P:guanethidine

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Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 754
Hot Single Events 200
Hot Interactions 19

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for guanethidine. They are ordered first by their pain relevance and then by number of times they were reported for guanethidine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11252 Cck Positive_regulation of Fos 6 0.78 0 3.79 99.06
2 INT141016 Il18 Positive_regulation of Gene_expression of Ifng 1 0.39 0.27 0.39 91.84
3 INT93478 Adcyap1 Regulation of Vip 1 0.31 0 0.1 90.16
4 INT73368 Ang1 Negative_regulation of Fabp6 1 0.00 0.44 0.56 87.16
5 INT131650 Cck Positive_regulation of Fosl1 1 0.17 0 0.8 85.36
6 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34 84.68
7 INT41868 GRP Regulation of Vip 1 0.01 0 0.84 82.08
8 INT41858 Nts Regulation of Vip 1 0.10 0 0.84 82.08
9 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84 82.08
10 INT41857 Avp Regulation of Vip 1 0.01 0 0.84 82.08
11 INT41861 Vip Regulation of Cck 1 0.02 0 0.84 82.08
12 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84 82.08
13 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84 82.08
14 INT41864 Nts Regulation of Cpe 1 0.01 0 0.84 82.08
15 INT41867 GRP Regulation of Cpe 1 0.00 0 0.84 82.08
16 INT41863 Avp Regulation of Cck 1 0.00 0 0.84 82.08
17 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84 82.08
18 INT41869 GRP Regulation of Cck 1 0.00 0 0.84 82.08
19 INT41866 Nts Regulation of Cck 1 0.01 0 0.84 82.08
20 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46 78.88
21 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01 77.28
22 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02 76.12
23 INT70495 CALCA Positive_regulation of CALCB 2 0.40 0 1.08 68.04
24 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54 54.64
25 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5 25.00
26 INT265359 Efs Positive_regulation of Car2 1 0.19 0.42 0.45 5.00
27 INT265360 Binding of Car2 and Daf2 1 0.18 0.09 0.22 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for guanethidine. They are ordered first by their pain relevance and then by number of times they were reported in guanethidine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 100.00
2 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 100.00
3 INT28729 Negative_regulation of Negative_regulation of Oprd1 3 0.43 0.33 2.79 100.00
4 INT24367 Negative_regulation of Localization of NPY 1 0.43 0.4 0.81 99.98
5 INT83958 Negative_regulation of Localization of Npy 3 0.37 0.34 0.47 99.98
6 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.84
7 INT73382 Regulation of Nqo1 13 0.58 1.58 6.16 99.84
8 INT8086 Negative_regulation of Localization of Npy 24 0.59 3.31 12.76 99.84
9 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38 99.84
10 INT7602 Negative_regulation of Negative_regulation of Scn11a 1 0.28 0.22 0.24 99.84
11 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88 99.84
12 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 99.82
13 INT15189 Localization of Npy 26 0.79 9.09 8.28 99.78
14 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 99.76
15 INT15763 Gene_expression of Da2-19 1 0.05 0.44 0.92 99.76
16 INT11243 Localization of NPY 33 0.78 11.18 19.24 99.72
17 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 99.68
18 INT20537 Negative_regulation of Bco2 2 0.29 1.03 0.97 99.66
19 INT92700 Negative_regulation of Nt5c1b 2 0.00 0.13 1.2 99.58
20 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 99.56
21 INT231346 Negative_regulation of Foxk1 3 0.41 1.92 0.9 99.52
22 INT3962 Regulation of AGT 50 0.62 20.96 13.01 99.52
23 INT398 Localization of AGT 45 0.78 16.97 11.54 99.52
24 INT129703 Negative_regulation of ptd 3 0.37 2.63 1.87 99.50
25 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73 99.42
26 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 99.40
27 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 99.36
28 INT110 Regulation of Adrb3 33 0.60 8.09 13.84 99.36
29 INT126530 Negative_regulation of Positive_regulation of Serpine1 3 0.43 2.62 0.38 99.28
30 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81 99.24
31 INT2649 Regulation of Calca 433 0.62 146.05 330.95 99.20
32 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 99.20
33 INT130452 Positive_regulation of Localization of HSD11B2 1 0.18 0.23 0.33 99.20
34 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 99.18
35 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 99.18
36 INT150853 Negative_regulation of Cxcl1 22 0.49 12.61 5.72 99.16
37 INT265357 Localization of Daf2 1 0.56 0.06 0.22 99.16
38 INT6107 Localization of Npy 180 0.81 26.76 81.67 99.00
39 INT23254 Positive_regulation of Localization of Npy 27 0.65 3.01 11.98 99.00
40 INT15508 Negative_regulation of nt 8 0.36 3.4 2.26 99.00
41 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 98.98
42 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63 98.96
43 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 98.84
44 INT7147 Localization of Vsig2 7 0.49 4.42 0.86 98.80
45 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 98.76
46 INT64261 Negative_regulation of Positive_regulation of Ngf 21 0.59 16.28 19.78 98.76
47 INT8699 Gene_expression of Nka1 45 0.67 6.41 22.56 98.76
48 INT7601 Negative_regulation of Scn11a 2 0.33 1.77 1.54 98.64
49 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 98.56
50 INT231342 Positive_regulation of Foxk1 1 0.27 0.88 0.44 98.56
51 INT4207 Regulation of Avp 267 0.62 63.72 115.33 98.52
52 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48 98.34
53 INT275 Regulation of Tns1 2 0.28 0.47 1.37 98.32
54 INT8824 Regulation of Vip 95 0.62 15.7 43.63 98.12
55 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 97.80
56 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 97.68
57 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 97.68
58 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 97.56
59 INT5729 Negative_regulation of EFS 7 0.50 0.25 3.35 97.40
60 INT83959 Regulation of Localization of Npy 2 0.33 0.09 0.53 97.40
61 INT70578 Negative_regulation of Mk1 1 0.04 0 0.62 97.30
62 INT1004 Regulation of Sst 140 0.62 18.52 94.84 97.26
63 INT110241 Negative_regulation of Positive_regulation of Lyz2 1 0.00 0.97 0.79 97.24
64 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 97.20
65 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 97.20
66 INT110240 Positive_regulation of Lyz2 1 0.00 0.96 0.79 97.08
67 INT65835 Gene_expression of EFS 1 0.37 0 0.92 96.78
68 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 96.64
69 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 96.52
70 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 96.52
71 INT24230 Localization of Tacr3 3 0.21 0 1.94 96.44
72 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86 96.24
73 INT133507 Regulation of Negative_regulation of Adrb2 1 0.18 0 0.17 96.24
74 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 96.08
75 INT3214 Localization of Ins1 527 0.80 196.9 79.26 96.08
76 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43 96.08
77 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1 96.08
78 INT31829 Positive_regulation of Efs 13 0.42 2.83 5.6 96.08
79 INT136052 Negative_regulation of Negative_regulation of Drd1a 1 0.13 0.66 0.27 96.08
80 INT8756 Gene_expression of Tac2 26 0.78 2.64 13.39 96.02
81 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 95.96
82 INT477 Localization of Avp 813 0.81 131.58 300.4 95.84
83 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 95.84
84 INT1114 Localization of Ins1 748 0.80 192.95 165.48 95.80
85 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 95.80
86 INT3439 Localization of Abat 1017 0.78 112.39 727.06 95.76
87 INT2660 Negative_regulation of Fabp6 58 0.49 33.74 18.27 95.52
88 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 95.52
89 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 95.44
90 INT83674 Negative_regulation of SCN10A 14 0.59 7.28 9.65 95.40
91 INT3123 Localization of Tyms 6 0.78 0.85 2.6 95.20
92 INT36643 Negative_regulation of Ctrb1 2 0.16 0.08 1.33 95.08
93 INT70496 Positive_regulation of EFS 3 0.29 0.2 0.84 95.04
94 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41 95.04
95 INT17821 Gene_expression of Pls1 4 0.32 2.19 1.96 95.04
96 INT26393 Localization of Eda 4 0.60 0.18 1.63 95.00
97 INT36400 Regulation of SCN10A 7 0.62 2.73 1.97 94.96
98 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 94.88
99 INT5300 Regulation of Insr 54 0.60 11.33 29.26 94.88
100 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 94.84
101 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 94.80
102 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 94.68
103 INT141015 Regulation of Il18 14 0.59 6.3 3.73 94.68
104 INT19071 Localization of Ache 66 0.81 5.1 16.27 94.48
105 INT42311 Regulation of HMI 9 0.43 0 1.64 94.04
106 INT42308 Regulation of ipv 4 0.38 2.72 1.17 94.04
107 INT42309 Negative_regulation of Regulation of ipv 1 0.08 0 0.31 94.04
108 INT26112 Positive_regulation of Hrh2 10 0.69 4.28 5.54 93.84
109 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 93.68
110 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 93.64
111 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06 93.40
112 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44 93.24
113 INT7377 Regulation of Efs 6 0.39 0.93 2.91 93.00
114 INT61577 Gene_expression of Chrm2 4 0.39 0.09 0.92 92.88
115 INT130456 Negative_regulation of Localization of HSD11B2 1 0.17 0.23 0.31 92.76
116 INT130458 Negative_regulation of HSD11B2 1 0.16 0.23 0.31 92.76
117 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48 92.64
118 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 92.52
119 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 92.44
120 INT7378 Negative_regulation of Efs 17 0.37 1.93 7.78 92.36
121 INT35406 Localization of Tnf 94 0.81 64.63 31.65 92.32
122 INT1005 Localization of Sst 385 0.81 26.31 244.56 92.32
123 INT946 Negative_regulation of Nts 60 0.57 4.61 34.44 92.32
124 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 92.32
125 INT4800 Negative_regulation of Negative_regulation of Nts 6 0.43 0.08 1.65 92.32
126 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59 91.84
127 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41 91.84
128 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 91.84
129 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 91.36
130 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68 91.20
131 INT150852 Positive_regulation of Localization of Cxcl1 5 0.51 2.82 1.72 91.20
132 INT130455 Localization of HSD11B2 1 0.27 0.23 0.3 91.16
133 INT3928 Localization of Bdkrb1 15 0.75 4.06 7.23 91.04
134 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58 91.00
135 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54 91.00
136 INT4431 Negative_regulation of Eda 10 0.46 3.53 6.81 90.96
137 INT2066 Localization of Agt 56 0.80 9.95 16.25 90.88
138 INT6361 Localization of Edn1 30 0.81 19.09 9.7 90.88
139 INT2952 Regulation of C4orf6 2 0.44 0 0.41 90.88
140 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 90.80
141 INT46754 Localization of F2r 7 0.78 2.36 3.24 90.80
142 INT5338 Regulation of Npy 92 0.62 25.54 51.24 90.80
143 INT62192 Regulation of Localization of F2r 2 0.60 0.59 0.7 90.80
144 INT73805 Phosphorylation of Gal 1 0.46 0.14 0.14 90.76
145 INT276 Regulation of Ache 83 0.62 16.75 25.99 90.48
146 INT150 Negative_regulation of CXCL11 4 0.57 3.34 1.12 90.36
147 INT231344 Gene_expression of Foxk1 1 0.41 0.89 0.42 90.32
148 INT11202 Positive_regulation of Pfkm 8 0.57 1.74 3.06 90.28
149 INT48081 Localization of Il1b 46 0.80 21.59 22.4 90.24
150 INT150856 Localization of Cxcl1 14 0.78 6.97 4.91 90.24
151 INT76814 Positive_regulation of Gene_expression of Tacr1 13 0.69 6.11 8.42 90.24
152 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 90.08
153 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 89.96
154 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 89.92
155 INT24337 Positive_regulation of Regulation of Npy 5 0.50 2.8 3.4 89.88
156 INT771 Regulation of Nts 93 0.61 13.13 53.57 89.84
157 INT21990 Negative_regulation of Ctrc 17 0.42 8.45 4.47 89.80
158 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35 89.76
159 INT274 Negative_regulation of Tns1 2 0.27 0.32 0.84 89.44
160 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 89.36
161 INT129702 Positive_regulation of ptd 1 0.59 0.62 0.84 89.36
162 INT52597 Negative_regulation of EPDR1 1 0.34 0 0.13 89.28
163 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 88.96
164 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 88.52
165 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79 88.48
166 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 88.40
167 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 88.40
168 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 88.40
169 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35 88.40
170 INT111145 Negative_regulation of Positive_regulation of Ifng 7 0.41 2.21 2.61 88.40
171 INT62191 Negative_regulation of Localization of F2r 1 0.35 0 0.26 88.36
172 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 88.32
173 INT13742 Gene_expression of Son 45 0.58 2.98 4.19 88.28
174 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 88.24
175 INT165727 Positive_regulation of spc 3 0.21 3.24 0.25 88.00
176 INT2140 Regulation of REN 104 0.62 28.24 24.49 87.96
177 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 87.88
178 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14 87.68
179 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15 87.68
180 INT48413 Gene_expression of nma 1 0.40 0 0.04 87.28
181 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 87.12
182 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88 87.12
183 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 87.12
184 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 87.12
185 INT48414 Gene_expression of Agtpbp1 1 0.07 0 0.04 86.92
186 INT1147 Negative_regulation of Ppa1 2 0.14 0 0.94 86.84
187 INT15502 Regulation of asp1 6 0.19 2.29 1.2 86.80
188 INT19277 Gene_expression of Thra 4 0.58 0.68 1.1 86.72
189 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 86.68
190 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 86.68
191 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 86.40
192 INT42310 Positive_regulation of Regulation of HMI 1 0.14 0 0.32 86.40
193 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 86.28
194 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 86.28
195 INT104547 Negative_regulation of Il18 24 0.59 17.89 6.01 86.24
196 INT8363 Localization of Nts 135 0.81 14.29 61.71 86.08
197 INT8361 Regulation of Localization of Nts 9 0.46 0.54 3.39 86.08
198 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 85.88
199 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59 85.84
200 INT52598 Gene_expression of EPDR1 1 0.47 0 0.13 85.52
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