P:hCN2

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pChart

Pain Term
Category Molecule
Synonyms Brain Cyclic Nucleotide Gated Channel 1, Hyperpolarization Activated Cyclic Nucleotide-gated Potassium Channel 1
Pain Specific No
Documents 15
Hot Single Events 35
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for hCN2. They are ordered first by their pain relevance and then by number of times they were reported for hCN2. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117217 Binding of Calca and Hcn2 1 0.25 0.17 0.68 100.00
2 INT145576 Binding of Adra2c and Hcn4 1 0.21 0.19 0.4 100.00
3 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4 100.00
4 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4 100.00
5 INT145574 Regulation of Binding of Adra2c and Hcn4 1 0.26 0.19 0.4 100.00
6 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for hCN2. They are ordered first by their pain relevance and then by number of times they were reported in hCN2. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117212 Gene_expression of Hcn2 13 0.78 5.83 8.19 100.00
2 INT108690 Gene_expression of Hcn1 19 0.76 7.2 8 100.00
3 INT163497 Gene_expression of Hcn3 5 0.76 8.4 4.33 100.00
4 INT117210 Binding of Hcn2 3 0.48 0.82 1.91 100.00
5 INT159769 Positive_regulation of Gene_expression of Hcn1 2 0.64 2.66 2.83 100.00
6 INT99049 Positive_regulation of Hcn1 5 0.43 0.68 2.75 100.00
7 INT159770 Positive_regulation of Gene_expression of Hcn2 2 0.67 2.65 2.82 100.00
8 INT117213 Gene_expression of Cnga4 4 0.50 1.05 2.13 100.00
9 INT117216 Localization of Hcn2 1 0.75 0.16 0.69 100.00
10 INT99050 Regulation of Hcn1 2 0.42 0.66 1.33 100.00
11 INT117215 Positive_regulation of Hcn2 1 0.50 0.15 0.92 100.00
12 INT144789 Negative_regulation of Hcn2 2 0.53 0.24 0.8 100.00
13 INT163498 Positive_regulation of Gene_expression of Hcn3 1 0.68 2.04 1.5 100.00
14 INT132967 Gene_expression of Hcn2 2 0.71 0.09 0.54 100.00
15 INT144790 Negative_regulation of Negative_regulation of Hcn2 1 0.53 0.06 0.4 100.00
16 INT159772 Regulation of Hcn2 1 0.26 0.53 0.71 100.00
17 INT138640 Transcription of Hcn2 2 0.66 0.51 1.05 100.00
18 INT245897 Transcription of Hcn1 1 0.49 0.07 0.64 100.00
19 INT141773 Negative_regulation of Hcn4 2 0.39 0.18 0.4 100.00
20 INT95492 Gene_expression of Nefh 20 0.67 12.68 10.46 99.98
21 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25 99.90
22 INT245894 Transcription of Hcn3 1 0.40 0 0.41 99.88
23 INT94030 Binding of Nefh 3 0.48 1.93 1.57 99.20
24 INT285168 Gene_expression of MALAT1 1 0.11 0 0.12 96.80
25 INT136672 Positive_regulation of Cnga1 11 0.58 4.46 4.61 96.24
26 INT158954 Regulation of Cnga1 4 0.39 0 1.4 94.60
27 INT33667 Gene_expression of Cnga1 15 0.72 10.09 10.4 93.92
28 INT140710 Regulation of Gene_expression of Cnga1 2 0.23 0.91 0.92 93.92
29 INT159771 Positive_regulation of Gene_expression of Cnga1 2 0.49 2.66 2.79 93.48
30 INT127407 Gene_expression of Hcn3 1 0.77 0.62 0.32 90.20
31 INT127408 Positive_regulation of Gene_expression of Hcn3 1 0.69 0.35 0.18 90.20
32 INT127410 Negative_regulation of Hcn3 1 0.42 0.34 0.18 88.80
33 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27 85.56
34 INT245895 Localization of Hcn1 1 0.74 0.47 0.98 84.16
35 INT117211 Positive_regulation of Cnga4 1 0.32 0.07 0.28 83.52
36 INT148710 Negative_regulation of HCN1 3 0.43 0 1.09 78.92
37 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 75.76
38 INT207667 Binding of Hcn4 2 0.35 0 0.28 75.72
39 INT245900 Regulation of Binding of Hcn4 1 0.36 0 0.22 75.72
40 INT148715 Gene_expression of HCN1 4 0.78 1.29 1.98 74.92
41 INT245899 Negative_regulation of Gene_expression of Hcn3 1 0.44 1.89 0.45 72.36
42 INT163499 Regulation of Gene_expression of Hcn4 1 0.23 0.9 0.49 71.84
43 INT285174 Gene_expression of MIR377 1 0.01 0 0.12 67.40
44 INT127409 Transcription of Hcn3 1 0.71 0.45 0.24 60.44
45 INT285165 Binding of MIR377 1 0.00 0 0.58 56.72
46 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 47.96
47 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 47.36
48 INT245896 Negative_regulation of Gene_expression of Hcn4 1 0.47 1.35 0.09 44.12
49 INT285175 Binding of MALAT1 1 0.06 0 0.15 43.68
50 INT148714 Regulation of HCN1 2 0.45 0.53 1.02 21.80
51 INT3500 Positive_regulation of Gene_expression of Gnrh1 25 0.69 4.59 6.69 16.72
52 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 15.76
53 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
54 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
55 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
56 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
57 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75 5.00
58 INT141038 Positive_regulation of Gene_expression of Hcn4 4 0.38 3.58 3.12 5.00
59 INT144274 Gene_expression of Cav3 28 0.78 3.21 2.47 5.00
60 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
61 INT257299 Binding of Pde5a 14 0.27 4.31 2.45 5.00
62 INT87838 Gene_expression of Dcn 7 0.75 0.74 0.79 5.00
63 INT285167 Binding of PSMC4 2 0.04 0.56 0.72 5.00
64 INT245898 Negative_regulation of Hcn4 2 0.40 1.84 0.49 5.00
65 INT271764 Binding of Cnga1 2 0.27 0.16 0.38 5.00
66 INT159139 Positive_regulation of MALAT1 3 0.41 1.73 0.33 5.00
67 INT245893 Negative_regulation of Gene_expression of Hcn1 1 0.40 0.35 0.17 5.00
68 INT285171 Localization of HCN1 1 0.60 0 0.15 5.00
69 INT285173 Binding of HCN1 1 0.26 0 0.09 5.00
70 INT334963 Positive_regulation of Positive_regulation of Cnga1 2 0.26 0 0.08 5.00
71 INT285166 Positive_regulation of Positive_regulation of MALAT1 1 0.08 0 0.05 5.00
72 INT337606 Localization of Cnga1 1 0.42 0 0.04 5.00
73 INT337607 Gene_expression of Guca1a 1 0.07 0 0 5.00
74 INT337605 Regulation of Gene_expression of Dcn 1 0.13 0 0 5.00
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