P:diabetic neuropathy

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pChart

Pain Term
Category Disorder
Synonyms Diabetes With Neurological Manifestations, Diabetic Mononeuropathy, Diabetic Peripheral Neuropathic Pain, Diabetic Peripheral Neuropathy, Diabetic Polyneuropathy, Polyneuropathy In Diabetes, Type I Diabetes Mellitus With Neurological Manifestations, Type Ii Diabetes Mellitus With Neurological Manifestations
Pain Specific No
Documents 1338
Hot Single Events 200
Hot Interactions 13

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for diabetic neuropathy. They are ordered first by their pain relevance and then by number of times they were reported for diabetic neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13 98.40
2 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48 95.32
3 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82 94.76
4 INT305334 Jun Positive_regulation of Gene_expression of Tcstv1 1 0.00 1.04 0.27 94.04
5 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76 92.20
6 INT166625 Acer3 Positive_regulation of Trpa1 1 0.01 1.91 1 90.84
7 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26 89.04
8 INT230245 Binding of CBFA2T2 and Cd2bp2 1 0.00 0.36 0.08 88.48
9 INT133854 Mcc Positive_regulation of Ngf 1 0.00 0.9 0.56 84.88
10 INT230760 VEGFA Positive_regulation of Flt1 1 0.03 0.96 0.12 84.16
11 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12 84.16
12 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73 84.00
13 INT266383 Binding of Ager and S100b 1 0.01 3.48 0.33 80.60
14 INT138073 Binding of TRPV1 and TUFMP1 1 0.03 0.46 0.86 76.56
15 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11 75.00
16 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82 74.64
17 INT266375 S100b Positive_regulation of Ager 1 0.02 1.8 0.31 74.64
18 INT266405 S100b Positive_regulation of Gene_expression of TFAM 1 0.00 1.02 0.21 74.64
19 INT266401 S100b Positive_regulation of S100b Positive_regulation of Ager 1 0.01 0.96 0.21 74.64
20 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41 73.60
21 INT324926 Ptpro Positive_regulation of Bdkrb2 1 0.01 2.25 1.5 71.88
22 INT166624 Acer3 Positive_regulation of Acer3 Positive_regulation of Trpa1 1 0.00 0.78 0.37 71.80
23 INT249851 VEGFA Positive_regulation of Gene_expression of Nos3 1 0.05 0.44 0.1 69.00
24 INT249848 Fgf2 Positive_regulation of Gene_expression of Nos3 1 0.33 0.44 0.1 68.64
25 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96 65.68
26 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67 61.00
27 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 58.96
28 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 58.96
29 INT148541 ST3GAL4 Positive_regulation of Positive_regulation of Trpv1 1 0.08 0.96 0.56 57.96
30 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 57.28
31 INT326571 Binding of Hsf1 and Hsp90ab1 1 0.16 1.19 0.03 52.88
32 INT326570 Hsp90ab1 Regulation of Csprs 1 0.08 1.17 0.03 52.88
33 INT148542 ST3GAL4 Regulation of Gene_expression of Trpv1 1 0.05 0.97 0.51 50.28
34 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73 49.68
35 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56 45.36
36 INT310700 PGR Regulation of Gene_expression of RPLP0 1 0.01 0.37 0.25 44.04
37 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25 41.56
38 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92 38.00
39 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44 32.24
40 INT312841 Pou3f1 Regulation of Gene_expression of Plp1 1 0.24 0.16 0.09 32.08
41 INT312843 Egr2 Regulation of Gene_expression of Plp1 1 0.31 0.16 0.09 32.08
42 INT312840 Egr2 Regulation of Gene_expression of Mag 1 0.31 0.16 0.09 31.44
43 INT312842 Pou3f1 Regulation of Gene_expression of Mag 1 0.24 0.16 0.09 31.44
44 INT312839 Egr2 Regulation of Gene_expression of Mbp 1 0.32 0.16 0.09 31.04
45 INT312845 Pou3f1 Regulation of Gene_expression of Mbp 1 0.25 0.16 0.09 31.04
46 INT312844 Pou3f1 Regulation of Gene_expression of Pmp22 1 0.27 0.16 0.09 30.64
47 INT312846 Egr2 Regulation of Gene_expression of Pmp22 1 0.35 0.16 0.09 30.64
48 INT310711 Binding of RPLP0 and Gabrg1 1 0.04 0.37 0.45 29.60
49 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43 27.36
50 INT262618 Binding of SOAT1 and Kras 1 0.00 0.81 0.12 26.48
51 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61 23.44
52 INT310701 RPLP0 Regulation of Positive_regulation of PGR 1 0.01 0.49 0.53 21.68
53 INT310712 Gabrg1 Positive_regulation of Gene_expression of PMP22 1 0.35 0.56 0.61 19.84
54 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81 15.36
55 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8 13.20
56 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8 12.72
57 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18 6.56
58 INT262580 Ngf Positive_regulation of Hspg2 1 0.03 0.35 0.72 5.52
59 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36 5.00
60 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
61 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
62 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
63 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
64 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
65 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
66 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
67 INT284860 Binding of Pdzd2 and Nav1 9 0.29 2.33 2.34 5.00
68 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3 5.00
69 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
70 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18 5.00
71 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
72 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9 5.00
73 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84 5.00
74 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69 5.00
75 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59 5.00
76 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 5.00
77 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 5.00
78 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
79 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
80 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45 5.00
81 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
82 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
83 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
84 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34 5.00
85 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32 5.00
86 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
87 INT314211 Ngf Positive_regulation of Gene_expression of Agtrap 1 0.04 1.15 1.3 5.00
88 INT330124 Positive_regulation of Bdkrb1 Positive_regulation of RT1-O2-ps 1 0.02 1.97 1.3 5.00
89 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29 5.00
90 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
91 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27 5.00
92 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27 5.00
93 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24 5.00
94 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24 5.00
95 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24 5.00
96 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18 5.00
97 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15 5.00
98 INT308172 Rvm Positive_regulation of Phosphorylation of GRIN1 1 0.50 0.68 1.14 5.00
99 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1 5.00
100 INT193328 Grid1 Regulation of Positive_regulation of Prkcg 1 0.00 0.1 1.1 5.00
101 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96 5.00
102 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96 5.00
103 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95 5.00
104 INT195927 Binding of Prkaca and Trpv1 1 0.07 0.28 0.92 5.00
105 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88 5.00
106 INT284855 Binding of S100a10 and Nav1 4 0.21 0.99 0.88 5.00
107 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
108 INT140660 Phax Negative_regulation of Trpv1 2 0.08 0.58 0.84 5.00
109 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83 5.00
110 INT281651 Phax Positive_regulation of Gene_expression of Trpv1 1 0.09 0.89 0.79 5.00
111 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78 5.00
112 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
113 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77 5.00
114 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76 5.00
115 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76 5.00
116 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75 5.00
117 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75 5.00
118 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75 5.00
119 INT219274 Binding of Cx3cr1 and Cx3cl1 1 0.17 1.08 0.74 5.00
120 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72 5.00
121 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71 5.00
122 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71 5.00
123 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
124 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71 5.00
125 INT262566 Par2 Regulation of Trpv1 1 0.20 0.57 0.71 5.00
126 INT262571 Phosphorylation of Trpv1 Positive_regulation of Localization of Calca 1 0.17 0.71 0.7 5.00
127 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
128 INT209250 TRPV1 Positive_regulation of Localization of DRGX 1 0.06 0.82 0.68 5.00
129 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 5.00
130 INT262570 Binding of Pax3 and Trpv1 1 0.02 1.05 0.67 5.00
131 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67 5.00
132 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
133 INT262576 Binding of Calca and Trpv1 1 0.13 1.05 0.66 5.00
134 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
135 INT259088 Trpv1 Positive_regulation of Calca 1 0.32 1.02 0.65 5.00
136 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
137 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
138 INT181084 Binding of S100a8 and S100a9 6 0.42 2.91 0.62 5.00
139 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61 5.00
140 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61 5.00
141 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61 5.00
142 INT324065 Ptger2 Positive_regulation of Prkaca 2 0.24 0.63 0.61 5.00
143 INT281650 Trpv1 Positive_regulation of Localization of Calca 1 0.12 0.71 0.61 5.00
144 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61 5.00
145 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61 5.00
146 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6 5.00
147 INT324925 Ros1 Positive_regulation of Bdkrb1 1 0.08 0.67 0.6 5.00
148 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 5.00
149 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
150 INT314208 Trap1 Positive_regulation of Mapk14 1 0.10 0.66 0.57 5.00
151 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56 5.00
152 INT281648 Negative_regulation of Binding of Trpv1 and Fig4 1 0.14 0.69 0.55 5.00
153 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55 5.00
154 INT281647 Binding of Trpv1 and Fig4 1 0.12 0.68 0.55 5.00
155 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54 5.00
156 INT281649 Negative_regulation of Binding of Calca and Trpv1 1 0.13 0.67 0.54 5.00
157 INT342689 Ptger4 Positive_regulation of Prkaca 1 0.03 0.24 0.51 5.00
158 INT262565 Prkaca Regulation of Negative_regulation of Trpv1 1 0.05 0.21 0.5 5.00
159 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
160 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48 5.00
161 INT342693 Binding of Prkaca and Gopc 1 0.01 0.23 0.48 5.00
162 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46 5.00
163 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 5.00
164 INT308170 Binding of thd and Tnfrsf14 1 0.00 1.84 0.46 5.00
165 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46 5.00
166 INT308171 Binding of TNF and thd 1 0.00 1.84 0.45 5.00
167 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
168 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44 5.00
169 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4 5.00
170 INT266393 Binding of Ager and Fn1 1 0.00 0.82 0.39 5.00
171 INT266382 Binding of Col4a1 and Fn1 1 0.00 0.82 0.39 5.00
172 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
173 INT266397 Binding of Ager and Col4a1 1 0.00 0.81 0.38 5.00
174 INT330120 Bdkrb2 Regulation of Bdkrb1 1 0.19 1.26 0.38 5.00
175 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37 5.00
176 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 5.00
177 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36 5.00
178 INT342687 Pdzd2 Regulation of Gene_expression of Nav1 1 0.19 0.3 0.35 5.00
179 INT266402 Binding of S100P and Ager 1 0.00 2.25 0.35 5.00
180 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34 5.00
181 INT342691 Pdzd2 Regulation of Nav1 1 0.19 0.48 0.34 5.00
182 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34 5.00
183 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34 5.00
184 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32 5.00
185 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32 5.00
186 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32 5.00
187 INT330389 Positive_regulation of Binding of TLR2 and TLR8 1 0.08 2.78 0.32 5.00
188 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31 5.00
189 INT330383 Binding of TLR2 and TLR3 1 0.07 2.77 0.31 5.00
190 INT330378 Positive_regulation of Binding of TLR2 and TLR3 1 0.10 2.78 0.31 5.00
191 INT330387 Binding of TLR2 and TLR8 1 0.06 2.77 0.31 5.00
192 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 5.00
193 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25 5.00
194 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24 5.00
195 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
196 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 5.00
197 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23 5.00
198 INT238802 Binding of Ager and Renbp 6 0.02 6.46 0.22 5.00
199 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 5.00
200 INT228457 Negative_regulation of Ins1 Positive_regulation of Gene_expression of Trpv1 1 0.05 1.01 0.21 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for diabetic neuropathy. They are ordered first by their pain relevance and then by number of times they were reported in diabetic neuropathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT65211 Binding of Prkcg 38 0.48 14.75 16.92 100.00
2 INT50440 Negative_regulation of Pnp 5 0.36 2.14 0.66 100.00
3 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48 100.00
4 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 100.00
5 INT140245 Binding of Gli3 3 0.36 2.65 1.46 100.00
6 INT71150 Binding of NGF 22 0.46 13.67 14.81 100.00
7 INT222029 Localization of Msc 5 0.39 1.88 0.42 100.00
8 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
9 INT117553 Regulation of MIF 10 0.56 12.76 8.67 100.00
10 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.98
11 INT152629 Positive_regulation of Bid 6 0.46 6.74 1.78 99.98
12 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 99.92
13 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 99.88
14 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 99.88
15 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 99.86
16 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 99.84
17 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 99.84
18 INT19768 Negative_regulation of LAMC2 11 0.57 10.54 5.32 99.84
19 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 99.84
20 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 99.80
21 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 99.80
22 INT10980 Gene_expression of GYPA 40 0.78 15.32 5.51 99.80
23 INT149108 Gene_expression of SOD3 2 0.67 0.85 0.19 99.80
24 INT100655 Regulation of BDNF 51 0.60 21.49 13.14 99.80
25 INT95318 Binding of Pain1 17 0.22 21.26 20.14 99.76
26 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 99.76
27 INT191668 Gene_expression of Phc2 5 0.32 3.25 0.85 99.74
28 INT209258 Gene_expression of SUB1 5 0.75 3.3 0.7 99.74
29 INT209254 Negative_regulation of Gene_expression of SUB1 1 0.01 1.4 0.56 99.74
30 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 99.74
31 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 99.68
32 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 99.64
33 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 99.60
34 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 99.60
35 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78 99.60
36 INT23834 Negative_regulation of AKR1B1 8 0.55 3.79 1.15 99.60
37 INT126585 Positive_regulation of Positive_regulation of PARP1 3 0.55 2.84 0.56 99.60
38 INT126584 Regulation of Positive_regulation of PARP1 1 0.24 0.78 0.49 99.60
39 INT291268 Gene_expression of Atr 1 0.06 1.48 0.57 99.54
40 INT151111 Gene_expression of Pain1 33 0.40 33.6 30.73 99.52
41 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 99.48
42 INT74688 Regulation of Nos1 55 0.62 22.16 25.3 99.46
43 INT20093 Binding of Akr1b1 3 0.36 0.38 0.33 99.46
44 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 99.42
45 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 99.40
46 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 99.40
47 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10 99.38
48 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88 99.38
49 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16 99.38
50 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 99.38
51 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 99.38
52 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 99.38
53 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 99.32
54 INT152977 Positive_regulation of Myt1 1 0.22 1.33 0.3 99.32
55 INT107674 Negative_regulation of Parp1 7 0.27 8.91 2.88 99.32
56 INT223033 Localization of Pain1 2 0.21 1.81 1.97 99.32
57 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75 99.26
58 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 99.24
59 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 99.20
60 INT100763 Regulation of Cpa2 1 0.08 1.82 1.03 99.20
61 INT93281 Negative_regulation of Folh1 12 0.50 5.55 10.63 99.20
62 INT249844 Regulation of Msc 1 0.23 2.79 0.54 99.20
63 INT100762 Regulation of Folh1 1 0.30 1.07 0.56 99.20
64 INT33407 Negative_regulation of Naaladl1 2 0.34 0.84 0.74 99.20
65 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 99.20
66 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39 99.18
67 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 99.16
68 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36 99.12
69 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 99.12
70 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49 99.12
71 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.12
72 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 99.02
73 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27 99.00
74 INT50895 Regulation of GYPA 10 0.60 4.05 1.95 98.92
75 INT61084 Gene_expression of Dcp1a 5 0.10 2.68 2.47 98.92
76 INT175214 Gene_expression of HSPB2 21 0.72 22.84 0.81 98.92
77 INT97411 Transcription of Dcp1a 1 0.09 0.66 0.79 98.92
78 INT3703 Negative_regulation of Grhpr 38 0.50 11.43 9.2 98.90
79 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 98.88
80 INT55781 Regulation of Csrp1 11 0.34 6.87 3.36 98.88
81 INT151906 Positive_regulation of Positive_regulation of Nfasc 2 0.11 1.98 0.98 98.84
82 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96 98.84
83 INT15156 Positive_regulation of Localization of NPPA 21 0.70 8.61 6.97 98.84
84 INT270628 Regulation of Ucp2 2 0.41 1.33 0.1 98.80
85 INT152975 Positive_regulation of Gene_expression of Myt1 1 0.33 0.67 0.17 98.76
86 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 98.76
87 INT298013 Binding of MNS1 1 0.35 1.14 0.13 98.72
88 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 98.68
89 INT74944 Positive_regulation of Gene_expression of HGF 31 0.70 17.69 6.68 98.68
90 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43 98.68
91 INT86280 Positive_regulation of Nfasc 14 0.62 6.56 3.84 98.64
92 INT103547 Gene_expression of TRPV3 47 0.78 17.06 13.34 98.64
93 INT7132 Localization of NPPA 53 0.81 19.79 10.86 98.64
94 INT123557 Gene_expression of Atf3 9 0.78 11.21 5.26 98.60
95 INT48240 Binding of Ngf 46 0.46 23.51 24.42 98.60
96 INT123787 Gene_expression of Bid 25 0.66 16 6.35 98.60
97 INT123558 Positive_regulation of Gene_expression of Atf3 2 0.70 1.45 0.43 98.60
98 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 98.60
99 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 98.60
100 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79 98.60
101 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 98.56
102 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 98.56
103 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 98.56
104 INT91926 Positive_regulation of Transcription of Kcnab3 2 0.08 0.95 1.35 98.52
105 INT97417 Positive_regulation of Transcription of LOC682801 1 0.02 0.6 0.71 98.52
106 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 98.52
107 INT152976 Binding of Myt1 1 0.18 0.6 0.16 98.40
108 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 98.36
109 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05 98.36
110 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 98.36
111 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 98.36
112 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27 98.36
113 INT312821 Binding of Ins2 2 0.37 2.13 0.46 98.36
114 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15 98.36
115 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 98.36
116 INT80251 Binding of Nos1 21 0.30 8.24 11.31 98.36
117 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 98.36
118 INT15744 Localization of GYPA 12 0.64 7.19 2.61 98.32
119 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 98.28
120 INT12054 Negative_regulation of MIA3 32 0.45 23.2 6.18 98.24
121 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12 98.24
122 INT308637 Positive_regulation of Gene_expression of MANEA 1 0.67 0.59 0.19 98.22
123 INT152974 Gene_expression of Myt1 1 0.37 0.67 0.17 98.20
124 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 98.20
125 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 98.20
126 INT5204 Positive_regulation of Gene_expression of AR 60 0.67 23.54 3.53 98.20
127 INT9126 Negative_regulation of Xdh 20 0.58 8.58 3.28 98.16
128 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 98.12
129 INT99327 Negative_regulation of PNKD 3 0.57 1.24 0.56 98.12
130 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 98.08
131 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 98.04
132 INT308639 Regulation of Gene_expression of MANEA 1 0.44 0.59 0.19 98.02
133 INT103585 Gene_expression of MANEA 4 0.75 2.12 0.31 98.02
134 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 98.00
135 INT140244 Positive_regulation of Akr1b3 3 0.69 2.8 1.12 98.00
136 INT87753 Transcription of Kcnab3 8 0.55 1.7 4.85 98.00
137 INT97414 Regulation of Transcription of Kcnab3 1 0.07 0.59 0.7 98.00
138 INT151907 Binding of Ecm1 6 0.11 2.48 0.83 97.92
139 INT91931 Positive_regulation of Kcnab3 4 0.13 2.14 3.81 97.92
140 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 97.88
141 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 97.84
142 INT16255 Negative_regulation of Ntf3 21 0.51 12.92 11.93 97.84
143 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 97.84
144 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 97.76
145 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 97.76
146 INT305322 Regulation of Olfr927-ps1 1 0.06 1.2 0.16 97.76
147 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 97.72
148 INT85048 Regulation of NGF 19 0.62 11.61 10.5 97.70
149 INT170240 Regulation of SOD3 1 0.38 0.54 0.16 97.68
150 INT312831 Negative_regulation of Lck 3 0.13 2.46 0.36 97.64
151 INT12001 Regulation of Ngf 97 0.62 54.64 76.25 97.60
152 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16 97.60
153 INT16256 Regulation of Ntf3 15 0.49 9.75 13.07 97.60
154 INT91927 Transcription of LOC682801 6 0.07 1.47 3.93 97.60
155 INT97412 Regulation of Transcription of LOC682801 1 0.02 0.54 0.65 97.60
156 INT4715 Positive_regulation of Xdh 20 0.69 6.57 2.28 97.60
157 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 97.56
158 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4 97.52
159 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01 97.44
160 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 97.44
161 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52 97.40
162 INT67915 Negative_regulation of Gtpbp4 18 0.33 6.31 10.17 97.40
163 INT3040 Gene_expression of MIA3 81 0.24 53.61 12.62 97.28
164 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 97.28
165 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59 97.24
166 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91 97.24
167 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57 97.24
168 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68 97.24
169 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69 97.24
170 INT330333 Gene_expression of Lap2 1 0.17 1.57 0.69 97.24
171 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 97.22
172 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 97.16
173 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 97.14
174 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 97.08
175 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 97.02
176 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 97.02
177 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 97.00
178 INT153763 Gene_expression of Mcm3 2 0.33 1.39 0.4 96.88
179 INT153764 Positive_regulation of Gene_expression of Mcm3 1 0.03 1.14 0.4 96.88
180 INT214 Localization of AVP 370 0.81 208.51 91.09 96.82
181 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84 96.76
182 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 96.72
183 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 96.72
184 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 96.68
185 INT141658 Positive_regulation of Gene_expression of Sod2 51 0.69 35.6 3.71 96.68
186 INT31226 Localization of PPY 20 0.78 9.93 6.8 96.68
187 INT130246 Negative_regulation of Gene_expression of TRPM8 4 0.59 3.35 1.14 96.56
188 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 96.56
189 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 96.48
190 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 96.44
191 INT101239 Gene_expression of NTF3 9 0.76 5.91 2.97 96.44
192 INT126582 Negative_regulation of Polb 1 0.01 0.54 0.19 96.40
193 INT153189 Gene_expression of Sema3a 19 0.75 14.37 4.21 96.28
194 INT153762 Positive_regulation of Gene_expression of Sema3a 6 0.49 4.56 1.65 96.28
195 INT312832 Negative_regulation of Ins2 1 0.37 0.64 0.09 96.28
196 INT2578 Binding of Ins1 74 0.48 33.57 12.92 96.24
197 INT96602 Positive_regulation of Binding of Ins1 4 0.65 1.59 0.7 96.24
198 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 96.20
199 INT74099 Negative_regulation of Dynll1 8 0.56 3.43 7.25 96.20
200 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 96.08
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