P:glial activation

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pChart

Pain Term
Category Process
Synonyms None
Pain Specific No
Documents 204
Hot Single Events 200
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for glial activation. They are ordered first by their pain relevance and then by number of times they were reported for glial activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT247851 Negative_regulation of Aqp4 Negative_regulation of Positive_regulation of Narfl 1 0.09 1.78 0.15 81.56
2 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83 81.36
3 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19 80.88
4 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19 80.88
5 INT333051 Binding of HIVEP1 and NOLC1 1 0.00 4.11 0.07 79.64
6 INT247843 Narfl Regulation of Aqp4 1 0.04 1.07 0.04 79.28
7 INT247855 Positive_regulation of Narfl Regulation of Aqp4 1 0.04 2.93 0.04 79.28
8 INT192864 Binding of Hspa5 and Mela 1 0.25 1.06 0.22 78.84
9 INT119772 Binding of Cd53 and Gfap 1 0.04 1.01 0.81 75.00
10 INT140168 Binding of Cx3cl1 and Cx3cr1 2 0.31 1.55 0.98 75.00
11 INT198931 Binding of Dlg4 and Lrp8 1 0.06 0.23 0.46 72.16
12 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42 68.80
13 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97 67.48
14 INT230500 Il1 Positive_regulation of Gene_expression of Tnf 1 0.07 1.83 0.4 65.28
15 INT230501 Il1 Positive_regulation of Gene_expression of S100a8 1 0.01 1.82 0.39 62.24
16 INT157459 Binding of CX3CR1 and CX3CL1 1 0.32 2.12 1.7 58.32
17 INT308172 Rvm Positive_regulation of Phosphorylation of GRIN1 1 0.50 0.68 1.14 57.72
18 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15 50.36
19 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15 50.36
20 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15 50.36
21 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15 50.36
22 INT100597 Regulation of RPL21P132 Positive_regulation of IL6 1 0.01 0.45 0.53 50.04
23 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 50.00
24 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31 50.00
25 INT187796 Binding of Tnf and Il1 1 0.09 1.85 0.48 50.00
26 INT187795 Positive_regulation of Binding of Tnf and Il1 1 0.13 1.87 0.48 50.00
27 INT200428 Sdcbp Positive_regulation of Gene_expression of Gfap 1 0.04 0.15 0.04 49.84
28 INT316059 Ps Regulation of Binding of Cd4 1 0.06 0.86 0.13 49.72
29 INT316058 Ps Regulation of Binding of Cd8a 1 0.02 0.86 0.13 49.72
30 INT333052 HIVEP1 Positive_regulation of Gene_expression of IL8 1 0.08 1.31 0.04 48.12
31 INT100596 RPL21P132 Positive_regulation of TNF 1 0.00 0.43 0.5 46.20
32 INT100595 RPL21P132 Positive_regulation of IL6 1 0.01 0.43 0.49 46.20
33 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97 43.08
34 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 0.11 1.57 1.37 40.64
35 INT100594 DCSTAMP Positive_regulation of Gene_expression of IL6 1 0.03 0.24 0.41 37.56
36 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4 35.52
37 INT190097 Binding of Hivep3 and Hivep3 1 0.14 0.78 0.42 34.68
38 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86 32.56
39 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86 32.56
40 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71 26.96
41 INT262826 Serpinf1 Negative_regulation of Gene_expression of TNF 1 0.29 1.83 0.28 26.04
42 INT346915 Il12a Positive_regulation of Positive_regulation of IFN1@ 1 0.20 1.26 0.34 23.28
43 INT247856 Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 1 0.03 21.36
44 INT247853 Positive_regulation of Narfl Negative_regulation of Gene_expression of Uchl1 1 0.03 0.54 0 21.36
45 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81 21.20
46 INT237419 Binding of Hif1a and Bace1 Positive_regulation of Bace1 1 0.06 1.2 0.15 17.96
47 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15 17.96
48 INT237420 Binding of Hif1a and Bace1 Positive_regulation of Positive_regulation of Bace1 1 0.06 1.2 0.15 17.96
49 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81 17.68
50 INT325767 Negative_regulation of Omd Positive_regulation of Ddc 1 0.01 0.38 0.25 14.08
51 INT266040 Binding of Acot1 and Amh-rs5 Positive_regulation of Positive_regulation of Nos3 1 0.00 0.21 0.09 6.32
52 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33 5.00
53 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17 5.00
54 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57 5.00
55 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06 5.00
56 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81 5.00
57 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75 5.00
58 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71 5.00
59 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 5.00
60 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38 5.00
61 INT352196 Igkv12-66 Negative_regulation of Gm10404 1 0.00 1.62 1.34 5.00
62 INT190130 Binding of CPOX and MRXS5 1 0.00 1.4 1.23 5.00
63 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2 5.00
64 INT332776 FSCN1 Positive_regulation of Grin1 1 0.02 0.21 1.12 5.00
65 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 5.00
66 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1 5.00
67 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06 5.00
68 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95 5.00
69 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92 5.00
70 INT215945 Binding of Mmp14 and Timp2 Positive_regulation of Mmp2 1 0.11 0.4 0.84 5.00
71 INT237379 Binding of Ebi3 and Il27 2 0.05 1.71 0.82 5.00
72 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82 5.00
73 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82 5.00
74 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75 5.00
75 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72 5.00
76 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67 5.00
77 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66 5.00
78 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66 5.00
79 INT222253 Binding of Cxcl10 and Fig4 1 0.09 0.66 0.65 5.00
80 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64 5.00
81 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61 5.00
82 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56 5.00
83 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55 5.00
84 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55 5.00
85 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55 5.00
86 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55 5.00
87 INT216918 Binding of Ca2 and Abat 1 0.01 0.45 0.53 5.00
88 INT216919 Ngf Positive_regulation of Gene_expression of P2rx3 1 0.18 0.69 0.53 5.00
89 INT292075 FSCN1 Positive_regulation of Gene_expression of Csnk1a1 1 0.03 0.57 0.52 5.00
90 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49 5.00
91 INT308170 Binding of thd and Tnfrsf14 1 0.00 1.84 0.46 5.00
92 INT346913 Binding of Kars and Positive_regulation of Gene_expression of Ros1 1 0.03 1.25 0.46 5.00
93 INT308171 Binding of TNF and thd 1 0.00 1.84 0.45 5.00
94 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 0.05 1.24 0.45 5.00
95 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45 5.00
96 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45 5.00
97 INT262815 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.39 2.73 0.44 5.00
98 INT262819 Gene_expression of Serpinf1 Negative_regulation of Binding of 1190002H23Rik 1 0.05 2.66 0.43 5.00
99 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42 5.00
100 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42 5.00
101 INT316063 Ps Positive_regulation of IL8 1 0.09 1.33 0.41 5.00
102 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41 5.00
103 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4 5.00
104 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39 5.00
105 INT237415 Il1rn Regulation of Il10 1 0.03 0.96 0.39 5.00
106 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39 5.00
107 INT237369 SOAT1 Negative_regulation of Phosphorylation of JAK1 1 0.00 0 0.38 5.00
108 INT329086 Binding of Gc and Scly 1 0.03 0.75 0.38 5.00
109 INT262824 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.39 1.56 0.37 5.00
110 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36 5.00
111 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35 5.00
112 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34 5.00
113 INT191128 Positive_regulation of P2RX7 Positive_regulation of Localization of Il1b 1 0.02 0.71 0.34 5.00
114 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34 5.00
115 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34 5.00
116 INT190652 Mdk Positive_regulation of Phosphorylation of Mapk1 2 0.50 0.85 0.33 5.00
117 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32 5.00
118 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32 5.00
119 INT349506 S100a8 Positive_regulation of Gene_expression of Nos2 1 0.02 0.67 0.28 5.00
120 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28 5.00
121 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27 5.00
122 INT262820 Binding of Aif1 and Serpinf1 1 0.01 1.3 0.27 5.00
123 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26 5.00
124 INT237380 Binding of Cdkn2d and Il12b 1 0.01 0.45 0.26 5.00
125 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25 5.00
126 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24 5.00
127 INT346912 Il6 Positive_regulation of Gene_expression of Il4 1 0.07 0.62 0.24 5.00
128 INT178720 NOVA2 Regulation of Fig4 1 0.01 0 0.23 5.00
129 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23 5.00
130 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22 5.00
131 INT262817 Serpinf1 Regulation of Positive_regulation of 1190002H23Rik 1 0.06 1.3 0.22 5.00
132 INT149791 Binding of Lrp8 and Reln 4 0.36 0.38 0.22 5.00
133 INT266038 Atp6v1e1 Positive_regulation of Positive_regulation of Mapk1 1 0.07 0.64 0.22 5.00
134 INT316054 Eif1 Positive_regulation of Il6 1 0.00 0.78 0.21 5.00
135 INT316062 Ps Positive_regulation of Il6 1 0.04 0.77 0.21 5.00
136 INT215944 Mmp14 Regulation of Eae1 1 0.03 0.95 0.2 5.00
137 INT333053 IL6 Positive_regulation of Gene_expression of HNRNPA1 1 0.02 2.39 0.2 5.00
138 INT215942 Regulation of Mmp14 Regulation of Eae1 1 0.03 0.95 0.2 5.00
139 INT316064 Binding of RBPJ and Csl 1 0.16 0.33 0.2 5.00
140 INT190651 Mdk Negative_regulation of Positive_regulation of Mapk1 1 0.40 0.23 0.19 5.00
141 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19 5.00
142 INT139848 Binding of Bace1 and Bace2 2 0.28 0.31 0.18 5.00
143 INT262818 Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.45 0.71 0.18 5.00
144 INT262822 Serpinf1 Negative_regulation of Negative_regulation of 1190002H23Rik 1 0.07 1.27 0.18 5.00
145 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17 5.00
146 INT349483 Cyp7b1 Negative_regulation of Ptpn2 Negative_regulation of Th 1 0.25 0.76 0.16 5.00
147 INT349505 Ptpn2 Negative_regulation of Slc6a3 1 0.19 0.7 0.16 5.00
148 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16 5.00
149 INT325532 Binding of Cx3cl1 and Cxcl10 1 0.28 0.67 0.16 5.00
150 INT266036 Gpr30 Positive_regulation of Positive_regulation of Mapk1 1 0.19 0.24 0.15 5.00
151 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13 5.00
152 INT220639 Binding of Apbb1 and Ighd 1 0.12 0.31 0.12 5.00
153 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12 5.00
154 INT220633 Binding of Kat5 and Ighd 1 0.09 0.32 0.12 5.00
155 INT283719 Id2 Regulation of Regulation of Hes7 1 0.00 0.31 0.12 5.00
156 INT149792 Binding of Reln and Vldlr 3 0.51 0.35 0.11 5.00
157 INT283710 Binding of Id2 and Hes7 1 0.01 0.13 0.11 5.00
158 INT262702 Bace1 Positive_regulation of Aplp2 1 0.14 0.25 0.09 5.00
159 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09 5.00
160 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09 5.00
161 INT262704 Bace1 Positive_regulation of Aplp1 1 0.15 0.25 0.09 5.00
162 INT222248 Binding of Cxcr3 and Cxcl10 1 0.35 0.48 0.09 5.00
163 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08 5.00
164 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08 5.00
165 INT192865 Binding of Esr1 and Pdia3 1 0.07 0.67 0.08 5.00
166 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 5.00
167 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08 5.00
168 INT262825 Serpinf1 Negative_regulation of Gfap 1 0.34 0.87 0.08 5.00
169 INT283721 Binding of Lpin1 and Id2 1 0.38 0.18 0.08 5.00
170 INT262821 Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.54 0.85 0.08 5.00
171 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 5.00
172 INT220629 Gene_expression of Bace1 Positive_regulation of Localization of Il1r2 1 0.17 0.19 0.07 5.00
173 INT220638 Gene_expression of Bace2 Positive_regulation of Localization of Il1r2 1 0.13 0.19 0.07 5.00
174 INT190094 Cep70 Positive_regulation of Transcription of Jun 1 0.00 0.05 0.06 5.00
175 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05 5.00
176 INT198923 Gene_expression of Lrp8 Positive_regulation of Gene_expression of Lifr 1 0.01 0 0.04 5.00
177 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04 5.00
178 INT190095 Negative_regulation of Binding of Hivep3 and Traf2 1 0.15 0.08 0.04 5.00
179 INT198922 Lrp8 Negative_regulation of Binding of Vldlr 1 0.19 0 0.04 5.00
180 INT190096 Binding of Hivep3 and Traf2 1 0.17 0.08 0.04 5.00
181 INT325766 Binding of Ddc and Omd 1 0.01 0.59 0.04 5.00
182 INT198917 Lrp8 Negative_regulation of Binding of Reln 1 0.15 0 0.04 5.00
183 INT266039 Binding of Acot1 and Amh-rs5 1 0.00 0.13 0.04 5.00
184 INT198930 Binding of Lrp8 and Vldlr 1 0.16 0 0.04 5.00
185 INT198919 Binding of Lrp1 and Lrpap1 1 0.07 0 0.04 5.00
186 INT198935 Lrp8 Negative_regulation of Binding of Reln and Reln 1 0.07 0 0.04 5.00
187 INT316060 Binding of Erbb4 and Ncor2 1 0.12 0.41 0.03 5.00
188 INT283720 Id2 Negative_regulation of Transcription of Cdkn2b 1 0.18 0.11 0.03 5.00
189 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03 5.00
190 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03 5.00
191 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03 5.00
192 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03 5.00
193 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03 5.00
194 INT283712 Id2 Regulation of Gene_expression of Fos 1 0.43 0 0.03 5.00
195 INT349511 Ptpn2 Positive_regulation of Ptpn2 Negative_regulation of Th 1 0.16 1.3 0.03 5.00
196 INT316056 Binding of Ncor2 and Tab2 1 0.12 0.41 0.03 5.00
197 INT316055 Binding of Erbb4 and Tab2 1 0.23 0.4 0.03 5.00
198 INT198920 Binding of Ldlr and Lrpap1 1 0.05 0.06 0 5.00
199 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0 5.00
200 INT220631 Gene_expression of Gga1 Positive_regulation of Bace1 2 0.24 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for glial activation. They are ordered first by their pain relevance and then by number of times they were reported in glial activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT18755 Positive_regulation of Rvm 79 0.60 60 92.93 100.00
2 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 100.00
3 INT93120 Localization of Gfap 21 0.78 8.42 3.7 100.00
4 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21 100.00
5 INT161734 Positive_regulation of Positive_regulation of Rvm 2 0.44 3.21 2.24 100.00
6 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 100.00
7 INT117642 Regulation of Gene_expression of Grin1 18 0.53 7.09 8.08 100.00
8 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64 100.00
9 INT112372 Positive_regulation of GPSM2 8 0.41 5.49 1.94 100.00
10 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 100.00
11 INT12148 Positive_regulation of IGKV1-5 24 0.57 3.13 1.25 100.00
12 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.96
13 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19 99.96
14 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.96
15 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 99.96
16 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 99.96
17 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 99.90
18 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 99.90
19 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 99.90
20 INT95312 Regulation of Slc6a1 3 0.27 0.77 1.09 99.90
21 INT68297 Binding of MAPT 9 0.47 4.45 0.75 99.88
22 INT72564 Localization of Il10 41 0.78 28.62 17.6 99.80
23 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 99.78
24 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.76
25 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 99.76
26 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.76
27 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 99.72
28 INT2683 Binding of SGSM3 6 0.36 7.98 1.2 99.72
29 INT6849 Localization of IL1B 229 0.81 112.56 69.63 99.68
30 INT187789 Positive_regulation of Positive_regulation of Bace1 18 0.50 16.18 1.87 99.68
31 INT49473 Gene_expression of MSR1 14 0.75 7.28 2.64 99.66
32 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.64
33 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.64
34 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79 99.56
35 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 99.52
36 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 99.52
37 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 99.46
38 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 99.46
39 INT121162 Gene_expression of Cx3cl1 22 0.78 11.56 14.59 99.44
40 INT157462 Negative_regulation of Binding of CX3CR1 1 0.42 1.62 1.36 99.42
41 INT17750 Localization of MRXS5 15 0.56 6.65 3.1 99.40
42 INT5966 Localization of Il1a 50 0.78 22.91 26.54 99.38
43 INT128921 Negative_regulation of Gene_expression of Ephb1 18 0.49 9.54 14.93 99.24
44 INT102485 Negative_regulation of Gene_expression of Rvm 2 0.36 1.45 1.38 99.24
45 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 99.18
46 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39 99.16
47 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 99.12
48 INT49555 Positive_regulation of Positive_regulation of Gfap 18 0.69 11.51 10.29 99.12
49 INT157461 Binding of CX3CR1 3 0.36 6.72 2.67 99.10
50 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 99.06
51 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 99.06
52 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 99.04
53 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19 99.04
54 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 99.00
55 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 98.98
56 INT63586 Regulation of Parp1 5 0.43 3.28 1.68 98.96
57 INT217380 Negative_regulation of Negative_regulation of Mtap2 2 0.27 1.18 0.31 98.88
58 INT217371 Negative_regulation of Negative_regulation of Syp 2 0.11 1.16 0.29 98.88
59 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 98.84
60 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 98.82
61 INT29144 Gene_expression of Rvm 41 0.52 29.23 47.76 98.76
62 INT165821 Positive_regulation of Aqp4 27 0.70 24.37 3.22 98.76
63 INT129610 Gene_expression of Id2 7 0.74 17.07 1.69 98.76
64 INT211548 Gene_expression of Lpin1 9 0.76 12.83 0.96 98.76
65 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 98.76
66 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79 98.76
67 INT235951 Positive_regulation of Positive_regulation of Aqp4 4 0.57 5.13 0.75 98.76
68 INT65500 Gene_expression of App 605 0.78 429.94 98.31 98.72
69 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 98.72
70 INT122769 Gene_expression of GFRA1 1 0.00 0.71 0.95 98.72
71 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65 98.64
72 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25 98.60
73 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 98.60
74 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 98.56
75 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 98.56
76 INT15001 Localization of Gfap 29 0.75 6.71 4.1 98.56
77 INT53784 Positive_regulation of Regulation of Gfap 7 0.50 3.31 4.68 98.52
78 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97 98.36
79 INT73673 Negative_regulation of Mtap2 9 0.32 8.25 1.4 98.36
80 INT185973 Negative_regulation of Syp 16 0.54 2.83 0.87 98.36
81 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 98.32
82 INT145929 Regulation of Bax 20 0.60 18.12 5.35 98.32
83 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 98.16
84 INT29704 Regulation of Casp3 51 0.56 22.13 22.79 98.12
85 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 98.08
86 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 98.04
87 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 98.00
88 INT222233 Gene_expression of Cxcl12 42 0.69 32.64 10.13 98.00
89 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91 97.96
90 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 97.90
91 INT6866 Regulation of Gfap 51 0.61 19.6 23.56 97.80
92 INT2225 Binding of Gfap 31 0.47 11.78 8.53 97.80
93 INT26640 Regulation of Pigm 17 0.35 3.94 7.02 97.80
94 INT12748 Binding of Pigm 2 0.32 0.31 1.87 97.80
95 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14 97.76
96 INT122041 Binding of Ppara 308 0.48 189.17 51.48 97.72
97 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83 97.44
98 INT247867 Positive_regulation of Positive_regulation of Narfl 1 0.11 5.16 0.05 97.40
99 INT74449 Positive_regulation of B4GALNT1 53 0.30 34.49 14.96 97.28
100 INT100821 Localization of Ros1 59 0.60 45.26 11.92 97.24
101 INT126197 Transcription of Bace1 13 0.72 7.34 3.87 97.20
102 INT217382 Regulation of Gene_expression of Bace1 26 0.61 17 1.76 97.20
103 INT220600 Regulation of Transcription of Bace1 2 0.42 0.95 0.81 97.20
104 INT247868 Positive_regulation of Narfl 1 0.11 37.11 0.68 97.12
105 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45 97.08
106 INT168784 Regulation of Positive_regulation of Slc6a1 1 0.45 0.87 1.01 97.04
107 INT233568 Positive_regulation of Apod 4 0.66 4.91 0.87 97.04
108 INT329079 Negative_regulation of Positive_regulation of Apod 1 0.03 1.54 0.54 97.04
109 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 97.00
110 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44 97.00
111 INT292060 Positive_regulation of Csnk1a1 1 0.53 6.03 4.57 96.96
112 INT292070 Binding of Csnk1a1 1 0.28 3.18 2.5 96.96
113 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 96.80
114 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 96.80
115 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35 96.80
116 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 96.80
117 INT17668 Positive_regulation of MCKD1 5 0.02 1.56 3.91 96.64
118 INT179455 Gene_expression of Trhde 3 0.05 1.79 0.88 96.60
119 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27 96.52
120 INT129685 Negative_regulation of FSCN1 7 0.05 3.44 5.69 96.40
121 INT56494 Localization of Ide 73 0.68 22.9 11.26 96.28
122 INT318182 Localization of Trhde 1 0.11 0.68 0.51 96.28
123 INT292049 Gene_expression of Csnk1a1 1 0.59 28.22 19.53 96.24
124 INT6852 Localization of TNF 883 0.81 705.95 270.84 95.92
125 INT92513 Regulation of Grin1 26 0.59 9.12 13.94 95.92
126 INT12082 Localization of IL6 365 0.81 241.78 105.78 95.92
127 INT111066 Regulation of Bace1 40 0.61 31.47 4.28 95.92
128 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 95.64
129 INT185487 Localization of Cxcl10 6 0.61 3.21 3.21 95.48
130 INT121161 Localization of Cx3cl1 14 0.75 10.07 10.61 95.40
131 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39 95.24
132 INT114638 Negative_regulation of Gene_expression of RT1-Ha 1 0.58 0.53 0.72 95.20
133 INT79259 Regulation of Itgal 4 0.40 2.94 0.23 95.20
134 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 94.92
135 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 94.84
136 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09 94.68
137 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 94.64
138 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 94.64
139 INT191120 Regulation of P2RX7 8 0.41 5.29 2.96 94.60
140 INT74241 Positive_regulation of Gene_expression of EDA 3 0.49 4.93 2.24 94.56
141 INT56404 Gene_expression of EDA 16 0.75 7.09 4.24 94.56
142 INT104464 Gene_expression of RT1-Ha 4 0.76 0.68 0.72 94.52
143 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 94.40
144 INT48663 Negative_regulation of Gene_expression of Gfap 45 0.59 18.34 19.84 94.04
145 INT74826 Gene_expression of Slc1a2 131 0.78 61.83 100.84 94.00
146 INT74827 Positive_regulation of Gene_expression of Slc1a2 52 0.70 26.54 50.63 94.00
147 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 93.92
148 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 93.72
149 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 93.72
150 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 93.32
151 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 93.20
152 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 93.12
153 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 93.00
154 INT20397 Positive_regulation of Itgax 12 0.46 6.48 1.19 92.96
155 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81 92.76
156 INT198871 Gene_expression of Lrpap1 1 0.18 0.14 0.34 92.72
157 INT198897 Positive_regulation of Gene_expression of Lrpap1 1 0.13 0.15 0.34 92.72
158 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 92.44
159 INT172559 Localization of Proc 16 0.02 21.49 2.08 92.32
160 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08 92.24
161 INT10706 Regulation of Il6 150 0.62 93.23 62.34 92.16
162 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3 92.16
163 INT126200 Negative_regulation of Bace1 73 0.58 50.19 7.44 91.84
164 INT95317 Positive_regulation of Slc6a1 6 0.69 5.91 7.94 91.76
165 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86 91.64
166 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 91.60
167 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 91.48
168 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 91.28
169 INT97596 Localization of S100a8 94 0.78 90.69 40.41 91.20
170 INT55343 Localization of Ros1 39 0.60 34.51 12.5 90.92
171 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 90.84
172 INT24605 Negative_regulation of Scly 6 0.34 3.98 1.71 90.80
173 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46 90.72
174 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 90.64
175 INT96744 Positive_regulation of Gene_expression of Cxcr4 14 0.68 7.92 5.75 90.64
176 INT1120 Gene_expression of C3 33 0.67 22.86 7.56 90.40
177 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 90.40
178 INT110231 Regulation of Gene_expression of Cxcr4 7 0.44 3.18 2.44 90.16
179 INT197360 Regulation of MCAT 6 0.09 7.86 1.78 90.08
180 INT108763 Gene_expression of Cd81 3 0.59 1.12 0.27 90.08
181 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69 89.92
182 INT49553 Regulation of Gene_expression of Gfap 42 0.62 17.04 23.65 89.64
183 INT198062 Regulation of CACNA1I 1 0.20 2.94 1.03 89.52
184 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 89.40
185 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72 89.40
186 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 89.04
187 INT97394 Regulation of Stat3 6 0.41 2.52 1.34 89.04
188 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29 89.04
189 INT325492 Regulation of Ep300 1 0.04 0.29 0.24 89.04
190 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02 89.00
191 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 88.96
192 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 88.96
193 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 88.96
194 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10 88.92
195 INT141385 Positive_regulation of Gene_expression of P2RX7 7 0.62 3.95 1.73 88.92
196 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68 88.64
197 INT13354 Transcription of TNF 108 0.72 85.81 42.32 88.64
198 INT105156 Phosphorylation of Gfap 23 0.79 11.85 13.76 88.64
199 INT105157 Positive_regulation of Phosphorylation of Gfap 8 0.67 6.48 6.38 88.64
200 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 88.56
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