P:hypoesthesia

From wiki-pain
Jump to: navigation, search

pChart

Pain Term
Category Pain type
Synonyms None
Pain Specific Yes
Documents 461
Hot Single Events 23
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for hypoesthesia. They are ordered first by their pain relevance and then by number of times they were reported for hypoesthesia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1 95.24
2 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24 84.64
3 INT111802 Binding of CD40LG and TFPI 1 0.14 0.62 0.16 76.80
4 INT351245 Binding of TNC and OPN1LW 1 0.03 0.89 1.31 30.64
5 INT351246 Binding of OPN1LW and NNT 1 0.03 0.53 1.45 5.00
6 INT328981 Binding of Mup1 and Cts 1 0.14 1.05 0.88 5.00
7 INT328982 Binding of Igfals and Cts 1 0.05 0.92 0.8 5.00
8 INT328976 Binding of Cst7 and Cts 1 0.08 0.92 0.79 5.00
9 INT328979 Binding of Muted and Cts 1 0.03 0.9 0.78 5.00
10 INT328978 Binding of Igfals and Muted 1 0.02 0.85 0.73 5.00
11 INT328980 Binding of Cst7 and Igfals 1 0.06 0.85 0.73 5.00
12 INT328975 Binding of Igfals and Mup1 1 0.11 0.85 0.73 5.00
13 INT328983 Binding of Cst7 and Muted 1 0.04 0.84 0.73 5.00
14 INT328977 Binding of Cst7 and Mup1 1 0.18 0.84 0.73 5.00
15 INT328974 Binding of Muted and Mup1 1 0.06 0.83 0.71 5.00
16 INT199595 FGF7 Positive_regulation of Transcription of TNF 1 0.40 0.58 0.11 5.00
17 INT199594 FGF7 Positive_regulation of NFE2L2 1 0.01 0.52 0.09 5.00
18 INT199604 Binding of FGF7 and Fgf1 1 0.03 0.21 0.08 5.00
19 INT199603 Positive_regulation of Binding of FGF7 and Fgf1 1 0.04 0.21 0.08 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for hypoesthesia. They are ordered first by their pain relevance and then by number of times they were reported in hypoesthesia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT152870 Positive_regulation of Stim2 1 0.15 1.3 1.41 100.00
2 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 99.60
3 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69 99.60
4 INT137811 Negative_regulation of NGFR 4 0.50 2.22 1.28 99.58
5 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 98.40
6 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 97.76
7 INT148721 Binding of PSMD1 13 0.31 4.78 1.76 96.36
8 INT28817 Binding of TRPV4 6 0.39 3.92 2.59 95.24
9 INT354726 Binding of Tymp 1 0.30 1.08 0.23 94.32
10 INT211375 Regulation of Gene_expression of TYMP 2 0.43 2.44 0.22 94.20
11 INT104356 Negative_regulation of Pgp 15 0.43 6.64 4.89 93.52
12 INT120722 Gene_expression of TYMP 35 0.75 19.26 1.31 92.24
13 INT8159 Binding of ELL 7 0.36 12.62 0.84 90.40
14 INT62001 Negative_regulation of Cd68 1 0.33 1.88 0.48 89.44
15 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 87.56
16 INT62002 Regulation of Cd68 6 0.35 7.89 0.86 86.16
17 INT5793 Binding of CTS 110 0.48 63.91 40.62 83.44
18 INT1793 Localization of CGA 379 0.81 67.38 114.69 82.96
19 INT2774 Binding of Crp 241 0.48 195.89 44.39 81.68
20 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 81.36
21 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 80.64
22 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 80.52
23 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 80.20
24 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 78.04
25 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 78.04
26 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56 78.04
27 INT120693 Positive_regulation of MEPE 7 0.50 8.22 0.79 78.04
28 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 76.80
29 INT85623 Gene_expression of ATXN1 6 0.58 5.14 0.9 74.56
30 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 73.96
31 INT46403 Gene_expression of ATN1 2 0.75 3.33 0.93 73.92
32 INT78203 Gene_expression of PMP22 12 0.63 7.49 3.58 73.64
33 INT85624 Gene_expression of GJB1 5 0.78 3.03 0.93 73.36
34 INT80901 Localization of Cts 2 0.58 2.04 1.68 71.92
35 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 70.56
36 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 69.92
37 INT97693 Gene_expression of REST 29 0.75 5.51 5.26 67.52
38 INT153635 Positive_regulation of Gene_expression of REST 10 0.54 1.38 1.6 67.52
39 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26 65.60
40 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04 64.12
41 INT3364 Binding of SGCG 87 0.47 31.93 17.24 63.04
42 INT335980 Regulation of Igfals 1 0.17 2.26 0.12 62.64
43 INT251830 Binding of TYMP 2 0.13 4.36 0.37 62.24
44 INT237652 Positive_regulation of Sfn 3 0.49 1.17 0.27 60.76
45 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 55.56
46 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 55.52
47 INT351255 Transcription of OPN1LW 1 0.16 1.15 1.27 50.44
48 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 50.32
49 INT240355 Gene_expression of srn 1 0.56 1.18 0.07 49.68
50 INT113865 Binding of CXADR 35 0.46 3.18 1.12 46.52
51 INT248274 Positive_regulation of Capn1 2 0.67 0.55 0 45.40
52 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 44.64
53 INT87969 Binding of Cts 15 0.41 10.67 8.93 44.56
54 INT237655 Binding of Sfn 1 0.42 3.62 2.55 44.00
55 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 39.24
56 INT53290 Gene_expression of OPN1LW 5 0.31 6.9 9.15 39.24
57 INT66077 Regulation of CHPT1 12 0.38 6.1 3.23 38.68
58 INT117172 Regulation of Hpt 7 0.41 3.39 0.52 38.36
59 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 36.60
60 INT124042 Localization of FGF7 10 0.80 4.13 0.57 36.40
61 INT199600 Negative_regulation of Localization of FGF7 1 0.35 1.09 0.16 36.40
62 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 34.88
63 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33 34.88
64 INT81765 Gene_expression of Cts 4 0.58 9.49 7.76 34.36
65 INT328970 Positive_regulation of Gene_expression of Cts 1 0.19 1.94 1.88 34.36
66 INT328971 Negative_regulation of Gene_expression of Cts 1 0.17 0.4 0.47 34.36
67 INT25402 Binding of Ptcra 10 0.34 3.54 1.85 34.12
68 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 33.64
69 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 33.64
70 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 32.96
71 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 30.24
72 INT105021 Binding of GOPC 187 0.40 60.39 20.38 30.08
73 INT237651 Negative_regulation of Sfn 3 0.51 1.7 0.49 27.64
74 INT285294 Localization of RCVRN 1 0.01 2.56 0 26.24
75 INT2442 Localization of Mb 38 0.80 24.74 6.33 25.00
76 INT55101 Gene_expression of Cst7 16 0.75 2.39 5.92 18.08
77 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 14.68
78 INT33039 Regulation of Ptcra 3 0.04 1.16 0.37 14.04
79 INT139738 Gene_expression of Ptcra 9 0.63 2.75 1.14 9.68
80 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 7.96
81 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 7.96
82 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 6.28
83 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
84 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
85 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
86 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
87 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
88 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
89 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
90 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
91 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 5.00
92 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
93 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
94 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
95 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
96 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 5.00
97 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
98 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
99 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 5.00
100 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 5.00
101 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 5.00
102 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 5.00
103 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 5.00
104 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51 5.00
105 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
106 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 5.00
107 INT7413 Positive_regulation of Localization of SST 37 0.69 5.64 13.94 5.00
108 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
109 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
110 INT36354 Localization of CTs 26 0.64 20.84 9.31 5.00
111 INT53288 Binding of OPN1LW 5 0.11 4.24 8.9 5.00
112 INT11146 Negative_regulation of CTS 26 0.51 10.33 8.77 5.00
113 INT79166 Regulation of TNC 12 0.44 9.42 8.13 5.00
114 INT100661 Regulation of Cst7 18 0.53 5.93 7.8 5.00
115 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 5.00
116 INT79168 Binding of TNC 39 0.47 16.51 7.55 5.00
117 INT169435 Gene_expression of CHPT1 17 0.61 10.04 7.37 5.00
118 INT98205 Gene_expression of PCBD1 10 0.61 14.78 7.27 5.00
119 INT99088 Gene_expression of HPT 5 0.59 9.1 6.72 5.00
120 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88 5.00
121 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 5.00
122 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 5.00
123 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
124 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61 5.00
125 INT156348 Regulation of Mup1 10 0.52 6.79 4.6 5.00
126 INT70756 Gene_expression of Adm 28 0.77 13.33 4.22 5.00
127 INT38285 Positive_regulation of SCLY 8 0.36 3.32 3.96 5.00
128 INT49191 Gene_expression of IFNAR1 14 0.41 9.96 3.84 5.00
129 INT214530 Positive_regulation of Mup1 7 0.58 5.5 3.74 5.00
130 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 5.00
131 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 5.00
132 INT76430 Gene_expression of SLC1A1 2 0.03 0.77 3.15 5.00
133 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 5.00
134 INT191125 Gene_expression of Igfals 12 0.25 12.96 2.89 5.00
135 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 5.00
136 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 5.00
137 INT83374 Gene_expression of FGF7 83 0.78 44.18 2.6 5.00
138 INT60440 Localization of PSMD1 10 0.74 3.94 2.57 5.00
139 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 5.00
140 INT238712 Positive_regulation of PCBD1 1 0.55 3.49 2.48 5.00
141 INT68367 Negative_regulation of PCBD1 4 0.59 2.8 2.42 5.00
142 INT81764 Negative_regulation of Cts 5 0.37 3.47 2.34 5.00
143 INT177328 Positive_regulation of CXADR 9 0.48 4.29 2.27 5.00
144 INT269217 Gene_expression of SNAI1 81 0.76 80.49 2.26 5.00
145 INT345985 Positive_regulation of Gene_expression of SLC1A1 1 0.01 0.35 2.2 5.00
146 INT215977 Localization of HPT 2 0.36 3.43 2.19 5.00
147 INT113439 Positive_regulation of OPN1LW 2 0.11 0.84 2.01 5.00
148 INT238713 Positive_regulation of Gene_expression of CHPT1 3 0.43 2.7 1.97 5.00
149 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
150 INT242856 Binding of Cst7 2 0.18 3.04 1.93 5.00
151 INT189003 Localization of CHPT1 8 0.64 4.75 1.82 5.00
152 INT175084 Gene_expression of Mup1 11 0.61 3.58 1.81 5.00
153 INT328967 Protein_catabolism of Mup1 1 0.55 2.36 1.75 5.00
154 INT44678 Phosphorylation of CTS 5 0.70 2.63 1.7 5.00
155 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53 5.00
156 INT200186 Binding of Igfals 5 0.19 4.46 1.52 5.00
157 INT238709 Binding of PCBD1 1 0.34 2.37 1.41 5.00
158 INT351254 Regulation of Regulation of TNC 1 0.14 0.55 1.4 5.00
159 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 5.00
160 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37 5.00
161 INT102228 Localization of Adm 9 0.69 1.58 1.34 5.00
162 INT147607 Binding of TERT 16 0.48 12.36 1.31 5.00
163 INT199601 Positive_regulation of FGF7 9 0.50 6.13 1.22 5.00
164 INT69745 Positive_regulation of CDT1 2 0.45 2.11 1.2 5.00
165 INT351256 Regulation of OPN1LW 1 0.10 0.55 1.17 5.00
166 INT3414 Positive_regulation of Negative_regulation of Alb 4 0.44 1.91 1.09 5.00
167 INT53291 Negative_regulation of Binding of OPN1LW 2 0.10 0.67 1.02 5.00
168 INT92288 Binding of Igfals 3 0.13 3.14 1 5.00
169 INT238710 Localization of MREG 1 0.05 1.16 0.93 5.00
170 INT238706 Localization of CDT1 1 0.17 1.16 0.93 5.00
171 INT199598 Binding of FGF7 4 0.48 2.83 0.9 5.00
172 INT238708 Phosphorylation of PCBD1 1 0.64 1.36 0.9 5.00
173 INT238711 Localization of PCBD1 1 0.59 1.3 0.85 5.00
174 INT150426 Regulation of Gene_expression of CTS 2 0.39 1.2 0.77 5.00
175 INT328969 Positive_regulation of Binding of Cts 1 0.19 0.77 0.77 5.00
176 INT138555 Negative_regulation of Tymp 3 0.39 3.31 0.74 5.00
177 INT328968 Regulation of Protein_catabolism of Mup1 1 0.23 0.84 0.71 5.00
178 INT328972 Binding of Mup1 1 0.31 0.8 0.69 5.00
179 INT328973 Binding of Muted 1 0.07 0.8 0.69 5.00
180 INT191123 Positive_regulation of Igfals 3 0.18 2.89 0.68 5.00
181 INT238714 Positive_regulation of MREG 1 0.03 3.32 0.67 5.00
182 INT215975 Regulation of HPT 3 0.26 2.75 0.66 5.00
183 INT238704 Regulation of Binding of PCBD1 1 0.41 1.22 0.61 5.00
184 INT8066 Binding of RASGRP1 10 0.36 4.65 0.58 5.00
185 INT127291 Transcription of ALB 7 0.67 4.26 0.55 5.00
186 INT199602 Positive_regulation of Gene_expression of FGF7 12 0.70 7.47 0.55 5.00
187 INT112627 Regulation of Cts 2 0.18 0.8 0.54 5.00
188 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 5.00
189 INT172851 Gene_expression of YES1 4 0.59 0.96 0.41 5.00
190 INT329026 Positive_regulation of Gene_expression of YES1 1 0.43 0.42 0.35 5.00
191 INT138556 Positive_regulation of TYMP 23 0.58 12.9 0.28 5.00
192 INT92990 Binding of Mthfr 2 0.37 2.42 0.25 5.00
193 INT238705 Binding of MREG 1 0.02 0.92 0.22 5.00
194 INT238707 Binding of CDT1 1 0.08 0.92 0.22 5.00
195 INT199599 Negative_regulation of Gene_expression of FGF7 3 0.48 0.78 0.19 5.00
196 INT224377 Gene_expression of TSPAN31 3 0.65 0.72 0.04 5.00
197 INT249062 Positive_regulation of Positive_regulation of DES 1 0.49 1.29 0.03 5.00
198 INT146812 Negative_regulation of Gene_expression of CTS 3 0.37 0 0.03 5.00
199 INT342154 Gene_expression of Rlf 1 0.65 0.2 0 5.00
200 INT335981 Regulation of Gene_expression of Igfals 1 0.17 0.83 0 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox