P:descending inhibitory control

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Pain Term
Category Process
Synonyms None
Pain Specific No
Documents 35
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for descending inhibitory control. They are ordered first by their pain relevance and then by number of times they were reported for descending inhibitory control. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT285661 Binding of Mgll and FAAH2 1 0.05 0.23 0.45 27.72
2 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
3 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
4 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
5 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
6 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
7 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
8 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
9 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
10 INT285659 Binding of Faah and Mgll 1 0.15 0.99 1.11 5.00
11 INT285660 Cnrip1 Negative_regulation of Kcnk3 1 0.00 0.23 0.85 5.00
12 INT285656 Cnrip1 Negative_regulation of Kcnk3 1 0.00 0.23 0.85 5.00
13 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
14 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
15 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for descending inhibitory control. They are ordered first by their pain relevance and then by number of times they were reported in descending inhibitory control. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
2 INT1663 Regulation of Nrm 12 0.55 2.73 12.73 100.00
3 INT142735 Regulation of RLS 33 0.53 45.83 11.35 100.00
4 INT51976 Positive_regulation of Regulation of Nrm 1 0.41 0.1 0.65 100.00
5 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.12
6 INT1715 Positive_regulation of Nrm 51 0.70 24 47.53 98.40
7 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 96.88
8 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89 86.76
9 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68 81.12
10 INT292 Localization of Penk 876 0.81 88.44 669.14 79.52
11 INT62254 Negative_regulation of FLII 20 0.48 4.11 9.44 79.44
12 INT10555 Gene_expression of FLII 37 0.75 7.81 17.6 76.72
13 INT135629 Binding of COMT 33 0.48 16.68 19.37 76.52
14 INT6148 Gene_expression of Nrtim1 34 0.42 10.17 12.27 76.32
15 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 76.16
16 INT230377 Transcription of Cnr2 2 0.53 1.06 1.07 75.48
17 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 75.00
18 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35 75.00
19 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 75.00
20 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 68.32
21 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 68.32
22 INT5817 Localization of Melm1 23 0.68 2.05 18.01 67.36
23 INT45636 Positive_regulation of Melm1 2 0.09 0.95 1.8 64.00
24 INT280067 Negative_regulation of Positive_regulation of Melm1 1 0.06 0.06 0.35 64.00
25 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 56.60
26 INT181249 Binding of TCEA1 8 0.32 2.12 3.66 54.08
27 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 47.76
28 INT107524 Gene_expression of Faah 17 0.78 7.93 11.91 46.08
29 INT153616 Gene_expression of Mgll 5 0.50 2.72 3.03 46.08
30 INT285646 Gene_expression of Naaa 4 0.28 1.01 1.84 46.08
31 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 40.80
32 INT5818 Negative_regulation of Localization of Melm1 7 0.27 0 6.27 34.32
33 INT189427 Gene_expression of FAAH2 3 0.16 0.23 0.42 27.72
34 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 25.00
35 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03 25.00
36 INT26531 Regulation of Srf 3 0.18 0.62 0.9 25.00
37 INT42132 Negative_regulation of TCEA1 13 0.51 4.12 6.28 17.16
38 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 17.08
39 INT48642 Positive_regulation of TCEA1 92 0.70 24.59 53.64 7.68
40 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
41 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
42 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
43 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
44 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 5.00
45 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
46 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
47 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
48 INT1396 Binding of Penk 355 0.48 22.79 269.65 5.00
49 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
50 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
51 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
52 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
53 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
54 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 5.00
55 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
56 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
57 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
58 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
59 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
60 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 5.00
61 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
62 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
63 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
64 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
65 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
66 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
67 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
68 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
69 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
70 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
71 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
72 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
73 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
74 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 5.00
75 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 5.00
76 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
77 INT63383 Binding of Cnr1 77 0.48 22.28 44.61 5.00
78 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
79 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
80 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 5.00
81 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78 5.00
82 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 5.00
83 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 5.00
84 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
85 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
86 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
87 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
88 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86 5.00
89 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57 5.00
90 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92 5.00
91 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 5.00
92 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
93 INT153613 Gene_expression of Napepld 42 0.77 6.7 20.94 5.00
94 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41 5.00
95 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 5.00
96 INT104527 Binding of FSCN1 18 0.23 14.75 19.6 5.00
97 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45 5.00
98 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
99 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
100 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
101 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 5.00
102 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
103 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 5.00
104 INT20216 Localization of NGF 40 0.80 18.16 16.61 5.00
105 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 5.00
106 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46 5.00
107 INT62629 Localization of CNR1 35 0.76 11.86 16.3 5.00
108 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 5.00
109 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 5.00
110 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82 5.00
111 INT71150 Binding of NGF 22 0.46 13.67 14.81 5.00
112 INT63553 Binding of PAG1 14 0.48 12.51 14.76 5.00
113 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76 5.00
114 INT39046 Positive_regulation of PTGER1 28 0.69 18.18 13.21 5.00
115 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 5.00
116 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 5.00
117 INT83601 Binding of CNR2 30 0.47 7.79 12.37 5.00
118 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
119 INT94545 Positive_regulation of C7orf49 37 0.69 12.91 11.19 5.00
120 INT72579 Localization of BDNF 56 0.80 14.84 10.65 5.00
121 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
122 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93 5.00
123 INT168396 Transcription of Cnr2 12 0.72 7.69 8.74 5.00
124 INT54978 Binding of EDNRA 36 0.41 14.97 7.86 5.00
125 INT92755 Regulation of MRGPRX1 26 0.27 3.63 7.37 5.00
126 INT75938 Regulation of TP53INP2 9 0.09 2.45 7.21 5.00
127 INT121419 Localization of Cnr2 11 0.80 4.98 7.14 5.00
128 INT177600 Gene_expression of C7orf49 21 0.52 7.1 6.92 5.00
129 INT111365 Positive_regulation of Gene_expression of Cnr2 8 0.70 5.52 6.83 5.00
130 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 5.00
131 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4 5.00
132 INT134585 Negative_regulation of Cnr2 10 0.43 3.98 6.16 5.00
133 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
134 INT33612 Binding of NTS 16 0.46 4.65 6 5.00
135 INT132682 Phosphorylation of Pag1 7 0.71 5.61 5.75 5.00
136 INT65262 Gene_expression of Lox 47 0.74 36.59 5.65 5.00
137 INT91147 Positive_regulation of Positive_regulation of Ppara 30 0.69 19.31 5.56 5.00
138 INT42133 Gene_expression of TCEA1 17 0.60 5.61 5.55 5.00
139 INT64270 Gene_expression of GRM2 10 0.75 1.72 5.41 5.00
140 INT14357 Positive_regulation of FCGR1A 10 0.44 7.14 5.4 5.00
141 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02 5.00
142 INT12825 Regulation of Localization of Melm1 6 0.22 0.4 4.96 5.00
143 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87 5.00
144 INT77429 Negative_regulation of Negative_regulation of CPOX 9 0.34 5.09 4.64 5.00
145 INT112040 Localization of P2RX2 6 0.73 4.69 4.3 5.00
146 INT167174 Negative_regulation of Gene_expression of FSCN1 6 0.06 3.05 4.25 5.00
147 INT77515 Positive_regulation of ASIC3 12 0.67 3.67 4.19 5.00
148 INT124622 Positive_regulation of ATF3 26 0.70 21.6 4.03 5.00
149 INT144051 Positive_regulation of Gene_expression of PTGER1 11 0.12 4.46 3.97 5.00
150 INT152743 Positive_regulation of Localization of BDNF 7 0.56 4.04 3.74 5.00
151 INT93200 Gene_expression of ASIC2 6 0.60 3.27 3.7 5.00
152 INT158843 Regulation of NALCN 6 0.04 2.89 3.63 5.00
153 INT109851 Negative_regulation of P2RX3 7 0.57 3.55 3.61 5.00
154 INT220078 Positive_regulation of Negative_regulation of KNG1 3 0.13 5.03 3.41 5.00
155 INT92151 Regulation of Faah 5 0.62 6.31 3.06 5.00
156 INT150870 Regulation of Gene_expression of Faah 3 0.45 2.65 2.87 5.00
157 INT88745 Gene_expression of GRM3 6 0.75 2.61 2.83 5.00
158 INT123910 Gene_expression of CXCL16 5 0.49 3.81 2.82 5.00
159 INT23157 Positive_regulation of Localization of Melm1 5 0.45 0.98 2.8 5.00
160 INT135000 Positive_regulation of Gene_expression of GRM2 1 0.49 1.27 2.62 5.00
161 INT181250 Localization of TCEA1 6 0.75 1.54 2.61 5.00
162 INT129191 Regulation of ATF3 8 0.61 17.04 2.54 5.00
163 INT95799 Binding of NTRK2 8 0.35 2.95 2.47 5.00
164 INT74292 Negative_regulation of GLRA1 2 0.37 1.3 2.34 5.00
165 INT230378 Negative_regulation of Gene_expression of Cnr2 5 0.43 1.08 2.1 5.00
166 INT278487 Positive_regulation of Gene_expression of Napepld 4 0.50 1.72 1.94 5.00
167 INT118291 Binding of TXK 19 0.10 11.77 1.94 5.00
168 INT144944 Positive_regulation of Negative_regulation of TRPV1 3 0.46 0.84 1.89 5.00
169 INT141385 Positive_regulation of Gene_expression of P2RX7 7 0.62 3.95 1.73 5.00
170 INT189838 Regulation of Positive_regulation of Cnr2 1 0.41 1.19 1.51 5.00
171 INT220079 Phosphorylation of NALCN 1 0.01 1.05 1.48 5.00
172 INT220077 Negative_regulation of Binding of TNFRSF1B 1 0.26 1.1 1.42 5.00
173 INT220073 Negative_regulation of Binding of NGF 1 0.23 1.1 1.39 5.00
174 INT220070 Negative_regulation of ASIC2 1 0.02 1.09 1.39 5.00
175 INT220076 Negative_regulation of Negative_regulation of GLRA1 1 0.00 0.66 1.37 5.00
176 INT221801 Localization of Lox 2 0.24 0.99 1.28 5.00
177 INT220075 Positive_regulation of GRM3 1 0.11 1.36 1.28 5.00
178 INT220080 Gene_expression of SSX3 1 0.01 1.06 1.23 5.00
179 INT3414 Positive_regulation of Negative_regulation of Alb 4 0.44 1.91 1.09 5.00
180 INT129186 Positive_regulation of Regulation of ATF3 3 0.50 3.01 1.02 5.00
181 INT220074 Localization of ATF3 1 0.18 1.17 1.01 5.00
182 INT285644 Binding of Gpr55 2 0.20 0.12 0.7 5.00
183 INT239014 Gene_expression of Ptpn22 2 0.37 1.58 0.52 5.00
184 INT285642 Negative_regulation of Napepld 3 0.21 0.78 0.25 5.00
185 INT285643 Positive_regulation of Napepld 1 0.15 0.35 0 5.00
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