P:lumbar region

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pChart

Pain Term
Category Anatomy
Synonyms None
Pain Specific No
Documents 499
Hot Single Events 55
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for lumbar region. They are ordered first by their pain relevance and then by number of times they were reported for lumbar region. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT351715 Pax3 Negative_regulation of Adarb1 1 0.00 0 1.19 87.00
2 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36 81.76
3 INT303106 CAMK4 Positive_regulation of Csf2 1 0.26 0.17 0.31 78.00
4 INT303105 CAMK4 Positive_regulation of Hras1 1 0.04 0.16 0.31 78.00
5 INT200059 Gtf3a Positive_regulation of Ndn 1 0.06 0.89 0 18.52
6 INT200057 Binding of Ndn and Ngfr 1 0.43 1.96 0 9.08
7 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18 5.00
8 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29 5.00
9 INT140660 Phax Negative_regulation of Trpv1 2 0.08 0.58 0.84 5.00
10 INT281651 Phax Positive_regulation of Gene_expression of Trpv1 1 0.09 0.89 0.79 5.00
11 INT281650 Trpv1 Positive_regulation of Localization of Calca 1 0.12 0.71 0.61 5.00
12 INT281648 Negative_regulation of Binding of Trpv1 and Fig4 1 0.14 0.69 0.55 5.00
13 INT281647 Binding of Trpv1 and Fig4 1 0.12 0.68 0.55 5.00
14 INT281649 Negative_regulation of Binding of Calca and Trpv1 1 0.13 0.67 0.54 5.00
15 INT287697 QRFP Regulation of Gene_expression of TNF 1 0.40 1.23 0.42 5.00
16 INT340850 Binding of IGHE and Baat 1 0.07 0.27 0.37 5.00
17 INT180194 CRH Positive_regulation of CRHR2 1 0.02 0.24 0.27 5.00
18 INT180195 CRH Regulation of CRHR2 1 0.01 0.24 0.27 5.00
19 INT212568 Fst Regulation of Gene_expression of Il2 1 0.30 0.07 0.24 5.00
20 INT349560 Olr779 Negative_regulation of Mtor 1 0.02 0.5 0.16 5.00
21 INT349559 Mtor Regulation of Pdpk1 1 0.03 0.42 0.14 5.00
22 INT288219 Cigs1 Regulation of Nrgn 1 0.00 0.87 0.1 5.00
23 INT317129 Gene_expression of Csn Positive_regulation of CASZ1 1 0.00 0.07 0.09 5.00
24 INT200063 Binding of MAGED1 and Ngfr 1 0.44 0.45 0 5.00
25 INT200060 Binding of Nuc and Ndn 1 0.10 0.29 0 5.00
26 INT200058 Binding of Ndn and Bbs4 1 0.30 0.29 0 5.00
27 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0 5.00
28 INT200053 Binding of Nuc and Ngfr 1 0.10 0.3 0 5.00
29 INT317128 Gene_expression of Ncs1 Negative_regulation of Csn 1 0.04 0.44 0 5.00
30 INT200064 Binding of MAGED1 and Mageh1 1 0.30 0.23 0 5.00
31 INT200061 Binding of Ngfr and Fez1 1 0.31 0.3 0 5.00
32 INT200056 Binding of Ndn and Fez1 1 0.31 0.28 0 5.00
33 INT200065 Binding of MAGED1 and Ntf3 1 0.32 0.23 0 5.00
34 INT200054 Binding of Ntf3 and Mageh1 1 0.24 0.22 0 5.00
35 INT200055 Binding of Ngfr and Mageh1 1 0.33 0.45 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for lumbar region. They are ordered first by their pain relevance and then by number of times they were reported in lumbar region. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5586 Binding of Fos 47 0.48 12.7 21.33 100.00
2 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 99.68
3 INT9321 Transcription of Igf1 25 0.69 10.2 6.08 99.68
4 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 99.68
5 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 99.68
6 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 99.68
7 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29 99.68
8 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 99.36
9 INT13432 Positive_regulation of Klkb1 23 0.57 5.36 8.65 99.28
10 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 99.24
11 INT8694 Binding of Lgals3 38 0.48 14.82 8.05 99.22
12 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.20
13 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.20
14 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1 99.08
15 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 98.88
16 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 98.52
17 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6 97.72
18 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 97.56
19 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 97.36
20 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 97.00
21 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92 96.80
22 INT52601 Positive_regulation of Il1rl1 12 0.66 1.34 2.22 96.16
23 INT340324 Regulation of Ppt1 1 0.13 1.17 1.47 95.60
24 INT110749 Gene_expression of Ppt1 9 0.34 0.51 1.49 95.60
25 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 95.00
26 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 94.96
27 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 94.76
28 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57 94.68
29 INT200089 Binding of CATR1 1 0.35 0.75 0.05 93.84
30 INT162 Regulation of Prl 794 0.62 165.01 322.24 93.32
31 INT15158 Positive_regulation of Vegfc 6 0.68 1.07 6.52 93.24
32 INT144313 Localization of HEXB 1 0.04 0.27 0.75 92.64
33 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 92.04
34 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 89.64
35 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03 88.76
36 INT16659 Gene_expression of Eef1a1 34 0.64 6.1 11.85 88.32
37 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 88.28
38 INT5587 Regulation of Fos 191 0.62 40.81 99.7 88.00
39 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 87.40
40 INT164975 Binding of ELN 6 0.35 6.38 0.64 87.40
41 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 86.08
42 INT198406 Localization of C2 5 0.65 1.42 1.01 85.80
43 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 85.60
44 INT105021 Binding of GOPC 187 0.40 60.39 20.38 85.16
45 INT348083 Positive_regulation of Ctsl1 1 0.08 0.21 0.4 83.88
46 INT23955 Regulation of Vim 16 0.25 14.21 2.04 83.44
47 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 83.00
48 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 82.92
49 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 81.84
50 INT74237 Positive_regulation of Ppt1 3 0.49 2.92 2.32 81.68
51 INT317124 Positive_regulation of Gene_expression of Ncs1 1 0.69 10.64 2.66 81.60
52 INT317117 Gene_expression of Ncs1 1 0.77 13.85 2.58 81.60
53 INT317123 Localization of Ncs1 1 0.75 0.16 0.2 81.60
54 INT23222 Binding of Phax 52 0.31 7.61 30.4 81.04
55 INT66544 Binding of Igf1 23 0.46 8.33 2.44 80.96
56 INT38929 Positive_regulation of Tns1 5 0.43 1.11 3.24 79.04
57 INT27627 Binding of Rac1 41 0.41 22.88 13.68 78.88
58 INT425 Localization of PRL 455 0.81 189.64 144.8 78.44
59 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 77.52
60 INT9968 Negative_regulation of Rab38 15 0.00 10.45 8.64 74.72
61 INT80194 Transcription of Rab38 4 0.04 1.85 2.35 74.72
62 INT135646 Negative_regulation of Transcription of Rab38 1 0.01 0.55 0.77 74.72
63 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 74.64
64 INT58919 Localization of Gap43 10 0.78 3.53 4.61 74.20
65 INT58920 Localization of Trafd1 1 0.11 0 0.91 74.20
66 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 73.88
67 INT117675 Transcription of Nav1 46 0.72 30.23 44.01 73.88
68 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 72.88
69 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 72.44
70 INT211002 Binding of SEA 2 0.30 0.31 0.15 70.56
71 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 70.40
72 INT93274 Gene_expression of QRFP 12 0.58 7 1.46 69.92
73 INT147584 Localization of AIS 38 0.63 12.83 5.27 68.36
74 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 67.96
75 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 67.36
76 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 67.32
77 INT47916 Positive_regulation of RIMS1 2 0.67 2.03 1.03 65.52
78 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 64.72
79 INT2649 Regulation of Calca 433 0.62 146.05 330.95 64.12
80 INT126505 Positive_regulation of Ntf3 26 0.70 9.17 4.92 61.04
81 INT36796 Positive_regulation of Hemgn 1 0.17 0.09 0.23 60.88
82 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 60.52
83 INT340842 Regulation of Gene_expression of Cd24a 1 0.42 0.08 0.53 59.60
84 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 59.44
85 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 59.36
86 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 59.36
87 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 59.20
88 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 58.80
89 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 58.72
90 INT57820 Positive_regulation of Om 12 0.12 3.19 3.56 58.64
91 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 58.24
92 INT200043 Positive_regulation of Ndn 1 0.47 1.37 0.13 58.08
93 INT22804 Positive_regulation of ALDOC 8 0.41 8.07 1.02 57.76
94 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 56.56
95 INT111482 Gene_expression of Cd24a 23 0.72 13.74 3.37 56.08
96 INT5817 Localization of Melm1 23 0.68 2.05 18.01 55.92
97 INT23157 Positive_regulation of Localization of Melm1 5 0.45 0.98 2.8 55.92
98 INT161600 Negative_regulation of QRFP 3 0.37 1.01 0.11 55.20
99 INT209820 Positive_regulation of Gene_expression of CAPN7 1 0.37 1.17 0.08 55.12
100 INT211045 Positive_regulation of CD6 1 0.49 0.56 0.26 54.72
101 INT22873 Positive_regulation of ELN 6 0.45 3.74 0.33 54.40
102 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 53.04
103 INT32217 Positive_regulation of Cntn3 1 0.05 0.14 1.06 52.80
104 INT197157 Gene_expression of CAPN7 19 0.51 11.33 0.4 52.72
105 INT209818 Localization of CAPN7 1 0.46 1.03 0.08 51.92
106 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64 50.96
107 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 50.36
108 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 50.36
109 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 50.36
110 INT173851 Localization of FN1 20 0.76 13.95 1.97 50.36
111 INT270304 Localization of FMOD 3 0.15 2.15 0.73 50.36
112 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 50.16
113 INT8801 Gene_expression of Csf3 71 0.74 45.6 10.83 50.12
114 INT15187 Positive_regulation of Gene_expression of Csf3 17 0.66 10.97 2.51 50.12
115 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77 49.84
116 INT122881 Negative_regulation of Ntrk3 10 0.51 5.52 2.04 49.84
117 INT200051 Negative_regulation of Gene_expression of Ntrk3 4 0.40 3.55 1.6 49.84
118 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 49.12
119 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 49.12
120 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38 49.12
121 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 47.68
122 INT200039 Negative_regulation of Ndn 1 0.41 5.89 0.29 44.88
123 INT32218 Binding of Cntn3 1 0.04 0.13 0.96 44.56
124 INT118701 Positive_regulation of Ncs1 2 0.69 4.13 2.03 43.20
125 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 43.04
126 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 42.52
127 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 41.96
128 INT30850 Gene_expression of MORF4 3 0.65 1.08 0.78 41.32
129 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95 40.28
130 INT317121 Positive_regulation of Positive_regulation of Ncs1 1 0.46 0.06 0.09 39.76
131 INT251 Regulation of INS 398 0.62 232.47 55.04 36.36
132 INT317122 Regulation of Positive_regulation of Ncs1 1 0.45 0.13 0.09 32.76
133 INT59784 Binding of DES 22 0.47 19.48 2.27 31.60
134 INT37216 Binding of SMN1 11 0.36 6.66 1.86 31.60
135 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 29.32
136 INT285761 Positive_regulation of LEO1 1 0.67 0.19 0.04 25.76
137 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 25.28
138 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 25.00
139 INT18578 Binding of Eef1a1 20 0.48 2.53 6.95 25.00
140 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8 24.68
141 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 24.32
142 INT89445 Gene_expression of MEPE 17 0.58 18.07 1.55 23.08
143 INT23221 Negative_regulation of Binding of Phax 10 0.37 1.57 5.97 22.48
144 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 20.64
145 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 19.76
146 INT108136 Binding of CAMK4 3 0.36 1.62 0.55 19.60
147 INT259689 Gene_expression of KRT35 1 0.03 6.1 0.52 18.96
148 INT129019 Gene_expression of Ndn 31 0.75 11.09 1.73 18.40
149 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 17.36
150 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 17.36
151 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 15.72
152 INT317119 Binding of Stk24 1 0.20 0.09 0.13 14.16
153 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98 11.08
154 INT192587 Negative_regulation of Protein_catabolism of GOPC 4 0.22 1.15 0.41 11.08
155 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 8.56
156 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 7.84
157 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 7.00
158 INT28714 Negative_regulation of Csf3 10 0.41 6.9 1.6 6.64
159 INT284259 Positive_regulation of Negative_regulation of Csf3 2 0.48 0.79 0.54 6.64
160 INT200044 Negative_regulation of Gene_expression of Ndn 1 0.40 0.29 0 5.36
161 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
162 INT292 Localization of Penk 876 0.81 88.44 669.14 5.00
163 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 5.00
164 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
165 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 5.00
166 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
167 INT287 Localization of Cck 518 0.81 86.84 364.04 5.00
168 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
169 INT1396 Binding of Penk 355 0.48 22.79 269.65 5.00
170 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
171 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 5.00
172 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 5.00
173 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
174 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
175 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 5.00
176 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
177 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
178 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
179 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
180 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 5.00
181 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 5.00
182 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
183 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 5.00
184 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
185 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 5.00
186 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
187 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
188 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
189 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 5.00
190 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
191 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 5.00
192 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
193 INT8534 Localization of Pax3 85 0.59 28.71 82.82 5.00
194 INT6107 Localization of Npy 180 0.81 26.76 81.67 5.00
195 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
196 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 5.00
197 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88 5.00
198 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47 5.00
199 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 5.00
200 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
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