P:ectopic activity

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Pain Term
Category Process
Synonyms None
Pain Specific No
Documents 119
Hot Single Events 32
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for ectopic activity. They are ordered first by their pain relevance and then by number of times they were reported for ectopic activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09 54.88
2 INT257720 Bdnf Regulation of Vgf 1 0.19 0.64 0.49 49.16
3 INT257719 Ngf Regulation of Vgf 1 0.22 0.64 0.48 49.16
4 INT257713 Ngf Positive_regulation of Transcription of Vgf 1 0.41 0.66 0.57 47.00
5 INT257715 Bdnf Positive_regulation of Transcription of Vgf 1 0.35 0.66 0.57 46.68
6 INT257717 Binding of Bdnf and Vgf 1 0.25 0.86 0.61 41.00
7 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
8 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
9 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17 5.00
10 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
11 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
12 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
13 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
14 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
15 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
16 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
17 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99 5.00
18 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86 5.00
19 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86 5.00
20 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
21 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
22 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00
23 INT222253 Binding of Cxcl10 and Fig4 1 0.09 0.66 0.65 5.00
24 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55 5.00
25 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55 5.00
26 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55 5.00
27 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55 5.00
28 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32 5.00
29 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32 5.00
30 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
31 INT257728 Binding of Pbx2 and Vgf 1 0.42 0.18 0.21 5.00
32 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
33 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
34 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
35 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
36 INT222248 Binding of Cxcr3 and Cxcl10 1 0.35 0.48 0.09 5.00
37 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
38 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
39 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
40 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for ectopic activity. They are ordered first by their pain relevance and then by number of times they were reported in ectopic activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14238 Positive_regulation of Cd69 19 0.60 17.75 6.07 100.00
2 INT47161 Protein_catabolism of Cd69 1 0.45 1.71 0.6 100.00
3 INT141036 Negative_regulation of Aifm1 1 0.00 1.26 1.07 100.00
4 INT48286 Positive_regulation of Myl3 6 0.33 3.2 0.77 99.96
5 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.20
6 INT44979 Positive_regulation of Pnp 11 0.59 5.61 2.41 98.16
7 INT77789 Positive_regulation of Tnfrsf1b 12 0.65 13.77 6.58 98.00
8 INT141037 Positive_regulation of Aifm1 3 0.45 3.32 1.38 97.80
9 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 97.44
10 INT117676 Positive_regulation of Transcription of Nav1 8 0.53 4.37 7.75 97.44
11 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 97.04
12 INT117675 Transcription of Nav1 46 0.72 30.23 44.01 97.04
13 INT97366 Regulation of Nav1 38 0.62 23.63 38.17 96.24
14 INT117674 Regulation of Gene_expression of Nav1 16 0.62 11.5 22.01 96.24
15 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 94.84
16 INT6852 Localization of TNF 883 0.81 705.95 270.84 93.92
17 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 93.24
18 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 92.64
19 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 92.16
20 INT48248 Gene_expression of Scn10a 38 0.78 19.3 25.05 91.24
21 INT85766 Gene_expression of Scn11a 19 0.78 6.82 8.24 91.24
22 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 91.04
23 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 89.92
24 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 89.92
25 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 89.92
26 INT71381 Localization of Nos1 33 0.79 11.46 8.05 89.60
27 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 86.44
28 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 83.92
29 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 82.64
30 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 82.00
31 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 82.00
32 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 80.44
33 INT54002 Negative_regulation of Dh 6 0.20 3.05 5.06 79.04
34 INT97695 Positive_regulation of Dh 3 0.33 1.44 1.1 77.84
35 INT12001 Regulation of Ngf 97 0.62 54.64 76.25 77.84
36 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 77.52
37 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5 76.84
38 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 76.08
39 INT77785 Negative_regulation of Gene_expression of Tnfrsf1a 4 0.56 3.1 1.35 76.08
40 INT47375 Localization of Pts 4 0.59 2.7 0.44 75.88
41 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54 75.00
42 INT70980 Negative_regulation of Scnn1g 8 0.23 3.11 5.31 75.00
43 INT8270 Positive_regulation of Ear11 8 0.60 1.74 3.42 75.00
44 INT70981 Regulation of Scnn1g 1 0.07 0.62 0.91 75.00
45 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 73.16
46 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 71.64
47 INT112207 Binding of Nav1 27 0.47 7.1 15.43 71.60
48 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 70.32
49 INT258046 Binding of DUT 1 0.01 0.63 0.15 69.76
50 INT100026 Gene_expression of Tnfrsf1b 73 0.72 43.26 23.23 69.44
51 INT131762 Positive_regulation of Gene_expression of Gucy1b2 1 0.19 1.73 1.14 67.52
52 INT131763 Gene_expression of Gucy1b2 4 0.21 2.45 1.51 67.52
53 INT145971 Localization of Nav1 20 0.81 10.3 18.11 67.52
54 INT186230 Positive_regulation of Timd4 2 0.01 2.54 2.93 64.20
55 INT50328 Positive_regulation of Vgf 8 0.70 13.98 6.37 63.44
56 INT220070 Negative_regulation of ASIC2 1 0.02 1.09 1.39 62.64
57 INT141038 Positive_regulation of Gene_expression of Hcn4 4 0.38 3.58 3.12 61.36
58 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25 61.00
59 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 59.56
60 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68 55.28
61 INT89959 Positive_regulation of Gene_expression of Aif1 14 0.58 7.44 5.05 55.28
62 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 52.12
63 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 51.80
64 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31 51.64
65 INT158843 Regulation of NALCN 6 0.04 2.89 3.63 46.28
66 INT257727 Transcription of Vgf 1 0.72 7.38 3.52 45.96
67 INT100748 Regulation of FOLH1 3 0.60 3.58 2.75 41.12
68 INT50325 Regulation of Vgf 2 0.62 4.4 2.58 41.00
69 INT88114 Gene_expression of Cd53 20 0.77 10.99 12.38 34.48
70 INT131761 Positive_regulation of Gucy1b2 1 0.16 1.38 1.07 34.00
71 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 33.52
72 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 31.12
73 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 31.12
74 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87 30.16
75 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 29.88
76 INT99336 Negative_regulation of FOLH1 30 0.57 8.83 11.53 25.12
77 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 25.00
78 INT93281 Negative_regulation of Folh1 12 0.50 5.55 10.63 25.00
79 INT21533 Positive_regulation of Il1f5 7 0.25 4.78 2.77 25.00
80 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 24.64
81 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 21.36
82 INT93200 Gene_expression of ASIC2 6 0.60 3.27 3.7 21.36
83 INT22066 Gene_expression of Phax 40 0.78 22.51 25.91 11.00
84 INT281645 Regulation of Gene_expression of Phax 3 0.08 2.51 2.44 11.00
85 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14 9.40
86 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 8.56
87 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
88 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
89 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
90 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
91 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
92 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 5.00
93 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
94 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
95 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
96 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
97 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
98 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
99 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 5.00
100 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
101 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
102 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
103 INT2541 Binding of Calca 200 0.48 67.14 134.62 5.00
104 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
105 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
106 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
107 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 5.00
108 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 5.00
109 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
110 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
111 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
112 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 5.00
113 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
114 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
115 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
116 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
117 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
118 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
119 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
120 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
121 INT3034 Localization of Ngf 126 0.81 50.81 72.84 5.00
122 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
123 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
124 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
125 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
126 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
127 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
128 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
129 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
130 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
131 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 5.00
132 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98 5.00
133 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
134 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 5.00
135 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
136 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
137 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
138 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
139 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14 5.00
140 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
141 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
142 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
143 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
144 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
145 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
146 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
147 INT63383 Binding of Cnr1 77 0.48 22.28 44.61 5.00
148 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
149 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 5.00
150 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
151 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
152 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 5.00
153 INT107576 Gene_expression of Atf3 114 0.78 72.42 38.64 5.00
154 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
155 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 5.00
156 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
157 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
158 INT103262 Localization of Nav1 53 0.81 19.23 34.44 5.00
159 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
160 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
161 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 5.00
162 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 5.00
163 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07 5.00
164 INT22499 Regulation of Calca 42 0.62 17.32 28.02 5.00
165 INT82882 Localization of Ccl2 61 0.80 41.96 28 5.00
166 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 5.00
167 INT111359 Localization of Cnr1 55 0.81 11.25 27.41 5.00
168 INT47685 Positive_regulation of Positive_regulation of Bdnf 32 0.70 20.05 27.03 5.00
169 INT127499 Positive_regulation of TRPA1 72 0.70 21.7 26.86 5.00
170 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 5.00
171 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 5.00
172 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
173 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
174 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
175 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92 5.00
176 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71 5.00
177 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 5.00
178 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 5.00
179 INT129157 Positive_regulation of Atf3 48 0.69 35.42 22.87 5.00
180 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 5.00
181 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14 5.00
182 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
183 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 5.00
184 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
185 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41 5.00
186 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
187 INT27018 Gene_expression of PTGER1 68 0.75 31.76 20.12 5.00
188 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45 5.00
189 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
190 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 5.00
191 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
192 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
193 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
194 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62 5.00
195 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 5.00
196 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
197 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28 5.00
198 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01 5.00
199 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
200 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
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