P:melanocortin 1 receptor

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Pain Term
Category Molecule
Synonyms Melanocortin-1 Receptor
Pain Specific Yes
Documents 395
Hot Single Events 200
Hot Interactions 129

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for melanocortin 1 receptor. They are ordered first by their pain relevance and then by number of times they were reported for melanocortin 1 receptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3 100.00
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76 100.00
3 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78 100.00
4 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71 100.00
5 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24 100.00
6 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82 100.00
7 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97 100.00
8 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15 100.00
9 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07 100.00
10 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52 100.00
11 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29 100.00
12 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2 100.00
13 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02 100.00
14 INT69870 ASIP Negative_regulation of Binding of MC1R and POMC 1 0.37 0 0.9 100.00
15 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94 100.00
16 INT276283 Atrn Positive_regulation of Binding of Mc1r and a 1 0.38 0.26 0.8 100.00
17 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79 100.00
18 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82 100.00
19 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74 100.00
20 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7 100.00
21 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68 100.00
22 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74 100.00
23 INT110526 OCA2 Regulation of MC1R 1 0.49 0.43 0.65 100.00
24 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76 100.00
25 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68 100.00
26 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68 100.00
27 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68 100.00
28 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68 100.00
29 INT104973 SGCG Regulation of Gene_expression of MC1R 1 0.67 0.17 0.63 100.00
30 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75 100.00
31 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74 100.00
32 INT97655 Binding of RBM25 and Mc1r 1 0.00 0.44 0.58 100.00
33 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27 100.00
34 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57 100.00
35 INT66020 Binding of Mc1r and RBM25 1 0.00 0.42 0.57 100.00
36 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06 100.00
37 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77 100.00
38 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77 100.00
39 INT93508 Binding of ASIP and Mc1r 1 0.02 0 0.47 100.00
40 INT73831 Binding of Mc1r and Pld1 1 0.00 0.16 0.45 100.00
41 INT99335 Binding of Agrp and Mc1r 1 0.30 0 0.77 100.00
42 INT201610 Binding of Mc1r and Braf 1 0.31 0.75 0.42 100.00
43 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45 100.00
44 INT128287 POMC Positive_regulation of RTCA 1 0.04 0.13 0.42 100.00
45 INT288370 a Positive_regulation of Mc1r 1 0.39 0 0.44 100.00
46 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57 100.00
47 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34 100.00
48 INT154674 Binding of MC1R and SNRPE 1 0.38 0.27 0.28 100.00
49 INT168202 Msx1 Negative_regulation of Gene_expression of Mc1r 1 0.21 0.49 0.35 100.00
50 INT97543 Gtf3a Negative_regulation of Mc1r 1 0.05 0.15 0.3 100.00
51 INT97549 KITLG Negative_regulation of Mc1r 1 0.01 0.15 0.3 100.00
52 INT97546 Pomc Negative_regulation of Mc1r 1 0.40 0.15 0.3 100.00
53 INT83585 Trh Positive_regulation of Mc1r 1 0.50 0.35 0.2 100.00
54 INT155702 MC1R Positive_regulation of CAMP 1 0.48 0 0.2 100.00
55 INT149973 MC1R Positive_regulation of Gene_expression of NR4A2 1 0.44 0.32 0.23 100.00
56 INT100280 TXN Positive_regulation of Gene_expression of MC1R 1 0.33 0.22 0.24 100.00
57 INT288368 Atrn Positive_regulation of Binding of a 1 0.48 0 0.19 100.00
58 INT112193 MC1R Regulation of Localization of Tnf 1 0.06 0.15 0.31 100.00
59 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13 100.00
60 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13 100.00
61 INT83584 Binding of Mc1r and Trh 1 0.36 0.17 0.1 100.00
62 INT81791 AGRP Negative_regulation of MC1R 2 0.47 0 0.28 99.96
63 INT288372 Atrn Positive_regulation of a 1 0.52 0 0.19 99.96
64 INT151136 MC1R Regulation of Mchr1 1 0.00 0.43 0.1 99.96
65 INT81792 AGRP Negative_regulation of INSRR 3 0.01 0 0.55 99.80
66 INT155703 POMC Positive_regulation of CAMP 1 0.49 0 0.2 99.74
67 INT69873 ASIP Negative_regulation of Binding of POMC 1 0.35 0 0.45 99.64
68 INT97547 KITLG Negative_regulation of Msx1 1 0.00 0.08 0.15 99.56
69 INT97542 Pomc Negative_regulation of Msx1 1 0.13 0.07 0.15 99.56
70 INT97545 Gtf3a Negative_regulation of Msx1 1 0.02 0.08 0.15 99.56
71 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02 99.40
72 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9 99.26
73 INT130287 POMC Regulation of Localization of IL10 1 0.12 0.1 0.59 99.18
74 INT130288 POMC Regulation of Gene_expression of VTCN1 1 0.01 0.1 0.59 99.18
75 INT97541 Gtf3a Negative_regulation of a 1 0.03 0.08 0.15 99.12
76 INT97544 Pomc Negative_regulation of a 1 0.19 0.07 0.15 99.12
77 INT97548 KITLG Negative_regulation of a 1 0.01 0.08 0.15 99.12
78 INT111284 AGRP Negative_regulation of MC4R 1 0.46 0 0.14 98.68
79 INT101040 Binding of MC3R and POMC 1 0.30 0.35 0.25 98.60
80 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62 98.20
81 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09 97.92
82 INT61798 Binding of NDP and POMC 2 0.22 0 0.66 97.76
83 INT100282 TXN Negative_regulation of Transcription of POMC 1 0.54 0.39 0.43 97.72
84 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02 97.68
85 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82 97.60
86 INT61799 Negative_regulation of Binding of NDP and POMC 1 0.20 0 0.41 96.80
87 INT107726 BIRC2 Regulation of ASIP 1 0.03 0.24 0.35 96.68
88 INT104975 MITF Regulation of Transcription of PRSS1 1 0.68 0.35 1.46 95.76
89 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44 95.52
90 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45 95.28
91 INT102762 Binding of POMC and TYR 1 0.12 0.35 0.69 95.28
92 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85 95.12
93 INT68852 MC1R Positive_regulation of Localization of POMC 1 0.31 0.47 0.19 94.88
94 INT68853 MC1R Regulation of Localization of POMC 1 0.30 0.47 0.19 94.88
95 INT71640 Binding of HLA-A and TYR 1 0.16 0.36 0.27 94.08
96 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13 93.60
97 INT81786 Binding of AGRP and GIPC1 1 0.01 0 0.13 93.60
98 INT106707 POMC Regulation of Binding of LAMB2 1 0.03 0.7 0.94 93.12
99 INT71643 Binding of HLA-A and TYRP1 1 0.24 0.36 0.26 92.80
100 INT71642 Binding of HLA-A and PMEL 2 0.20 1.05 0.26 92.32
101 INT71639 Binding of MLANA and PMEL 1 0.27 0.36 0.26 92.32
102 INT71641 Binding of MLANA and HLA-A 1 0.28 0.36 0.26 91.76
103 INT100279 TXN Negative_regulation of Gene_expression of HSP90B2P 1 0.13 0.3 0.24 91.20
104 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05 90.68
105 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69 89.68
106 INT81790 Regulation of Binding of AGRP and MC1R 1 0.26 0 0.12 89.68
107 INT127995 Binding of RHCE and MINOS1 1 0.03 0.33 0.16 88.96
108 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12 88.84
109 INT77874 Uvbi1 Positive_regulation of POMC 1 0.01 0.34 0.12 88.84
110 INT77862 IL1B Positive_regulation of POMC 1 0.43 0.34 0.12 88.84
111 INT77860 TNF Negative_regulation of POMC 1 0.28 0.34 0.12 88.84
112 INT69874 POMC Negative_regulation of TYRP1 1 0.13 0 1.07 88.76
113 INT288371 Binding of Atrn and a 1 0.39 0 0.74 88.40
114 INT69871 ASIP Negative_regulation of TYRP1 1 0.36 0 1.07 88.32
115 INT77873 Uvbi1 Positive_regulation of MC1R 1 0.01 0.34 0.12 88.28
116 INT77857 TNF Negative_regulation of MC1R 1 0.35 0.34 0.12 88.28
117 INT77858 IL1B Positive_regulation of MC1R 1 0.55 0.34 0.12 88.28
118 INT100281 POMC Negative_regulation of Gene_expression of HSP90B2P 1 0.24 0.29 0.23 86.80
119 INT201618 Uvbi1 Positive_regulation of Phb 1 0.04 0.28 0.09 86.60
120 INT162273 KITLG Negative_regulation of Gene_expression of Tyr 1 0.13 0.3 0.17 85.88
121 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98 85.84
122 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16 84.84
123 INT178266 Raly Regulation of a 1 0.14 0.97 0.16 84.84
124 INT201609 Uvbi1 Positive_regulation of Gene_expression of Mc1r 1 0.05 0.57 0.17 84.64
125 INT201611 Uvbi1 Negative_regulation of Bop1 1 0.03 0.3 0.08 81.40
126 INT94654 Trpc2 Positive_regulation of Positive_regulation of Tyr 1 0.40 0 0.08 81.40
127 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38 81.20
128 INT114905 TGFB1 Positive_regulation of Transcription of COL7A1 1 0.02 0.08 0.21 81.20
129 INT94653 Tyrp1 Positive_regulation of Positive_regulation of Tyr 1 0.39 0 0.08 81.04
130 INT127996 Binding of POMC and MINOS1 1 0.02 0.17 0.08 79.64
131 INT162270 Kitl Positive_regulation of Gene_expression of Tyr 1 0.34 0.18 0.08 79.36
132 INT128499 KLK7 Regulation of Gene_expression of MC1R 1 0.01 0.09 0.15 78.96
133 INT111283 Regulation of Binding of AGRP and MC4R 1 0.48 0 0.12 77.84
134 INT111285 Positive_regulation of Binding of AGRP and MC4R 1 0.50 0 0.12 77.84
135 INT288374 Binding of MLANA and Msx1 1 0.09 0 0.08 76.20
136 INT201622 Binding of Mark3 and Mc1r 1 0.33 0.74 0.15 76.04
137 INT201615 Binding of Mark3 and Uvbi1 1 0.03 0.36 0.08 76.04
138 INT201616 Uvbi1 Positive_regulation of Mark3 1 0.03 0.36 0.08 76.04
139 INT201619 Binding of Cdk11b and Mc1r 1 0.28 0.74 0.15 75.64
140 INT201621 Binding of Cdk11b and Uvbi1 1 0.02 0.36 0.08 75.64
141 INT201613 Uvbi1 Positive_regulation of Cdk11b 1 0.03 0.36 0.08 75.64
142 INT129219 IFNG Positive_regulation of Gene_expression of ICAM1 1 0.13 0.1 0.25 75.24
143 INT99172 Pomc Positive_regulation of Tyr 1 0.35 0.17 0.69 75.00
144 INT99170 Binding of Mc1r and Tyr 1 0.11 0.2 0.64 75.00
145 INT89187 Agrp Negative_regulation of Mc3r 1 0.33 0 0.51 75.00
146 INT89186 Agrp Negative_regulation of Mc4r 1 0.40 0 0.51 75.00
147 INT100284 TXN Positive_regulation of Gene_expression of POMC 1 0.65 0 0.19 75.00
148 INT82802 Binding of ABL2 and POMC 1 0.00 0 0.14 75.00
149 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89 75.00
150 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19 75.00
151 INT137579 Bms1 Negative_regulation of TNF Positive_regulation of NFKB1 1 0.08 0.42 0.41 75.00
152 INT99171 Negative_regulation of Pomc Positive_regulation of Tyr 1 0.22 0.08 0.35 75.00
153 INT99173 Pomc Positive_regulation of Pomc Positive_regulation of Tyr 1 0.25 0.08 0.35 75.00
154 INT108637 Binding of MC1R and NCOR2 1 0.00 0.1 0.32 75.00
155 INT155530 IRF6 Regulation of Gene_expression of IL8 1 0.06 0.79 0.26 75.00
156 INT155529 IRF6 Regulation of Transcription of IL6 1 0.08 0.79 0.26 75.00
157 INT72116 Binding of PCSK1 and POMC 1 0.32 0 0.15 75.00
158 INT72117 Binding of PCSK2 and POMC 1 0.30 0 0.15 75.00
159 INT83586 Binding of MC2R and Trh 1 0.02 0.19 0.07 75.00
160 INT83587 Binding of MC4R and Trh 1 0.01 0.19 0.07 75.00
161 INT83588 Binding of MC3R and Trh 1 0.28 0.19 0.07 75.00
162 INT83589 Binding of CALCRL and Trh 1 0.01 0.18 0.07 75.00
163 INT129220 IFNG Positive_regulation of ICAM1 1 0.09 0.1 0.25 74.68
164 INT201608 Binding of Mc1r and Uvbi1 1 0.03 0.93 0.15 73.64
165 INT355542 Binding of XRCC3 and BCC1 1 0.00 1.19 0.07 73.60
166 INT77861 IL1B Regulation of Gene_expression of MC1R 1 0.49 0.31 0.12 73.36
167 INT81731 POMC Regulation of Gene_expression of TNF 1 0.28 1.07 0.39 69.36
168 INT107722 ASIP Negative_regulation of EIF4E1B 1 0.02 0.43 0.07 65.44
169 INT107727 ASIP Negative_regulation of RRM2 1 0.29 0.43 0.07 65.12
170 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13 64.96
171 INT107724 ASIP Negative_regulation of NR4A3 1 0.15 0.43 0.06 64.88
172 INT107725 ASIP Negative_regulation of EVI2B 1 0.41 0.43 0.06 64.48
173 INT312662 Binding of CSTF2 and DSE 1 0.06 0.1 0.53 64.00
174 INT114904 POMC Negative_regulation of Localization of FSD1L 1 0.02 0.09 0.2 63.52
175 INT331109 Tpnr1 Regulation of Gene_expression of Calca 1 0.06 0.97 0.94 62.16
176 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 61.76
177 INT168203 Binding of Mc1r and Msx1 1 0.19 0.64 0.25 60.40
178 INT161095 Agrp Regulation of MC1R 1 0.45 0 0.15 59.64
179 INT355687 Art2b Positive_regulation of Gene_expression of Mc3r 1 0.02 1.01 0.48 51.48
180 INT114903 POMC Regulation of Gene_expression of COL7A1 1 0.06 0.2 0.36 50.24
181 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0 33.52
182 INT86634 POMC Positive_regulation of TYR 2 0.42 0 0.24 25.00
183 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
184 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
185 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
186 INT314263 Binding of CPOX and PTGES3 1 0.01 1.7 0.44 5.00
187 INT203169 CPOX Regulation of Gene_expression of PTGER2 2 0.00 0.48 0.29 5.00
188 INT314273 Uvbi1 Positive_regulation of Gene_expression of PTGER2 1 0.00 0.45 0.19 5.00
189 INT314269 Binding of PTGES and PTGES3 1 0.12 0.68 0.18 5.00
190 INT314270 CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.17 5.00
191 INT351032 Binding of CD80 and CD96 1 0.01 0.36 0.09 5.00
192 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09 5.00
193 INT314264 Negative_regulation of CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.09 5.00
194 INT314267 Binding of CPOX and PTGES 1 0.03 0.34 0.09 5.00
195 INT314265 PTGER2 Positive_regulation of Gene_expression of PTGES2 1 0.00 0.19 0.08 5.00
196 INT293973 Binding of POMC and Mc1r 1 0.37 1.8 0.07 5.00
197 INT314274 Uvbi1 Regulation of Gene_expression of PTGER2 1 0.00 0.18 0.06 5.00
198 INT288369 Binding of Laptm5 and Mgrn1 1 0.05 0 0.04 5.00
199 INT314268 SUPT4H1 Positive_regulation of Gene_expression of PTGER2 1 0.01 0.13 0.03 5.00
200 INT314266 SUPT4H1 Positive_regulation of SPTLC1 1 0.02 0.13 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for melanocortin 1 receptor. They are ordered first by their pain relevance and then by number of times they were reported in melanocortin 1 receptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 100.00
2 INT21737 Binding of MC1R 129 0.48 45.45 56.54 100.00
3 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01 100.00
4 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 100.00
5 INT55251 Gene_expression of a 142 0.67 81.21 23.03 100.00
6 INT84712 Regulation of MC1R 36 0.62 9.34 16.91 100.00
7 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09 100.00
8 INT71030 Binding of Mc1r 39 0.48 10.27 12.02 100.00
9 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 100.00
10 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91 100.00
11 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34 100.00
12 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22 100.00
13 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5 100.00
14 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01 100.00
15 INT93507 Gene_expression of ASIP 14 0.60 3.98 7.55 100.00
16 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 100.00
17 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93 100.00
18 INT94652 Binding of a 15 0.48 4.18 5.4 100.00
19 INT69700 Transcription of MC1R 15 0.71 4.32 5.62 100.00
20 INT97264 Binding of Mc1r 9 0.36 4.27 4.53 100.00
21 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 100.00
22 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 100.00
23 INT64450 Gene_expression of Mc1r 13 0.77 9.22 5.43 100.00
24 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
25 INT211708 Regulation of a 4 0.42 1.92 3.15 100.00
26 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54 100.00
27 INT59447 Negative_regulation of Tyr 12 0.56 4.57 3.32 100.00
28 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 100.00
29 INT61136 Localization of MC1R 8 0.75 2.8 2.85 100.00
30 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65 100.00
31 INT155045 Negative_regulation of Gene_expression of Mc1r 7 0.43 1.04 2.33 100.00
32 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92 100.00
33 INT331097 Gene_expression of Rhoay-ps1 1 0.11 0.92 3.01 100.00
34 INT1416 Transcription of POMC 40 0.72 10.71 15.38 100.00
35 INT178246 Negative_regulation of Gene_expression of a 8 0.43 4.27 2.19 100.00
36 INT112050 Regulation of Mc1r 5 0.45 1.36 2.1 100.00
37 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85 100.00
38 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65 100.00
39 INT162871 Localization of Mc1r 6 0.75 0.61 1.72 100.00
40 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91 100.00
41 INT93505 Positive_regulation of Positive_regulation of Mc1r 2 0.70 0.33 1.45 100.00
42 INT178249 Regulation of Gene_expression of a 4 0.35 2.3 1.39 100.00
43 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26 100.00
44 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12 100.00
45 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59 100.00
46 INT128003 Negative_regulation of Gene_expression of MC1R 4 0.59 1.56 1.41 100.00
47 INT118984 Negative_regulation of Mc1r 1 0.53 1.19 1.05 100.00
48 INT118985 Negative_regulation of Gene_expression of Mc1r 5 0.53 1.01 1 100.00
49 INT106860 Regulation of Transcription of MC1R 1 0.45 0 1 100.00
50 INT139549 Positive_regulation of Mc1r 2 0.17 0.7 0.94 100.00
51 INT67890 Positive_regulation of Gene_expression of SGCG 26 0.67 9.91 6.41 100.00
52 INT178252 Transcription of a 3 0.67 0.73 0.9 100.00
53 INT1295 Binding of Pomc 85 0.48 12.92 42.8 100.00
54 INT107474 Positive_regulation of Negative_regulation of Mc1r 1 0.61 0.41 0.89 100.00
55 INT85626 Positive_regulation of Transcription of Mc1r 2 0.50 1.12 1.1 100.00
56 INT128000 Gene_expression of RHCE 9 0.75 1.39 1.18 100.00
57 INT148353 Binding of XRCC3 1 0.15 0.29 0.71 100.00
58 INT153419 Regulation of Binding of MC1R 1 0.40 1.38 0.7 100.00
59 INT186541 Positive_regulation of ADRA1A 3 0.45 2.29 0.86 100.00
60 INT125413 Regulation of Regulation of MC1R 1 0.45 0.09 0.78 100.00
61 INT97654 Gene_expression of RBM25 1 0.00 0.59 0.65 100.00
62 INT162196 Binding of Tyrp1 2 0.31 0.69 1.35 100.00
63 INT66019 Binding of RBM25 1 0.00 0.42 0.57 100.00
64 INT331103 Regulation of Transcription of Mc1r 1 0.61 1.1 1.09 100.00
65 INT61441 Negative_regulation of Gene_expression of Tyr 3 0.10 0.69 2.4 100.00
66 INT161378 Binding of BRAF 1 0.08 2.24 0.48 100.00
67 INT69701 Positive_regulation of Transcription of MC1R 5 0.46 2 0.51 100.00
68 INT323338 Positive_regulation of Positive_regulation of Tyrp1 2 0.13 1.53 1.4 100.00
69 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 100.00
70 INT113978 Positive_regulation of Localization of MC1R 1 0.24 1.2 0.51 100.00
71 INT199560 Binding of Braf 4 0.30 8.83 4.8 100.00
72 INT88278 Binding of Kit 33 0.37 24.45 4.13 100.00
73 INT154675 Binding of SNRPE 1 0.36 0.54 0.38 100.00
74 INT211706 Negative_regulation of Localization of Mc1r 1 0.42 0 0.37 100.00
75 INT37204 Gene_expression of HCL1 4 0.65 0.76 1.54 100.00
76 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 100.00
77 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 100.00
78 INT21254 Regulation of Positive_regulation of POMC 12 0.61 3.64 4.67 100.00
79 INT11696 Gene_expression of HLA-A 50 0.78 41.25 14.1 100.00
80 INT142717 Positive_regulation of Negative_regulation of MC1R 1 0.47 0.36 0.28 100.00
81 INT37435 Negative_regulation of Tyr 6 0.14 0.96 2.94 100.00
82 INT62421 Gene_expression of Trpc2 8 0.68 5.48 0.67 100.00
83 INT27144 Negative_regulation of Dct 4 0.16 1.48 0.46 100.00
84 INT117115 Regulation of Positive_regulation of MC1R 1 0.33 0.38 0.29 100.00
85 INT288358 Positive_regulation of Binding of Mc1r 1 0.41 0 0.19 100.00
86 INT75846 Positive_regulation of MC4R 7 0.70 5.73 1.05 100.00
87 INT195206 Binding of BCC1 15 0.41 21.3 0.62 100.00
88 INT144700 Gene_expression of Kras 21 0.41 12.28 0.57 100.00
89 INT124450 Regulation of Grpr 1 0.16 0.24 0.19 100.00
90 INT140434 Negative_regulation of MTSS1 2 0.25 0.27 0.1 100.00
91 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34 99.98
92 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 99.96
93 INT214117 Gene_expression of Mc5r 4 0.57 2.88 2.34 99.96
94 INT89181 Gene_expression of Mc3r 33 0.77 22.48 11.85 99.96
95 INT105608 Positive_regulation of Mc3r 9 0.68 8.53 4.83 99.96
96 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 99.96
97 INT18995 Binding of CEL 23 0.47 14.46 4.5 99.96
98 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 99.92
99 INT85631 Positive_regulation of Tyrp1 40 0.64 18.73 10.84 99.92
100 INT178248 Negative_regulation of a 4 0.43 1 0.46 99.92
101 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53 99.92
102 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04 99.90
103 INT75053 Gene_expression of MC3R 4 0.53 0.41 1.16 99.90
104 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 99.90
105 INT80333 Localization of CLCN2 1 0.73 0 0.68 99.90
106 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 99.88
107 INT111733 Binding of Asip 1 0.21 0.68 0.88 99.88
108 INT2260 Gene_expression of Tyr 30 0.49 7.05 11.31 99.88
109 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67 99.88
110 INT695 Binding of POMC 304 0.48 56.66 126.85 99.84
111 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 99.84
112 INT162073 Negative_regulation of Transcription of POMC 1 0.34 0.34 0.88 99.84
113 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 99.84
114 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56 99.80
115 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 99.80
116 INT178260 Positive_regulation of a 6 0.50 3.09 2.08 99.80
117 INT74423 Localization of IL10 91 0.80 61.6 22.95 99.80
118 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94 99.80
119 INT331093 Regulation of Tg(MYC)1Led 1 0.04 0.14 0.99 99.80
120 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47 99.76
121 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 99.76
122 INT355684 Positive_regulation of Mc5r 1 0.12 0.84 0.98 99.76
123 INT88269 Binding of ASIP 4 0.19 0.41 1.82 99.74
124 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 99.74
125 INT7376 Positive_regulation of CAMP 17 0.67 6.39 6.6 99.74
126 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 99.72
127 INT107467 Binding of Atrn 3 0.43 0.35 0.75 99.72
128 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 99.70
129 INT107729 Negative_regulation of DCT 1 0.27 0.48 0.35 99.68
130 INT107620 Binding of PTGES 25 0.48 5.49 4.24 99.66
131 INT71114 Regulation of NDP 1 0.12 0 0.61 99.66
132 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69 99.64
133 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 99.62
134 INT117244 Gene_expression of GABBR1 5 0.33 2.19 4.36 99.62
135 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 99.62
136 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 99.60
137 INT149974 Positive_regulation of Gene_expression of NR4A2 4 0.41 0.52 0.58 99.60
138 INT105898 Regulation of SLC45A2 3 0.26 0.07 1.05 99.48
139 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 99.46
140 INT201592 Gene_expression of Vmn1r71 3 0.07 1.08 3.44 99.44
141 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.44
142 INT61500 Binding of FN1 39 0.48 27.33 3.13 99.40
143 INT35406 Localization of Tnf 94 0.81 64.63 31.65 99.40
144 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67 99.40
145 INT25831 Gene_expression of NR4A2 20 0.74 2.73 4.92 99.36
146 INT5118 Regulation of SST 97 0.62 34.35 51.74 99.36
147 INT150187 Gene_expression of Slc45a2 1 0.07 0 0.1 99.36
148 INT80822 Positive_regulation of MRGPRX1 30 0.67 3.66 7.73 99.34
149 INT443 Localization of POMC 1020 0.81 284.52 443.17 99.32
150 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 99.26
151 INT31648 Binding of Trh 11 0.48 2.09 5.48 99.24
152 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9 99.18
153 INT124389 Gene_expression of GRK6 3 0.70 1.14 2.16 99.18
154 INT13435 Positive_regulation of RTCA 31 0.60 7.19 8.5 99.16
155 INT10712 Localization of RHCE 3 0.28 1.15 1.69 99.12
156 INT89180 Gene_expression of Agrp 54 0.78 14.29 8.84 99.12
157 INT134149 Negative_regulation of Gene_expression of NFKB1 7 0.55 4.25 3.63 99.06
158 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 99.06
159 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33 99.04
160 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.02
161 INT91608 Negative_regulation of ASIP 3 0.40 0.51 2.04 99.00
162 INT99331 Binding of Agrp 6 0.40 1.08 2.3 99.00
163 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 99.00
164 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 98.98
165 INT331098 Negative_regulation of Positive_regulation of Mc4r 1 0.32 1.08 1.07 98.96
166 INT214122 Negative_regulation of Mc3r 5 0.43 3.59 2.14 98.96
167 INT331095 Negative_regulation of Mc2r 1 0.36 1.07 1.06 98.96
168 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 98.90
169 INT331104 Regulation of Rhoay-ps1 1 0.07 0.93 1.53 98.88
170 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.86
171 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07 98.84
172 INT130289 Gene_expression of VTCN1 3 0.45 1.61 0.81 98.82
173 INT13354 Transcription of TNF 108 0.72 85.81 42.32 98.80
174 INT67060 Negative_regulation of Transcription of TNF 17 0.59 12.94 5.88 98.80
175 INT79016 Gene_expression of Gstt1 4 0.44 0.59 0.7 98.72
176 INT64523 Binding of Ndp 10 0.33 2.72 7.29 98.72
177 INT140242 Regulation of GRK6 1 0.25 0.31 0.67 98.68
178 INT143846 Positive_regulation of INPP5K 5 0.40 6.4 1.17 98.60
179 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 98.46
180 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9 98.46
181 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4 98.46
182 INT1591 Negative_regulation of Binding of POMC 18 0.59 1.74 7.91 98.44
183 INT91442 Binding of PTGDR2 6 0.46 1.5 2.2 98.42
184 INT91441 Binding of MINOS1 3 0.03 0.31 1.35 98.42
185 INT9660 Regulation of TNF 363 0.62 312.94 139.99 98.40
186 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09 98.40
187 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 98.32
188 INT57243 Transcription of SGCG 10 0.69 3.43 3.04 98.26
189 INT210838 Positive_regulation of Mc4r 17 0.53 6.79 3.06 98.22
190 INT102763 Gene_expression of TBC1D4 3 0.03 0.81 2.76 98.20
191 INT178255 Localization of a 4 0.65 0.72 1.1 98.20
192 INT102969 Positive_regulation of Gene_expression of ADRBK1 7 0.46 1.21 2.87 98.20
193 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46 98.18
194 INT276281 Regulation of Atrn 1 0.21 0.73 0.68 98.18
195 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 98.18
196 INT145073 Regulation of Gene_expression of ASIP 1 0.27 0 0.83 98.16
197 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 98.16
198 INT136861 Negative_regulation of CPD 1 0.31 0.57 0.57 98.16
199 INT138726 Positive_regulation of Gene_expression of Msx1 5 0.53 1.73 1.2 98.12
200 INT81796 Binding of AGRP 62 0.36 37.19 5.3 97.92
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