P:cryotherapy

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pChart

Pain Term
Category Treatment
Synonyms None
Pain Specific No
Documents 572
Hot Single Events 55
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for cryotherapy. They are ordered first by their pain relevance and then by number of times they were reported for cryotherapy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
2 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05 5.00
3 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 5.00
4 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 5.00
5 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 5.00
6 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 5.00
7 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
8 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17 5.00
9 INT234113 COL18A1 Negative_regulation of Phosphorylation of VEGFA 1 0.26 0.17 0.16 5.00
10 INT234112 Binding of VEGFA and COL18A1 1 0.21 0.16 0.15 5.00
11 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15 5.00
12 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13 5.00
13 INT254643 Binding of Mapk8ip1 and Slc9a3r2 1 0.00 0.27 0.12 5.00
14 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 5.00
15 INT188356 Binding of Cd28 and Positive_regulation of Localization of Cd4 1 0.30 0.18 0.11 5.00
16 INT188360 Binding of Cd28 and Positive_regulation of Localization of Cd8a 1 0.09 0.18 0.11 5.00
17 INT199595 FGF7 Positive_regulation of Transcription of TNF 1 0.40 0.58 0.11 5.00
18 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11 5.00
19 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 5.00
20 INT188357 Csf2 Positive_regulation of Socs3 1 0.36 0.15 0.1 5.00
21 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1 5.00
22 INT199594 FGF7 Positive_regulation of NFE2L2 1 0.01 0.52 0.09 5.00
23 INT199604 Binding of FGF7 and Fgf1 1 0.03 0.21 0.08 5.00
24 INT199603 Positive_regulation of Binding of FGF7 and Fgf1 1 0.04 0.21 0.08 5.00
25 INT188361 Il4 Positive_regulation of Socs1 1 0.14 0.15 0.08 5.00
26 INT188359 Csf2 Regulation of Cish 1 0.13 0.52 0.07 5.00
27 INT225957 Binding of KRT3 and KRT12 1 0.18 0.06 0 5.00
28 INT239406 Binding of MTTP and TAOK1 1 0.02 0.51 0 5.00
29 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0 5.00
30 INT239407 Binding of MTTP and PADI1 1 0.23 0.5 0 5.00
31 INT239408 Binding of PADI1 and TAOK1 1 0.01 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for cryotherapy. They are ordered first by their pain relevance and then by number of times they were reported in cryotherapy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT326616 Binding of CA5P 4 0.21 2.26 0.19 100.00
2 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
3 INT86531 Regulation of Transcription of Prl 2 0.44 1.48 0.59 100.00
4 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 100.00
5 INT134338 Gene_expression of CD55 23 0.65 13.01 1.38 99.98
6 INT139108 Gene_expression of Hgd 3 0.38 4.69 0.6 99.98
7 INT286993 Localization of CA5P 23 0.63 14.38 0.89 99.90
8 INT8799 Negative_regulation of Csrp1 24 0.58 11.01 6.86 99.72
9 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 99.68
10 INT20176 Transcription of Prl 15 0.72 7.32 2.25 99.68
11 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 99.68
12 INT15062 Transcription of Gnrhr 9 0.65 1.88 3.2 99.68
13 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 99.52
14 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 98.60
15 INT158 Localization of Prl 2431 0.81 378.96 952.2 98.48
16 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 98.48
17 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 98.40
18 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64 97.92
19 INT281024 Transcription of Hars 1 0.26 0.4 0.34 97.80
20 INT126502 Negative_regulation of Hars 2 0.27 0.47 0.34 97.80
21 INT116540 Binding of Twist1 35 0.48 16.32 2.85 96.48
22 INT175997 Localization of HEPACAM 6 0.31 5.91 0.39 95.64
23 INT175994 Negative_regulation of HEPACAM 3 0.18 2.02 0.28 95.64
24 INT4785 Gene_expression of PAM 6 0.58 3.47 0.64 95.60
25 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 94.88
26 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 94.56
27 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 94.36
28 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 94.36
29 INT94028 Regulation of Twist1 37 0.44 22.41 5.33 94.20
30 INT71727 Negative_regulation of Icam1 25 0.45 17.76 5.73 93.52
31 INT78963 Positive_regulation of CCL1 7 0.08 4.58 5.09 93.32
32 INT34354 Gene_expression of SRMS 8 0.59 9.62 1.02 92.20
33 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 91.68
34 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 91.12
35 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 90.96
36 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 90.68
37 INT738 Regulation of POMC 459 0.62 111.19 243.74 90.68
38 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 90.40
39 INT3970 Positive_regulation of Sord 9 0.70 4.29 3.93 90.32
40 INT45324 Positive_regulation of Otc 8 0.59 3.94 3.36 90.32
41 INT136850 Positive_regulation of Arg1 10 0.50 6.96 2.47 90.32
42 INT42116 Positive_regulation of ME1 5 0.05 1.56 1.33 90.32
43 INT160852 Regulation of CD55 5 0.16 5.28 0.56 89.28
44 INT160851 Regulation of Hgd 1 0.03 1.66 0.25 89.28
45 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 89.04
46 INT216867 Localization of PDXP 4 0.28 6.31 0.62 85.08
47 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 83.64
48 INT281025 Positive_regulation of Phosphorylation of Pomc 1 0.10 0.14 0.3 82.56
49 INT30280 Phosphorylation of Pomc 2 0.16 0.13 0.73 82.56
50 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 80.64
51 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 80.64
52 INT2149 Positive_regulation of Oxt 181 0.70 24.8 85.43 80.36
53 INT7469 Positive_regulation of Gene_expression of Oxt 18 0.59 4.7 14.36 80.36
54 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 80.12
55 INT29441 Negative_regulation of Gene_expression of Cea 6 0.20 5.97 0.55 80.12
56 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 79.96
57 INT40102 Positive_regulation of Phosphorylation of POMC 3 0.44 0.57 1.3 79.84
58 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88 79.84
59 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 79.84
60 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 79.40
61 INT42459 Positive_regulation of Gene_expression of Pag1 19 0.25 13.49 12.22 78.96
62 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 78.36
63 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 77.40
64 INT152033 Negative_regulation of MAGEE1 1 0.42 0.46 0.24 75.72
65 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 74.72
66 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 73.80
67 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 73.60
68 INT46643 Negative_regulation of HYAL1 7 0.37 4.65 1.55 73.20
69 INT102631 Localization of HYAL1 4 0.26 1.79 0.46 73.20
70 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 72.60
71 INT128051 Gene_expression of FGF10 9 0.78 2.31 1.56 72.40
72 INT165058 Negative_regulation of MID1 14 0.37 10.82 4.67 71.68
73 INT7134 Localization of KNG1 127 0.79 65.73 67.97 70.40
74 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99 68.64
75 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 67.88
76 INT58755 Binding of PAM 6 0.34 3.09 0.97 67.44
77 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 65.52
78 INT134795 Positive_regulation of Scrib 30 0.22 36.91 2.81 63.08
79 INT255622 Positive_regulation of PAM 7 0.18 4.89 0.87 62.32
80 INT354597 Positive_regulation of Positive_regulation of PAM 1 0.09 1.41 0.03 62.32
81 INT195206 Binding of BCC1 15 0.41 21.3 0.62 60.48
82 INT156827 Localization of MRI1 25 0.65 16.06 8.33 58.68
83 INT93274 Gene_expression of QRFP 12 0.58 7 1.46 57.96
84 INT205040 Gene_expression of CLTA 7 0.19 7.64 0.25 55.44
85 INT192533 Positive_regulation of CLTA 4 0.13 4.98 0.1 55.44
86 INT30610 Localization of PCa 35 0.65 13.91 4.25 54.16
87 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 54.16
88 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 50.96
89 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 50.96
90 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 50.80
91 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 50.00
92 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 50.00
93 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 50.00
94 INT65119 Negative_regulation of Des 4 0.41 1.29 2.14 50.00
95 INT239516 Negative_regulation of Gene_expression of QRFP 1 0.09 0.26 0.06 49.92
96 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 49.60
97 INT207891 Positive_regulation of Gene_expression of Lmrq1 5 0.28 3.87 0.05 44.96
98 INT191731 Gene_expression of Lmrq1 31 0.43 14.46 0.34 44.56
99 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 36.84
100 INT113319 Positive_regulation of QRFP 5 0.40 3.86 0.1 35.92
101 INT239514 Positive_regulation of Gene_expression of CLTA 1 0.14 1.69 0.05 35.92
102 INT239513 Positive_regulation of Gene_expression of QRFP 1 0.10 0.54 0.03 35.92
103 INT84526 Binding of QRFP 3 0.07 1.45 0.48 35.40
104 INT9210 Regulation of IL6 166 0.62 125.61 49.95 34.48
105 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 34.48
106 INT10835 Regulation of IL8 79 0.49 53.04 24.14 34.48
107 INT105378 Regulation of IL12A 6 0.26 8.82 2.15 34.48
108 INT29636 Localization of PAM 5 0.73 2.1 0.87 34.00
109 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56 32.60
110 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 30.68
111 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 29.40
112 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 25.88
113 INT284765 Gene_expression of BCC1 22 0.56 29.32 0.14 22.08
114 INT239515 Localization of QRFP 1 0.15 0.45 0.04 19.32
115 INT239517 Negative_regulation of Localization of QRFP 1 0.09 0.46 0.04 19.32
116 INT239512 Negative_regulation of Gene_expression of CLTA 1 0.12 0.47 0.04 18.88
117 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 17.52
118 INT2105 Negative_regulation of Rhd 10 0.41 4.9 3.4 13.04
119 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 12.96
120 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 10.56
121 INT180264 Positive_regulation of BCC1 11 0.59 12.81 0.2 6.36
122 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
123 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
124 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
125 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
126 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
127 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
128 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
129 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
130 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
131 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
132 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
133 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
134 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
135 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
136 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
137 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
138 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
139 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
140 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
141 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
142 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
143 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
144 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
145 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
146 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
147 INT90 Localization of Gast 400 0.81 137.67 113 5.00
148 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
149 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
150 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
151 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
152 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
153 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
154 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
155 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
156 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 5.00
157 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
158 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
159 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
160 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
161 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
162 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
163 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
164 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 5.00
165 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
166 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
167 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
168 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
169 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
170 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 5.00
171 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
172 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
173 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
174 INT4776 Localization of TAC1 82 0.78 16.89 45.21 5.00
175 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
176 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
177 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
178 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
179 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
180 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
181 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 5.00
182 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
183 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
184 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
185 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
186 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
187 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 5.00
188 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
189 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
190 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
191 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
192 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
193 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
194 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
195 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
196 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
197 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
198 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
199 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 5.00
200 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
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