P:methadone

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 7934
Hot Single Events 200
Hot Interactions 12

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for methadone. They are ordered first by their pain relevance and then by number of times they were reported for methadone. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31 100.00
2 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02 100.00
3 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09 99.96
4 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08 99.96
5 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46 96.04
6 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 91.88
7 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 91.28
8 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98 86.52
9 INT168303 Binding of SNRPB and UGT2B7 1 0.20 0 1.09 86.40
10 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 85.60
11 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56 83.20
12 INT155086 CASP1 Negative_regulation of DAXX 1 0.21 1.26 0.45 80.92
13 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75 79.52
14 INT168717 Mapk8 Positive_regulation of Mapk8 Negative_regulation of Oprk1 1 0.19 0.26 1.75 79.52
15 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75 79.52
16 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44 79.08
17 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93 73.36
18 INT153041 Positive_regulation of Binding of Gpm6a and LOC100359830 1 0.01 0 1.01 73.36
19 INT153042 Binding of Gpm6a and LOC100359830 1 0.01 0 1.01 73.36
20 INT153040 Binding of LOC100359830 and LOC100360318 1 0.00 0 1.01 72.96
21 INT153039 Binding of G2e3 and LOC100360318 1 0.00 0 1.01 72.96
22 INT145726 Binding of Abcb1a and Alms1 1 0.32 0.48 0.56 70.12
23 INT85565 Oprd1 Regulation of KCNJ6 1 0.00 0 0.51 69.68
24 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34 69.04
25 INT544 Binding of ALB and GC 1 0.13 0 0.55 68.72
26 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2 66.08
27 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31 65.56
28 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16 63.36
29 INT209130 Binding of Riok3 and Sugt1 1 0.00 0.44 0.4 59.84
30 INT209133 Binding of Bcl2a1a and Riok3 1 0.00 0.44 0.4 59.84
31 INT160880 Pld2 Positive_regulation of Oprm1 1 0.07 0.08 0.63 56.76
32 INT160882 Pld2 Positive_regulation of Gene_expression of Oprm1 1 0.06 0.08 0.63 56.76
33 INT267644 Binding of Das and RLS 1 0.06 1.04 0.35 52.40
34 INT296786 Gopc Regulation of Positive_regulation of Il1 1 0.02 1.37 0.77 50.72
35 INT296798 Gopc Regulation of Positive_regulation of TNF 1 0.01 1.37 0.77 50.72
36 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77 50.32
37 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77 50.32
38 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76 50.32
39 INT121551 Binding of CYP2B6 and Regulation of CYP3A 1 0.21 0 0 50.00
40 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0 50.00
41 INT121550 Binding of CYP2B6 and Regulation of CDH17 1 0.01 0 0 50.00
42 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0 50.00
43 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0 50.00
44 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0 50.00
45 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62 49.84
46 INT113931 Mors1 Positive_regulation of Gtpbp4 1 0.02 0 0.67 33.52
47 INT160881 Positive_regulation of Oprm1 Positive_regulation of Positive_regulation of Pld2 1 0.05 0.08 0.48 30.16
48 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 24.72
49 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8 5.00
50 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26 5.00
51 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78 5.00
52 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
53 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65 5.00
54 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65 5.00
55 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65 5.00
56 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65 5.00
57 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
58 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
59 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
60 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45 5.00
61 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
62 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
63 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
64 INT199285 Tg(Foxn1)E1Hon Regulation of Gene_expression of Mapt 1 0.01 0.52 0.36 5.00
65 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
66 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
67 INT312803 F2 Positive_regulation of NPEPPS 1 0.01 1.32 0.32 5.00
68 INT312802 F2 Positive_regulation of Binding of NPEPPS 1 0.01 1.33 0.32 5.00
69 INT199286 Tg(Foxn1)E1Hon Regulation of Gene_expression of Oprm1 1 0.13 0.32 0.28 5.00
70 INT44441 GNRH1 Positive_regulation of Localization of FSHR 2 0.15 0.86 0.26 5.00
71 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26 5.00
72 INT271852 Ngf Positive_regulation of Gene_expression of tf 1 0.34 1.36 0.21 5.00
73 INT271853 Ngf Positive_regulation of Gene_expression of Egr1 1 0.53 1.36 0.21 5.00
74 INT210551 Binding of KCNH2 and KCNE2 1 0.08 0 0.19 5.00
75 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17 5.00
76 INT260363 Gopc Regulation of Oprd1 1 0.16 0.41 0.15 5.00
77 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11 5.00
78 INT199284 Binding of Polr2a and Vmn1r66 1 0.00 0.19 0.11 5.00
79 INT280451 IER5 Positive_regulation of Phc1 1 0.00 0.56 0.09 5.00
80 INT311083 DST Regulation of FOS 1 0.03 0.15 0.08 5.00
81 INT300246 Binding of ABCB6 and HSR 1 0.11 1.86 0.08 5.00
82 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08 5.00
83 INT230883 Binding of IGHE and tryptase 1 0.01 0.23 0.07 5.00
84 INT230868 Binding of MCS and TNF 1 0.04 0.77 0.05 5.00
85 INT311082 DST Regulation of MAPK8 1 0.02 0.07 0.04 5.00
86 INT217075 Binding of Acsm3 and Slc26a4 1 0.04 2.11 0.04 5.00
87 INT230882 Binding of MCS and tryptase 1 0.03 0.23 0.03 5.00
88 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 5.00
89 INT246480 Binding of ALB and SHBG 2 0.14 1.45 0.03 5.00
90 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0 5.00
91 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0 5.00
92 INT300244 Binding of HLA-B and HSR 1 0.08 0.95 0 5.00
93 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 0.00 1.39 0 5.00
94 INT334922 GNRHR Positive_regulation of Gene_expression of PLOD1 1 0.08 0.53 0 5.00
95 INT334919 GNRH1 Positive_regulation of Gene_expression of CGA 1 0.03 0.52 0 5.00
96 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 5.00
97 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0 5.00
98 INT191577 Binding of Pde6b and Tst 1 0.02 0.48 0 5.00
99 INT347265 Gbp1 Negative_regulation of Maoa 1 0.00 0 0 5.00
100 INT315856 FLT3 Positive_regulation of Gene_expression of PDGFA 1 0.01 1.15 0 5.00
101 INT334917 GNRHR Positive_regulation of Gene_expression of FSHR 1 0.05 0.53 0 5.00
102 INT270758 GNRHR Positive_regulation of Localization of FSHR 1 0.08 0.68 0 5.00
103 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 0.01 1.39 0 5.00
104 INT334920 GNRH1 Positive_regulation of Gene_expression of PLOD1 1 0.16 0.52 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for methadone. They are ordered first by their pain relevance and then by number of times they were reported in methadone. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
2 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 100.00
3 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 100.00
4 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 100.00
5 INT1782 Regulation of Gh1 125 0.62 22 55.74 100.00
6 INT3112 Regulation of Odc1 39 0.62 4.73 13.69 100.00
7 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 100.00
8 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 100.00
9 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01 100.00
10 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 100.00
11 INT416 Regulation of LH 253 0.62 31.48 125.55 100.00
12 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 100.00
13 INT184 Regulation of Ephx1 10 0.60 0.54 3.27 100.00
14 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23 100.00
15 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56 100.00
16 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 100.00
17 INT546 Binding of ALB 311 0.48 85.98 60.14 100.00
18 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
19 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 100.00
20 INT17145 Binding of Cyp2c22 19 0.42 1.39 6.8 100.00
21 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 100.00
22 INT16404 Regulation of CD4 54 0.61 33.05 10.29 100.00
23 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 100.00
24 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28 100.00
25 INT2396 Regulation of Maoa 25 0.62 6.04 13.27 100.00
26 INT878 Regulation of Gene_expression of Gh1 13 0.43 1.13 6.98 100.00
27 INT2219 Regulation of Gene_expression of LH 11 0.45 0.79 6.73 100.00
28 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
29 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69 100.00
30 INT113806 Transcription of CYP2B6 7 0.67 1.75 1.73 100.00
31 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79 100.00
32 INT53546 Negative_regulation of Binding of CYP2B6 5 0.43 0.24 1.67 100.00
33 INT81766 Binding of Cacna2d2 7 0.23 2.57 1.25 100.00
34 INT7035 Regulation of CGA 87 0.45 29.04 28.45 100.00
35 INT1378 Negative_regulation of Regulation of Prl 27 0.43 9.16 9.9 100.00
36 INT27687 Regulation of Cp 20 0.53 9.75 10.8 100.00
37 INT94776 Binding of MT1E 1 0.35 0.15 1.29 100.00
38 INT28168 Regulation of Binding of Cyp2c22 1 0.39 0 0.9 100.00
39 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89 100.00
40 INT20083 Regulation of Regulation of LH 11 0.61 0.57 6.89 100.00
41 INT42769 Regulation of CNP 1 0.43 0 0.67 100.00
42 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12 100.00
43 INT19072 Regulation of Gene_expression of Ache 14 0.62 2.74 5.29 100.00
44 INT29229 Regulation of NCOR2 20 0.42 5.75 8.08 100.00
45 INT3644 Regulation of Grhpr 7 0.28 0.92 3 100.00
46 INT20230 Negative_regulation of Positive_regulation of Alb 15 0.56 12.44 4.11 100.00
47 INT41222 Regulation of Localization of HTC2 2 0.24 0 1.29 100.00
48 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 100.00
49 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
50 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52 100.00
51 INT2436 Regulation of Regulation of Ephx1 1 0.47 0 0.51 100.00
52 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 100.00
53 INT67589 Gene_expression of MT1E 8 0.51 7.52 1.09 100.00
54 INT136980 Negative_regulation of Positive_regulation of Nr1i2 1 0.48 0.33 0.72 100.00
55 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 100.00
56 INT5300 Regulation of Insr 54 0.60 11.33 29.26 100.00
57 INT13743 Regulation of Gene_expression of Avp 30 0.62 6.9 11.66 100.00
58 INT36616 Positive_regulation of Binding of ALB 8 0.67 3 2.07 100.00
59 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 100.00
60 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
61 INT197197 Localization of DURS1 1 0.49 0 0.9 100.00
62 INT19279 Negative_regulation of Negative_regulation of IL2 3 0.43 1.62 0.79 100.00
63 INT29230 Regulation of Binding of NCOR2 2 0.08 0 0.79 100.00
64 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 100.00
65 INT38432 Gene_expression of GPHB5 2 0.49 0 0.4 100.00
66 INT9905 Gene_expression of DECR1 11 0.75 2.49 2.43 100.00
67 INT38433 Gene_expression of GRHPR 3 0.06 0.42 0.48 100.00
68 INT122448 Regulation of Gene_expression of ABCB1 13 0.62 3.67 3.5 100.00
69 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 100.00
70 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 100.00
71 INT77665 Binding of Nme4 1 0.02 0 0.54 100.00
72 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 99.98
73 INT83682 Positive_regulation of Abcb1a 22 0.68 3.3 15.6 99.98
74 INT45427 Positive_regulation of Cacna2d2 20 0.49 11.89 4.85 99.98
75 INT38858 Positive_regulation of Gene_expression of SGSM3 5 0.49 4.15 3.05 99.98
76 INT75521 Positive_regulation of Positive_regulation of SGSM3 13 0.67 7.99 13.54 99.98
77 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 99.98
78 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 99.98
79 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 99.98
80 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97 99.98
81 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 99.98
82 INT21186 Negative_regulation of Binding of Ptprg 28 0.44 1.78 27.04 99.98
83 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 99.98
84 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 99.98
85 INT1850 Binding of OXA1L 77 0.48 7.61 15.22 99.98
86 INT82185 Positive_regulation of Negative_regulation of TP53BP2 1 0.36 1.01 0.96 99.98
87 INT2397 Gene_expression of Maoa 12 0.77 11.85 3.88 99.98
88 INT1558 Positive_regulation of Dnahc8 30 0.69 5.78 22.19 99.98
89 INT34402 Regulation of Localization of Tshb 3 0.39 0.66 2.09 99.98
90 INT34403 Regulation of Tshb 2 0.23 0 1.06 99.98
91 INT54707 Positive_regulation of Adrbk1 14 0.67 0.51 9.51 99.98
92 INT73870 Positive_regulation of Regulation of Adrbk1 1 0.47 0.17 1.66 99.98
93 INT27316 Negative_regulation of TPO 7 0.38 7.26 4.42 99.98
94 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 99.96
95 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 99.96
96 INT212171 Gene_expression of CDIPT 5 0.37 2.58 2.92 99.96
97 INT45724 Positive_regulation of Lipc 2 0.08 0.84 0.58 99.96
98 INT50580 Binding of PPIG 39 0.36 11.17 12.34 99.92
99 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 99.92
100 INT21087 Negative_regulation of Ppp3ca 2 0.32 0.31 0.58 99.92
101 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 99.90
102 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.84
103 INT10284 Binding of ORM1 16 0.48 0.98 7.73 99.84
104 INT274389 Regulation of CDIPT 2 0.09 1.69 2.96 99.84
105 INT12412 Binding of MPG 21 0.47 3.92 4.94 99.84
106 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 99.84
107 INT23767 Positive_regulation of SERPINA7 6 0.67 1.96 1.2 99.84
108 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11 99.84
109 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 99.84
110 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44 99.84
111 INT117328 Negative_regulation of Abcb1b 4 0.42 1.44 1.04 99.84
112 INT18585 Regulation of Ugt1a10 4 0.03 0.54 2.69 99.84
113 INT110270 Negative_regulation of Regulation of Ugt1a10 1 0.00 0.15 0.87 99.84
114 INT48883 Negative_regulation of GRIN3B 19 0.54 14.53 11.5 99.84
115 INT9895 Binding of GHR 18 0.36 4.8 5.65 99.84
116 INT876 Localization of Gh1 843 0.80 67.75 340.82 99.82
117 INT234 Binding of Alb 151 0.48 52.34 32.97 99.82
118 INT425 Localization of PRL 455 0.81 189.64 144.8 99.82
119 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95 99.82
120 INT65519 Regulation of Gene_expression of Reg1 1 0.01 0 0.89 99.82
121 INT205497 Binding of NOLC1 13 0.35 15.91 0.91 99.82
122 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 99.80
123 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 99.80
124 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 99.80
125 INT128393 Negative_regulation of Binding of Chrna7 1 0.07 0 1.08 99.80
126 INT59 Regulation of Adrb1 25 0.42 8.32 9.78 99.80
127 INT162411 Gene_expression of Bhd 1 0.16 0.44 0.6 99.80
128 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 99.78
129 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75 99.78
130 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 99.78
131 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15 99.78
132 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 99.78
133 INT56941 Negative_regulation of Aox1 1 0.35 0 0.69 99.78
134 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 99.76
135 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 99.74
136 INT65521 Positive_regulation of Psen1 1 0.43 0 0.66 99.74
137 INT3645 Positive_regulation of Grhpr 17 0.42 3.64 6.06 99.72
138 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 99.72
139 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 99.72
140 INT3682 Binding of Ppr1 10 0.42 1.87 2.96 99.72
141 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73 99.72
142 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.70
143 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.70
144 INT50581 Regulation of PPIG 26 0.55 8.96 4.32 99.70
145 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 99.70
146 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 99.68
147 INT24871 Negative_regulation of Binding of IGHE 10 0.58 2.87 2.64 99.68
148 INT22946 Gene_expression of MBD2 4 0.25 0.26 0.98 99.68
149 INT197137 Regulation of Negative_regulation of BDNF-AS 1 0.05 0.65 0.18 99.68
150 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.66
151 INT3359 Regulation of YY1 32 0.60 8.19 19.2 99.66
152 INT72011 Positive_regulation of Binding of Ptprg 42 0.50 2.72 39.89 99.64
153 INT1898 Regulation of Crh 220 0.62 61.33 102.64 99.64
154 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 99.64
155 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 99.64
156 INT36698 Binding of CHRM3 5 0.48 1.97 1.49 99.64
157 INT163162 Gene_expression of Crot 2 0.57 1.13 1.82 99.64
158 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 99.62
159 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 99.62
160 INT125108 Binding of Chrna7 4 0.47 0.8 2.03 99.60
161 INT3630 Localization of Tshb 12 0.60 1.8 4.46 99.60
162 INT13467 Positive_regulation of ABCB1 36 0.68 9.68 8.95 99.58
163 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66 99.58
164 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.56
165 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.56
166 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 99.56
167 INT57189 Negative_regulation of Gene_expression of Chat 5 0.56 1.35 1.07 99.56
168 INT60145 Regulation of Negative_regulation of Ltp 4 0.23 1.82 4.09 99.56
169 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 99.56
170 INT61118 Gene_expression of Nefl 11 0.75 4.02 4.02 99.56
171 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 99.54
172 INT64973 Negative_regulation of ZNF525 1 0.14 0 0.73 99.54
173 INT38859 Gene_expression of SGSM3 14 0.75 12.98 4.09 99.54
174 INT7909 Positive_regulation of Positive_regulation of Got1 8 0.49 6.44 3.06 99.54
175 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 99.52
176 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.52
177 INT36581 Binding of Orm1 6 0.48 0.47 1.73 99.52
178 INT85564 Negative_regulation of KCNJ6 6 0.25 0 3.24 99.52
179 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93 99.52
180 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53 99.52
181 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.50
182 INT21185 Binding of Ptprg 213 0.47 13.49 157.75 99.48
183 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.48
184 INT98146 Negative_regulation of Niacr1 4 0.43 0 2.21 99.48
185 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 99.46
186 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.44
187 INT1138 Positive_regulation of IgG-2a 16 0.68 5.59 8.11 99.44
188 INT67704 Negative_regulation of Negative_regulation of CYP2B6 3 0.41 1.69 1.66 99.44
189 INT44971 Positive_regulation of Dhrs4 3 0.60 1.08 0.61 99.44
190 INT65520 Gene_expression of Reg1 4 0.20 1.45 1.97 99.44
191 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 99.40
192 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 99.40
193 INT2671 Positive_regulation of Odc1 82 0.70 11.03 29 99.40
194 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 99.40
195 INT117329 Regulation of Abcb1b 1 0.44 0 0.89 99.40
196 INT8775 Binding of IGHE 167 0.48 102.61 23.54 99.40
197 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14 99.40
198 INT612 Positive_regulation of Orm1 15 0.68 5.24 6.73 99.38
199 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 99.38
200 INT187 Positive_regulation of Ephx1 17 0.69 0.51 3.69 99.36
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