 Negative_regulation of Gene_expression of Tnf 1 0.07 0.97 0.15 5.00
17 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11 5.00
18 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1 5.00
19 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
20 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
21 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
22 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 5.00
23 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 5.00
24 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03 5.00
25 INT353551 Pck1 Regulation of SLC17A5 1 0.00 0 0 5.00
26 INT279798 APAF1 Positive_regulation of CASP3 1 0.01 1 0 5.00
27 INT353549 Pck1 Regulation of Gene_expression of Gpt 1 0.00 0 0 5.00
28 INT279802 ATP6V0A2 Negative_regulation of ERBB3 1 0.00 1.96 0 5.00
29 INT308542 Binding of AIM1 and AIM2 1 0.12 0 0 5.00
30 INT185733 Hpse Positive_regulation of Gene_expression of Tnfrsf11b 1 0.20 0.24 0 5.00
31 INT353550 Pck1 Regulation of Gpt 1 0.00 0 0 5.00
32 INT311816 CD79A Positive_regulation of RAB27A 1 0.01 0.47 0 5.00
33 INT262413 Binding of EPHB1 and ADHD1 1 0.17 0.1 0 5.00
34 INT279800 ATP6V0A2 Positive_regulation of Phosphorylation of MAPK8 1 0.01 1.03 0 5.00
35 INT194268 Binding of PLA2G2A and NHP2 1 0.00 0 0 5.00
36 INT279803 ATP6V0A2 Negative_regulation of MCF2 1 0.00 1.95 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for complementary and alternative medicine. They are ordered first by their pain relevance and then by number of times they were reported in complementary and alternative medicine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 100.00
2 INT32165 Binding of CALM1 92 0.48 24.19 29.57 100.00
3 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 100.00
4 INT7339 Localization of CALM1 46 0.75 16.15 16.47 100.00
5 INT191765 Regulation of CALM1 15 0.52 9.52 8.56 100.00
6 INT232307 Localization of Calm1 5 0.74 9.99 8.71 100.00
7 INT30117 Gene_expression of Calm1 18 0.71 17.45 13.18 100.00
8 INT158672 Positive_regulation of Calm1 10 0.44 4.79 5.86 100.00
9 INT209411 Negative_regulation of Gene_expression of CALM1 10 0.37 2.21 3.11 100.00
10 INT33568 Phosphorylation of CALM1 10 0.55 2.31 2.91 100.00
11 INT175482 Positive_regulation of Gene_expression of CALM1 12 0.44 3.47 6.54 100.00
12 INT93007 Regulation of Gene_expression of CALM1 7 0.41 3.47 6.08 100.00
13 INT46281 Binding of Calm1 8 0.48 5.54 5.22 100.00
14 INT29556 Negative_regulation of CALM1 26 0.57 9.08 6.04 100.00
15 INT204725 Positive_regulation of Localization of CALM1 7 0.47 2.78 2.13 100.00
16 INT241610 Binding of Tcam1 1 0.28 5.31 1.67 100.00
17 INT72633 Negative_regulation of Calm1 2 0.37 0.21 1.8 100.00
18 INT97016 Regulation of Binding of CALM1 4 0.39 0.79 2.09 100.00
19 INT232308 Regulation of Calm1 2 0.39 2.49 1.54 100.00
20 INT43358 Positive_regulation of Binding of CALM1 2 0.60 0 1.09 100.00
21 INT150384 Binding of RCT 10 0.25 3.1 2.05 100.00
22 INT241609 Localization of Tcam1 1 0.44 0.36 0.75 100.00
23 INT320188 Regulation of Gene_expression of Calm1 2 0.39 2.48 1.39 100.00
24 INT251099 Positive_regulation of Gene_expression of Calm1 4 0.43 2.06 1.43 100.00
25 INT232306 Phosphorylation of Calm1 1 0.55 0 0.6 100.00
26 INT160283 Localization of NHS 7 0.65 2.48 1.52 100.00
27 INT232305 Regulation of Localization of Calm1 1 0.39 0.21 0.47 100.00
28 INT137858 Binding of NHS 14 0.32 2.94 0.57 100.00
29 INT328169 Regulation of Regulation of CALM1 2 0.23 0.66 0.7 100.00
30 INT251100 Transcription of Calm1 2 0.59 1.67 1.03 100.00
31 INT213750 Positive_regulation of NHS 14 0.59 2.17 1.43 100.00
32 INT227596 Protein_catabolism of CALM1 1 0.75 0.09 0.26 100.00
33 INT7337 Regulation of Localization of CALM1 4 0.39 1.1 1.15 100.00
34 INT178900 Localization of Tcm 10 0.70 4.06 0.82 99.96
35 INT204724 Positive_regulation of Localization of Tcm 2 0.47 0.45 0.25 99.96
36 INT25965 Gene_expression of Pxk 9 0.78 2 0.78 99.96
37 INT36354 Localization of CTs 26 0.64 20.84 9.31 99.92
38 INT169689 Localization of CD2AP 2 0.73 0.05 0.24 99.92
39 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 99.90
40 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 99.80
41 INT117754 Gene_expression of NHS 34 0.57 9.27 3.28 99.76
42 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 99.64
43 INT190809 Gene_expression of sld 2 0.14 0.27 1.11 99.62
44 INT221362 Regulation of Sertad1 1 0.01 0.78 0.24 99.56
45 INT9664 Binding of LBP 127 0.48 94.9 63.42 99.18
46 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 98.98
47 INT13379 Binding of Pxk 5 0.48 0.91 1.51 98.60
48 INT144689 Regulation of RCT 49 0.53 25.91 9.6 98.52
49 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 98.48
50 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 98.32
51 INT4819 Gene_expression of ACTG1 2 0.30 0.22 0.67 97.88
52 INT109102 Binding of Tcm 13 0.39 3.67 0.58 97.72
53 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6 97.40
54 INT27819 Gene_expression of CD2AP 2 0.25 0.09 0.37 96.32
55 INT194270 Gene_expression of NHP2 1 0.04 0.09 0.09 94.36
56 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 93.72
57 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 92.96
58 INT157167 Positive_regulation of Gene_expression of Tcm 3 0.41 1.54 0.36 92.96
59 INT1623 Gene_expression of Rnase1 7 0.55 1.79 1.7 92.16
60 INT243658 Localization of IL-17 4 0.63 3.21 1.51 92.04
61 INT194276 Transcription of NEPNP 1 0.25 0 0.05 90.40
62 INT194269 Gene_expression of NEPNP 3 0.50 1.1 0.05 90.40
63 INT46961 Positive_regulation of Tcm 7 0.41 2.47 1.04 90.32
64 INT98148 Negative_regulation of IL17 18 0.49 11.71 5.99 88.64
65 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 88.24
66 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 88.08
67 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 88.08
68 INT157943 Positive_regulation of IL-17 10 0.58 6.65 2.43 87.24
69 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42 85.76
70 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 85.76
71 INT138307 Regulation of Tcm 15 0.39 4.1 0.81 84.76
72 INT72564 Localization of Il10 41 0.78 28.62 17.6 84.28
73 INT50040 Localization of Il4 15 0.67 8.26 7.69 84.28
74 INT96234 Localization of Il13 11 0.62 10.94 5.48 84.28
75 INT50037 Localization of Il5 7 0.58 4.14 2.3 84.28
76 INT2555 Positive_regulation of Localization of Penk 116 0.70 24.35 119.73 84.24
77 INT292 Localization of Penk 876 0.81 88.44 669.14 83.60
78 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 83.36
79 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 76.44
80 INT203636 Positive_regulation of CD2AP 4 0.13 1.27 0.28 76.44
81 INT115579 Positive_regulation of Positive_regulation of Il10 7 0.68 4.82 2.91 74.72
82 INT221364 Gene_expression of Sertad1 3 0.19 2.18 0.37 73.76
83 INT36751 Gene_expression of ZMYND10 7 0.75 3.92 0.32 67.52
84 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 66.12
85 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 65.72
86 INT117117 Positive_regulation of REM1 12 0.40 10.1 3.33 64.88
87 INT220120 Regulation of RGD1563494 2 0.09 3.41 1.15 64.40
88 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73 64.08
89 INT74286 Regulation of Il10 42 0.44 28.06 19.44 63.76
90 INT164533 Positive_regulation of Regulation of Il10 4 0.46 2.09 1.06 63.76
91 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 63.52
92 INT44880 Gene_expression of REM1 21 0.30 5.3 2.43 63.52
93 INT194273 Regulation of NHP2 1 0.03 0.24 0.03 63.04
94 INT8775 Binding of IGHE 167 0.48 102.61 23.54 62.72
95 INT104902 Regulation of ASIC1 6 0.51 5.17 3.13 59.36
96 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66 59.36
97 INT75746 Regulation of ZMYND10 3 0.44 0.5 1.31 59.36
98 INT157942 Regulation of IL-17 8 0.38 4.02 2.1 59.04
99 INT167820 Regulation of Gene_expression of Tcm 2 0.39 0.06 0.03 57.76
100 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 56.84
101 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 56.84
102 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 56.64
103 INT170755 Positive_regulation of Positive_regulation of IFN1@ 17 0.67 8.72 3.65 56.64
104 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 55.96
105 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 55.96
106 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 55.36
107 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 55.36
108 INT54238 Positive_regulation of UFM1 7 0.32 3.17 1.43 54.44
109 INT202716 Gene_expression of NMS 4 0.49 4.56 0.57 51.60
110 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 50.80
111 INT5586 Binding of Fos 47 0.48 12.7 21.33 49.56
112 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 49.28
113 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 47.52
114 INT157941 Gene_expression of IL-17 65 0.65 20.39 9.89 45.04
115 INT243660 Negative_regulation of Gene_expression of IL-17 15 0.49 4.22 2.08 45.04
116 INT53776 Positive_regulation of Hspd1 17 0.70 10.64 1.23 42.16
117 INT443 Localization of POMC 1020 0.81 284.52 443.17 39.64
118 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 39.44
119 INT9482 Positive_regulation of Gene_expression of Jun 60 0.69 9.95 18.61 36.32
120 INT279806 Regulation of TYMS 2 0.05 1 0.12 36.16
121 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 35.60
122 INT353468 Negative_regulation of Regulation of IL-17 1 0.08 0.76 0.44 35.40
123 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 34.48
124 INT353467 Regulation of Regulation of IL-17 1 0.05 0.82 0.5 33.40
125 INT202715 Binding of NMS 3 0.27 6.92 0.65 32.68
126 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 32.32
127 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 31.80
128 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 25.68
129 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 22.44
130 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 21.36
131 INT338134 Positive_regulation of Gene_expression of ZMYND10 1 0.49 0.58 0 20.96
132 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 18.44
133 INT242656 Regulation of Hist1h2aa 3 0.04 2.68 0.92 18.28
134 INT185730 Negative_regulation of Negative_regulation of Dlat 2 0.14 0.35 0.21 16.88
135 INT205264 Negative_regulation of CMM 1 0.29 0 0 16.88
136 INT42317 Negative_regulation of Dlat 21 0.43 3.13 4.11 16.36
137 INT161019 Positive_regulation of Gene_expression of Dlat 6 0.32 1.19 0.79 16.00
138 INT97649 Gene_expression of Dlat 48 0.66 13.77 8.94 15.00
139 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 14.80
140 INT52980 Positive_regulation of Dlat 20 0.37 5.14 4.06 11.24
141 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 10.48
142 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 10.24
143 INT138764 Positive_regulation of Hsf1 7 0.69 3.89 0.64 7.68
144 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 6.24
145 INT45812 Protein_catabolism of Gabrg1 12 0.79 1.93 8.76 6.04
146 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
147 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
148 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
149 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
150 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
151 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
152 INT738 Regulation of POMC 459 0.62 111.19 243.74 5.00
153 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
154 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
155 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 5.00
156 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
157 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
158 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
159 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 5.00
160 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
161 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
162 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
163 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
164 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
165 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
166 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
167 INT7028 Localization of Pdyn 90 0.81 8.89 73.54 5.00
168 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
169 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
170 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
171 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
172 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
173 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 5.00
174 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
175 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
176 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
177 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83 5.00
178 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
179 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
180 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
181 INT12717 Binding of Pck1 85 0.47 12.49 54.81 5.00
182 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
183 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
184 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
185 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 5.00
186 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
187 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
188 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
189 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
190 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
191 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
192 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
193 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
194 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34 5.00
195 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
196 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
197 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
198 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
199 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
200 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
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