P:member 8

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pChart

Pain Term
Category Molecule
Synonyms Long Transient Receptor Potential Channel 6, Short Form Of The TRPM8 Cationic Channel, Subfamily M, Transient Receptor Potential Cation Channel, Transient Receptor Potential Cation Channel Subfamily M Member 8, Transient Receptor Potential P8, Transient Receptor Potential Subfamily M Member 8
Pain Specific Yes
Documents 187
Hot Single Events 200
Hot Interactions 25

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for member 8. They are ordered first by their pain relevance and then by number of times they were reported for member 8. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT210160 Binding of TNFRSF8 and TXN 1 0.47 4.16 0.48 100.00
2 INT208909 Ubl4 Regulation of MBOAT7 1 0.00 0.17 0.1 100.00
3 INT208906 Ubl4 Regulation of Mboat7 1 0.02 0.18 0.1 100.00
4 INT208907 Ubl4 Regulation of Rpl37 1 0.02 0.18 0.1 100.00
5 INT159132 Klf9 Positive_regulation of Smc5 1 0.01 0.48 0.2 99.60
6 INT168827 Binding of TRPC4AP and UBR1 1 0.00 0.34 0.1 99.12
7 INT168829 Binding of DDB1 and TRPC4AP 1 0.02 0.34 0.1 99.12
8 INT156836 ETS1 Positive_regulation of Phosphorylation of MAPK7 1 0.14 0 0.1 98.68
9 INT156838 MAPK7 Positive_regulation of Phosphorylation of ETS1 1 0.13 0 0.1 98.68
10 INT156832 MAPK7 Positive_regulation of Transcription of CYP24A1 1 0.35 0 0.1 98.68
11 INT149221 Binding of Ryr1 and Trpc3 5 0.40 0 0.37 98.16
12 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33 96.72
13 INT156829 EGF Positive_regulation of MAPK3 2 0.08 0.87 0.1 96.72
14 INT168828 Binding of DDB1 and UBR1 1 0.00 0.67 0.19 96.64
15 INT107884 Stat3 Positive_regulation of JUN 1 0.08 0 0.17 95.60
16 INT107883 Stat3 Positive_regulation of Gene_expression of JUN 1 0.08 0 0.1 95.60
17 INT136499 PTGER2 Positive_regulation of TRPC7 1 0.13 0.52 0.09 94.40
18 INT237810 Itpr3 Positive_regulation of Localization of Car2 2 0.08 0.68 0.45 93.80
19 INT107876 PDGFD Positive_regulation of Gene_expression of TRPC6 1 0.20 0 0.17 92.12
20 INT208910 Ubl4 Regulation of Regulation of FDX1 1 0.01 0.85 0.45 90.72
21 INT166723 Binding of Vdr and Rxrb 1 0.11 0.31 0.09 88.40
22 INT166724 Binding of Vdr and Rxra 1 0.28 0.32 0.09 88.40
23 INT158545 Binding of Trpc3 and Jph2 1 0.55 0 1.24 87.92
24 INT107878 Gene_expression of JUN Positive_regulation of Gene_expression of TRPC6 1 0.20 0 0.09 85.76
25 INT107885 Negative_regulation of TRPC6 Negative_regulation of Trpc4 1 0.01 0 0.08 82.56
26 INT146937 Egf Regulation of Trpm6 1 0.03 0.27 0.11 80.00
27 INT166945 Ngf Positive_regulation of Trpv1 1 0.01 0.47 1.88 76.48
28 INT161175 Binding of Trpc6 and Mapk1 1 0.32 1.49 0.23 75.40
29 INT161174 Binding of Ang and Trpc6 1 0.29 0.74 0.11 75.40
30 INT161178 Binding of Nfkb1 and Trpc6 1 0.35 0.74 0.11 75.40
31 INT166947 Ngf Positive_regulation of KNG1 1 0.00 0.47 1.86 75.32
32 INT156839 Binding of CYP24A1 and MAPK3 1 0.31 0 0.07 74.92
33 INT156835 Binding of MAPK3 and TRPV6 1 0.21 0 0.07 74.92
34 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15 74.32
35 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15 74.32
36 INT316249 DBT Regulation of TRPM8 1 0.08 1.28 0.15 73.76
37 INT156830 Binding of CYP24A1 and TRPV6 1 0.32 0 0.07 73.44
38 INT156828 Positive_regulation of Binding of CYP24A1 and TRPV6 1 0.42 0 0.07 73.44
39 INT107877 JUN Positive_regulation of Gene_expression of TRPC6 1 0.13 0 0.07 73.32
40 INT107886 Stat3 Positive_regulation of Gene_expression of TRPC6 1 0.38 0 0.07 73.08
41 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1 71.60
42 INT142745 Atp6v1e1 Regulation of Gene_expression of Trpv6 1 0.07 0 0.07 69.80
43 INT149220 Binding of Trpc1 and Trpc3 1 0.35 0 0.18 64.48
44 INT142744 Esr1 Regulation of Transcription of Trpv6 1 0.42 0 0.06 64.08
45 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06 62.88
46 INT142746 Atp6v1e1 Regulation of Trpv6 1 0.17 0 0.06 58.72
47 INT292383 Binding of Itpr3 and Mrvi1 1 0.18 0 0.11 56.28
48 INT149219 Binding of Ryr1 and Trpc1 1 0.35 0 0.11 56.04
49 INT147426 Mcoln3 Negative_regulation of Zfp419 1 0.01 0.1 0.05 51.16
50 INT272389 Bcar1 Negative_regulation of Gene_expression of Trpv6 1 0.01 0 0.1 50.68
51 INT164217 Binding of Cdx1 and Cdx2 1 0.36 0 0 50.00
52 INT164219 Binding of Proc and Slc5a8 1 0.01 0 0 50.00
53 INT164216 Binding of Cdx1 and Slc5a8 1 0.35 0 0 50.00
54 INT164218 Regulation of Binding of Cdx1 and Cdx2 1 0.27 0 0 50.00
55 INT301044 Binding of Csn2 and Trpm1 1 0.09 2.17 0.03 49.04
56 INT161179 Positive_regulation of Ang Positive_regulation of Trpc6 1 0.31 0.5 0 48.20
57 INT161176 Ang Positive_regulation of Positive_regulation of Trpc6 1 0.31 0.5 0 47.48
58 INT161177 Ang Positive_regulation of Trpc6 1 0.31 0.5 0 46.92
59 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88 41.20
60 INT209195 IL1B Regulation of Gene_expression of TRPC3 1 0.26 0 0.11 37.00
61 INT191182 Binding of IRF1 and PRPF31 1 0.06 0.09 0.03 27.24
62 INT191183 Binding of GRB2 and RECQL5 1 0.37 0.17 0 24.00
63 INT191186 Binding of EGFR and RECQL5 1 0.35 0.34 0 24.00
64 INT191181 Binding of EGFR and H3F3B 1 0.32 0.17 0 21.92
65 INT191185 Binding of GRB2 and H3F3B 1 0.34 0.08 0 21.92
66 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1 21.48
67 INT209196 IL1B Positive_regulation of Gene_expression of TRPC3 1 0.68 0.23 0.15 12.08
68 INT272388 Esr1 Regulation of Transcription of Trpv6 1 0.03 0.13 0.06 9.76
69 INT271511 Binding of Phb2 and Glrb 1 0.04 1.7 0.84 5.00
70 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77 5.00
71 INT224280 Bdnf Positive_regulation of Creb1 3 0.30 0.62 0.77 5.00
72 INT326193 Bdnf Positive_regulation of Car2 2 0.14 0.11 0.62 5.00
73 INT317251 Npy Positive_regulation of Gpr119 1 0.32 0 0.25 5.00
74 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
75 INT210990 Binding of KCNMA1 and PKDREJ 1 0.00 0.6 0.19 5.00
76 INT299370 Binding of Mapk8 and Life1 1 0.04 0.73 0.18 5.00
77 INT194134 Binding of HLA-E and IGAD1 1 0.02 1.01 0.15 5.00
78 INT270655 Adipoq Positive_regulation of IL8 Positive_regulation of Adipoq 1 0.00 1.19 0.15 5.00
79 INT194136 Binding of HLA-E and INS 1 0.01 0.95 0.15 5.00
80 INT194135 Binding of CD79A and HLA-E 1 0.07 1.01 0.15 5.00
81 INT271513 Binding of Glrb and Spha2 1 0.16 0.18 0.13 5.00
82 INT329473 SLC7A7 Regulation of Ca2 1 0.04 0.1 0.13 5.00
83 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12 5.00
84 INT295540 Binding of Gh and Ghrl 2 0.10 0.13 0.12 5.00
85 INT270667 Binding of Bcat1 and Prh1 1 0.01 0.89 0.12 5.00
86 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12 5.00
87 INT317259 Pyy Positive_regulation of Ins1 1 0.02 0.33 0.12 5.00
88 INT210161 INCENP Positive_regulation of TNFRSF8 1 0.02 0.93 0.12 5.00
89 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12 5.00
90 INT258714 Camk1g Positive_regulation of Gpd1 1 0.46 0.07 0.11 5.00
91 INT317243 Npy Positive_regulation of Tap2 1 0.08 0 0.1 5.00
92 INT210993 Binding of SEA and PKDREJ 1 0.05 0.17 0.1 5.00
93 INT210992 Binding of KCNMA1 and SP3 1 0.00 0.17 0.1 5.00
94 INT317260 Pyy Positive_regulation of Tap2 1 0.09 0 0.1 5.00
95 INT210989 Binding of FSCN1 and SP3 1 0.00 0.17 0.1 5.00
96 INT313482 Binding of MTOR and SST 1 0.01 0 0.1 5.00
97 INT301043 P9Ehs1 Regulation of Trpv1 1 0.00 0.06 0.1 5.00
98 INT210157 Binding of TNFRSF8 and TNFSF8 1 0.13 1.5 0.1 5.00
99 INT313486 GOPC Positive_regulation of P2RX1 1 0.13 0 0.1 5.00
100 INT210988 Binding of SP3 and PKDREJ 1 0.01 0.17 0.1 5.00
101 INT301041 Grm6 Regulation of Trpv1 1 0.00 0.06 0.1 5.00
102 INT210994 Binding of SEA and SP3 1 0.00 0.17 0.1 5.00
103 INT210991 Binding of FSCN1 and PKDREJ 1 0.00 0.17 0.1 5.00
104 INT329476 SLC7A7 Regulation of Gpr55 1 0.12 0.1 0.09 5.00
105 INT313484 Binding of P2RX1 and SST 1 0.04 0 0.09 5.00
106 INT329474 Binding of SLC7A7 and Ca2 1 0.03 0.4 0.08 5.00
107 INT340318 Gopc Regulation of Ntrk2 1 0.24 0.1 0.08 5.00
108 INT337812 Dgkb Regulation of Igkv4-54 1 0.07 1.27 0.08 5.00
109 INT266997 Mdk Negative_regulation of Bdnf Positive_regulation of Dusp6 1 0.03 0.1 0.07 5.00
110 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07 5.00
111 INT267014 Bdnf Negative_regulation of Gene_expression of Pdp1 1 0.07 0.08 0.07 5.00
112 INT340317 Binding of Shc1 and Positive_regulation of Frs2 1 0.19 0 0.07 5.00
113 INT267016 Bdnf Positive_regulation of Egr1 1 0.12 0.09 0.07 5.00
114 INT267017 Bdnf Positive_regulation of Dusp6 1 0.13 0.1 0.07 5.00
115 INT317261 Binding of Gpr119 and Zglp1 1 0.08 0 0.07 5.00
116 INT267005 Negative_regulation of Mdk Negative_regulation of Gene_expression of Pdp1 1 0.02 0.09 0.07 5.00
117 INT340320 Binding of Shc1 and Positive_regulation of Pik3r1 1 0.23 0 0.07 5.00
118 INT317256 Binding of Pyy and Gpr119 1 0.29 0 0.07 5.00
119 INT317253 Binding of Pyy and Zglp1 1 0.12 0 0.07 5.00
120 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07 5.00
121 INT267041 Negative_regulation of Pik3cg Negative_regulation of Bdnf Positive_regulation of Dusp6 1 0.02 0.1 0.07 5.00
122 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07 5.00
123 INT267012 Pik3cg Positive_regulation of Arc 1 0.01 0.1 0.06 5.00
124 INT267000 Mdk Negative_regulation of Positive_regulation of Baiap2 1 0.03 0.1 0.06 5.00
125 INT267004 Mdk Positive_regulation of Egr2 1 0.04 0.1 0.06 5.00
126 INT267013 Pik3cg Positive_regulation of Egr2 1 0.01 0.1 0.06 5.00
127 INT266998 Pik3cg Negative_regulation of Mdk Positive_regulation of Arc 1 0.00 0.1 0.06 5.00
128 INT267010 Mdk Negative_regulation of Mdk Positive_regulation of Arc 1 0.00 0.1 0.06 5.00
129 INT317247 Ffar1 Positive_regulation of Localization of Gpr119 1 0.10 0.12 0.06 5.00
130 INT267040 Negative_regulation of NOS1 Negative_regulation of Positive_regulation of Baiap2 1 0.02 0.1 0.06 5.00
131 INT317249 Gpr119 Positive_regulation of Localization of Ffar1 1 0.10 0.12 0.06 5.00
132 INT267001 Mdk Positive_regulation of Arc 1 0.02 0.1 0.06 5.00
133 INT266993 Negative_regulation of NOS1 Negative_regulation of Mdk Positive_regulation of Arc 1 0.00 0.1 0.06 5.00
134 INT271512 Binding of Glrb and Traf1 1 0.09 0.1 0.05 5.00
135 INT317245 Binding of Npy2r and Pyy 1 0.09 0 0.05 5.00
136 INT317255 Pyy Positive_regulation of Localization of Npy 1 0.49 0 0.05 5.00
137 INT270664 Ensa Positive_regulation of Localization of Ins1 1 0.02 0.89 0.05 5.00
138 INT271510 Binding of Glrb and rs 1 0.00 0.26 0.05 5.00
139 INT317244 Binding of Npy and Pyy 1 0.26 0 0.05 5.00
140 INT338019 Egf Positive_regulation of AR 1 0.07 1.02 0.05 5.00
141 INT317257 Binding of Tap2 and Pyy 1 0.06 0 0.05 5.00
142 INT297850 Snx1 Positive_regulation of Protein_catabolism of P9Ehs1 1 0.01 0.31 0.05 5.00
143 INT317242 Binding of Tap2 and Npy 1 0.05 0 0.05 5.00
144 INT316248 ESR1 Regulation of Gene_expression of TRPM8 1 0.34 0.17 0.05 5.00
145 INT270666 Binding of Idd6 and Idd19 1 0.37 0.8 0.05 5.00
146 INT317246 Binding of Npy2r and Npy 1 0.08 0 0.05 5.00
147 INT210155 TXN Positive_regulation of Gene_expression of TNFRSF8 1 0.49 0.22 0.05 5.00
148 INT317252 Npy Positive_regulation of Localization of Pyy 1 0.49 0 0.05 5.00
149 INT329468 Gpr55 Positive_regulation of Positive_regulation of Ca2 1 0.07 0.49 0.05 5.00
150 INT210156 Binding of TNFSF8 and TXN 1 0.10 0.4 0.04 5.00
151 INT270659 Wnk1 Regulation of Napg 1 0.04 1.12 0.04 5.00
152 INT210151 TNFSF8 Positive_regulation of Positive_regulation of TNFRSF8 1 0.14 0.14 0.04 5.00
153 INT270661 Regulation of Wnk1 Regulation of Napg 1 0.04 1.13 0.04 5.00
154 INT210158 TNFSF8 Positive_regulation of TNFRSF8 1 0.13 0.14 0.04 5.00
155 INT276583 Binding of Wt1 and IgG 1 0.07 0 0.04 5.00
156 INT267003 Bdnf Positive_regulation of Elk1 1 0.03 0.09 0.03 5.00
157 INT303557 Binding of Dysf and Fgf22 1 0.01 0.45 0.03 5.00
158 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03 5.00
159 INT267038 NOS1 Regulation of Bdnf 1 0.05 0.07 0.03 5.00
160 INT299368 Mkks Positive_regulation of Mapk8 1 0.41 0.17 0.03 5.00
161 INT210154 TXN Regulation of Gene_expression of FASLG 1 0.09 0.23 0.03 5.00
162 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03 5.00
163 INT303559 Binding of Fgf7 and Dysf 1 0.01 0.44 0.03 5.00
164 INT236235 HLA-A Positive_regulation of CD8A 1 0.01 1 0.03 5.00
165 INT267011 Pik3cg Regulation of Bdnf 1 0.06 0.07 0.03 5.00
166 INT313485 MTOR Positive_regulation of Gene_expression of P2RX1 1 0.16 0 0.03 5.00
167 INT267036 CAMK4 Regulation of Bdnf 1 0.03 0.07 0.03 5.00
168 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03 5.00
169 INT267006 Bdnf Positive_regulation of Mdk 1 0.07 0.18 0.03 5.00
170 INT329993 Binding of CACNA1C and KCNMA1 1 0.32 0.19 0 5.00
171 INT339047 Binding of PITX2 and SNRNP70 1 0.00 0.52 0 5.00
172 INT210159 Binding of PRDX1 and TXN 1 0.21 0 0 5.00
173 INT266225 Bhlhe23 Regulation of Gene_expression of Gtf3a 1 0.01 0.33 0 5.00
174 INT329946 Binding of Stmn2 and Trpc5 1 0.03 0.15 0 5.00
175 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0 5.00
176 INT329996 Binding of SGCD and AKAP6 1 0.37 0.46 0 5.00
177 INT329477 Binding of IRF6 and Gpr55 1 0.01 0.53 0 5.00
178 INT276586 Binding of Wt1 and Actn1 1 0.34 0.41 0 5.00
179 INT236246 Binding of CD8A and Birc5 1 0.04 1.34 0 5.00
180 INT351834 Binding of Gmcl1 and GSTK1 1 0.03 0.42 0 5.00
181 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0 5.00
182 INT353189 Plxna3 Negative_regulation of Cyp4a8 1 0.01 0.35 0 5.00
183 INT292390 Binding of Lrmp and Mrvi1 1 0.17 0.05 0 5.00
184 INT329990 Binding of KCNMA1 and SNRNP70 1 0.03 0.96 0 5.00
185 INT210163 Binding of FAS and TXN 1 0.19 0 0 5.00
186 INT329472 Binding of IRF6 and Ca2 1 0.00 0.26 0 5.00
187 INT266999 Mdk Positive_regulation of Regulation of Bdnf 1 0.07 0.05 0 5.00
188 INT338018 Binding of AR and Flna 1 0.11 0.33 0 5.00
189 INT339048 SNRNP70 Regulation of PSORS2 1 0.00 0.45 0 5.00
190 INT329475 Binding of SLC7A7 and Gpr55 1 0.09 0.52 0 5.00
191 INT272390 Olfr714 Regulation of Transcription of Trpv6 1 0.06 0 0 5.00
192 INT266232 Car8 Positive_regulation of Gene_expression of Trpm1 1 0.39 0.1 0 5.00
193 INT329478 SLC7A7 Positive_regulation of Ca2 1 0.04 0 0 5.00
194 INT267018 Bdnf Positive_regulation of Gene_expression of Creb1 1 0.10 0 0 5.00
195 INT301042 Binding of Csn2 and Nyx 1 0.07 0.51 0 5.00
196 INT292384 Itpr3 Regulation of Car2 1 0.07 0 0 5.00
197 INT297848 Binding of Fzd4 and Ndp 1 0.04 1.19 0 5.00
198 INT338013 Binding of Ngfrap1 and Ngfr 1 0.06 1.3 0 5.00
199 INT292387 Lrmp Regulation of Itpr3 1 0.45 0.31 0 5.00
200 INT339043 SNRNP70 Regulation of PITX2 1 0.00 1.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for member 8. They are ordered first by their pain relevance and then by number of times they were reported in member 8. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 100.00
2 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85 100.00
3 INT159620 Gene_expression of TRPM1 7 0.75 7.96 1.65 100.00
4 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 100.00
5 INT159614 Gene_expression of Trpm1 13 0.77 9.47 1.25 100.00
6 INT101593 Positive_regulation of Gene_expression of TRPM8 16 0.70 13.79 4.23 100.00
7 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 100.00
8 INT33241 Localization of INSRR 10 0.10 1.24 3.08 100.00
9 INT110942 Transcription of TRPM8 16 0.69 13.69 1.31 100.00
10 INT118177 Regulation of Trpv5 6 0.60 0.79 0.98 100.00
11 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01 100.00
12 INT142501 Transcription of Tyrp1 4 0.18 2.09 3.71 100.00
13 INT208886 Gene_expression of Rpl37 1 0.10 0.14 0.56 100.00
14 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 100.00
15 INT123198 Localization of TRPM8 6 0.81 3.24 1.53 100.00
16 INT208860 Gene_expression of Psmb10 5 0.04 1.71 0.44 100.00
17 INT115853 Transcription of Trpm8 15 0.68 7.72 4.1 100.00
18 INT147088 Gene_expression of HHEX 5 0.65 4.86 0.99 100.00
19 INT110945 Transcription of PSCA 1 0.69 4.01 0.38 100.00
20 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
21 INT30168 Gene_expression of Dnahc8 20 0.65 4.17 1.73 100.00
22 INT190571 Gene_expression of Eef2 9 0.35 1.64 0.43 100.00
23 INT130246 Negative_regulation of Gene_expression of TRPM8 4 0.59 3.35 1.14 100.00
24 INT147083 Gene_expression of Cdkal1 4 0.35 1.5 0.3 100.00
25 INT143779 Positive_regulation of Trpc6 3 0.70 2.22 0.9 100.00
26 INT119994 Negative_regulation of Trpv2 5 0.58 3.04 1.58 100.00
27 INT208854 Gene_expression of Eif3a 1 0.26 0.28 0.26 100.00
28 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 100.00
29 INT147087 Gene_expression of SLC30A8 8 0.74 1.79 0.24 100.00
30 INT160623 Gene_expression of Trpv5 6 0.59 1.02 1.43 100.00
31 INT266210 Gene_expression of Plk5 1 0.63 0.71 0.31 100.00
32 INT147084 Binding of Slc30a8 4 0.37 1.95 0.2 100.00
33 INT156172 Transcription of Trpv4 3 0.72 1.19 0.19 100.00
34 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 100.00
35 INT208877 Gene_expression of Leng8 1 0.03 0.07 0.18 100.00
36 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 100.00
37 INT303543 Gene_expression of Il1f8 1 0.42 3.28 1.43 100.00
38 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 100.00
39 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02 100.00
40 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 100.00
41 INT149217 Gene_expression of Kcnip3 2 0.63 6.31 5.26 100.00
42 INT160634 Gene_expression of Slc8a1 2 0.64 2.12 1.92 100.00
43 INT141995 Gene_expression of TRPV6 2 0.69 1.15 1.02 100.00
44 INT149215 Regulation of Gene_expression of Kcnip3 2 0.36 0.18 0.66 100.00
45 INT191164 Gene_expression of CD70 5 0.66 3.01 0.59 100.00
46 INT143780 Positive_regulation of Positive_regulation of Trpc6 2 0.47 0.72 0.41 100.00
47 INT160629 Gene_expression of S100g 1 0.20 0.19 0.37 100.00
48 INT138314 Positive_regulation of Golga1 1 0.06 0 0.29 100.00
49 INT266201 Gene_expression of Plekhm1 1 0.03 0 0.16 100.00
50 INT164774 Gene_expression of Igsf1 1 0.22 0.55 0.15 100.00
51 INT194149 Gene_expression of YIPF7 1 0.03 0.93 0.15 100.00
52 INT164773 Negative_regulation of Gene_expression of Igsf1 1 0.12 0.55 0.15 100.00
53 INT194147 Gene_expression of SLAMF8 1 0.03 0.92 0.14 100.00
54 INT197707 Gene_expression of SLC39A8 1 0.22 0.28 0.1 100.00
55 INT149211 Regulation of Gene_expression of Trpc3 2 0.60 0 0.1 100.00
56 INT156855 Regulation of Gene_expression of TRPV6 1 0.32 0 0.1 100.00
57 INT156173 Positive_regulation of Transcription of Trpv4 1 0.61 0.43 0.1 100.00
58 INT62331 Gene_expression of TNFRSF8 26 0.72 17.75 2.08 99.96
59 INT134381 Regulation of Trpm8 25 0.54 8.31 8.25 99.96
60 INT152956 Negative_regulation of Trpm7 1 0.44 0 0.2 99.92
61 INT208836 Regulation of Ubl4 1 0.19 0 0.52 99.88
62 INT25475 Positive_regulation of TRPC6 7 0.64 0.3 0.55 99.84
63 INT110940 Gene_expression of PSCA 3 0.58 3.48 0.2 99.76
64 INT167834 Gene_expression of Slc30a8 1 0.60 0.2 0.55 99.74
65 INT32648 Gene_expression of Tyrp1 80 0.66 17.9 16.59 99.72
66 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24 99.70
67 INT51869 Negative_regulation of Dmd 24 0.52 10.4 2.18 99.68
68 INT150317 Binding of SLC30A8 4 0.36 0.66 0.19 99.62
69 INT110943 Transcription of KLK2 1 0.30 3.41 0.28 99.54
70 INT110944 Transcription of PCA 3 0.52 2.49 1.13 99.54
71 INT166721 Gene_expression of Trpv6 2 0.78 2.68 3.03 99.50
72 INT142740 Gene_expression of Trpv6 15 0.78 6.1 2.06 99.50
73 INT146936 Gene_expression of Trpm6 2 0.28 0.22 0.25 99.50
74 INT136773 Negative_regulation of Trpv6 2 0.43 0.55 0.23 99.50
75 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 99.44
76 INT164445 Localization of Sost 1 0.17 0.37 0.2 99.36
77 INT118884 Gene_expression of IRF1 5 0.66 2.71 2 99.36
78 INT107881 Phosphorylation of PDGFD 1 0.15 0 0.1 99.36
79 INT164448 Localization of ABCA8 1 0.73 0.19 0.1 99.36
80 INT118184 Negative_regulation of Trpv5 3 0.43 1.23 0.21 99.34
81 INT149216 Binding of Trpc3 15 0.48 0 1.33 99.32
82 INT144522 Gene_expression of Trpc3 27 0.76 3.31 3.37 99.32
83 INT5489 Localization of CA2 172 0.80 39.46 33.56 99.16
84 INT136778 Negative_regulation of S100g 4 0.14 0.63 0.2 99.12
85 INT30373 Localization of CCKAR 5 0.68 0.17 1.79 99.08
86 INT100644 Gene_expression of Igf2bp2 3 0.19 0.68 0.31 99.04
87 INT147079 Gene_expression of Ext2 2 0.66 1.04 0.1 99.04
88 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 99.02
89 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 99.02
90 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89 99.02
91 INT158484 Localization of P9Ehs1 1 0.04 0.16 0.24 98.92
92 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 98.86
93 INT142500 Transcription of Trpa1 11 0.67 5.27 2.78 98.86
94 INT156851 Positive_regulation of Phosphorylation of MAPK7 1 0.32 0 0.1 98.68
95 INT156856 Phosphorylation of MAPK7 1 0.52 0 0.1 98.68
96 INT75006 Gene_expression of Gstm1 6 0.45 2.19 0.29 98.56
97 INT69705 Positive_regulation of TXN 8 0.63 2.35 0.89 98.52
98 INT159618 Transcription of Trpm1 8 0.69 11.42 1.21 98.32
99 INT159621 Transcription of TRPM1 1 0.52 2.49 0.39 98.32
100 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08 98.24
101 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 98.20
102 INT145628 Negative_regulation of Trpc6 1 0.40 0 0.13 98.16
103 INT99119 Gene_expression of Cacna2d3 7 0.65 1.41 2.21 98.12
104 INT210193 Binding of TXN 31 0.44 6.88 0.78 98.12
105 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93 98.12
106 INT337805 Phosphorylation of Dgkb 1 0.80 2.89 0.51 98.12
107 INT266220 Gene_expression of Scgn 1 0.71 1.19 0.15 98.12
108 INT156854 Phosphorylation of ETS1 1 0.24 0 0.1 98.12
109 INT156849 Phosphorylation of CYP24A1 1 0.59 0 0.1 98.12
110 INT8740 Localization of Gcg 65 0.78 19 9.81 98.08
111 INT8744 Regulation of Localization of Gcg 14 0.60 2.06 4.3 98.08
112 INT147078 Phosphorylation of Ext2 1 0.07 0.37 0.1 98.02
113 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 97.96
114 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57 97.96
115 INT69771 Positive_regulation of Kcnma1 6 0.52 0.31 0.74 97.84
116 INT163543 Positive_regulation of Localization of INSRR 1 0.03 0 0.68 97.68
117 INT170454 Gene_expression of Nkx3-1 3 0.58 2.54 0.45 97.68
118 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66 97.68
119 INT3057 Gene_expression of Ptgfr 60 0.58 14.54 11.73 97.68
120 INT159116 Gene_expression of Gnb2l1 12 0.77 2.79 9.49 97.68
121 INT236281 Gene_expression of Mt3 3 0.20 1.46 0.21 97.68
122 INT337972 Gene_expression of Steap1 1 0.51 0.58 0.17 97.68
123 INT337992 Gene_expression of Tmem30a 1 0.44 0.58 0.17 97.68
124 INT338000 Gene_expression of Gas5 1 0.45 0.56 0.17 97.68
125 INT338008 Gene_expression of PCGEM1 1 0.34 0.57 0.17 97.68
126 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 97.64
127 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 97.52
128 INT164212 Transcription of Cdx1 1 0.52 0.18 0.1 97.28
129 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 97.20
130 INT109430 Positive_regulation of Trpa1 119 0.70 44 49.14 96.92
131 INT178841 Localization of SNRNP70 27 0.78 10.35 1.71 96.84
132 INT301039 Positive_regulation of Gene_expression of Trpm1 1 0.46 0.55 0.23 96.80
133 INT88678 Gene_expression of CYP27B1 8 0.75 2.11 0.41 96.68
134 INT298393 Phosphorylation of TNFRSF8 1 0.29 1.63 0.1 96.68
135 INT107898 Gene_expression of Trpv2 27 0.76 10.55 9.28 96.64
136 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54 96.48
137 INT351828 Positive_regulation of SLC7A8 1 0.15 1.07 0.18 96.44
138 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 96.36
139 INT181054 Positive_regulation of S100a9 14 0.56 9.83 4.6 96.36
140 INT301036 Binding of Trpm1 1 0.36 0.55 0.23 96.32
141 INT208869 Gene_expression of Il12rb2 1 0.20 0 0.28 96.24
142 INT208890 Gene_expression of Irak1 7 0.65 2.42 1.87 96.24
143 INT161171 Regulation of Gene_expression of Trpc6 1 0.60 0.6 0.14 96.24
144 INT272378 Regulation of Gene_expression of Trpv6 1 0.62 0.63 0.68 96.16
145 INT53285 Gene_expression of Cyp2c11 20 0.76 5.43 1.17 96.16
146 INT136775 Positive_regulation of Transcription of Cyp24a1 1 0.07 0.16 0.1 96.16
147 INT136770 Positive_regulation of Cyp24a1 2 0.18 1.16 0.1 96.16
148 INT6301 Positive_regulation of Trpc6 8 0.67 4.15 1.59 96.00
149 INT160437 Gene_expression of Trpc6 24 0.78 9.09 4.75 95.84
150 INT160438 Positive_regulation of Gene_expression of Trpc6 6 0.70 3.44 1.29 95.84
151 INT136777 Transcription of Cyp24a1 2 0.18 0.78 0.1 95.72
152 INT145128 Gene_expression of Trpc6 12 0.75 5.59 1.17 95.68
153 INT168841 Protein_catabolism of UBR1 2 0.03 0.42 0.14 95.36
154 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 95.32
155 INT136500 Gene_expression of TRPC7 1 0.56 0.52 0.1 95.32
156 INT165036 Gene_expression of S100a9 38 0.77 38.33 7.84 95.24
157 INT120433 Regulation of TRPM8 11 0.62 8.56 3.78 95.20
158 INT156852 Positive_regulation of Transcription of CYP24A1 1 0.44 0 0.1 95.12
159 INT219845 Regulation of HSD17B6 1 0.44 0 0.1 95.08
160 INT167519 Gene_expression of Ubl4 7 0.43 5.28 3.2 95.04
161 INT89105 Gene_expression of Gapdh 27 0.75 4.32 1.15 95.04
162 INT208842 Regulation of Gene_expression of Gapdh 3 0.26 0.38 0.19 95.04
163 INT208868 Regulation of Gene_expression of Ubl4 1 0.12 0.38 0.19 95.04
164 INT154101 Gene_expression of Ide 1 0.11 1.48 0.19 95.00
165 INT116831 Binding of Ryr1 11 0.47 0.12 0.9 94.96
166 INT127718 Regulation of Gene_expression of TRPM8 8 0.62 10.43 2.07 94.88
167 INT119702 Transcription of CYP24A1 4 0.69 1.61 0.16 94.76
168 INT119706 Regulation of Transcription of CYP24A1 2 0.44 0.57 0.09 94.76
169 INT169174 Gene_expression of H19h 1 0.00 0.85 0.14 94.72
170 INT161486 Regulation of Ramp1 2 0.61 1.64 1.16 94.68
171 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 94.20
172 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 94.20
173 INT95286 Regulation of Localization of Nfkb1 6 0.60 3.82 0.71 94.20
174 INT168561 Positive_regulation of Trpm2 2 0.66 1.38 0.81 94.12
175 INT36039 Gene_expression of Itpr3 19 0.72 3.75 2.93 94.12
176 INT169178 Gene_expression of Abcg8 1 0.35 0.84 0.14 94.12
177 INT96860 Positive_regulation of Binding of Ang 3 0.33 1.4 0.21 93.92
178 INT208875 Localization of Il12rb2 1 0.21 0 0.27 93.80
179 INT126948 Phosphorylation of NEK3 3 0.09 1.89 0.22 93.76
180 INT156203 Positive_regulation of Phosphorylation of NEK3 1 0.08 0.38 0.09 93.76
181 INT156200 Negative_regulation of Phosphorylation of NEK3 1 0.07 0.38 0.09 93.76
182 INT109431 Gene_expression of Trpa1 123 0.78 51.84 59.98 93.64
183 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 93.64
184 INT96511 Negative_regulation of Positive_regulation of Trpv1 35 0.59 10.95 19.79 93.60
185 INT351825 Gene_expression of SLC25A22 1 0.19 2.02 0.38 93.52
186 INT160645 Regulation of Trpv6 2 0.60 2.15 0.27 93.44
187 INT142743 Transcription of Trpv6 5 0.72 0.91 0.32 93.44
188 INT160631 Regulation of Transcription of Trpv6 2 0.26 0.8 0.13 93.44
189 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 93.36
190 INT272376 Regulation of Trpv6 12 0.62 0.47 0.53 93.36
191 INT164126 Negative_regulation of TRPM2 2 0.42 0 0.32 93.24
192 INT56494 Localization of Ide 73 0.68 22.9 11.26 93.16
193 INT91436 Localization of MCOLN1 1 0.27 0.36 0.13 93.12
194 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 93.08
195 INT111298 Gene_expression of ACTN4 12 0.70 9.42 2.6 93.04
196 INT106984 Regulation of P2RX1 12 0.60 2.05 1.75 93.04
197 INT145129 Positive_regulation of Gene_expression of Trpc6 4 0.67 2.91 0.51 92.84
198 INT17561 Localization of Car2 303 0.79 60.95 44.52 92.68
199 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 92.44
200 INT9822 Binding of Agtr2 9 0.36 3 3.93 92.00
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