P:long acting opioid

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pChart

Pain Term
Category Drug class
Synonyms Long-acting Opioid, Opioid Long-acting, Slow Release Opioid
Pain Specific Yes
Documents 91
Hot Single Events 40
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for long acting opioid. They are ordered first by their pain relevance and then by number of times they were reported for long acting opioid. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11296 Tmem27 Positive_regulation of Localization of LH 1 0.16 0 0.51 93.08
2 INT29837 Gnrh1 Positive_regulation of LH 6 0.67 0 3.53 82.08
3 INT121551 Binding of CYP2B6 and Regulation of CYP3A 1 0.21 0 0 5.00
4 INT121550 Binding of CYP2B6 and Regulation of CDH17 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for long acting opioid. They are ordered first by their pain relevance and then by number of times they were reported in long acting opioid. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT847 Regulation of Lhb 131 0.61 22.08 46.54 100.00
2 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
3 INT6299 Regulation of Localization of Lhb 104 0.61 8.98 48.79 100.00
4 INT2379 Positive_regulation of Localization of LH 349 0.70 27.86 144.53 99.68
5 INT1045 Localization of LH 1211 0.81 87.04 456.25 99.36
6 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 99.36
7 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 99.16
8 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 99.08
9 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 99.08
10 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 98.94
11 INT1898 Regulation of Crh 220 0.62 61.33 102.64 97.76
12 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 97.76
13 INT162 Regulation of Prl 794 0.62 165.01 322.24 97.52
14 INT5127 Localization of Lhb 488 0.80 50.48 162.66 97.52
15 INT158 Localization of Prl 2431 0.81 378.96 952.2 97.30
16 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 96.16
17 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 96.16
18 INT5515 Negative_regulation of Positive_regulation of Pomc 25 0.58 8.73 11.88 96.16
19 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 95.80
20 INT11590 Regulation of Negative_regulation of LH 10 0.39 2.02 4.25 94.80
21 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 94.24
22 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93 93.72
23 INT11294 Localization of Tmem27 1 0.20 0 1.04 93.08
24 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 92.72
25 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 92.72
26 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 90.20
27 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 89.04
28 INT2165 Localization of Cga 41 0.80 4.02 19.53 87.88
29 INT8088 Regulation of Localization of Cga 28 0.60 2.37 13.91 87.88
30 INT10557 Regulation of Positive_regulation of LH 13 0.62 2.76 9.58 86.72
31 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 85.36
32 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 83.96
33 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 83.32
34 INT21379 Transcription of Crh 65 0.72 15.64 27.92 82.24
35 INT7565 Transcription of Pomc 69 0.72 14.46 27.41 82.24
36 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 82.20
37 INT2158 Negative_regulation of Positive_regulation of LH 41 0.58 4.52 17.75 82.08
38 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 81.84
39 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 81.12
40 INT9785 Negative_regulation of Positive_regulation of Gnrh1 18 0.43 1.88 7.35 81.12
41 INT416 Regulation of LH 253 0.62 31.48 125.55 77.56
42 INT5939 Regulation of Gene_expression of Oxt 27 0.51 2.84 9.1 75.80
43 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 75.36
44 INT21438 Binding of Trim13 10 0.47 0.26 8.76 75.00
45 INT30104 Binding of Eh 1 0.02 0 0.55 75.00
46 INT5533 Binding of Oxt 43 0.48 8.69 18.35 72.48
47 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 66.40
48 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23 56.96
49 INT1308 Localization of Pomc 457 0.81 66.83 217.5 55.44
50 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77 55.44
51 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 54.32
52 INT10344 Localization of Jun 23 0.73 6.36 7.46 52.24
53 INT1463 Binding of Pomc 129 0.48 15.89 56.27 45.04
54 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 42.64
55 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 40.56
56 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 29.92
57 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
58 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
59 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 5.00
60 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 5.00
61 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
62 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
63 INT164366 Localization of NLRP1 26 0.71 5.9 16.54 5.00
64 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
65 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 5.00
66 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
67 INT158070 Localization of Aes 23 0.65 19.93 10.9 5.00
68 INT164368 Localization of VTA1 5 0.53 3.33 8.47 5.00
69 INT54368 Positive_regulation of VTA1 13 0.59 3.81 8.13 5.00
70 INT264641 Binding of AES 25 0.42 18.56 6.98 5.00
71 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 5.00
72 INT251958 Gene_expression of VTA1 9 0.58 7.26 5.6 5.00
73 INT65356 Localization of LEP 46 0.79 41.17 5.43 5.00
74 INT7055 Positive_regulation of Binding of FAIM3 4 0.34 1.22 4.34 5.00
75 INT16478 Positive_regulation of Plg 29 0.45 18.07 4.07 5.00
76 INT27660 Binding of CFP 21 0.40 12.47 3.51 5.00
77 INT54369 Regulation of VTA1 4 0.38 3.03 3.18 5.00
78 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 5.00
79 INT114412 Localization of HCL1 18 0.56 3.69 2.96 5.00
80 INT257950 Regulation of Localization of NLRP1 3 0.08 0.27 2.6 5.00
81 INT164367 Negative_regulation of Localization of NLRP1 3 0.34 1.43 2.5 5.00
82 INT69314 Binding of CYP3A 16 0.48 1.78 2.19 5.00
83 INT304987 Positive_regulation of Localization of VTA1 1 0.31 0.64 2.1 5.00
84 INT46407 Binding of ATN1 4 0.36 5.85 1.81 5.00
85 INT304985 Negative_regulation of Localization of VTA1 1 0.28 0.7 1.52 5.00
86 INT304986 Regulation of Gene_expression of VTA1 1 0.38 1.87 1.24 5.00
87 INT115304 Regulation of SNAP25 7 0.60 1.24 0.95 5.00
88 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 5.00
89 INT114411 Regulation of Localization of HCL1 3 0.22 0.14 0.66 5.00
90 INT157892 Binding of PNLIP 5 0.25 4.58 0.65 5.00
91 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41 5.00
92 INT127937 Negative_regulation of Positive_regulation of CYP3A 1 0.43 0 0 5.00
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