P:hyperpathia

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pChart

Pain Term
Category Pain type
Synonyms None
Pain Specific Yes
Documents 121
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for hyperpathia. They are ordered first by their pain relevance and then by number of times they were reported for hyperpathia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 5.00
2 INT308172 Rvm Positive_regulation of Phosphorylation of GRIN1 1 0.50 0.68 1.14 5.00
3 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1 5.00
4 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95 5.00
5 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75 5.00
6 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71 5.00
7 INT308175 Negative_regulation of Mapk14 Negative_regulation of Localization of TNF 1 0.03 0.89 0.61 5.00
8 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56 5.00
9 INT308170 Binding of thd and Tnfrsf14 1 0.00 1.84 0.46 5.00
10 INT308171 Binding of TNF and thd 1 0.00 1.84 0.45 5.00
11 INT353208 NEUROG2 Positive_regulation of Gene_expression of HTR1A 1 0.05 0.35 0.31 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for hyperpathia. They are ordered first by their pain relevance and then by number of times they were reported in hyperpathia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT77887 Negative_regulation of Spt 7 0.50 3.9 0.54 99.44
2 INT164452 Gene_expression of Sptlc1 1 0.65 1.36 0.29 98.16
3 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 97.20
4 INT39819 Localization of C4A 4 0.62 3.1 0.72 96.84
5 INT164450 Positive_regulation of Gene_expression of Sptlc1 1 0.39 0.53 0.09 90.36
6 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 89.24
7 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55 89.24
8 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 85.80
9 INT164451 Positive_regulation of Gene_expression of Zmat3 7 0.02 3.38 0.44 85.80
10 INT353223 Gene_expression of Neurog3 1 0.07 3.11 2.41 80.56
11 INT175535 Gene_expression of GPC3 5 0.29 4.17 1.74 74.88
12 INT286803 Gene_expression of Neurog2 2 0.27 2.73 1.55 73.20
13 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 63.08
14 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 52.80
15 INT20944 Gene_expression of Mcf2l 13 0.58 5.96 4.76 50.88
16 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 45.28
17 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 42.72
18 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 42.36
19 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 37.84
20 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 37.52
21 INT174785 Localization of Hspg2 2 0.06 2.18 1.24 8.24
22 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
23 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
24 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
25 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
26 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
27 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
28 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
29 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
30 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
31 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
32 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
33 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
34 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
35 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
36 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
37 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
38 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 5.00
39 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
40 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
41 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
42 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
43 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
44 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 5.00
45 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 5.00
46 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
47 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 5.00
48 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 5.00
49 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
50 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
51 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
52 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
53 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
54 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
55 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
56 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 5.00
57 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
58 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
59 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
60 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
61 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 5.00
62 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
63 INT63383 Binding of Cnr1 77 0.48 22.28 44.61 5.00
64 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
65 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
66 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 5.00
67 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 5.00
68 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
69 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94 5.00
70 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
71 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
72 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
73 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 5.00
74 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
75 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
76 INT111359 Localization of Cnr1 55 0.81 11.25 27.41 5.00
77 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68 5.00
78 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
79 INT9781 Binding of INSRR 64 0.31 19.1 25.2 5.00
80 INT25607 Binding of Il1 82 0.47 64.4 23.9 5.00
81 INT100026 Gene_expression of Tnfrsf1b 73 0.72 43.26 23.23 5.00
82 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 5.00
83 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16 5.00
84 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
85 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54 5.00
86 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 5.00
87 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84 5.00
88 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98 5.00
89 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
90 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
91 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86 5.00
92 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 5.00
93 INT96299 Positive_regulation of Localization of Bdnf 35 0.70 15.67 16.09 5.00
94 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02 5.00
95 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 5.00
96 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31 5.00
97 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
98 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 5.00
99 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58 5.00
100 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 5.00
101 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85 5.00
102 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62 5.00
103 INT112428 Positive_regulation of Gene_expression of P2rx4 12 0.68 12.67 9.57 5.00
104 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 5.00
105 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 5.00
106 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42 5.00
107 INT389 Gene_expression of Ace 21 0.67 10.31 8.1 5.00
108 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
109 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14 5.00
110 INT168399 Localization of Cnr2 12 0.81 4.37 6.77 5.00
111 INT77789 Positive_regulation of Tnfrsf1b 12 0.65 13.77 6.58 5.00
112 INT153959 Phosphorylation of GRIN1 8 0.80 4.07 6.18 5.00
113 INT134585 Negative_regulation of Cnr2 10 0.43 3.98 6.16 5.00
114 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 5.00
115 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03 5.00
116 INT113373 Positive_regulation of Gene_expression of Tnfrsf1b 15 0.65 8.64 4.79 5.00
117 INT189842 Negative_regulation of Gene_expression of Cnr2 8 0.59 4.21 4.67 5.00
118 INT158416 Localization of Mapk1 19 0.67 5.32 4.18 5.00
119 INT101301 Gene_expression of Aif1 17 0.42 16.43 4.06 5.00
120 INT110021 Positive_regulation of Gene_expression of Mapk14 29 0.46 19.06 3.86 5.00
121 INT64310 Negative_regulation of GRIN2A 7 0.42 2.16 3.49 5.00
122 INT11107 Binding of Lbp 12 0.42 4.42 3.41 5.00
123 INT203154 Positive_regulation of Gene_expression of Lts1 6 0.17 3.68 2.67 5.00
124 INT96803 Negative_regulation of Gene_expression of P2rx3 6 0.51 3.65 2.49 5.00
125 INT10667 Localization of HTR1A 4 0.78 1.43 2.03 5.00
126 INT134916 Localization of Aif1 3 0.73 1.58 2 5.00
127 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94 5.00
128 INT77586 Positive_regulation of Gene_expression of HTR1A 6 0.46 3.54 1.51 5.00
129 INT351303 Regulation of Binding of Cnr2 1 0.10 0.66 1.39 5.00
130 INT351302 Regulation of Regulation of Cnr1 1 0.10 0.78 1.39 5.00
131 INT101302 Positive_regulation of Gene_expression of Aif1 5 0.37 3.56 1.23 5.00
132 INT121052 Binding of NOS2 3 0.35 3.12 1.12 5.00
133 INT91598 Positive_regulation of Localization of HTR1A 3 0.49 0.51 1.03 5.00
134 INT251561 Binding of Tnfrsf14 3 0.13 6 0.89 5.00
135 INT82928 Positive_regulation of Eln 7 0.69 3.54 0.77 5.00
136 INT235079 Negative_regulation of Phosphorylation of TNF 2 0.41 1.16 0.6 5.00
137 INT353221 Binding of Neurog3 1 0.04 0.24 0.1 5.00
138 INT353219 Regulation of Gene_expression of Neurog2 1 0.10 0.16 0.03 5.00
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