P:metalloproteinase

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pChart

Pain Term
Category Family
Synonyms Metalloproteinases
Pain Specific No
Documents 1398
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for metalloproteinase. They are ordered first by their pain relevance and then by number of times they were reported for metalloproteinase. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33 100.00
2 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6 100.00
3 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76 100.00
4 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86 100.00
5 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81 100.00
6 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 100.00
7 INT314037 THL Negative_regulation of Localization of Plau 1 0.17 1.64 0.99 100.00
8 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 100.00
9 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75 100.00
10 INT219686 Binding of CEL and COPD 1 0.12 11.35 1.26 100.00
11 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 0.00 0.74 1.25 100.00
12 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25 100.00
13 INT202040 CAMK2N2 Negative_regulation of MMP7 1 0.00 0.73 1.24 100.00
14 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24 100.00
15 INT202039 CAMK2N2 Negative_regulation of MMP1 1 0.00 0.73 1.24 100.00
16 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83 100.00
17 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3 100.00
18 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9 100.00
19 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89 100.00
20 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89 100.00
21 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88 100.00
22 INT121700 IL12RB1 Positive_regulation of Gene_expression of MMP1 1 0.06 0.22 0.9 100.00
23 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27 100.00
24 INT187174 RPS3AP9 Negative_regulation of MMP2 1 0.00 0.9 1.22 100.00
25 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2 100.00
26 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91 100.00
27 INT144069 Positive_regulation of TRPV1 Positive_regulation of Gene_expression of MMP1 1 0.43 1.35 1.03 100.00
28 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85 100.00
29 INT215945 Binding of Mmp14 and Timp2 Positive_regulation of Mmp2 1 0.11 0.4 0.84 100.00
30 INT190147 MMP12 Positive_regulation of MMP2 Positive_regulation of Protein_catabolism of MMRN1 1 0.03 0.87 0.9 100.00
31 INT260895 CRH Regulation of MMP1 1 0.11 0.31 0.74 100.00
32 INT219685 Binding of MMP12 and COPD 1 0.27 5.59 0.74 100.00
33 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85 100.00
34 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83 100.00
35 INT314051 THL Negative_regulation of Localization of Mmp2 1 0.14 1.1 0.62 100.00
36 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74 100.00
37 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8 100.00
38 INT175626 TIMP1 Positive_regulation of Gene_expression of MMP9 1 0.03 0.72 0.57 100.00
39 INT175627 TIMP1 Positive_regulation of MMP2 1 0.03 0.71 0.56 100.00
40 INT175623 TIMP1 Positive_regulation of MMP9 1 0.03 0.71 0.56 100.00
41 INT121697 IL4I1 Positive_regulation of Gene_expression of MMP3 1 0.06 0.27 0.7 100.00
42 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54 100.00
43 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74 100.00
44 INT196522 Binding of MMP1 and TIMP1 1 0.39 0.29 0.53 100.00
45 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53 100.00
46 INT314043 THL Negative_regulation of Mmp2 1 0.22 2.11 0.53 100.00
47 INT190177 Gene_expression of IL13 Regulation of Gene_expression of IL4 1 0.04 0.05 0.68 100.00
48 INT190171 Gene_expression of IL4 Regulation of Gene_expression of IL13 1 0.04 0.05 0.68 100.00
49 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68 100.00
50 INT190172 Gene_expression of IL13 Regulation of MMP12 1 0.12 0.05 0.68 100.00
51 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7 100.00
52 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52 100.00
53 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74 100.00
54 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65 100.00
55 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65 100.00
56 INT190170 IL4 Regulation of Gene_expression of IL13 1 0.04 0 0.62 100.00
57 INT190175 IL13 Regulation of Gene_expression of IL4 1 0.04 0 0.62 100.00
58 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15 100.00
59 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6 100.00
60 INT190166 IL13 Regulation of MMP12 1 0.12 0 0.59 100.00
61 INT314053 VEGFA Positive_regulation of Gene_expression of Mmp2 1 0.02 0.2 0.47 100.00
62 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7 100.00
63 INT314044 THL Negative_regulation of Transcription of Mmp9 1 0.20 0.81 0.45 100.00
64 INT314050 THL Negative_regulation of Transcription of Mmp2 1 0.16 0.81 0.44 100.00
65 INT345308 Binding of ABCA1 and TIMP2 1 0.00 0.21 0.52 100.00
66 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69 100.00
67 INT263049 Positive_regulation of Binding of Mmp2 and Mmp9 1 0.35 0.83 0.69 100.00
68 INT196348 PTGER2 Negative_regulation of Negative_regulation of MMP2 1 0.01 0.29 0.43 100.00
69 INT314042 THL Negative_regulation of Gene_expression of Mmp2 1 0.19 2.97 0.42 100.00
70 INT224702 Timp2 Positive_regulation of Binding of Mmp14 and Mmp9 1 0.00 0.81 0.65 100.00
71 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65 100.00
72 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12 100.00
73 INT295705 Binding of IK and TNF 1 0.00 0.27 0.64 100.00
74 INT157935 Negative_regulation of TRPV1 Negative_regulation of Gene_expression of MMP1 1 0.42 0.1 0.68 100.00
75 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5 100.00
76 INT236832 CSF2 Regulation of CXCL13 1 0.09 0.34 0.45 100.00
77 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5 100.00
78 INT314046 THL Negative_regulation of Localization of Mmp9 1 0.13 0.95 0.39 100.00
79 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07 100.00
80 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78 100.00
81 INT102163 Binding of TNF and Mmp9 1 0.12 0.88 0.78 100.00
82 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78 100.00
83 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77 100.00
84 INT295721 CSF2 Positive_regulation of MMP9 1 0.06 0.32 0.6 100.00
85 INT144070 Gene_expression of TRPV1 Positive_regulation of Positive_regulation of MMP1 1 0.43 0.68 0.52 100.00
86 INT144072 Gene_expression of TRPV1 Positive_regulation of MMP1 1 0.43 0.68 0.52 100.00
87 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6 100.00
88 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07 100.00
89 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92 100.00
90 INT190145 Binding of JUN and MMP12 Positive_regulation of Positive_regulation of PIK3CA 1 0.01 0.57 0.57 100.00
91 INT190146 Positive_regulation of PIK3CA Positive_regulation of Binding of JUN and MMP12 1 0.01 0.57 0.57 100.00
92 INT190148 Binding of JUN and MMP12 Positive_regulation of MMP12 1 0.33 0.57 0.57 100.00
93 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56 100.00
94 INT198970 GAPDH Negative_regulation of ADAMTS3 1 0.47 0 0.35 100.00
95 INT198971 GAPDH Negative_regulation of ADAMTS5 1 0.47 0 0.35 100.00
96 INT179845 Il11 Positive_regulation of Negative_regulation of Timp1 1 0.14 0 0.35 100.00
97 INT198969 GAPDH Negative_regulation of TIMP1 1 0.47 0 0.35 100.00
98 INT219684 Binding of MMP12 and GOPC 1 0.09 3.11 0.38 100.00
99 INT219683 Binding of CEL and GOPC 1 0.04 3.11 0.38 100.00
100 INT205728 Mmp9 Positive_regulation of Gene_expression of Mmp3 1 0.29 0 0.52 100.00
101 INT205727 Mmp3 Positive_regulation of Gene_expression of Mmp9 1 0.29 0 0.52 100.00
102 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97 100.00
103 INT157934 TRPV1 Positive_regulation of Positive_regulation of MMP1 1 0.45 0.07 0.57 100.00
104 INT187176 Binding of BSG and MMP1 1 0.09 1.18 1.08 100.00
105 INT260896 CRH Positive_regulation of Localization of MMP9 1 0.15 0.15 0.3 100.00
106 INT218707 Mmp1a Negative_regulation of MMP1 1 0.00 2.03 0.38 100.00
107 INT342624 VEGFA Negative_regulation of Mmp2 1 0.09 1.54 0.58 100.00
108 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57 100.00
109 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57 100.00
110 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54 100.00
111 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29 100.00
112 INT144071 TRPV1 Positive_regulation of Gene_expression of MMP14 1 0.21 0.5 0.58 100.00
113 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59 100.00
114 INT124427 NPEPPS Positive_regulation of Protein_catabolism of COL7A1 1 0.00 0.56 0.84 100.00
115 INT340616 COL4A4 Regulation of MMP9 1 0.12 0.95 0.32 100.00
116 INT340615 COL4A4 Regulation of MMP2 1 0.11 0.95 0.32 100.00
117 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 100.00
118 INT355539 Gnptg Positive_regulation of Mmp23 1 0.00 1.18 0.35 100.00
119 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14 100.00
120 INT148548 Cd44 Positive_regulation of Regulation of NPEPPS 1 0.00 0.29 0.42 100.00
121 INT148547 Cd44 Positive_regulation of NPEPPS 1 0.00 0.29 0.41 100.00
122 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65 100.00
123 INT106808 RECK Negative_regulation of MMP2 1 0.40 0.5 0.83 100.00
124 INT316737 Il1 Positive_regulation of Mmp1a 1 0.01 0.64 0.54 100.00
125 INT316738 Il1 Positive_regulation of Mmp3 1 0.02 0.63 0.54 100.00
126 INT224701 Timp3 Negative_regulation of TNF 1 0.01 0.65 0.34 100.00
127 INT354790 MMP3 Negative_regulation of Gene_expression of OSM 1 0.00 0.27 0.31 100.00
128 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 100.00
129 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 100.00
130 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 100.00
131 INT150268 MMP8 Regulation of Transcription of SFTPA1 1 0.05 0.43 0.75 100.00
132 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 100.00
133 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 100.00
134 INT309000 Ins1 Positive_regulation of Gene_expression of Mmp9 1 0.20 1.03 0.22 100.00
135 INT309002 Ins1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.22 100.00
136 INT203105 MMP3 Negative_regulation of Gene_expression of IL10 1 0.06 0.69 0.56 100.00
137 INT348924 Mmp1 Regulation of Gene_expression of Renbp 1 0.03 0.95 0.26 100.00
138 INT302379 Crp Positive_regulation of Gene_expression of Ccl2 1 0.10 4.58 0.84 100.00
139 INT205057 MMP3 Negative_regulation of MMP2 1 0.35 3.02 0.2 100.00
140 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2 100.00
141 INT218709 Mmp1a Negative_regulation of TIMP1 1 0.00 1.84 0.28 100.00
142 INT218660 Mmp1a Negative_regulation of Timp1 1 0.02 1.84 0.28 100.00
143 INT277065 CRP Positive_regulation of Gene_expression of MMP1 1 0.41 1.52 0.47 100.00
144 INT277064 CRP Positive_regulation of Gene_expression of TIMP1 1 0.15 1.47 0.45 100.00
145 INT113473 RETNLB Positive_regulation of MMP14 1 0.01 0.37 0.64 100.00
146 INT314049 THL Negative_regulation of Gene_expression of Plau 1 0.20 2.91 0.19 100.00
147 INT207460 MMP3 Positive_regulation of Positive_regulation of LGALS3 1 0.13 0.26 0.19 100.00
148 INT60063 IL1B Regulation of NPEPPS 1 0.00 0.29 0.42 100.00
149 INT152296 Regulation of Mmp9 Negative_regulation of Tsc22d1 1 0.08 0.16 0.66 100.00
150 INT152299 Mmp2 Negative_regulation of Tsc22d1 1 0.16 0.16 0.66 100.00
151 INT152298 Mmp9 Negative_regulation of Tsc22d1 1 0.13 0.16 0.66 100.00
152 INT152297 Mmp2 Negative_regulation of Mmp9 1 0.39 0.16 0.65 100.00
153 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18 100.00
154 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28 100.00
155 INT133002 Mmp9 Regulation of Negative_regulation of Igfbp3 1 0.26 0.39 0.42 100.00
156 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24 100.00
157 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24 100.00
158 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28 100.00
159 INT181928 RLN1 Positive_regulation of TIMP1 1 0.00 0.1 0.17 100.00
160 INT117137 Gene_expression of ROS1 Positive_regulation of Protein_catabolism of Egf 1 0.00 0 0.16 100.00
161 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24 100.00
162 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23 100.00
163 INT314039 THL Negative_regulation of Binding of Mmp2 1 0.16 1.62 0.14 100.00
164 INT180960 Protein_catabolism of COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14 100.00
165 INT180963 COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14 100.00
166 INT314041 THL Negative_regulation of Gene_expression of Mmp9 1 0.13 1.86 0.14 100.00
167 INT252902 PTTG1 Regulation of MMP2 1 0.01 1.5 0.14 100.00
168 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14 100.00
169 INT224462 Positive_regulation of F2RL1 Positive_regulation of MMP1 1 0.10 0.47 0.28 100.00
170 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14 100.00
171 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95 100.00
172 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33 100.00
173 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33 100.00
174 INT318185 MUC5AC Positive_regulation of Gene_expression of MMP3 1 0.09 0.86 0.13 100.00
175 INT117136 NPEPPS Positive_regulation of Hbegf 1 0.00 0 0.12 100.00
176 INT203104 MMP3 Positive_regulation of Gene_expression of IFN1@ 1 0.25 0.33 0.48 100.00
177 INT194915 Csf2 Positive_regulation of Gene_expression of Mmp1a 1 0.01 0.85 0.52 100.00
178 INT194916 Kitl Positive_regulation of Gene_expression of Mmp1a 1 0.00 0.85 0.52 100.00
179 INT194918 Csf2 Positive_regulation of Gene_expression of VEGFA 1 0.02 0.85 0.52 100.00
180 INT194919 Kitl Positive_regulation of Gene_expression of VEGFA 1 0.01 0.85 0.52 100.00
181 INT181995 TIMP1 Negative_regulation of Mmp9 1 0.01 1.38 0.4 100.00
182 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33 100.00
183 INT264333 IL-17 Positive_regulation of Gene_expression of Mmp1a 1 0.05 2.88 1.18 100.00
184 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16 100.00
185 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07 100.00
186 INT150784 ZNF398 Positive_regulation of Localization of THBS3 1 0.07 1.02 1.07 100.00
187 INT238091 Binding of GRIP1 and Mmp24 1 0.00 0 0.98 100.00
188 INT238092 Binding of SHBG and Mmp24 1 0.04 0 0.98 100.00
189 INT127430 VEGFA Negative_regulation of Gene_expression of TIMP1 1 0.43 0.6 0.5 100.00
190 INT335994 Timp1 Regulation of Col7a1 1 0.01 0.36 0.37 100.00
191 INT277066 MMP1 Positive_regulation of Gene_expression of TIMP1 1 0.16 0.76 0.24 100.00
192 INT163403 VEGFA Positive_regulation of MMP2 1 0.52 0.13 0.23 100.00
193 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17 100.00
194 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16 100.00
195 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16 100.00
196 INT203629 IL8 Negative_regulation of Timp1 1 0.05 0 0.1 100.00
197 INT203628 Cxcl1 Negative_regulation of TIMP2 1 0.01 0 0.1 100.00
198 INT203589 IL8 Negative_regulation of VEGFA 1 0.03 0 0.1 100.00
199 INT203583 IL8 Negative_regulation of TIMP2 1 0.03 0 0.1 100.00
200 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1 100.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for metalloproteinase. They are ordered first by their pain relevance and then by number of times they were reported in metalloproteinase. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 100.00
2 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 100.00
3 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 100.00
4 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 100.00
5 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 100.00
6 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 100.00
7 INT99610 Localization of MMP9 126 0.79 48.46 32.67 100.00
8 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 100.00
9 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 100.00
10 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55 100.00
11 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 100.00
12 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 100.00
13 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04 100.00
14 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 100.00
15 INT34487 Localization of MMP2 56 0.81 31.41 23.61 100.00
16 INT16290 Gene_expression of BSG 60 0.68 38.73 32.86 100.00
17 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 100.00
18 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 100.00
19 INT49379 Localization of MMP12 26 0.77 13.07 16.93 100.00
20 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 100.00
21 INT110809 Gene_expression of Mmp1 20 0.75 18 14.49 100.00
22 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 100.00
23 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
24 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 100.00
25 INT103210 Localization of MMP1 43 0.78 12.15 15.13 100.00
26 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39 100.00
27 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 100.00
28 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 100.00
29 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69 100.00
30 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89 100.00
31 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 100.00
32 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 100.00
33 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
34 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 100.00
35 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1 100.00
36 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4 100.00
37 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 100.00
38 INT81486 Localization of MMP3 31 0.81 12.94 15.21 100.00
39 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 100.00
40 INT12339 Localization of IL8 437 0.81 251.87 117.39 100.00
41 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 100.00
42 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 100.00
43 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 100.00
44 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 100.00
45 INT55740 Gene_expression of Timp1 53 0.75 28.63 13.85 100.00
46 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 100.00
47 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 100.00
48 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 100.00
49 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93 100.00
50 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 100.00
51 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07 100.00
52 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 100.00
53 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 100.00
54 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 100.00
55 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 100.00
56 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91 100.00
57 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98 100.00
58 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28 100.00
59 INT34485 Negative_regulation of Localization of MMP2 17 0.50 9.96 10.49 100.00
60 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 100.00
61 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71 100.00
62 INT111398 Localization of Mmp2 37 0.76 23.78 7.17 100.00
63 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 100.00
64 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74 100.00
65 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 100.00
66 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 100.00
67 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76 100.00
68 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 100.00
69 INT67568 Positive_regulation of Localization of MMP2 14 0.31 8.58 6.79 100.00
70 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08 100.00
71 INT110810 Positive_regulation of Gene_expression of Mmp1 9 0.52 4.2 5.11 100.00
72 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37 100.00
73 INT97331 Positive_regulation of Timp1 20 0.45 13.32 8.57 100.00
74 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 100.00
75 INT48233 Negative_regulation of Gene_expression of MMP1 34 0.58 12.94 9.08 100.00
76 INT102987 Regulation of MMP3 23 0.60 9.35 9.54 100.00
77 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36 100.00
78 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 100.00
79 INT99606 Negative_regulation of Localization of MMP9 23 0.57 7.15 5.47 100.00
80 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 100.00
81 INT111397 Localization of Timp1 17 0.70 11.67 8.76 100.00
82 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
83 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 100.00
84 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45 100.00
85 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96 100.00
86 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 100.00
87 INT168600 Binding of Mmp9 14 0.44 12.79 6.92 100.00
88 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 100.00
89 INT6852 Localization of TNF 883 0.81 705.95 270.84 100.00
90 INT111903 Regulation of Mmp2 9 0.61 3.95 7.98 100.00
91 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 100.00
92 INT94122 Negative_regulation of Mmp23 21 0.37 15.81 8.03 100.00
93 INT152293 Regulation of Mmp9 9 0.49 6.57 6.01 100.00
94 INT220861 Positive_regulation of Mmp8 14 0.50 12.21 4.6 100.00
95 INT11359 Gene_expression of PLAU 84 0.76 49.54 12.31 100.00
96 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 100.00
97 INT113671 Negative_regulation of Mmp3 26 0.49 6.33 7.88 100.00
98 INT155780 Gene_expression of Mmp8 19 0.77 15.85 6.33 100.00
99 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 100.00
100 INT110811 Positive_regulation of Mmp1 5 0.60 2.96 2.83 100.00
101 INT87468 Negative_regulation of Mmp2 24 0.57 10.79 5.55 100.00
102 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13 100.00
103 INT94431 Transcription of MMP1 14 0.56 4.1 3.66 100.00
104 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 100.00
105 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96 100.00
106 INT20493 Regulation of MMP12 3 0.52 0.89 3.65 100.00
107 INT108628 Regulation of MMP2 27 0.60 14.85 6.06 100.00
108 INT74629 Gene_expression of Mmp7 17 0.55 12.78 7.58 100.00
109 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 100.00
110 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 100.00
111 INT190202 Negative_regulation of Localization of MMP12 1 0.36 1.29 3.12 100.00
112 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 100.00
113 INT90202 Protein_catabolism of MMP2 15 0.94 7.47 5.41 100.00
114 INT243034 Positive_regulation of Rarb 1 0.04 4.07 2.52 100.00
115 INT245286 Localization of Plau 6 0.66 9.56 2.58 100.00
116 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 100.00
117 INT123551 Regulation of Mmp2 17 0.57 11.6 6 100.00
118 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51 100.00
119 INT190188 Regulation of Localization of MMP12 1 0.44 0.39 2.8 100.00
120 INT1285 Localization of Mmp13 12 0.78 8.98 4.93 100.00
121 INT141146 Gene_expression of Mmp13 18 0.38 8.61 5.54 100.00
122 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 100.00
123 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 100.00
124 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 100.00
125 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 100.00
126 INT168381 Positive_regulation of Mmp3 24 0.58 19.12 7.03 100.00
127 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 100.00
128 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41 100.00
129 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12 100.00
130 INT6481 Binding of TNF 624 0.48 510.2 214.82 100.00
131 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 100.00
132 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 100.00
133 INT180923 Negative_regulation of Localization of Mmp2 6 0.46 7.84 2.17 100.00
134 INT129964 Negative_regulation of MMP13 23 0.55 6.48 4.21 100.00
135 INT230060 Binding of Timp1 7 0.47 5.61 3.2 100.00
136 INT185898 Gene_expression of MMP10 8 0.49 5.36 2.68 100.00
137 INT94433 Negative_regulation of TIMP2 16 0.55 9.38 4.78 100.00
138 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 100.00
139 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36 100.00
140 INT29502 Localization of Mmp2 18 0.79 3.49 4.64 100.00
141 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 100.00
142 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 100.00
143 INT89791 Transcription of Mmp3 7 0.33 2.28 4.64 100.00
144 INT243033 Localization of Mmp8 8 0.65 5.59 2.52 100.00
145 INT130603 Binding of Timp1 9 0.35 8.52 3.04 100.00
146 INT192298 Negative_regulation of MMP7 7 0.27 3.71 3.29 100.00
147 INT60067 Localization of NPEPPS 9 0.26 3.36 4.15 100.00
148 INT184257 Positive_regulation of Gene_expression of Mmp8 7 0.49 6.32 2.74 100.00
149 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 100.00
150 INT60415 Regulation of NPEPPS 13 0.27 5.81 3.78 100.00
151 INT133312 Binding of MMP9 25 0.42 16.79 3.83 100.00
152 INT190189 Positive_regulation of Localization of MMP12 4 0.58 2.87 3.18 100.00
153 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 100.00
154 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09 100.00
155 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 100.00
156 INT107242 Binding of MMP3 14 0.47 12.06 5.11 100.00
157 INT68974 Localization of Mmp9 10 0.80 4.84 3.35 100.00
158 INT55690 Positive_regulation of Localization of TIMP1 8 0.50 4.77 3.28 100.00
159 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 100.00
160 INT106468 Regulation of Gene_expression of MMP2 11 0.50 3.53 2.77 100.00
161 INT190186 Negative_regulation of Gene_expression of MMP12 5 0.38 5.37 2.17 100.00
162 INT243030 Binding of Mmp8 1 0.10 2.4 1.82 100.00
163 INT132994 Positive_regulation of Localization of Mmp9 12 0.42 9.4 3.75 100.00
164 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97 100.00
165 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34 100.00
166 INT120124 Transcription of MMP3 9 0.69 2.15 2.38 100.00
167 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58 100.00
168 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 100.00
169 INT99895 Positive_regulation of Mmp14 10 0.58 6.64 2.72 100.00
170 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 100.00
171 INT5454 Localization of CRH 124 0.79 79.18 41.53 100.00
172 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 100.00
173 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 100.00
174 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 100.00
175 INT82871 Protein_catabolism of MMP1 13 0.96 10.71 4.09 100.00
176 INT295688 Positive_regulation of Regulation of MMP9 1 0.14 0.67 1.51 100.00
177 INT160914 Positive_regulation of Positive_regulation of Mmp9 7 0.57 4.69 4.52 100.00
178 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3 100.00
179 INT170305 Regulation of Gene_expression of Mmp9 11 0.33 5.7 2.8 100.00
180 INT99897 Positive_regulation of Gene_expression of Mmp14 7 0.36 6.33 2.51 100.00
181 INT138141 Transcription of Mmp2 10 0.64 6.52 2.99 100.00
182 INT105985 Transcription of Mmp9 11 0.66 8.55 3.02 100.00
183 INT115464 Gene_expression of Plau 41 0.72 30.21 2.79 100.00
184 INT123883 Positive_regulation of Gene_expression of Mmp3 16 0.60 4.42 3.74 100.00
185 INT220047 Negative_regulation of Gene_expression of Mmp3 4 0.29 5.93 3.95 100.00
186 INT263046 Negative_regulation of Gene_expression of Mmp2 7 0.34 5.98 2.09 100.00
187 INT215928 Binding of Timp2 1 0.23 0.79 1.66 100.00
188 INT168383 Positive_regulation of Mmp13 27 0.67 17.9 6.27 100.00
189 INT170324 Negative_regulation of Gene_expression of Mmp1a 8 0.13 6.28 2.94 100.00
190 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 100.00
191 INT192152 Negative_regulation of Mmp14 3 0.24 1.69 1.72 100.00
192 INT161206 Negative_regulation of Localization of Mmp9 10 0.59 9.68 3.59 100.00
193 INT183810 Positive_regulation of Positive_regulation of MMP9 9 0.52 4.15 2.46 100.00
194 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41 100.00
195 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 100.00
196 INT15610 Localization of GOPC 223 0.65 68.26 28.7 100.00
197 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 100.00
198 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12 100.00
199 INT151309 Positive_regulation of Positive_regulation of MMP3 5 0.60 2.62 2.5 100.00
200 INT86293 Positive_regulation of Gene_expression of Mmp2 21 0.64 11.69 3.79 100.00
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