P:dextromethorphan

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Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 569
Hot Single Events 172
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for dextromethorphan. They are ordered first by their pain relevance and then by number of times they were reported for dextromethorphan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73 94.72
2 INT215290 Siglec1 Negative_regulation of Decr1 1 0.00 0.68 0.41 64.88
3 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73 64.16
4 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81 26.64
5 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
6 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 5.00
7 INT246519 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.25 0.08 1.42 5.00
8 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
9 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
10 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
11 INT215275 Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 1.37 0.38 5.00
12 INT255804 DSP Negative_regulation of Gene_expression of Il6 1 0.01 0.36 0.36 5.00
13 INT255803 Cat Negative_regulation of Gene_expression of Il6 1 0.05 0.35 0.35 5.00
14 INT215274 Tlr4 Positive_regulation of Ros1 2 0.02 1.48 0.28 5.00
15 INT215279 Siglec1 Regulation of Rac2 1 0.01 0.74 0.27 5.00
16 INT215273 Siglec1 Regulation of Ncf2 1 0.01 0.73 0.26 5.00
17 INT215289 Siglec1 Regulation of Cyba 1 0.01 0.74 0.26 5.00
18 INT215280 Siglec1 Regulation of Cybb 1 0.01 0.74 0.26 5.00
19 INT215271 Siglec1 Regulation of Ncf4 1 0.01 0.73 0.26 5.00
20 INT215286 Siglec1 Negative_regulation of Gene_expression of Ros1 1 0.00 2.76 0.25 5.00
21 INT215282 Siglec1 Regulation of Gene_expression of Ros1 1 0.00 0.55 0.18 5.00
22 INT215278 Siglec1 Regulation of Tlr4 1 0.01 0.55 0.18 5.00
23 INT215292 Siglec1 Regulation of Tlr4 Positive_regulation of Ros1 1 0.00 0.55 0.18 5.00
24 INT215287 Siglec1 Regulation of Ros1 1 0.00 0.55 0.18 5.00
25 INT215291 Siglec1 Regulation of Positive_regulation of Ros1 1 0.00 0.55 0.18 5.00
26 INT215270 Binding of Ncf1 and Ncf4 1 0.05 0.38 0.17 5.00
27 INT215269 Binding of Ncf2 and Ncf4 1 0.02 0.38 0.17 5.00
28 INT307627 Binding of BMP1 and CSF2 1 0.01 0.33 0.12 5.00
29 INT215283 Tlr4 Positive_regulation of Localization of Ncf1 2 0.05 1.04 0.11 5.00
30 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08 5.00
31 INT215284 Siglec1 Negative_regulation of Binding of Mpz 1 0.01 0.63 0.08 5.00
32 INT215276 Gene_expression of Mpz Positive_regulation of Gene_expression of Ros1 1 0.01 0.4 0.05 5.00
33 INT215281 Mpz Positive_regulation of Gene_expression of Ros1 2 0.01 1.01 0.05 5.00
34 INT215288 Gene_expression of Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 0.4 0.05 5.00
35 INT215277 Siglec1 Negative_regulation of Gene_expression of Mpz 1 0.02 0.48 0.03 5.00
36 INT215272 Siglec1 Regulation of Mpz 1 0.01 0.67 0.03 5.00
37 INT215285 Siglec1 Negative_regulation of Positive_regulation of Ros1 1 0.00 0.48 0.03 5.00
38 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0 5.00
39 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for dextromethorphan. They are ordered first by their pain relevance and then by number of times they were reported in dextromethorphan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT79620 Positive_regulation of DEM1 1 0.20 0.43 1.16 100.00
2 INT136964 Gene_expression of Dmp1 10 0.75 3.69 2.83 100.00
3 INT79621 Regulation of DEM1 1 0.08 0.2 0.79 100.00
4 INT79619 Regulation of Gene_expression of TP53INP2 2 0.15 0.41 1 100.00
5 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 100.00
6 INT21662 Gene_expression of Cpz 4 0.51 1.14 3.36 100.00
7 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 100.00
8 INT76217 Gene_expression of Spdef 13 0.62 4.86 2.32 100.00
9 INT153881 Regulation of Gene_expression of Spdef 3 0.07 0 0.5 100.00
10 INT153882 Regulation of Spdef 3 0.07 0 0.5 100.00
11 INT10120 Negative_regulation of Positive_regulation of Pdyn 14 0.58 6.05 10.19 99.98
12 INT5598 Negative_regulation of Pdyn 95 0.59 14.4 55.43 99.98
13 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 99.98
14 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 99.88
15 INT124093 Negative_regulation of Gene_expression of Gadd45a 2 0.35 1.52 0.71 99.88
16 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 99.86
17 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 99.84
18 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.84
19 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.84
20 INT53015 Gene_expression of TP53INP2 50 0.78 9.05 26.23 99.82
21 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.80
22 INT180534 Gene_expression of SARS 40 0.59 35.47 0.81 99.80
23 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 99.78
24 INT5561 Negative_regulation of GRIN2D 10 0.50 2.46 4.88 99.78
25 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97 99.78
26 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 99.70
27 INT24527 Negative_regulation of Gal 12 0.59 7.16 6.29 99.68
28 INT124091 Negative_regulation of Gene_expression of Myo1b 1 0.04 1.08 0.8 99.68
29 INT117143 Negative_regulation of Gene_expression of Cxcr1 4 0.33 5.35 2.78 99.68
30 INT117147 Negative_regulation of Gene_expression of Cxcl2 19 0.55 15.33 6.57 99.68
31 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 99.68
32 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.66
33 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32 99.60
34 INT124090 Gene_expression of Gadd45a 9 0.63 3.25 0.99 99.60
35 INT93240 Gene_expression of Pgpep1 7 0.59 1.69 0.44 99.58
36 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34 99.56
37 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 99.56
38 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48 99.56
39 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 99.54
40 INT62725 Regulation of GRIN2D 6 0.45 2.98 5.68 99.52
41 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 99.52
42 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 99.44
43 INT32576 Positive_regulation of Npap60 1 0.38 0.34 0.58 99.44
44 INT124092 Gene_expression of Myo1b 3 0.41 1.22 0.82 99.38
45 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 99.38
46 INT83950 Gene_expression of Cxcr1 31 0.59 27.76 13.91 99.38
47 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 99.38
48 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 99.38
49 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 99.36
50 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 99.28
51 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 99.20
52 INT65102 Regulation of Ntf4 3 0.43 0.05 3.42 99.20
53 INT181636 Positive_regulation of Gene_expression of BMP1 2 0.44 4.46 0.68 99.16
54 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 99.04
55 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 99.04
56 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39 99.04
57 INT12231 Positive_regulation of Localization of Nts 17 0.70 4.54 13.85 98.90
58 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 98.84
59 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63 98.84
60 INT60995 Negative_regulation of Positive_regulation of Homer1 9 0.38 1.63 9.63 98.82
61 INT54785 Binding of LOC502940 2 0.18 0.07 0.52 98.76
62 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 98.72
63 INT22557 Gene_expression of BMP1 3 0.59 20.18 4.73 98.64
64 INT8363 Localization of Nts 135 0.81 14.29 61.71 98.62
65 INT79622 Negative_regulation of Binding of TP53INP2 2 0.14 0.43 1.83 98.60
66 INT76701 Binding of TP53INP2 13 0.31 0.55 8.13 98.60
67 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 98.54
68 INT105754 Regulation of St13 8 0.28 0.75 11.41 98.38
69 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35 98.36
70 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 98.36
71 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 98.28
72 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 98.14
73 INT25198 Regulation of Pkia 3 0.27 0.51 3.31 97.76
74 INT797 Regulation of Penk 812 0.62 111.13 542.24 97.52
75 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63 97.52
76 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 97.32
77 INT145786 Binding of WWOX 2 0.35 0.59 0.55 97.16
78 INT58852 Positive_regulation of Enc1 20 0.49 7.51 13.25 96.96
79 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57 96.96
80 INT16131 Negative_regulation of GBE1 37 0.30 10.32 8.15 96.84
81 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 96.80
82 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 96.60
83 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02 96.60
84 INT79780 Gene_expression of Cyp4a3 14 0.56 5.19 1.12 96.60
85 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 96.08
86 INT51722 Positive_regulation of Localization of HELLS 1 0.05 0.37 0.76 96.08
87 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 95.84
88 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 95.68
89 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27 95.68
90 INT36517 Negative_regulation of MCF2 14 0.42 6.43 1.02 95.60
91 INT51724 Localization of HELLS 2 0.49 1.02 0.81 95.52
92 INT92514 Regulation of Grin2b 22 0.50 11.07 16.92 95.52
93 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25 95.36
94 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44 95.28
95 INT217252 Regulation of Gene_expression of SARS 1 0.26 0 0.05 95.28
96 INT22897 Positive_regulation of Tmprss11d 1 0.49 0.4 1.07 94.94
97 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49 94.32
98 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 93.80
99 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92 93.80
100 INT103553 Positive_regulation of Positive_regulation of MTX1 1 0.01 0.53 0.69 93.44
101 INT4803 Transcription of Penk 435 0.72 59.09 182.4 93.12
102 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38 93.08
103 INT88790 Negative_regulation of Gene_expression of Dlg4 6 0.59 1.53 4.66 93.00
104 INT6826 Transcription of Pdyn 130 0.71 22.19 54.88 92.72
105 INT51723 Regulation of HELLS 2 0.30 1.03 0.75 92.72
106 INT14126 Gene_expression of Grina 13 0.67 4.63 4.57 92.68
107 INT88789 Gene_expression of Dlg4 26 0.78 4.41 12.74 92.52
108 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23 92.52
109 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 92.48
110 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 92.28
111 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65 92.28
112 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77 92.28
113 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82 92.04
114 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31 92.04
115 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93 92.04
116 INT134878 Negative_regulation of Negative_regulation of Dlg4 1 0.35 0.27 0.93 92.04
117 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 91.76
118 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 91.60
119 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66 91.48
120 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78 91.48
121 INT97100 Negative_regulation of Dlg4 16 0.58 6.18 14.36 91.48
122 INT134876 Negative_regulation of Phosphorylation of Dlg4 1 0.35 0.27 0.93 91.48
123 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19 91.16
124 INT5567 Positive_regulation of Pkia 12 0.69 1.67 14.1 91.04
125 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67 90.96
126 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 90.96
127 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 90.96
128 INT134873 Phosphorylation of Dlg4 3 0.80 0.5 1.42 90.96
129 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44 90.64
130 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 90.64
131 INT12634 Gene_expression of Pkia 3 0.55 0.38 5 90.64
132 INT282596 Localization of BMP1 2 0.61 4.04 1.97 90.64
133 INT307635 Positive_regulation of Localization of BMP1 1 0.38 1.35 0.36 90.64
134 INT307630 Negative_regulation of Localization of BMP1 1 0.32 1.41 0.21 90.64
135 INT60145 Regulation of Negative_regulation of Ltp 4 0.23 1.82 4.09 90.44
136 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 90.24
137 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 90.00
138 INT307631 Positive_regulation of Binding of BMP1 1 0.38 2.99 0.24 90.00
139 INT135520 Positive_regulation of KCNJ9 2 0.07 0.18 1.91 89.92
140 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 89.88
141 INT22898 Negative_regulation of Gls 2 0.45 1.52 3.19 89.84
142 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 89.68
143 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 89.48
144 INT50580 Binding of PPIG 39 0.36 11.17 12.34 88.96
145 INT50581 Regulation of PPIG 26 0.55 8.96 4.32 88.96
146 INT93575 Regulation of Binding of PPIG 1 0.44 0.15 0.18 88.96
147 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16 88.60
148 INT2802 Negative_regulation of Asrgl1 14 0.59 2.69 7.37 88.56
149 INT113876 Negative_regulation of Phosphorylation of Creb3 2 0.17 0.81 2.18 88.24
150 INT6177 Binding of Htr1a 65 0.47 17.65 30.59 88.12
151 INT30160 Positive_regulation of ADRA2B 14 0.29 1.92 4.37 87.60
152 INT134877 Gene_expression of Creb3 2 0.18 0.31 1.39 87.40
153 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 87.36
154 INT118702 Regulation of Ncs1 2 0.53 1.59 0.47 87.20
155 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 87.12
156 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 86.96
157 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89 86.64
158 INT57923 Gene_expression of CYP3A 12 0.71 2.62 2 86.44
159 INT134825 Gene_expression of Cyp2d22 1 0.62 0.18 0.86 86.32
160 INT113878 Phosphorylation of Creb3 4 0.24 1.12 3.43 86.32
161 INT134826 Positive_regulation of Gene_expression of Cyp2d22 1 0.37 0.1 0.31 86.32
162 INT19109 Positive_regulation of CYP3A5 7 0.67 1.48 1.51 85.60
163 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 83.84
164 INT76024 Negative_regulation of Cyp3a11 7 0.53 2.96 3.16 82.88
165 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 82.84
166 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6 82.56
167 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76 82.28
168 INT12838 Gene_expression of SIGMAR1 30 0.78 3.52 6.81 82.24
169 INT3920 Localization of Ldha 241 0.81 83.08 58.72 81.88
170 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94 81.08
171 INT13338 Regulation of Sigmar1 22 0.57 2.91 11.35 81.00
172 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 80.20
173 INT120807 Binding of NOL3 10 0.45 3.62 3.97 79.84
174 INT134874 Regulation of Dlg4 3 0.58 0.28 2.12 79.76
175 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22 79.52
176 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 79.48
177 INT29020 Positive_regulation of pcp 18 0.45 3.5 6.39 78.96
178 INT163516 Negative_regulation of Positive_regulation of PRB1 1 0.15 0.08 0.45 77.76
179 INT6762 Binding of Srms 56 0.31 6.62 30.27 75.92
180 INT307634 Binding of BMP1 1 0.36 3.12 3.26 75.20
181 INT307632 Regulation of Binding of BMP1 1 0.34 1.53 0.12 75.20
182 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51 75.00
183 INT82072 Positive_regulation of Ntf4 5 0.41 1.05 2.49 75.00
184 INT21661 Regulation of Negative_regulation of Gls2 1 0.02 0.26 0.6 75.00
185 INT21664 Negative_regulation of Gls2 1 0.02 0.26 0.6 75.00
186 INT21663 Regulation of Negative_regulation of Asrgl1 1 0.03 0.21 0.6 75.00
187 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 75.00
188 INT6431 Positive_regulation of Ass1 36 0.24 8.08 10.43 75.00
189 INT45112 Positive_regulation of PRB1 20 0.60 6.49 2.85 73.76
190 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 72.96
191 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 72.92
192 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 72.56
193 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66 72.44
194 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33 72.16
195 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 71.44
196 INT262375 Binding of Fmod 1 0.20 12.37 10.1 71.36
197 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93 71.12
198 INT93241 Positive_regulation of Pgpep1 1 0.05 0 0.32 70.80
199 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 70.36
200 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 69.92
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